Octretide joint proton pump inhibitors in treating non-variceal gastrointestinal bleeding a Metaanalysis

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1 Chin J Gastroenterol Hepatol Jun 2012 Vol. 21 No. 6 doi /j. issn Meta Cochrane Library Pubmed 2 Revman Meta Meta R A zhangchali1987@ 163. com yahoo. com Octretide joint proton pump inhibitors in treating non-variceal gastrointestinal bleeding a Metaanalysis ZHANG Chali YU Honggang Department of Gastroenterology Renmin Hospital of Wuhan University Wuhan China Abstract Objective To evaluate the efficacy of octretide joint proton pump inhibitors in treating non-variceal gastrointestinal bleeding. Methods All the randomized controlled trials RCTs about treating non-variceal gastrointestinal bleeding with octretide joint proton pump inhibitors were collected by searching Cochrane Library Pubmed Wangfang. The assessment of methodological quality and data extraction of the included studies were performed independently by two reviewers and Meta-analysis was conducted with Revman 5. 0 software. Results A total of 6 studies involving 484 patients met inclusion criteria. The results of Meta-analysis showed that octretide joint proton pump inhibitors was effective in treating non-variceal gastrointestinal bleeding. Conclusion Octretide joint proton pump inhibitors is effective in treating non-variceal gastrointestinal bleeding. Because of the lower methodological quality and publication bias of the included trials it is necessary to perform more high-quality and large scale randomized controlled trials to make the conclusion more reliable. Key words Octretide Proton pump inhibitors Upper gastrointestinal bleeding Non-variceal Meta-analysis H + - K + -ATP 8% ~ H + K % ph ph > 6. 0 ph < 5. 0 LH GnRH 30% ~ 40% 5-HT

2 Chin J Gastroenterol Hepatol Jun 2012 Vol. 21 No Oct- 1 25% ~ 40% reotide Upper gastrointestinal hemorrhage UGIB Omeprazole Pantoprazole Upper gastrointestinal bleeding ph ph > Cochrane Reviewer s Handbook 2 / 4 A B Meta C Cochrane Lirary Pubmed Revman P > 0. 1 I 2 50% Meta h Z μ P < OR 1 95% = + / h 24 h 48 h

3 Chin J Gastroenterol Hepatol Jun 2012 Vol. 21 No. 6 1 Tab 1 The basic situation of the study ml μg /h 7 d 3 d 40 mg ml q 12 h μg 5% P < mg ~ 50 μg /h mg + 3 d ml q 12 h 4 3 P < mg mg + 20 ml ~ μg /h 40 2 d mg ml 6 q 12 h P < ~ 50 μg /h 40 3 d mg ml q 12 h mg P > mg + 20 ml 1 25 ~ d 50 μg /h mg q 12 h P >

4 Chin J Gastroenterol Hepatol Jun 2012 Vol. 21 No mg ~ 50 μg /h 3 d 40 mg ml q 12 h P > B P = I 2 = 0% Meta Z = P < OR = % CI Meta Fig 1 The total effective rate of Octretide peptide proton pump inhibitors combined treatment of varicose veins upper gastrointestinal bleeding Meta OR = > 1 OR 24 h OR 2 Fig 2 The OR funnel figure of the treatment of non-variceal gastrointestinal bleeding

5 Chin J Gastroenterol Hepatol Jun 2012 Vol. 21 No. 6. 2nd ed. Beijing Higher Edu Li YP. Evidence-based medicine M cation Press M h 48 h48 h prilosec treatment J Xu YS Wang Q Liu YZ Pharmaceutical Journal J Liu SD Lin GB Xiang SH et al. The non-variceal gastrointestinal bleeding clinical observation of octretide joint pantoprazole treatment 5 jiang Medical Journal J Li XB. The peptic ulcer clinical observation of Octretide joint panto- Meta 887. prazole in 36 cases with gastrointestinal bleeding J ceuticals A 36 J nal bleeding clinical observation J. J Li Y. The drug therapy of upper gastrointestinal bleeding Chinese J. 10 Cao LJ. Pantoprazole in the treatment of the non-variceal gastrointestinal bleeding clinical observation J. Yiayao Qianyan Practical Medicine Journal J Arabi Y Al Knawy B Barkun AN et al. Pro /con debate Octreotide J has an important role in the treatment of gastrointestinal bleeding of un- 11 Kang DY Hong Q Liu GJ et al. Investigating and dealing with known origin J. Critical Care publication bias in Meta analysis J. Chinese Journal of Evidencebased Medicine Yin SL Liu XM He L et al. Report guidelines for systematic review and meta-analysis a systematic review J. Chinese Journal of Evidence-based Medicine J /Meta J Meng H. The peptic ulcer clinical observation of Octretide peptide joint. China Modern Doctor J. et al. The non-variceal gastrointestinal bleeding clinical observation of octretide joint pantoprazole treatment J. Strait J. Zhe China Pharma-. 9 Lu L. Octretide peptides in the treatment of the non-variceal gastrointesti-. Modern Journal of Integrated Traditional Chinese and Western Medicine Meta

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