DTI. (diffusion tensor, imaging, DTI) DTI R749.3;R445

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1 (FA [(0.296 ± 0.030(0.302 ± 0.030(0.326 ± 0.026P < 0.05] [(0.560 ± 0.031(0.568 ± 0.025(0.581 ± 0.028P < 0.05] (P > 0.05 R749.3;R445 A MRI fiber tracking study on the white matter integrity in schizophrenia and their siblings. HAO Yihui GAO Jinsong ZHANG Huiran OUYANG Xuan LIU Haihong LI Youhui SONG Xueqin LIU Zhening. Department of Psychiatry of the First Affiliated Hospital of Zhengzhou University Zhengzhou China. Tel: Abstract Objective To identify whether the integrity of brain white matter is abnormal in schizophrenia patients and their unaffected siblings. Methods White matter density was compared among schizophrenic patients their unaffected siblings and healthy controls using voxel-based morphometry and the brain regions showing significant difference among groups were defined as the region of interest (ROI. Fiber tracking was then used to reconstruct the white matter fiber within ROI and then the fractional anisotropy (FA was compared among three groups. Results Both schizophrenia patients and their siblings showed significant reduction of FA in the left prefrontal cortex (PFC and genu of corpus callosum as compared healthy controls [(0.296 ± (0.302 ± (0.326 ± P < 0.05; (0.560 ± (0.568 ± (0.581 ± (P < While no significant difference was found between the patient group and the sibling group (P > Conclusions The disruption of white matter integrity in the left PFC and genu of the corpus callosum might be the susceptibility biological marker for schizophrenia. Key words Schizophrenia Unaffected siblings Fiber tracking White matter integrity [2] DTI 9 [1] (diffusion tensor imaging DTI 973 ( ( : [3-6] :2007CB ( DTI * ( zheningliu@yahoo.com.cn

2 726 Chin J Nerv Ment Dis Vol.37 No.12 December T (three-dimentional gradient-e- cho sequence :TR / TE :1 (DSM- ; = 12.1 / 4.2 ms (FOV 24 cm 24 cm 2 18 ~ 45 ;3 (positive mm 172 and negative syndrom scale PANSS 60 ; 4 9 ;5 ; ~ 41 (24.39 ± ~ s / mm 2 96 (20.15 ± ~ (b = 0 : TR = ms; TE = (12.50 ± 2.16 :1 ms; matrix = ; FOV = 24 cm 24 cm;nex ;2 5min ;3 = 5 = 4 mm = 0 mm 30 DSM- ;4 : :1 MRIcro DICOM ;2 18 ~ 45 ;3 9 ANALYZE ;4 1 1 (statistical parameter mapping 2 SPM2 30 ANALYZE ~ 39 (25.37 ± ~ 18 DSM- ; mm 3 ( ; : :1 18 ~ 45 ; 2 9 ;3 ; ~ 41 (25.00 ± ~ 18 (13.77 ± ( 掊 2 = 0.64 P > 0.05 (F = 0.04 P > 0.05 (F = 2.14 P > 0.05 DTI [7] 1.2 (GE signa 1.5T Twinspeed Milwaukee 2 16min10s 13 b = (Montreal Neurology Institute MNI (n = 152 (12.87 ± 2.70 :1 ; 2 5min ; 3 ( FWHM 8 mm FWHM Gaussian kernel VBM PANSS DTI (P < > T MATLAB6.5 XJVIEW

3 727 MRIcro(1.39 Build 1 http: / / (region of interest ROIs 1 ROI MRIcro Kanaan ROI DICOM ANALYZE b0 ~ b13 14 FA ROI FA (b0 b1 ~ b13 13 ; 2 MABLAB6.5 SPM2 14 SPM2 ROI MNI mm 3 ; 3 14 MedINRIA (http: / / www -sop.inria.fr / asclepios / software / MedINRIA FA ; 2 4 ROIs ( 10 mm FA 0.2 FA 1.3 SPSS VBM ( A B (least significant difference LSD 3 FA α = : 3 FA [(0.296 ± (0.302 ± (0.326 ± F = 4.31 P < 0.05] 2 FA (P = 0.006; P = (P > FA [(0.560 ± 0.031(0.568 ± 0.025(0.581 ± 0.028F = 3.13P < 0.05]; FA (P = 0.025;P = (P > A 3B A B (FA A ;B * LSD P < 0.05 A 3 FA B

4 728 Chin J Nerv Ment Dis Vol.37 No.12 December 2011 MRI (vertical displacement FA Camchong [4] DTI ( [3] Knochel [14] FA [4] Price [8] [15] ROI FA FA Rotarska- Jagiela [9] 50% FA FA Kubicki [10] 32 DTI ROI FA FA FA FA [1] Sadock BJ SVA Schizophrenia. In: Sadock BJ Sadock VA eds. Kaplan and Sadock's synopsis of psychiatry: behavioral sciences / clinical psychiatry. (10th ed. [J]. New York:Wolgters Kluwer and Lippincott Williams & Wilkins 2007:467. FA ; FA [2] Le BD Mangin JF Poupon C et al. Diffusion tensor imaging: P 0.05 concepts and applications[j]. J. Magn Reson Imaging (4: [3] Hoptman [6] (11: FA ;Munoz Maniega [11] [4] Camchong J Lim KO Sponheim SR et al. Frontal white matter FA integrity as an endophenotype for schizophrenia: diffusion tensor ;Karlsgodt [12] imaging in monozygotic twins and patients' nonpsychotic relatives [J]. Front Hum Neurosci 20093: [5] Ellison-Wright I and Bullmore E. Meta-analysis of diffusion FA tensor imaging studies in schizophrenia[j]. Schizophr Res (1-3:3-10. FA Narr [13] [6] Hoptman MJ Nierenberg J Bertisch HC et al. A DTI study. [J].

5 729 [7] [8] [9] [10] [11] of white matter microstructure in individuals at high genetic risk for schizophrenia [J]. Schizophr Res (2-3: [12] Karlsgodt KH Niendam TA Bearden CE et al. White matter [J] integrity and prediction of social and role functioning in subjects 32(5: Price G Cercignani M Parker GJ et al. Abnormal brain connectivity in first-episode psychosis: a diffusion MRI tractography study of the corpus callosum[j]. Neuroimage (2: Rotarska-Jagiela A Schonmeyer R Oertel V et al. The corpus [13] [14] at ultra-high risk for psychosis [J]. Biol Psychiatry (6: Narr KL Cannon TD Woods RP et al. Genetic contributions to altered callosal morphology in schizophrenia [J]. J Neurosci (9: Knochel C Oertel-Knochel V Schonmeyer R et al. Inter- callosum in schizophrenia-volume and connectivity changes hemispheric hypoconnectivity in schizophrenia : Fiber integrity affect specific regions[j]. Neuroimage (4: Kubicki M Styner M Bouix S et al. Reduced interhemispheric and volume differences of the corpus callosum in patients and unaffected relatives[j]. Neuroimage (2: connectivity in schizophrenia-tractography based seg [15] Friedman JI Tang C Carpenter D et al. Diffusion tensor mentation of the corpus callosum [J]. Schizophr Res (2-3: imaging findings in first-episode and chronic schizophrenia patients[j]. Am J Psychiatry (2: Mu 觡 oz Maniega S Lymer GK Bastin ME et al. A diffusion tensor MRI study of white matter integrity in subjects at high genetic risk of schizophrenia[j]. Schizophr Res (2-3: ( : ( :!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!! ( 714 MRI MRS MLD [4] MLD MRI MLD MRS MLD [3] ASA [5] MLD MRI MLD - (Guilain-Barre syndromegbs : GBS ASA MLD MLD [1] Singh RK Leshner RT Kadom N et al. Isolated cranial nerve MLD MLD enhancement in metachromatic leukodystrophy[j]. Pediatric Neu (5: ( 1 rology [2]. [J] (7: [3]. [J] (4: MRI CT T 2 [4] MLD MRI. : 3 [J] (6: T 1 WI [5]. T 2 WI [J] (2: R742 ( : (magnetic resonance A ( : spectroscopy MRS MLD