Chloé Picq. To cite this version: HAL Id: tel

Transcript

1 Relations neurodigestives et stimulation vagale basse-fréquence chez le rat anesthésié : implications du système nerveux central et du système immunitaire Chloé Picq To cite this version: Chloé Picq. Relations neurodigestives et stimulation vagale basse-fréquence chez le rat anesthésié : implications du système nerveux central et du système immunitaire. Sciences agricoles. Université de Grenoble, Français. <NNT : 2012GRENV037>. <tel > HL Id: tel Submitted on 9 Jan 2013 HL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L archive ouverte pluridisciplinaire HL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.

2 BCDEE BCDEFBFBEC FDBEE BD D F ECDE ECDCBEE DDEC EDFB FE ED B BB EDBE B BE CBDD FC ECFDDED C B CBEE EBEE E DDBCBE Université Joseph Fourier / Université Pierre Mendès France / Université Stendhal / Université de Savoie / Grenoble INP

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48 FFFFFFFFFFFFEFEFE F FF FFE FE E FE FFE FE FFEEEEEEEFFFEEEFDFE FDFEFEFFFFF EEEEEFEEEFFEFEFEEEFEE EFEEEEFFEFFEEFEFFFEFF EE EEDF F FE EFFE F FFEFFEFFFEEFFFFFF EEFEFFEEFEEFE CE EEEECDEBBFFFBEF FFFEFFFEF CDFD FEFFEFEEEEEFEEEEFE FFEEFEFEEFEFEEDFFFF FFFFEEFFFEFFEFFFEFE EFFFEFFEFEFFEFFFFFF FEEDFFEFFFE EFEFFFEFEFFFEF FEFFFFFFFFEFEFFFEFFEFFE EFFFFFFFFFFFEEF FFFFFFFF FF F FEE EFF FF FE EF EEEFFEEEFFEFEFEFFEFEFE FEECFFFFEFFEFEFFFEFFE BCDEFFFEFFEBBFEFFF

49 FFFEFFEFFECF FEFEFEFFFEFEFFFEEEFEFF FFEFEFFEFFEEEFEF FEFFEFEFFF FFEFECFFFEFFEEEFEF FEFFFEEF FEEFEFFFEFF EFFFFFFFFFF EFFEFEFEFFFFEF EFFFFEFFFEFFEF FEFEFFFEFFEFE F FFFFFFFFFFFFEF FF FE FFE FE FE F FE FE FE FE F FE FE FE F FE FE FE EFEFFEFFFFEFFEFFFE FFFFF F F FF F F EF F E E EFE FFE F FE EFE EFE FF F E F FFFEFFEFFEEFEEFE FFFEFFFCEFEDEE FEDFEFEFEFFEEFFFFFF FFFFEFFEFF ECEC FEEEFFFEFFEFEEF FFFFFEFEFEFFFEEFFE FFFFEFEFFFEFEE FEFEFFEEEFFFFFFEE FFFFFEFEFEFFF F F FF F F F F F F F EFFEFFFFFFFEFFEDFEE FEFFFFBEFE BCDEFFFEFFEBBFEFFF

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51 EFFFFFFFFEFEFFEE EEFFFEFEFEFEFFEFEFFEE FEEFFFFFEFEFDEFEFE FEFFFFFEEEEFFFE FFFFFEEFEFEFEEEFE FEFFFEFEFFFFFF FFDEFFEFEEFEEFFFF E F EE F F FEFFF F DE E E F FF FFF FFFFFEFFEFEFFEFEEFEEFF FFFEFEFEFFEFEFFFF FFFFFEEFFEEFEFFEEFFEFF F FE EF F FFF FF F F FEEFFFEFFEEFEEFEFFFEFEFFFFE FF DDC C C CC CE CEECE B EDDCCCCCDE FEEFE FFEFEFFFF FFFFFFEFEFFEFF FE E F F FF FE FEFFEFEFEFEFFEFF FFFFFFFEFFFFFFF FFFFFEFDEFEEFEFE FFFEFFEFEFEFEFDEF FFEEFFEEFEFFFFEFFFFFFEDFE BCDEFFFEFFEBBFEFFF

52 EFFEEFEFFEFEFFFE FFFFEFFE E FEEDFFFFEFFFFFF EFEEFFEFFEFEFFFEEFFEE FFEFFFFFEFEEDFFFFE DFEFEFFEFFFEFFFEFF F EF F EF FDF F F FEF F FE EFEFEFFFEFFFFFFEEEFEFEFEEFE FEFEFFFFEEEFFEFEFFEFE FEBFEFEFFE F F FEFF F EFE FFE F FE EFEFDFFFEFFDFFFFEFFEFFFF E F FE F F EF FF F F F F EFFFDFEFFFFFFFFFDFF FEFFFEFFFEF F F EFDF F F F E FFFEFEEDFEFFEFFDF EEE FEFFEFEFFFFFEEFEFE FFEEFFEEFEFFEFFEEFEEFFFEFFFFE FE FE FE F FE FFE EF FF F FFEFFEFEFEFEFFFEFEFF EEFEFFFFEFECFFFFFFEFE F BCDEFFFEFFEBBFEFFF

53 ECC FFEFFEFFEC FECCFC FB FEFFEFEEFFEFEEEFFFEFFE FEEFEFFEFEF EFFF FEFEFEEEFEFEFEFCFFEFF FFEFEEEEEFEEEEFE FE FE E EE E E FE EEE E FEFF FE FEEEEFFEFFFEFFDFF EFFEFEFFEFFFFEEF FFEFFFEFEEFFEFFEFFEFFFEFE FFFEFEFEFFEFFEF FE FEFECCFEFFFEFEEFEE FEEFEFFFFEFEFFFFFFFEEFEF BCDEFFFEFFEBBFEFFF

54 EEFEFEFFFFEFFEC FFFFFEFFFFEDFEFFC FF FE FFE C F C FE EE FE FF EF F FFCFEDFFFEFFEEFF FFEFECFEFFFECFEFEFF EEE o FECEFFFEFFFEE FFFECFECFFCFECFEF FFFFCFFFF FEFEFFEFEFEFFFEEEEFC EEFEEFFEFEEEDF CFCEDDEFFFEDF FCFE CFCEDDEFFEDF FEF CFCED D EF F EDFFEFFEF CFCEDBEDFEEFEFFFFE FFEFEFECEDFFF CEEFFFFFF FFEF FEEFFFCBCFCFBCFFE E FE FE FE FE E FE E F FE EFFFF o FECEFFFEFFFFEFE FECFECFFEFEFFEFFEF FEDFEEFE FEFECFFFFFFCEFFEEF FFEFEFFEFFFFEFEEFEEEF EFFFEEEEEEEEFEFFF FFFFEFFEFCFFEFFEFFEFEEEFFE FFFFFFFFEFFEFE BCDEFFFEFFEBBFEFFF

55 FEFECFFFFEFFCFFF EFEFFEFEFFFFFFEFEFEFFEF FECEEEEFEFFFFEFEFFEFEEFE FEFEFEFEFEFFFEFFEEFFE FECFFFEFEFFFEFFEEF FEEEDFFEEFEFFF FF FEFEFEFFFEFFEFEFEEF E FF EEFEF EE F FF E FF F EF FFFEDFFFFFEFFEFEFF FFFFFFFFFCFFFFFF EFFFFFEFEFEFEFFEEFFEDFE EEEEFEEFFFEFEEFFFFEFE EDEFFEEFFFFFF FB D FEFFEFEFFEFFEEFFEFFE FEFFEFEFEFFEFFEFEFE FEFFFEFFEEFDEF FEFEFEEFEFEFEEEFE o FEFEFFEFEFFFEFEFE FEFDFEFFEFFEFFEFFFE FEFEFEFFEEFEEEE EFFFFFFFFFEFF FFFFE o FEFEEFEEEEEEFEEEEEFF FFFEFEFFFFFFEFEF EF o FEFEEFEEEFEEFFFF EFFEEEDFFFFEEDF EEEEFEFFFEFEFEE FEEFEFEEFFEFF BCDEFFFEFFEBBFEFFF

56 o FE EFE E E E E FE EEE F F FFFFEFFEFEFEFEFFFF EFFEFFFFFEFFF F EF FE FFE F F F F EE E E E DF F EF F E FE FFE F FE FE FE F F EF F FEFEEFFFEFEFFEEEFEFEFE o FEFEFEFEFFEFFEFFEFEE FEFEEFEFEEEEEEFFFF FEFFFEFFEEFFEEFF FFEEEE o FE FE F E FE FFE FE F F FFEFEEEFEFEFFFEFE FE F EE E FF E EF F F FE E FEEFFFFEFFEFEEFE FE E FE EEE FF FFE FE FE FF FFFFFF o FEFFEFFEFEFFEEFFFEFEEEFE FFE FFE FE FF F EF F F FFE FEE FE FE F DFE E F F F FE FEFFEEEFFEEEFEEEEF EFFEFFFFFFEFEEFFF FEFFEFECFE FFE F E FE EEF FE FF FE FE FEEFFEEFFFEDFEFECFE FFFFFEEFFF FE FEFFEFFEFEFFFEFFEFEFFE FFFFEEFFEFEFEFEFFFFEFFEFEF FEFEFEFEEEEFFEEFFFFEEE EFFEEEFEFFEFEEFEFEE BCDEFFFEFFEBBFEFFF

57 BCDEFFFEFFEBBFEFFF FFFEEEFFFEFFFFFEFEE FEFFFFF E DDC EDDC C CC E FFE EFFFEC FEEF FEFEEF EE FEEF FEFEEF EE EFFF F C FFFFF EFE CEE F F F FFEFFE F EEDDCCCECCEFF FCFCFFFCFCFCFFEC FEFFFCFFFC EFFEFEFFFEFF EFFFEFFEFFFFEFECF FFEFFDFFFFFFCFFDFE FFFEFFEFFEEFFEFEFE EEFFEFEFFFEFFCFF FFFEFFFCDFFEFFFFFFEC FFFEFFCFEFECFFFEEFFEFEFFEFE

58 FFEFEFEFECFEFEFFE FEFFEEFF FEFECFFFEFEEFFFCF EFEEEFFEFCEFFFFF FFEFEFEEEFFCFEFFFF EECCEFCFFEFFDF CFC DCCBBD D FFEFFEEFFFFEE FFEEFFEEFEFFFFFFF EFFFEFFFEFFEFFFFEEFEE FEEEEEEFFEFEFFEEFF FEFFEFFFFFEFFFFF FFDFEFF FEEFFEFEFE FEFFEFEEFFEFEFFEFEEFEEDFFE FEFEEDFDBEFFEFEFEFFEFE EFFEFEFEFEFFEFFEFFEEFEFEFFEE EFFEFEEFEFFFFFFFFFEFEEFEFF FEFEEFEEFEFEFEC FEEEFEEFEFFEFEFEFDFEF FFFEFEFECFFF FFFECF BCDEFFFEFFEBBFEFFF

59 E EF E F EF F F FE F EFEFEEFFFFFFFFF FEFEFEFFEFFFEFEFFFF FEFFEFF EDEFFEFFEFEFFEEEEFEE F EF F FE FFE FF FE EEE E F FE FE FE CFEFEFFEFFEFEEFEFFFFFFF FF F F FE EF FEEFEFEEEEFEFEEFFFFE FE E EE FE F FE FE FE C FFEFFEFFFEFEE FFFFEFFEEFFFEFFEFE EFEFFEFFFEFECFFFF EFFFFFFFEFEEEFEFFF BCDEFFFEFFEBBFEFFF

60 BCDEFFFEFFEBBFEFFF C E CC FEFEFEC FFEFFEEFE FEFFEEFEEEFE EFE FFDF FECFE FFE FECFFE FEFEEFEC FEEFEFFEEFE EEFEEFEFFEFEFE FF FFFEDFE FEFEFFEC FEEFEF EFEFFEEFEEEFE FF FFFEDFE C FEF FEFFFECE FFC C FF C FFF FEFEF FC F FEFE F FEFEFE FFEFFEFFE FF FEFFEFEFE EFFF EE CEFE FEF FE FECFFF CCFEFE EFE F FFEFEC EEDCCEECDC

61 ECEE FFFEFFFEFFFFFFF FFFEFEFEFEFFFEFEEFFEFEEDFFE FFEFFFFFEFFEFEFF FFFFFEFFFFEFEFEEFEFFEFFE FFEFEFFFE FDCFDBFDFDFBBFCD EFFFFFEFFFEEFFEFFEFFE FEFEEFFEFFFF FEFFEFFFEFFFFFFEFFEFFE FEFFEFFEFEEFEFECFFEFEF FEFEFEFFEFEFFEFEFF EFFFFFFFFEEFFEF FFEFFFFEFFFFEFFEF F FF F EF F F FF F EFFFEFECFEF FEFFFEEEEFECFEEFFE FEFEFFFFFFFFFEDFEFFE EEEFFFEEFFFEFEFEEE CFFEFEEFEFFEFE FFEFFFFEFEECFF EEFFFEFEFEFFEFFFFFE EFFEFEFFEFEFEFEFFCFE FEEEEFFEFFFFFEEFE FEFFEEFEFFEFEFFFFF FFFFFFCFEEFFFF FFFFF FFFFEFFFFE FFFFFEF BCDEFFFEFFEBBFEFFF

62 CBD D FFEEFEFFFFFEFFFFF FFEFEFFFFEFFFFEFEFFFE FFFFEFFEFFFFEFFFFFF FFFEFFEFFEFFFFEFFFDF FFF FEFFFFEFF F FFFF EFF FFF EEDDEFCDDEDDCF FFF F FE FF F F E F EF F F FE FE EFFEFFFCEFEFFFEFEEFFFF FFFFFF FFFEEFFFEEFFEEFFFFEFFEE FFEEFFFEEFEFEFEFEFEEFE FEFEFFEFFEFEEEFFFFFEEEFEEFF FFEFEEEE BCDEFFFEFFEBBFEFFF

63 FFFFFEEEEFEEEFEEFEF FEFFEFEFECEFEEFF FFFEFFFFFFFFEFEFE FFEFFEFFEFEFEFEF ECE FFEEFFFEFEFEEFEFFF FE F FF EE FF F EF F F F FE FEEEFFEEFFEFFEEFE FFFFDFFEEFFF EF FFFFFEDFEFFFFFEFFF EF E F EEDF F EF FF FEFF F E E FF EFFFEFFEFEFFEFF FFFEFFFFEFEFFEFFF FFEFEEEFEFEEFEFDFEFE DFEFFFEEFDFEEFEEFF FFFEFEFFEFFEFEFDFEEFFFE CFFFEFEFEFFEFFE FEFFFFEFFFFEFEFE EEFFEEFEEFFFE EFDFECFEFED FE FF F FF F F EF F FE FE EFE FE DFE E E F E F FF F BCDEFFFEFFEBBFEFFF

64 FFFFEFEFFFEFFFEFF FFFEFFFEEFFFEFF FFFFFEFFEFEFEEFFFFEFFFE D FFFFEFFEDFEFFFEF EFEFEFEFFEFEFEFEFFE FEFFDFEFDFFFFEFEFEE EEFFEFE DCCBBC D FFEFFFFEFFFFFEFFEFE EFEFEFFFFEEFEF EFFFFEFEFFEFEFFEFFDFEFFFE EFFEEFEFEFECF FEFFFFEFFFEF FFEFEFFFFFFFEFF FFFFEFFFFFFFFF FEEEFFFEEFEFFF FFFFFFFFFFEFFEFFE FE E F EFF F EF EE F F E FE FFE FFE EF EF FE FFE FEEFEFEFFFFFFFEFEFFEFE FFFFEFFFEEFFEFEFEFEFF FEFEFFEEEFEFFFFF FFFEFEFEFEFEEFFF FEEFF EFEFEFFEFFFFF FFEFFFEFFEFFEEEEFF FFFEFFEEFEFEF FFFEFFFFFEF FFFEFFFEEFFFFFDF EFFFEFFFFFFFFEFF FFFFEFFFEFFEEEEE BCDEFFFEFFEBBFEFFF

65 FFFFFEFFFEFFF FEFEEF FE F E F F EFF F FE E EF F FFFEFDFFFEFCDEE FFEFFFEFFFFFFFEFFF FFFEEFFFFEFCEF FEFFFFFFFFEFFEFFFF FFEEFFFFEFCEF FFEEEFFEFFFFFFFF FFFFFFFFFFFFFF FEFFFFEFFFFEEFF FFFFFEFFF FEFEFEFFEFFFFCFEEE FFFFFFFFFFFE FFE FE EDF FE FEFE FE FE FE FFE FFEFFFFFFFFFFEFFEFFF FFFFEFEFFFFFF F F F F FF F F DF EF FF F F E FF F F EF FE FFE FFEFFFFEEFFFFEFFFEF FEFFFFEFFFFFFFEFFE EEFEFEEFFFFEFEFE EFEFFFFFFFFFFFEFE FECEFEFFFFFE FFFEFECFEFEC FFFFDEEBFEFFE EEFEFFFFFEFEFE FEFFFEFFEFEFEFF FFEFFEFEDEFE EFFFFFFFEEFFFF FFFFFFFFFFF FFFFFEFEFEFEFFEFE EFFFF BCDEFFFEFFEBBFEFFF

66 ECECDCDECFC EEFEFFF ECEDEFFFFE FEFFEFEFEFFFFF FFFFFFEFFEEFEFFFF FEFFFEFEFEFFEFFFF BCDEFFFEFFEBBFEFFF

67 DCCE FEEFEFFEFFEFEFFF FF F FF FE F F EDF F B EFEFEFFDFFEF F E FE FE FE FE F FE FE FF EF FFFFEFEFEFEEFEFEFFFEF EFEFEEFFEFEFFFFFF FFFFEFEEFFFFEFFF FEEDFEFFEFFFEFEFEF FCFFFEFEFFEFFE FFEFEEFF FEFFFFFFFEE FEFFFEFFEFFFEFFF FFEFFFFFEFFEF FFFFFFFEFF FCBCFCBCFFFEFEF FDEFCBCFEEFEFFEFDEFCFEEF FF FEFEEFFFFFFFFFEFFFFFE FFFFEFEFFEFEEEEEFFFF EEEFFEFEEFEFFFEFFFFE FEFEFFFCF FEEFFEFFDFBFFDF FEEFFFFFCFEEFFFFE FFEEFFFEFFFFDFFEFF FEFE FFE FE FFE FE E F FE FFE F F F FE FFE FEFFFFFDFFEFFFFFF EFFFEFFCFFFEFFF FFEFFEFEFEFEFFEFFFFEFEF BCDEFFFEFFEBBFEFFF

68 FF FEF FE F FE FE F FE C FF FFFEEFFFFBFFFF FEFFEEEFFFEEFFEFEFFFF FFE DFF E FE FE E FF F FEFFEFFFFEFEFFFFEEFE FEEFFFFFFFEFFFFFE FFEFEFFEFEFCFEEDFFEFE FFFEFEFFFFFFEFF FFFFFEFEFFFDFEFE FFEFFFEFEFEFFE EFFFFEFFFFE FEEFEFEFEEFEEFEFF FEFFEFFFFFEFEEEFFEF FEDEFFFEEFFFFEEFEFE FFEDEFEEFEFEEEFEFEEEEFEFFFFE FFFFFFEFFEFFEFF FEFFEFFE FEEFEFFEEEFEEFEFFE FE E E F F FE FE EE FE F FE EEFFFFEFEFEEFFFFFFF FFEEFEEDFEFEEFEEFEEFEFEEFEF FFFFFFFEFFFFFFFEFEC EEFEFEFFFFEFEEDFEFFEEFFE EEFEFFEFEFFFFE EFFFEFFEFFFEFFEFFFFE FFEEEFEFFEEFFFFFEFE FEFE BCDEFFFEFFEBBFEFFF

69 FFFFEEFFEFFEEFE FEFFEFEFFFFFFFEEEFEFFF FEFFFEFFEFFFEFEFFE FEFEFFEEEFEFFEEF FFFEEFFEFEEE CEDCCE FFEFFEFFEFEFFEFEDFE FEFEFEEFEFFE EFEDFEFEFEFEFEFFFE EBD ED ED C FED BBEED E F F EFEEDFFFFFEFFFFF FFEEFEFFFDF FEFEFFEFFEFEFEEFFFF FCCFFFFEFFEEEFFFFEDFEF FEFFFF F E E E EF DF FEF FEFFFDFFEFFDFEEFF FFFFFCFFDFEF FDFFEFFFFEEFEFEF FFFCFEFFCFFEEFEFEF FFEFFFFFEEEEFEEEFFFF EEFFEEEEFEEDEFEFEEE FFEFFEFEFEFFFEEEFEFFEFE BCDEFFFEFFEBBFEFFF

70 CCCC CC CC BCDEFFFEFFEBBFEFFF

71 EEEDDEEEC DE FFFDFFEEFEFFFEEFFFEEFFF EFFFFEFFFEFFFF FEEFFFEFFEFFEFFFFFFFFF EFFEEFFFFEFFFF EFFEEFFFFFFFFFF EEFFFFEFFEFFFFFFEFFFEFEFF FE F F FF F F E E EEF FF F EF E FFFEFFEFEFFFEF C FEFEFEEFFFEFFFE FEEFEEFFEFEFFFFFFFFF FEDFEFEEEFFEEEEFFE EFBFFEEEEFEFEEDFFCFE EFEEEEFFFEEFFEFFFFFFFE EFEFEEEFEFEF FEEFFFEFEFEFEFEFFEFFEFFFE FEFEFEFFEFEEEFFEEEFFFFFFE E FEEFEEEFEEFFEDEFFEEFE EEFEFFEFFFFEEFEFFEFE FFEFEFFFF FEFEFEDFEFEFE FEFDEEFEFFFEFEFEFEFEFFE FEFEFEFEFFFEFFEFFEEEFE BCDEFFFEFFEBBFEFFF

72 EFFFFFFFFFEEEFF EFFEFEFEFFEEEFEFFF FFFFFEEFFFF EFE FE FFE FE EBE E F FF FE EFEFEFFFCFFFEFF FFFFFEFFFEFFFF CEC FEFEFFFFEEFEEFEFEFFE FEEFFFFFFFF FEF FF F F F EF E FFFEFFFEFEEFEFFFE FFEFEF BCDEFFFEFFEBBFEFFF

73 DE FFFDFFEEEFFEFFEFEEFFFF EEDFFFFFEFFFFEEEF FFFEFFFFFFF FFFFFEFFFEFEFFFCF FEFFFEFFEFEFFEFFEEF FFEFFEFFEFFFFFEFFFF EFFFFFFFEFFFF EFEEEEFF EF C E FFEFEEFFFEFFEF FFFEFEFEEFFFFFF FFFFEFEFF EEFFFFEFFDFFFFFFF FE FE E E E FF FEDF F FE FFE FFE FFEFFFFFFFF E EFFEEFEEFEFE CFF F FBDFFEF DFFFEFEEFF FFFD BCDEFFFEFFEBBFEFFF

74 FEEFFEEEFEEFFEFEEDFFFFEF EFFFFEFFBDFEF FFFFFEFFBFEFE F F FF FF F F FEEF EF F B DF E CFFFFFFEFDFF EFFEEEDFFFFFFFFF FFFFFFFFEFFFFFF EFFEEFEFFFFFFFEF FFFFFEFFFFFFF FFFFFFFFF FFFEFEEFEEEFEFFF EEFFFEFFFEEFFFFF FFFFEFFFFF FEEFEFFEEDEFEFEEFEFFEF EFEFEFEFEFEFEFFFF FFDEEFFFEFFFFFF FFFFFEFFFEFFFF FEFFEFEFFFFEEFFF FFFEFEEEEFE BCDEFFFEFFEBBFEFFF

75 Haut Interne Externe Vers le stimulateur Bas ECCECFEFFF EDDECEC CCEC FDDFCDF E F F F F FF FF F EFEEFEEEFFEFFFFEFF FFFFEFEDEFEFDFFEF EEEFFFFFFFFEEEFF FFDFEFFFFFFFEFEFFFE EEDFEFFFF FFFEFFEEFFEFFEFF FFFFFEFFFFFFFFF FFFEEFFFFEFEFFEFEFEEF FFFEFFFEEEFFFEFEF EFFFEFFFEEEFEF FEFEFFEFFEFE FFFEDFEFEEEEFE BCDEFFFEFFEBBFEFFF

76 B EFFFFFFFFFEFE FFE FEFFFEFE FF F FEF F FE FFEFFFFFFEFFFEF EFFEFFFFFEEFFFEFEFEEE FFFFEFEFFFFEFFFEFEFFEEE FFFFEFFFFEFFEFEF ECCFFFFEEEFFFF FFEEEFFF ECDBFFBDEFD FFFEEEFFFEEFFFFFFEE F F F F F B E FF F FF FFEFFEFFFF E F F FE FFE EFE FE FFE E EF FE FFE F F FFE FE F FF FF FEFFFFEEFFF FFFEEEFEF BCDEFFFEFFEBBFEFFF

77 EC FFFEEEFEEFEFF FFFFFFFEFFEFFFFF FEEFEFFEFFEFEFEFFEFFEFF FEFFEFFFFFEFEFEFEF FEFEEFFEFDFFFFEEFFE FFF F E EF F E FF F FFFEF Stimulateur Electrode de stimulation EECFEEEEEFE 2V 500 µsec EECCCCEECE FFEFFFEEFEFFEFEEFF EFFFEFFFFFEFFF E FE DFE F E E F FFFF FE FFFE FEEEFFEEFEEFEFEFE FFFFFFFE FFEFEEE BCDEFFFEFFEBBFEFFF

78 FE FF FFEFE CEFEEFFEFEFFEFFE BCCECEDCCD FEFFFEEFFFFEFB EFFFFEFFFFEEFFEFE FFFFFFFEFEFEEDCED EEDEEEFFFFFEEEFFEEE E FEEEEEFFFFFFEEE FEFFFFFFFFFFF FEFFFFEFFFEFFFF FFFFFFFFFFFEF FFEEFEEFEFFFFEFFEFFEEF FFDFFFFFFFFEFFF FEFEEFEFEEFEEEDFFF FFFFEFFDFEFE F FE F FEF E E E FEF FF F B FFEFFFEFEEFEFFFFFFFFE F F F FEEE EF F FEE F F F FFBFFFFFFF BCE FEFFFEEFEEEFCFEF FEEDFFFFEEEFFFEF FFFFFFDFFFEFEFFEFFFFF BCDEFFFEFFEBBFEFFF

79 EFFEFFFFFFFEFFFFF FEFFEEFEFFF FEEFFFFEFEDDDED DEEFEEFEFEFEFEFEFE E FF F E F EFF D FD D ED FEEFCFEECFEFE FFEEE FEFEFEDFEEFEFEEEEEFEEEF FEFFEFEFEEFFEFEFEFE FEFFFFEDFEEECECE FFEFFEEFEFEEFFF FFFEFEEFF FFFEFFFFFEFEFF FFFEFEEFFEFEFFEFF FEFFFEFEE ECE FFEFFEFEFFFEFF F BCDEFFFEFFEBBFEFFF

80 CD EFEFEFEEFEBE EFFFFFFEFF FEFEEFEFFFEFFF FFFFEEFEFCFDDEEFE E FEFEEFEFEFEFFEFFF FFFCFEFEFEFEFEDFFFE FEEFEDEEFEFEFFFF FEFEDFCFFE EEF FEEFEEEFEFEE EFEEFEFEEEFE EFEFFEFFEEFFFEEFFF EFFFFFEFEE EEFEFFFEFEEFFFFFEFEF EFFFFEFEFEFEEFEF FFEFFFFEFFFFDFEFFFE F F EF F EF FF F F F F FFFEEFFF EC EFFEFFEFEFFEFEFEFFE F E DF EF F EF FEEE FEFFEFFFFFFE EFEEFEFFEEEFFE FEDFFFFFEFFEE FFFFEFFEDFEFEFEFEFE EFFFFFEFFF EEFCFFFEFFEFFEFEEDFFF FFEFEFFFEEFEFEEFEFFFE BCDEFFFEFFEBBFEFFF

81 EFFFFEEEFFEEFEDE EFEFEFEEFFEEFEFE EF C F F F F F E F F FFEFEDFEFFEEFEF EFEEFEFEFFFDFFFFCEFDF FFEFEEFFFEFFFE E BCDEFFFEFFEBBFEFFF

82 E CECDEE FFEFEEFFFEFFFEF FEDFEFEFEEEFFFFFEFE FFFFFEFFFFFFE FFEEFEEEFEEFEEEFEEE BFCCCFBCFBCFDFCDC FEEEEFFEEEFEEFF E E F F F FEFF FE EE F FE F F FFFEFEFEFFEFEFEFFEFFFF EFFFEFFFFFFFFF FFFFEFFFFEEFEFEF FDFEFFEEEF FEFFFFFFFFEFFFFF EFFF FFFFFEFFFFEF EFFFFFEFEF FFF FEFFFFFFEFEFFF FFFFFEFFFEEFFF FEFFEEEEFEEFFEFEF FEEFEFEFEFEFFEFEFEFEFEF FFFEFFEFFEEFEFE FFFFEFFDFFEEFFE FFFEFEFEFFFEDFEFEFFEE FFEFEEFFE BCDEFFFEFFEBBFEFFF

83 EDDDDDEECECEDE ECFFFEFEFEFFF EDDDDDEECEEEDE ECFFFEFEFEFFF D BFCCCFCCFDFCDEFF FEFFFEFFFFFFFEF EFEEFFFEFFEFFEFFE FFFFEFFFEFFEFFFF F FE E FE F EE EF F EF FDF EDEFFEFFDEFFEFFEDE FFEDEFFFFEDEFEFFF FEFFDEFFEFFEEFF BCDEFFFEFFEBBFEFFF

84 FF F F DE FF F E E F EF F EEEFFFEFFEEFEFFFF EFFFFDEFFEEFE EEFEFFEFEEEEFF EFFFFFFFEFFEFEEFFFEFFE FFFFFEFFEEFEFFEE FFEFFEEEFEEEE ECCDEEDCCECF CCFCFDECEFFF EFC FFEFEEFECDEDBBBDED FEFFEFFFEFFFFEEFEFF EFEEFFFEF FFFFFFEFEFFF EFFEFFFFFFEFEEFEE FFFEFFEFEEFEEEFEFFFE EFCFFEFFEFFFFEFE FFEFEFFEFEFFFFFEE BCDEFFFEFFEBBFEFFF

85 FE FE E EFE EF F E F F E F F FFFEFEFF ECEFFFFFEEEFEDF ECDEDBBBDEFFFFFF FE E E F C F EFE FEEF F F DE FEFFFEEFFFF FEFEEE FFFEFEEEFFEFFEFF FFFFFFFF EFFFFFFEEFFFFE FE FF EE FE FE FFE EFFE F F FEEDFEF B FFEFFEFFEEFEFFEEEFFF FEEFEFFFEFEFFFFFEEEF FFEFEFFEFEFFEFF FFFEFFFFFEEEFFFF EFFFFEEFFFFFEF BCDEFFFEFFEBBFEFFF

86 FEFEFFFFEFEFFFEEEFFF FEFEEFFEEFFFFFFEF EFFFEEEF E C E EC DD E E FE EEFEFFFEEEFFF ECDBFFBDEFD FFFFFFFFFFF FEEFEFEFFFEFEEEFFF FFFFFEEFFEFFFEE FEFFFEEEEFFFEDEF FFFFFFFFFE EFEEFFFFFFEFFEEFFFF FFEFFEEEFFEDEFFF EFEEFFFEFFFF BCDEFFFEFFEBBFEFFF

87 FFFEEDEFEFFEFEEFE FFEEEFEFFFFFFFFEFFFEFF FF ECECFFEEEFE FEFEFEFFFEEFEFFFFFFF EFEEFEFEFFEFFFFFFFF FEFFEFEEFF FDCDEC F F FE FFE E FE FE EFFE F FE EEFEFEFEFEFEEBEEFEFEF FEFEFEEBEFFEFFEEFFEFFE EEEEEFEFFFEFEFEFFEFE FEFFFEFEFEFEFEFFF CFEFEFEEFFFEFFEFFEF FEEEEFEFFFFCEFFF EFEFFFFFFEFEFFFEF FFFF BCDEFFFEFFEBBFEFFF

88 EECCDDCECFEFEFEEFFE DEFEFEEEFEDEFEFEFFEEFEF FFEFEFEEFEEFFEFFEE EEFEEEEFFEFE BCDEFFFEFFEBBFEFFF

89 Cervelet ECEEF FEFFFEFFEFEFFFFE FFEFFFFEFFFEFE FEFFEFEEFFFEDFFFF FFFFFFF EC EFFFFFEEFFEFFFEFE EEFFEDEFFFFEFF FF C F EF EF FE E EFE FFFDFEFFEEEFFEFFEEFE FFFE E E F EFE DE E EF E F E EF C F F F F F E FFFFECEEFEFEF FEBFEFEEFEEF EFEFEFFEFFEFEEFEFEFFFEEFEF FFFFFEFEFFFEDFEFFF EFFFEFEFEFDFEFFEFFEFEFEEFE FFEEFFCFFFFEFEFEFFFE FFEEFFEDFEFEE DFEFEFFFEE EEFEFEDFEEEFEFFFDF FFFFEFFFF EEEFFEFEEEFFFFFE DFEFFEFEFDFEFEDE FFEFFFE BCDEFFFEFFEBBFEFFF

90 FEDFEFFEFFEDEFEDFE FFEFFEFEFEFEFFFFE FFEFDFEFEFEFFFEFE FFFE EFFFEEEFFFEFFFF EEFFDFEEFDFEFFCF EFFFFEFFEFEFFEFFEFFE EFFEEEFFFFC EFFFFC FEEEFFFCFFFFEFFF FFFFDFEFFEEFDEFEFEFE EEFFFDFFEEFFFFFFE E E EE E FF EFF F F FFFEDFEFFEFEFEFFFEFFE FEDFEFFEFEFEFFFEEFFFF FFEFFFFFFFF FEFEFFFFEFFFFEFFEFFFEF DFFEEFFEFFEFEFFFEFFFE EFFFEFDFFEFF FEFEFEFCFFFFFEEEFFFEFFFE FFEEEF BCDEFFFEFFEBBFEFFF

91 ECEEFEFFFEFEFDFEFEEF EFFFFFFEFFEFFEFEFFFF FFEFFEEFFFFFEFEEEFE FEFFFFFFFFFFEFFEFFFFF FEFEEFFEDFEFEFFFFFFFEFFEE EFFFFFFFFFDFFEFEFEFE DFEEFFFFFEF CEEF BCDEFFFEFFEBBFEFFF

92 EC CDEFFEFFFEEFEFFEFFEEFFFF FFEFEFEFEFEFFEEFF EFFFFFFEFFEFEFFEFE FFFEEEFFEFEFFEF EFEFEEFEEFEFFF EEEFEFEECFEFEFEFEF FEEFFFFFFEEFFEFFEEEFF FEFEFFFFEFEFEFEEEEFE FFEFEFEFFFEEFEFEFFFEEFFEFEF EFFEDFEFFEFFFFEF EFFEFFFFEFEEFFFE DFFFFFFFEEFFEF FFEFFEFEFE EFCDEFFEFFEFFFEFF FEFFEFFFFFFF FFFFEFFFFEEFFEFFE FFFFFEFEFEF FFEEEFEFECFEFFFEFF FFFFFEEFEFEEFFEF FFFFEEFFEFEEFFEFCFFFEEFF FDFDFEFEFFEFECEFFFFEFE F E F F FEF FF EF F EEF FFFFEFDFEFEFEFFEFFF EFEEEFFEEEEEFFE FEFFEFEFEEEFEFF FFEFFFFFE DFE F E E F F E F E F FEFCFEFFDFFFFFFEF FF F E F E E FE E FEFEFFEFF FFFFFFFFE BCDEFFFEFFEBBFEFFF

93 FFFFFFFEFEFF FFEFFEFEFCFEFEEFE FEFEFEEFEFFECFFFFE FFEFFFFFFF FEEDEFFEFFEFEFEEFFEEFFF EFFEFEFEFEEFFFEEFFF FF F EF EF FE FE C F EFFEEFEEFFFFFFEFFF FEFFEEFFFEFEFFF FF FEFEFEFEEFEFEFFFFEEF EEFEEFEEFEFFEEFFFFFEFE EFFFFFEFEFEFEFFEEF FEFFEFFFEFFFE EEFEFEFFFEFFFE EEFEEFFFFDFEFEFE FFFFEFEFEFEFEFFEEFE FFFFFFF FFEFEFEEFFFFEEE EFCFEFFFEFFF FFEFEFEFEFFEEFEFFF FFFFEFFF FFFFFFEFEFEFFEFFF FEFFEFFFFFEEFFEFEF EFFEFEFFFEEFFEFEF FFFFFFFFFFEFEFEFE FFEEFFEEFEFEF FEFFFEFFFF EFFEFEFEFFEE FEEFEFFEFEFEF FFFFEEFEFEFEFE EEFFEEEFEFEFEFFEE FEEFFFEEEFEFEF FFEEEFFFFEFFEFF BCDEFFFEFFEBBFEFFF

94 EDFFFFFFEFEFEFFEFFE FEFFEFFFFFEEFEFEFFFEDFEF FEFEFEFEEFEEFFEF E F FE FFE E F F FEEF EF FE FE E EFFEFEFEFEFEFFFEFFEFEFE EE F EF EF C F EE F EE C F F EE F F FE FF F F FFEEEFEFFFFF EFEFFFFEFFEFEFEFFE FFFFEEEFFFEEF FFEFFFFFFEE FFFFFEEFEEFEEFFFEFFF EEDF F F EEDF FF F F FE FE FEEEFEFFEFFFEFEFFFF FFEFFFFFFEFFEFEFFFFF FFEFEEFEFFE FEFEFFEEFFEFEFFEFEFEFEFEFFFEF FFEFEEFFFFFFFFEF FEFFEFEFFEEFEFFFEFFEFFEFE FEFEFFFEEFFEFFFEFEFEFFEFF EFFEFEFFEFEFEFEFEFEFFFFFF FFEFFEFEFEDFFEEFEF EFFFFFEEFEFFEEFFEFE FFEFE EFFFFFFFFFEFF F FE F FF F F FFE F E EEFFEFFFEEFEEEF FFFEEEFFFFEFFEFFEFE EEFFEFEFEEFEFEE FEFFFFFEFFFFFFE EFE FF EEDF F F F EEDF EFFFEEDFFFEFEF FEEFEFFEEDFFFEEDF FF F E FE EEFE E F F E F F BCDEFFFEFFEBBFEFFF

95 FEFFFFDEFEFFEEFFEEF EFEFEEFFFFFEFF EEFFFEFEFFFFFFF EFFFFFFEFFEFFEE FFEEFEEEFFEEEFFFFFE EEFFEFFEFFEEFEEFEFFE FFEFFFFFFEF FE F F EF FE FFE F FE FFE FEFE FF FFFEEFFEFEFEEFEEFFF FFEFFEEFEEFEEFFFEF EFFFFEEFFEFEFEFFEEFE FEFEFFFFFEFF EFEFFFEEFFFEF FFEFEEFFEEEFEFF FF F F F FE E FEF E FE EEFE FFE FE E F FF E FE FE FFEFFEEFFFFFEFEFFEFE FEFFCFFEFFEFEEFFEFFF EFFFEFEEEFEFEFEFEFFE FFEEFFFFFEFEFFEFEF EFFEDFEFFFEFDFEFF FFCFEEEFFFFFFEFFEFE FFEEFEFFFFEFF FFEFFFEFFFEEEFEFFE FEFEEEFEFFFEFFFFEDFE EF FE FE FFFE E EF F FF EF FE FEFFFEFFFEFFEEFEFFEFF FEEEFEFFEFFFDFFFFF FEFEFFEFFECFEFEFEEFEFEFEE FEFEFCFEFFFFEFEFFF EEFEFEEFFFFFFEEDFF FEEDFFFF EEFFFFFFFFFEFFFEFE FFFFFFFFF BCDEFFFEFFEBBFEFFF

96 FFEEEFFFFFFFF FFFFEFEFFEFFFFFFFF FFFFEEFFFEFEEFFEFE FFEFFFEFEFFEEFFFFFF FEEFFFFFF FFFFEEFFFEFFFFEFEFFF FFEEEFFFEFFFF EFEFFFFEFEFFFFEFEFF FFFFEFFEFFFFFFF FFFFEFEEFEEEFEFFEFFEEF BCDEFFFEFFEBBFEFFF

97 CCC CC C BCDEFFFEFFEBBFEFFF

98 EEEDDECE DDEEEC DE FFFEFEFFEFFEFEFEFEFFE EEEFEEFEFFEFFFFFF F FF F FE FEEFE EF F E FE FFE FEFEF C FEEFEFFFEFEFEFFE FFEFFFEEEEFFEEFFEFFFE FFFEEEFFFFEFEFF F FFEFEEEFFEE FEFEEFEFEE FEFEEEEEEE F F FFFDEEFFFFFEEE EFEEFEFF E F FF F EE EFF FFE FE E FEEE EFF FFEEFEEEEFFEEEF EFFFFFFEFFFFEFF FEFEFEEEEFEEFEFEEF FEEFEEEF EFEFFFFFFFFBFFEEF F F FE C E FE FE E F FEFFFFFF FF FFFEFFFF FEFFFFCFEC BCDEFFFEFFEBBFEFFF

99 FFFFEEEEFFFF FFFFFFFFEFEFFEE FE EEFFFFEEEEFEEFE FFEFEEFE FEFFEFEEFEFEEFEFFFEFFF FFFFFEFCFFFEEFEEEEFEFEEE EFFEFFEFCFEEFEF FEFEEEEFEFEEEFFEFF FEFFFEFEEDFFEEFE CEC FFFEEFFFFFFEFEEF EFEEFEFFEF F F DFE FE F EF EFF EFF FE FFFEFFEEFFEEFE FEFEFFEEFEEEFFFFF F F F F F E FE FFE FE C EFEFEFEFFFFEEEFEFF FDFFFFFFEFEFFEE F F EF F DF F EF F FEF F FFF BCDEFFFEFFEBBFEFFF

100 DE EEFFFFFFFDEFEFF FFFFFEFFEFFEFEEFEFFE FEFEEFFEFEFFFE F F E E F F FE FECFEFEFEFFFFFF FF FFFEFFFFFFFFEFFEFEFEF EEDFFEDFFFFEEFEEFE FF FF F F F F E F FFFFFEFFFF FFFFEDFEEFEF EFFEEF DEFFFFFFFFFFFFEDE EEFFFFEFFEEFEFEFEFFF FEFFFFFEEFEF DF E E E F F E FF FE E DF F E F EFEFFFEFFE EEEFFFEFFFFE FDFFEFFFFEDFFEFFF FFF FFFFFFFFFFFFFEFEEFE EFFEFEFFEFEFEF BCDEFFFEFFEBBFEFFF

101 C E FFEFEFEEFEFFEFFF FFE EF F F FE E F FFFFEFEFFFEFFFEFFF FEFFEFFEFFFFFEEFFEFEEF FEFFEFFFFFEFFEE FFEFDEEFFFFFDEFFE DFFEFFFE FEEFFEEFEEFEFE CFF F FBDFFEF DFFFEFEEFF FFFD FEFFFEFEFEFFFEEFEFEEE FEFFFFEFFFFFFFE FEFFEFFF FFEEFFFFFFFFF ECCC BCDEFFFEFFEBBFEFFF

102 FFEFEEFE FEEFFEFEEDFFFFEFFFDFF FFEFFEFFFF FFFFB EFEFFFEFFFEEFFEFFFF E E F E F F F F FEEF FFFFFFFFFFFFF EFFFFFFEFEEFEF EFDFFFFFFFFFEE F F E F FE FE FFE F EEDF F FFFEEFFFFEFEFEDEFE F DF FE F E EEF F F F EE FFFDFEFFFFFFFFDF FFFFFEFEFFEFF E EFFEEFFFFFFFFEF EFFFFEFEF FDFFFF FEFFFFFFEFEEFF FFFFFFFF EF E FE E FEEE EF F F F DF F FFEFEFEFFEFFCFEFFF EEFFEFFFFFF EFEFFFFFFFFEFFF FFFFEEFFFFFFFFEFF EFFEFFFFFEEFFFFFF EEFFFEF BCDEFFFEFFEBBFEFFF

103 Electrodes ECEC ECCEDEECEC EC FFFEEEFEFFFFFFFEF EFFEFFEFFCFEFEDFEFEEFE FF FE E FF E E E F FE FE EFFE EEFEFE FEFEFEFEFFFEEFEF FEFFFEFFF FF FFEFE CEFE FFEFFE FFEFEEEEF BCDEFFFEFFEBBFEFFF

104 EECE CEE FEFFEEFFEEF EFFEFFFFF F F E F F F E EFFF FEEF FFEFFFEF FEFF FEFF FFEEFEFFDEEFFFF FFEEE FFEEFEFFDEEFFFFFF EEE E CFFFEDEFEFEEFFEEFF FEEFFFFBFFFF F FF F EEF F EF EF FE EEE FEEFEFFEFFEEFEECE ED BED C C BEEBED BFBD CEBED FD BEF F BCDEFFFEFFEBBFEFFF

105 CDE DDCF FEFFFFFFDFFFFEF FFEFEDEBDEDEFFF EFFDEBDDFFEFFEFF EFFEFFFFFEEFFFFE FFEFEFEFFFEFFEEFEFEFFF EFEFFFB DF FEDFEF FFFEFEDEFFEFFEFEF FFEFEEFFFEEDEFFF FFEEFFFFFFF EEFEFFFFFFFFEEFEF BBFCBDFF FFEEFFFEFEFFEFEF EFEFEFFFFFFE FFFEFEFEFEEFEEEF FFFEFFEFFEEFEDFEEFEFBEFEFEDD EDFFF C CEE C ECCC EFFE EFFE EFFE C EFFE EFFE EFFE B C EFFE F EFFE E C E CE ECE F C EF F FEF F F FF F FF FEFEFFEFEBFEFFE FFEFFFEEFFEEFEE BCDEFFFEFFEBBFEFFF

106 FBFFEFFEFFEFFFFFF FEFFEFEFEFFF CF FEFFEEFEEEFFEFEFEF FFFEFEFEFFEFEFEEFE EFFFEFEEFEFEFFEFFEFE FEFEFEFEFFFFEFFF CFFEF BCDEFFFEFFEBBFEFFF

107 ECEDCEDDCE CECCE BCDEFFFEFFEBBFEFFF

108 FFDFD FFFEFEDB FFEFE FFEEFEEFEFFEFEFEEE EEFEFEFEFFEFFEFFEFFEFFEFE EEFEFEFEFFEFFEFEFFFE FEFEFFDEFEEFEF FFFEFFFFEDBDEBDEDE EFFEFFEFEBF EFFFEFFEFEFFEEFEE EFFFFFEEEFEFE FFEFFEEFFFF FFFEFFE FEEFEFEFEFEFEFFEFEEFEFE EFEFFFFCEBFDEDBBC CDDCCFFD FEFEFFFFFFEEFFEF FFFFFEFFEFEEFEFFFFFEFEFE FEEFFFFEFEFEEFE FEFFEFEFEEEFFFFFEFEE FFFEFFEFFEFEFFEFF FFEFEFEFEEFFEFFEDFEFFEFFFFE EFFEFEFEFEFFFEFFFFFEFEDF FEFFFEFFFFFFDFEFE DFEFFEFFEEEFFFEFEEFEF FFF F F F EF F C FFF FFFFFFFF BCDEFFFEFFEBBFEFFF

109 EDCBEB FE F FFFF F F F F FE DFE FFF F F DF FEFFF F F EFE F F F FFFFFEF FEFFFFEFEFEFFFFEFEF FFFFFEEFFFFE FEFEFFFFFEFFFEFFFFEFFF EECFCFEFEE CFEEFFFEFFFFEFE F EEF F F F FE F E F F EFFFFF FEEFFFEFFFEFFFF FFFFFFFFEFFFEFFFFEF DFEFFFEFFFEFF FFFFFFFFEFFFEFEEFEEFEEFE FEDEEEFFFFFFFE FEFEEFEFFEFCFFF FEFFFEEFEFEFFEF FFFEEFFFFEEFEFFEF FEFFFFFFFFEFFFFFF FE F F F FF F FEFF F EF FFFFFEFFCFECEFFEFFEE FFEEFFFFEEFFEFF FFEFFFEFEFFFFEF EFFFEEEEFFFFFEEFEDFE FEFEFEEFFFFFFEDFEFEEF EFFFFFFFFFFEFEEEEFF FFEFFFFFEDEFF FFF BCDEFFFEFFEBBFEFFF

110 DC FFEEFEFFFFEFFE FEFEFFFFFEFEFE CFEFFEFEFEFEFEFEFFFEFC FFFFFFFFEEFEFFFE EEFEEFFFFEFF EFFFEFEFECDDDFE EFFEFFEFFFFFEEEFEF EFEEFFEFEFEEEFF DCFCCDCF FE E FEF EE F EFDF CFFE FFFF FFEEFFFEFEFFF FEFEF D DCDCCED EFEFFEFEFFFFFEE CEEFFEFFFEFFFFFFFFE FFEFEFFEFEFEB EFFFEFFC FFCFFFEFB D FCECBDFDD EFFFCFEBDBDDEBDDBEEDDFF FF E F F F EF F F FF DE EFFFEFEFFE - FEFFE - FFFEFEFFFEFEFFEFEFF FFFEEEFFFFECFFEEFFFF FEFEFFFEFEFEEFFEFFEFEFE - FFFEFEFFECEFEEF FFFFEFEFE BCDEFFFEFFEBBFEFFF

111 CF FFFEEFFFEFEFFFEFFE EFEEFFEFFFEFE FFEEDEFFFEEF FEF FEDFEFEEEFEDFEFEF FEEEFFFFF F FE FE FE C F FFF FEFE - FFFFFFFFEEF F F E EFF F E FF FFEFEFFFFFFEF FFEF - FFFFECFE FFFFEEFFEFEFFFF EFFEFFEF BCDEFFFEFFEBBFEFFF

112 C DF FB FB B F CB FE EFE FE EFE FE EFE FE CCCCC CCCC CCC CCCCCC CC CCCCC CCCCCC EFE CCCC FE CCCCC EFE CCCC FE CCCCCCC EFE CCCCCCCCC FE EFE FE EFE FE EFE FE EFE CCCCCC CCCC CCCCC CCCCCC CCCCC CCCCCC CCCCC CCCCCCCC ECCCBFFEDFEFECFF FFFEFFDBDBEFCFCDCCED EDBBEBEFEBDFBDDDDFDEEDEFEBDDFEDBDD C BD EFBD FBD BED D FFF F FFFF DD DBCCDBCCC FE EF E F EE F E FFFEFFFFFFE FFFFEFFFFF EFEEFFFFFEDFEFEFF FFEEDFEFFFEEFEEFFFFFDFF FFFFFEEEEFCFF FEFEFFFEEDFEEEEF FE E FEFFE F FE FE E E FE EF BCDEFFFEFFEBBFEFFF

113 FFEFFEFFFFEFEEFEFFEFEEFEF FE FFFFFEFEFEFEFE C FFFF E FEEFEEEFEEFEFFFEFE FFFFEFFFEEEEFFE F F FE FE F EFE F EEFF EFEEFFEEEEEFEFDFEFFFFF E BCDEFFFEFFEBBFEFFF

114 E EDDCDE CFFCBDCFDBDCF FFEFFEEEEDFFFF E FF F F F FFE EEE FE EFEFDFFFEEEFEFEF FFEFFFEFEEFEEE EEEEEFEEEEFEEFEFE FFE FE FFE E FE E FFE E F F E EEFFFFFFEFFEF FFFFEFEEF Contrôle isoflurane CDE CEE CEE CEE CEE CEE BFF BB B B C F BB B B FD CBDBF CBDB CBDB CBDB CBDB CBDB CBD CBD CBDE CBDE CBDE CBDE BCDEFFFEFFEBBFEFFF CDE CDE CDE EECDDCECECCCEC DECECDEFEEFFEEEFFFFF FFFFFEFFEFFFFFEFEEF

115 FEFEFEFEEFFFFFFEFFE CFEFFFFEFEFF FFFFFF FFFFFFF F FFEFFFFFFEEE FEFFE o FEFFFF F o FECFFFFF o FECFFFF F o FECEFFFF F FFFEFEFFECEEFFFCFFEF EFEFFFFFECFF FFF FFFEFEEEFFFF FFEEEEEFE o FECFFFF o FEFFFF o FFEFFFF FEFEFFEFFFFEFFEEFE EEEFEEFE BCDEFFFEFFEBBFEFFF

116 Nombre de cellules spléniques (x 1000) Nombre de cellules spléniques (x 1000) Nombre de cellules spléniques (x 1000) Contrôle Sham 20 min Cellularité totale Sham 3h * * NSV 20 min NSV 3h Nombre de lymphocytes T CD3 * Contrôle Contrôle Sham 20 min Sham 20 min Sham 3h Sham 3h NSV 20 min NSV 20 min NSV 3h NSV 3h Nombre de cellules spléniques (x 1000) Nombre de cellules spléniques (x 1000) Nombre de cellules spléniques (x 1000) Nombre de lymphocytes totaux Contrôle Sham 20 min Sham 3h * NSV 20 min Nombre de lymphocytes T CD4 400 * Contrôle Contrôle Sham 20 min Sham 3h NSV 20 min Nombre de TCR γδ CD3 Sham 20 min Sham 3h NSV 20 min ECEDDCECECCE F F F F FE F F FE C F F FECFFFECFFFECEEFF EFEEEEFDEEEFFFFFF Nombre de lymphocytes T CD4 CD25 30 * * NSV 3h NSV 3h NSV 3h BCDEFFFEFFEBBFEFFF

117 FEFFEFFFFFFFFFE DEFFEEEEFEFEEEEDFFFF EFEFEEEEFEEFEEFFEE F CDDCCFFD FFFFFFEFEEEFE FEEFEEFFEFEEFEFEEFEFFEF EFFEFEEFECFFFEFE EFEFFFFFEFEEFEE EFEFEFFEFEFEFEFEEFEFBEFE EFEFEE C CDE CDE CDE CDE CDE CEE D CEE D CEE D CEE D CEE D C CDE CDE CDE CDE CDE CEE D CEE D CEE D CEE D CEE D E E C CC DD C C EEECCEC FE EE F FE F E EFE F FE F EF FF EF FE EFF FF FE FFE FE F FE F F FF FEFEFFFFEF FFFFFEFEFEFF FE EE FE E F FF F E F FEE EF E F FFDEFFFFDEFF BCDEFFFEFFEBBFEFFF

118 EEFEFFFEFFEFEEF EFDFFEFECFFFEFEEE EFEEEFEFEFEFEFFFFF EFFFFEEFEEDFFEEFEEF FEFFFEFEFFEEEFF FEEFEEEFFFFFFFEFFEEFF F F EE E E F FE E F FEEF F E FE FE FE FE FFE FE FEEFE E EFFFFFFF EDDEC CFFCBDCFDBDCF FEFEFFEEFEEFEFFFFEFFE EFEEFFEEFFEFFDFF FFFFFEFEEFEEEEF Contrôle pentobarbital C C C C CEE CEE CEE CEE CEE BFF BB B B C F BB B B FD CBDBF CBDB CBDB CBDB CBDB CBDB CBD CBD CBDE CBD CBDE CBDE EECDDCECECCCEC DECEECFEEFFEEEFFFF FFFFEFFEFFFFFEFEEF BCDEFFFEFFEBBFEFFF

119 C F EF F F EF F EFFFFFFEEFEFEFF Nombre de cellules spléniques (x 1000) Contrôle isoflurane Sham 20 min i Cellularité totale splénique * * Isoflurane Sham 3h i NSV 20 min i NSV 3h i Contrôle pentobarbital Pentobarbital Sham 20 min p Sham 3h p NSV 20 min p NSV 3h p E E C E CE DD CC F FEFFEEFEEFFFFF EFFFFEF FDFFCBDCF FEEFEFFFFFF FEFEFECFFF FEFFFFFFEFF FCFEFFFFEEFF EFFFFFF FFFEFFFFFFFFECF EFFFFFCFEC EFFFFFFFFEFEF EFEFF BCDEFFFEFFEBBFEFFF

120 Pourcentage de lymphocytes T CD4 CD25 + Pourcentage de CD25+/CD Contrôle isoflurane Sham 20 min i Isoflurane Sham 3h i NSV 20 min i NSV 3h i Contrôle pentobarbital ** * Pentobarbital Sham 20 min p Sham 3h p NSV 20 min p NSV 3h p Contrôle Pourcentage de NKT/LT Sham 20 min Sham 3h NSV 20 min EDDECEFFF FECFEFFFFEFFEEF FFFEEFEEFFF FFFFFFFFFFFFC FE FECEFE FFEEFEEEFF FEFE FFFFFFFFFFFF CFDFDFDFFCBD CF % NKT/ lymphocytes T ** *** * ** NSV 3h FFEEFEFEEFFFEE FFEEEEFFFEFEFF FFEFFFFFFFEFFF FFECFEFF EFF F FF EEF FF EFF F FECEFFFEFEF FFFEFFEFEF FFFFFEEFFF FFEFFFEFFFFF FEFFFFF BCDEFFFEFFEBBFEFFF

121 Nombre de lymphocytes T CD3 N ombre de cellules (x )500* Contrôle Sham 20 min Sham 3h NSV 20 min NSV 3h Nombre de lymphocytes T CD4 400 * Control Pento Sham 20 min Sham 3h NSV 20 min E DD CE E E C E F F FE C F F FE C EFE DE EE F F EEF F E FEEEFFFFF Nombre de cellules (x 1000) EFFFEFFE FE F FE FE FFE E EF FE EEE FE EFE CFEFEEEFEFEFEFFFFE EFEEEEFEFFFEFEEEEFE EFEFEFFFFFFEEEFFEF FEFFEFEF CDDCCFFDFDCF CD EFFEFEEFEFEEFEFFEF FFEFEEFEEEEFFEFEFFEFEFE EFEFEFFEFEEFEEFFE C C C C CEE D CEE D CEE D CEE D CEE D CEE D EECCCDDCC EEECCECFF 0 C C C NSV 3h C BCDEFFFEFFEBBFEFFF

122 FEFFEFFFEFEFF FF FE FFE FE F FE F FE E FEEE F EFFFCFFEFEE FFEFEFFEFEFF FEFFEFEEFFEEFEE FFEEFEFEEFFFFFEEFEEE EFEEEFFEFFEEEF F FE EFE E F EFF F F FE EF FE FEEFFFEFEEFEFFEFFE EFEFFEFEFEFEFEFFFE EFFFEFEFEFEEFEEFFFE FFEEFEFFEFEFFEFEFEFEEF FFEEEFEEFEEFEFEFF FFFEFEFEFFEFFFFDFFEFFF EFFFFEFFFFE EFEEEEF FFEFFEFEFFFEFCFEFE FFFFFFEEFEEFFFCFEEFE EEEEFEEFEEEEFFBEFFFB FE E FEEE F F E F EF F EFCFEEFEFFFEFFFFE FFFFFFEFEFFFF FFFFEFFEFFF BCDEFFFEFFEBBFEFFF

123 pg/ml Contrôle i Sham 3h i ctivés TNFα Sham 20 min i NSV 3h i NSV 20 min i N Contrôle i N Sham 3h i N Sham 20 min i N NSV 3h i N NSV 20 min i pg/ml Contrôle p ctivés Sham p TNFα NSV p *** N Contrôle p N Sham p N NSV p ECCCEEEE EFE EEE F E FEEE EF EF EFE EEE F E FEEEFFFFFEFEEFEEF FFEEFEEEEFFEFBFFBFEEFEEE F FE FE FFE FE F E F E F EF F FFFFEEFEFEEEFEFEFEEFEFF EFEEFFFEFFFFFFEFF FFFEFFFEFEFFEFFE FEEFEF EEDDCECCDECEE BCDEFFFEFFEBBFEFFF

124 CB FEFFECEEFEEFEDEEEFE FFFEFEDFEEEECFCFE FFFFEEFFEFEFFFFE FFEFFEF FEFFEFEDFEFEFEFFFFFEFFF DFFFFFEEDFEFFF C FEFFEFEDFEEFEFFFEFFEEF FEFEFEFFEFEEFEEEEFFF FFEEEFEEFEEFFEEFEFF FEEFEEEEFFFEFFEFEFE FFEFFFFFFF EFEFEEEEFFFFFFFF EEFFEFEEEFFFFF FFEEFFEEFEFEEE FEFFEFEFFFEFE FFF BCDEFFFEFFEBBFEFFF

125 1.5 *** ** NFκbia 2.5 * IL-2 Unité relative Unité relative Contrôle i Sham 20 min i Sham 3h i NSV 20 min i NSV 3h i 0.0 Contrôle i Sham 20 min i Sham 3h i NSV 20 min i NSV 3h i 1.5 * IL-2ra ** 1.5 Foxp3 Unité relative Unité relative Contrôle i Sham 20 min i Sham 3h i NSV 20 min i NSV 3h i 0.0 Contrôle i Sham 20 min i Sham 3h i NSV 20 min i NSV 3h i 1.5 TNF-α Unité relative Contrôle i Sham 20 min i Sham 3h i NSV 20 min i ECCCDEEF FFDFBFFFFEDFEFFFFC NSV 3h i BCDEFFFEFFEBBFEFFF

126 1.5 NFκBia * 2.0 IL-2 Unité relative Unité relative Contrôle p Sham 20 min p Sham 3h p NSV 20 min p NSV 3h p 0.0 Contrôle p Sham 20 min p Sham 3h p NSV 20 min p NSV 3h p 1.5 IL-2ra 1.5 Foxp3 * Unité relative Unité relative Contrôle p Sham 20 min p Sham 3h p NSV 20 min p NSV 3h p 0.0 Contrôle p Sham 20 min p Sham 3h p NSV 20 min p NSV 3h p 1.5 TNF-α Unité relative Contrôle p Sham 20 min p Sham 3h p NSV 20 min p NSV 3h p ECCECF FFDFBFFFFEDFEFFFFC FEFEEFFFEEFEEEFFE FEEEFFFEEEEF FDFFEEFEFFFF FEFEFFFFFFFFFEFEFE BCDEFFFEFFEBBFEFFF

127 FEFFEEFFFEFF FFFFEFF C 1.5 * I contrôle P contrôle I sham 20 min P sham 20 min I sham 3h P sham 3h * 1.5 I NSV 20 min P NSV 20 min I NSV 3h P NSV 3h ** * I Contrôle P Contrôle I Sham 20 min P Sham 20 min I Sham 3h P Sham 3h I NSV 20 min P NSV 20 min I NSV 3h P NSV 3h BCDEFFFEFFEBBFEFFF I Contrôle P Contrôle I Sham 20 min P Sham 20 min I Sham 3h P Sham 3h I NSV 20 min P NSV 20 min I NSV 3h P NSV 3h ECCCCCDEE CFFDFBFFFFEDFEFFF FCEFF

128 EC FFFFEFFFFFFFFFEEFE FFE E F FE FE F DFE FEFFFEEFFEFEEFFFEFFE EFFEFFEFEFEFFFEEE FFFEEFFEFFEEFFFFFEEFFFEFF FEDEFFFEEFFFFFEFFEFEEFEF EFFFFEEFFFFFFFEF FEFFDEFEFEFEFFFFEFEEE EFFEEFFFFEFFEFEEFFF EFFDEFFFFEFFFFEFF CFEEFEEDFFEEFEEEFEFFFE EFEFEEEFF EFFFEFFFFFFFFFF FEFFFFFFEFFFEFFEEF FFEEFFBFFDFFEFFEF EFFEFEFECFFEEF FFFFEFEEEEFFF FFFEFFEFEEFEEF FFEFFEFFCEEFCEEF FFFFFEFFEFEDEDFFFF FFEFFFEFFFFEEFFFEE FEFFEFFEFEFEF FFFEFECFEFEFE FFEFEEFFFEEF DEEEEEEFEFFFFEFFFEF FF FE FE EEE FE F F F F E FEEEEFFEEEFFDFEEFFE FEEEFFEEFEFFFEFC FEEFEFFFFFFEFFEEFFF FFCEFEEFEEEEFEEFEEEFF EEFFFFEEFEEFEFEFEEEEFEE FEEEEFFEFFFDEFEFFFFEE BCDEFFFEFFEBBFEFFF

129 FEFEEDFEFFFEFFEFF FFEEEFEEFFEEFEEFFEEF ECFFFFEEEFFEFEEFE FFEEFEEEFEFEEEEF EFFEFEEFFFFEEFEFEFEEFEEEEF FEFEFFEEFFFEEFEEEFF FFFFEEFEFFEFF EFFEFEFEEEFFFFFF FFFFFFFEFEF FFFEFFFFFEEFEEEEF FEFE F FF EFF FF F F F F FE F E F F F F F FE FFE F EEF F F EF E F F F F F EE FFFEDEFFFEFEFEFE EFFFFFFEFF FEEFEEEFFEEFFEFFEFEEFE FEFFEFFFFEFEDFEFEFE FEFFFFFE FFFFFFFFFFEFFEEFEF FFFFEFFEFFFE FFEFFFFFFEFFEFEFEF FEEFEEEFEFFFFEEF EFEFFFFEFEFEFFF FEFFEEFEFEFEFEFEFE FFFEEFEFFFFF FFEFFEEFFEDFEFEFF FB FF EF FE DFE E F E FE EE FFF F FE E FFE F F F EEFFFFFFEFFEFEEFE FEFFEFEFEEFFEFFFEEF FFFFEFFFFFFEFEEFE EFFFFFEFFFFFFFEF FEFEFFFFEFFFFEFEEE EFEEFEFFF BCDEFFFEFFEBBFEFFF

130 FEFFEFFFFFFFEFF FFFECFFFECEFEFEE FFFFFFFFF FECFFEFFFFF F FE EE FF F FE F DEF EF F FFEFFFFFFFFFFFF EFFFFFFEFEFFFF FFFFEDFFFFECFF FFFFFEFEFFEEFFEFEEFEEEFDEFFF FEFEEFEEFEEEFFEE FFEEFEEFEFEFFFEFF FFFFFEFEFFFEEDFEF E FE FF EF F FF F E FE FFFEFFEFEEFE FFFEEFEFEFEEFEFF FEFFFEFEFFFEDFEFEF FFFFEEEFEFEFEF E F FEEF F E FE FE FE FFE FE FEEFE E F F F F E F FEEFEFFF FFFFFFEFFFEEFEEFEFF EFFEEFFFFFEFEFEEEEFEEDFF FFFFEFFFFFEFEFFEFEF FFFFEFFFEFEEFFFFF FFFFFFEFEFFFE FEFFFCFEFFEEFE FFE FE FE FE F FF F E F FE FEFFCFDFEF FFCFEFEFFE FEFFEFEFFFFFEFFE FEC FF FE FFE FE F EFE F EEDFFFFEFFEFEEFEFE FEFFFEFFFF FFFFEFFFFEFFEFF FFFFEEFFFEEEFFF BCDEFFFEFFEBBFEFFF

131 FF F F F EF EFF FE FE FFEFE FEFFCFFFFFFFF FFFFFFFEFFF EFFFEFEFFE FEFFEFFEFEFECEFE FFFEEFFEEFFF FECEFEFFEFFEFEDEE FFFFEDFFFFFEFE FEEFEFFFFFFEFFDFFEFE EEEFEEEFDEFEEFFEFFFE FFEFDFFF FEEEFFFFEEFFFEFF DF F E F EF E FEF F FE FE FEEFEEEEFEEFEEEFFFF EFFFFEEEFFFFEEFEEFEEE FEFFFFFFEFFEEEEFE FFFEFFEEFEFF FEFEFECF FE FEE F F F F EF F F EFFFFFFFFF EFFFFFEFEFEFFFFFF FEFFFFEFECE FFFEFFFFCFEFECFEC EFEFFEFEFFEEEFFEEFE FEFEFFEEFFFFFFFFFFFEEEE FEEFEEFFEEEFFFFFF F F F F F F FFE FE EE EFEEFEFFEFF FFFEFCFEEFEFEEEFFDEFF FFEFFEDFFEFEFECFFECF FEFFEFEFEFFDFFEEFFF FFFEFFEFEFEFFDFFEF FFEFFFFFEEEFEEFFFFFF EEFEEFEFFEFFFFEE BCDEFFFEFFEBBFEFFF

132 FFFEEEFEFEFFFEFEFEFFFF FFFE BCDEFFFEFFEBBFEFFF

133 CCC CCCCC C BCDEFFFEFFEBBFEFFF

134 EEEDDEEE CECEF DE FFFDFFEFEFFEFFEFEF FFFEFFFEEFEFF FFEFFFFFFC C FFF FFF E FE FF F E FF FEFEEEFFF FFEFEEEFFEE FF FFE FE FEE F F F F F F F FDF EFCBFEEFEFEEEFFF FFFEEF FFFDEEFFBFFFE EEEFEEFEFFFFEEEFEFEFE FFFEFFFFFEFF C E FEEEFFFEFFFFEEFE FEFEFFEFFEFFEEFFBFFEFF FEFE FEFFEFEEFEFEEFEFEFECF F FE F FF F FF FF F E F F EFFE FFEFFFFF FCFFFFEFEFEF EFEFEFEFEFFEEEFEFFFFFF BCDEFFFEFFEBBFEFFF

135 FFEEEEFFFFEEF FEEEFFEF FEFEEFFFEFFE FFFCFEFFFFEEFFBFFFE FFFF FECEFEFEFEFFFFF FFFEFFFFEEFCFF FFFFFEEFF CEC FEFEEFFFFFEFEFEC EFEFFEEFFFF FFFFEFFFEFEFFF EFFEF FEFFFFFFFFEFEEF FEEEFFEFEFEF BCDEFFFEFFEBBFEFFF