NJA. National Journal of Andrology Zhonghua Nan Ke Xue Za Zhi http / /www. androl.

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1 1043 NJA National Journal of Andrology Zhonghua Nan Ke Xue Za Zhi http / /www. androl. cn R698 A premature ejaculation PE 1-3 PE / PE PE PE PE PE PE 1 ~ 2 min PE PE PE PE PE PE PE PE 1 2 / % 30 ~ 60 s 5 PE Ⅳ- diagnostic and statistical manual of mental disorders IV-Text revision DSM- IV -TR PE 6 international society for sexual medicine ISSM PE 1 min PE PE 1 2PE 3PE 4 5

2 PE PE PE PE quality of life QoL PE PE / 3 1 PE PE 2 IELT 3 IELT 4 QoL erectile dysfunction ED PE 1 4 PE PE 3 1 IELT PE PE PE IELT IELT IELT IELT / = IELT 2 = 3 = 4 = PE PE IELT IELT PE IELT 21 IELT 2. 1 PE IELT PE 2% ~ 5% PE 80% 80% 22 PE 3-4 IELT PE 20% ~ 30% 9 0 = 4 = PE 0 = 4 = PE patient-reported outcome PRO PE % / 5- IELT PE PE 3. 2 PE PROs 18 PE PE PE PE 2. 3 PE PE premature ejaculation diagnostic tool PEDT PE Arabic index of premature

3 1045 ejaculation AIPE PE 25 PE PE premature ejaculation profile PEP 26 Peyronie index of premature ejaculation IPE 27 male sexual health 29 questionnaire ejaculatory dysfunction MSHQ-EjD PE 3 2 CIPE > 3 min 4 ~ 5 min 6 ~ 10 min < 30 s 1 min 2 min 3 min 11 ~ 20 min > 21 min CIPE = 3 PE PE IELT 1a A IELT IELT 2a B PROs PE PROs 3 C PE PE ED 3 C 3 C 4 SSRIs 3 PE PE 5 selective serotonin reuptake inhibitors SSRIs 4 PE PE 1 PE PE 4. 1 / PE PE SSRIs PE start-stop 30 2

4 ~ 2 1 ~ 2 3 SSRIs 50% ~ 60% ~ ED SSRIs SSRIs SSRIs 5% 20 ~ 30 min SSRIs SSRIs PE Tmax 1. 5 h TEMPE 35 PE 7. 5 mg mg TEMPE 42 1 min 4. 9 min mg 1 ~ 3 h 0. 9 min 1. 6 min P < TEMPE 5 ~ 10 min ED ~ 12 PE 30 mg 60 mg 0. 9 min min min min 30 mg 60 mg SS SS 9 51% 58% 1 h 30 mg SS 60 mg 8. 7% 20. 1% 3. 9% 6. 8% g SS 5. 9% 6. 8% 3. 0% 6. 2% IELT min min 32% min 18. 5% 2 SS % PE SSRIs 7- PE SSRIs 67. 1% IELT SD 3. 7 SSRIs IELT 2. 6 ~ 4. 3 vs min mg PE 2 Cochrane SSRIs 36. 3% 44. 5% vs 15% IELT ~ 40 mg 5 25 ~ 200 mg 10 ~ 60 mg PDE - 5 PE 25 ~ 50 mg SSRIs 46-49

5 α PE PE PE PE 4 PE 1 4 PE ED 2a B PE 3 C PE 1a A SSRIs PE SSRIs pm 1a A SSRIs 7 PE 1a A SSRIs off-line 1b A PDE5 2B C 1b A 3 C 1 * PE * Lue et al IELT = PE = ED = SSRIs = 5-

6 1048 Behav Sharlip I. Diagnosis and treatment of premature ejaculation The physician's perspective. J Sex Med suppl 2N Shabsigh R. Diagnosing premature ejaculation A review. J Sex Med suppl 4N Waldinger MD Schweitzer DH. Changing paradigms from an historical DSM-III and DSM-IV view towards an evidence based definition of premature ejaculation. Part I Validity of DSM-IV-TR. J Sex Med Waldinger MD Schweitzer DH. Changing paradigms from an historical DSM-III and DSM-IV view towards an evidence based definition of premature ejaculation. Part II Proposals for DSM-V and ICD-11. J Sex Med Waldinger MD. The need for a revival of psychoanalytic investigations into premature ejaculation. J Mens Health Gend Waldinger MD. Premature ejaculation State of the art. Urol Clin North Am Waldinger MD. Premature ejaculation Different pathophysiologies and etiologies determine its treatment. J Sex Marital Ther American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 4th Ed. Text Revision. Washington D. C. American Psychiatric Publishing Inc McMahon CG Althof SE Waldinger MD et al. An evidencebased definition of lifelong premature ejaculation Report of the International Society for Sexual Medicine ISSM ad hoc committee for the definition of premature ejaculation. J Sex Med Godpodinoff ML. Premature ejaculation Clinical subgroups and etiology. J Sex Marital Ther St. Lawrence JS Madakasira S. Evaluation and treatment of premature ejaculation A critical review. Int J Psychiatr Med Waldinger MD Schweitzer DH. The use of old and recent DSM definitions of premature ejaculation in observational studies A contribution to the present debate for a new classification of PE in the DSM-V. J Sex Med Waldinger MD Hengeveld MW Zwinderman AH et al. An empirical operationalization study of DSM-IV diagnostic criteria for premature ejaculation. Intern J Psychiatry Clin Pract Waldinger MD. The neurobiological approach to premature ejaculation. J Urol Rowland D Perelman M Althof S et al. Self-reported premature ejaculation and aspects of sexual functioning and satisfaction. J Sex Med Rowland DL Patrick DL Rothman M et al. The psychological burden of premature ejaculation. J Urol Byers ES Grenier G. Premature or rapid ejaculation Heterosexual couples' perceptions of men's ejaculatory behavior. Arch Sex 18 Althof SE Symonds T. Patient reported outcomes used in the assessment of premature ejaculation. Urol Clin North Am vii. 19 Giuliano F Patrick DL Porst H et al. Premature Ejaculation Results from a five-country European observational study. Eur Urol Patrick DL Althof SE Pryor JL et al. Premature ejaculation An observational study of men and their partners. J Sex Med Patrick DL Rowland D Rothman M. Interrelationships among measures of premature ejaculation The central role of perceived control. J Sex Med Rosen RC McMahon CG Niederberger C et al. Correlates to the clinical diagnosis of premature ejaculation Results from a large observational study of men and their partners. J Urol Symonds T Perelman M Althof S et al. Further evidence of the reliability and validity of the premature ejaculation diagnostic tool. Int J Impot Res Symonds T Perelman MA Althof S et al. Development and validation of a premature ejaculation diagnostic tool. Eur Urol Arafa M Shamloul R. Development and evaluation of the Arabic Index of Premature Ejaculation AIPE. J Sex Med Patrick DL Althof SE Pryor JL et al. Premature ejaculation An observational study of men and their partners. J Sex Med Althof S Rosen R Symonds T et al. Development and validation of a new questionnaire to assess sexual satisfaction control and distress associated with premature ejaculation. J Sex Med Rosen RC Catania JA Althof SE et al. Development and validation of four-item version of Male Sexual Health Questionnaire to assess ejaculatory dysfunction. Urology Shabsigh R. Diagnosing premature ejaculation A review. J Sex Med Semans JH. Premature ejaculation A new approach. South Med J Grenier G Byers ES. Rapid ejaculation A review of concep-tual etiological and treatment issues. Arch Sex Behav Metz ME Pryor JL Nesvacil LJ et al. Premature ejaculation A psychophysiological review J Sex Marital Ther De Amicis LA Goldberg DC LoPiccolo J et al. Clinical follow-

7 1049 up of couples treated for sexual dysfunction. Arch Sex Behav Hawton K Catalan J Martin P et al. Long-term outcome of sex therapy. Behav Res Ther Henry R Morales A Wyllie MG. TEMPE Topical eutectic-like mixture for premature ejaculation. Expert Opin Drug Deliv Dinsmore WW Hackett G Goldmeier D et al. Topical eutectic mixture for premature ejaculation TEMPE A novel aerosol-delivery form of lidocaine-prilocaine for treating premature ejaculation. BJU Int Henry R Morales A. Topical lidocaine-prilocaine spray for the treatment of premature ejaculation A proof of concept study. Int J Impot Res Xin ZC Choi YD Seong DH et al. Sensory evoked potential and effect of SS-cream in premature ejaculation. Yonsei Med J Xin ZC Choi YD Lee WH et al. Penile vibratory threshold changes with various doses of SS-cream in patients with primary premature ejaculation. Yonsei Med J Urol Safarinejad MR Hosseini SY. Safety and efficacy of tramadol in the treatment of premature ejaculation A double-blind placebocontrolled fixed-dose randomized study. J Clin Psychopharma- Huang XK Lu YP Luo SW et al. Zhonghua Nan Ke Xue Za Zhi col Waldinger MD. Premature ejaculation Definition and drug treatment. Drugs Med Dai JC Li LG. Zhonghua Nan Ke Xue Pryor JL Althof SE Steidle C et al. Dapoxetine Study Group. Efficacy and tolerability of dapoxetine in treatment of premature ejaculation An integrated analysis of two double-blind randomised controlled trials. Lancet Shabsigh R Patrick DL Rowland DL et al. Perceived control over ejaculation is central to treatment benefit in men with premature ejaculation Results from phase III trials with dapoxetine. BJU Int Zhang XS Wang YX Huang XY et al. Zhonghua Nan Ke Xue Za Zhi Chen J Keren-Paz G Bar-Yosef Y et al. The role of phosphodiesterase type 5 inhibitors in the management of premature ejaculation A critical analysis of basic science and clinical data. Eur Urol McMahon CG McMahon CN Leow LJ et al. Efficacy of type-5 phosphodiesterase inhibitors in the drug treatment of premature e- jaculation A systematic review. BJU Int Wang WF Minhas S Ralph DJ. Phosphodiesterase 5 inhibitors in the treatment of premature ejaculation. Int J Androl Tang WH Ma LL Zhao LM et al. Zhonghua Nan Ke Xue Hsieh JT Chang HC Law HS et al. In vivo evaluation of serotonergic agents and alpha-adrenergic blockers on premature ejaculation by inhibiting the seminal vesicle pressure response to electrical nerve stimulation. Br J Urol Basar MM Yilmaz E Ferhat M et al. Terazosin in the treatment of premature ejaculation A short-term follow-up. Int Urol Nephrol Cavallini G. Alpha-1 blockade pharmacotherapy in primitive psychogenic premature ejaculation resistant to psychotherapy. Eur 54 Salem EA Wilson SK Bissada NK et al. Tramadol HCL has promise in on-demand use to treat premature ejaculation. J Sex Xiiong GG Wu FH Chen SH et al. Zhonghua Nan Ke Xue Za Zhi Zhang CY Zhang HF Guo J et al. Zhonghua Nan Ke Xue Za Zhi Mao XM Zheng SB Sei AY. Zhonghua Nan Ke Xue Zhang SJ Zhao YM Zheng SG et al. Zhonghua Nan Ke Xue Za Zhi

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