Project management έργων αξιοποίησης φυσικών προϊόντων. Κωνσταντίνος Γαρδίκης, MSc, PhD, Scientific Affairs Director

Transcript

1 Project management έργων αξιοποίησης φυσικών προϊόντων Κωνσταντίνος Γαρδίκης, MSc, PhD, Scientific Affairs Director

2 PROJECT MANAGEMENT IN INNOVATION

3 5ετής Πυξίδα Στρατηγικής

4 Πυξίδα Στρατηγικής 1 Βιώσιμη εταιρεία Η Πυξίδα μας καθοδηγεί για να είμαστε η «Ηγέτιδα Κόσμος εταιρεία» στον κλάδο. Growth: Emerging Markets & Travel Retail 2 Φυσικά, Αποτελεσματικά, Ολιστικά προϊόντα 3 Δημιουργικοί και ηθικοί άνθρωποι 5 Ευρύ χαρτοφυλάκιο ποιοτικών προϊόντων και υπηρεσιών 4 Εταιρεία Kosmos που ικανοποιεί τις ανάγκες και προσδοκίες των πελατών 6 Σημαντική κερδοφορία 7 Εταιρεία που επικονιάζει τον τρόπο ζωής APIVITA. 4

5 Ο όμιλος APIVITA FARM APIGEA APIVITA SPAIN APIVITA JAPAN APIVITA USA 5

6 Διαφοροποίηση Η Αόρατη Διάσταση της Διαφοροποίησης Όραμα Φιλοσοφία Αξίες Εμπνεύσεις Αποστολή Είναι Η Ορατή Διάσταση της Διαφοροποίησης APIVITA Natural-Effective-Holistic products APIVITA HIVE, εγκαταστάσεις APIVITA Experience Store APIVITA FARM, APIGEA 6

7 5 year sustainability plan APIVITA Loyals LOHAS Naturalites Cultural Creatives Ecomoms Millennials Kosmos APIVITA Loyals LOHAS Naturalites Cultural Creatives Ecomoms Millennials Brand identity Brand Places Brand HGMCC* Brand experiences Brand networks Brand loyalty Brand Evolution Brand Societing Brand Community APIVITA Virtual Store APIVITA e-community APIVITA Annual Events APIVITA Experience Stores APIVITA Loyalty Scheme APIVITA HIVE APIVITA Experience Store APIVITA consistent and simple messages APIVITA brand personalities APIVITA Opinion Leaders aligned with APIVITA Word of mouth, word of mouse Brand DNA Brand Hubs Brand HGMCC * APIVITA ID* APIVITA ECD* APIVITA CASI* APIS* Academia APIVITA Society/ Kosmos Brand Sustainability Brand Kosmos Brand Language Brand Loyalty 2022 APIVITA HIVES APIVITA Rituals APIVITA E-vangelists *HGMCC Holistic Green Marketing & Corporate Communication *ID Innovation & Diversification *ECD Effective Customer Dialogue *CASI Consistent Authentic Social Interaction *APIS Academia 7 APIVITA Pedagogy, Innovation & Sustainability

8 Σχεδιασμός Στρατηγικής Όραμα Είναι - Εμπνεύσεις Φιλοσοφία - Αξίες Αποστολή Στρατηγική γαλάζιων ωκεανών Ανθρώπινο Δυναμικό & Υποδομές Πελάτες Brand Στρατηγικός Χάρτης Εσωτερικές Διεργασίες Οικονομική ανάπτυξη Κοινωνική Ευθύνη Έργα - Διαδικασίες Προσωπικοί στόχοι Αποτελέσματα Στρατηγικής Ικανοποιημένοι μέτοχοι Ενθουσιασμένοι πελάτες Αποτελεσματικές Διεργασίες Επιτυχημένο Brand Ενδυναμωμένοι Συνεργάτες Αειφόρος Ανάπτυξη 8

9 Σχεδιασμός Στρατηγικής 5-ΕΤΗΣ ΠΥΞΙΔΑ ΣΤΡΑΤΗΓΙΚΗΣ Υψηλού επιπέδου στρατηγικός χάρτης που ορίζει τις γενικές κατευθύνσεις για την εταιρεία, μέσα από συγκεκριμένους στόχους και ευκαιρίες, με σκοπό τη δημιουργία βιώσιμης και κερδοφόρας μακροπρόθεσμης ανάπτυξης 3-ΕΤΗΣ ΕΤΑΙΡΙΚΗ ΣΤΡΑΤΗΓΙΚΗ Συγκεκριμένο, απτό στρατηγικό σχέδιο και επιλογές, με σκοπό την ανάπτυξη της αγοράς και τη μεσοπρόθεσμη κερδοφόρα ανάπτυξη ΕΤΗΣΙΟΣ ΠΡΟΥΠΟΛΟΓΙΣΜΟΣ Βραχυπρόθεσμοι στόχοι και σχέδια για τη διασφάλιση των παραδοτέων του 1 ου βήματος της 3-ετούς στρατηγικής 9

10 M A R K E T R E Q U I R E M E N T S S A T I S F I E D C U S T O M E R S FINANCE- BUSINESS PLANNING MARKETING SALES GREECE INT/NAL BUSINESS R&D MANU FACTURING PROCUREMENT LOGISTICS HUMAN RESOURCES INF/TION SYSTEMS MANAGEMENT SYSTEMS CORPORATE COM/TION Διεργασιακό Σύστημα APIVITA 10

11 6 ος Στρατηγικός Χάρτης ΚΟΙΝΩΝΙΚΗ ΕΥΘΥΝΗ Περιεχόμενα Αειφορία Στρατηγική σε 4 πυλώνες Έκθεση Αειφορίας 11

12 ΑΕΙΦΟΡΙΑ Ως εταιρεία που εμπνέεται από τη φιλοσοφία και τις αξίες της σύμμετρης και βιώσιμης ανάπτυξης ξεκινάμε με γνώμονα τρεις αλληλοσυνδεόμενες συνιστώσες: PEOPLE PLANET PROFIT ΑΝΘΡΩΠΟΙ ΠΛΑΝΗΤΗΣ ΟΙΚΟΝΟΜΙΑ Η προσέγγισή μας κατά τη διαδικασία λήψης αποφάσεων ενσωματώνει όλες τις αξίες, την ηθική, τις κοινωνικές προσδοκίες, τα ζητήματα και τις διαδικασίες που πρέπει να λάβουμε υπ όψιν, προκειμένου όχι μόνο να εκμηδενίσουμε κάθε επιβάρυνση που προέρχεται από τις δραστηριότητές μας, αλλά και να δημιουργήσουμε οικονομική, κοινωνική και περιβαλλοντική προστιθέμενη αξία. 12

13 ΚΟΙΝΩΝΙΚΗ ΥΠΕΥΘΥΝΟΤΗΤΑ Όλες οι δραστηριότητές μας δημιουργούν προστιθέμενη αξία και για τους 4 πυλώνες: ΚΟΙΝΩΝΙΑ ΠΕΡΙΒΑΛΛΟΝ ΕΡΓΑΣΙΑ ΑΓΟΡΑ Οι εμπνεύσεις μας, το όραμά μας, η αποστολή μας, η φιλοσοφία μας, οι αξίες μας, το «είναι» μας και οι διαχρονικές δεσμεύσεις μας υποστασιοποιούνται μέσα από στρατηγικές, πολιτικές, διαδικασίες, δράσεις, προϊόντα και υπηρεσίες και επικονιάζονται σε όλα τα εμπλεκόμενα μέλη με ειλικρίνεια και διαφάνεια. 13

14 SINCE 1979 GREEK GREEN INNOVATI VE COMPAN Y ROADMAP TO SUSTAINABIL ITY 5-year plan APIVITA Innovation Team

15 STRATEGIC GOALS 1. 5-year plan: 90% of natural raw materials sourced from own sources and/or Greek farmers and beekeepers. 2. Plant based raw materials: 100% ORGANIC CERTIFIED 3. HERBS for APIVITA extracts, plant oils and own produced essential oils: 100% from Greece 100% organic certified 4. BEE BASED raw materials: 100% GREEK certified (traceability) 5. BEE BASED raw materials: 100% sourced by APIGEA

16 Φιλοσοφία Ανάπτυξης Προϊόντων Η ομάδα Έρευνας & Ανάπτυξης της APIVITA μετουσιώνει τη φιλοσοφία της εταιρείας, την έμπνευση και τις αξίες της σε καινοτόμες συνθέσεις φυσικών, αποτελεσματικών, ολιστικών προϊόντων

17 APIVITA, Στρατηγική Γαλάζιων Ωκεανών Από τους υφάλους του ανταγωνισμού, στον απέραντο ωκεανό των ευκαιριών διάκρισης Blue Ocean Strategy, W. Chan Kim & R. Mauborgne

18 PROJECT MANAGEMENT IN INNOVATION

19 PROJECT

20 PROGRAM

21 PROJECT CHARACTERISTICS

22 PROJECT MANAGEMENT TARGETS

23 PROJECT MANAGEMENT FLOW CHART

24 PROJECT INITIATION

25 PROJECT ORGANISATION

26 PROJECT ACTIVITIES ANALYSIS

27 PROJECT TIME ORGANISATION

28 FUND MANAGEMENT

29 TECHNOLOGY MANAGEMENT

30 PROJECT BUDGET

31 IMPLEMENTATION AND CHECK

32 ΑΛΛΗΛΕΠΙΔΡΑΣΕΙΣ ΣΥΜΜΕΤΕΧΟΝΤΩΝ

33 Target

34 GREEK FRAMEWORK PROGRAMS

35 BeeCosmAge Bee-based natural products as potential cosmeceutical agents with health promoting properties against UV-induced skin photo-ageing

36 Core Idea Development of high quality cosmeceuticals based on fully characterized (according to flora and geographic region) bee products The innovative research processes will be carried out applying the most modern green technologies and antiageing biological research

37 Participants Participants Country Dept. Scientist in charge 1 APIVITA S.A Greece Depart. Research & Development Dr. Konstantinos Gardikis 2 University of Ioannina (UoI Greece Pathologic Anatomy Dr. Anna Gousia 3 Democritus University of Thrace (DuTh) Greece Molecular Pharmacology Dr. Aglaia Pappa 4 University of Athens (UoA) Greece Pharmacognosy Dr. Nektarios Aligiannis 5 Nanchang University (NCU) China Food Science & Technology Dr. Liping Luo

38 Work flow Characterization, extraction (UoI, DuTh, UoA, NCU) Sample collection (API, NCU) Green extraction: MAE SFE SWE PLE Formulation, Scale up (API) Collection of samples from organic sources Pollen analysis State-of-the-art technology for the evaluation of raw materials/extracts Metabolomics Melissopalinology Toxicity profile Antioxidant & antiageing efficacy Encapsulation, formulation and QC of new natural products And cosmetics based on high quality/tech bee products

39 Objectives Collection and characterization of bee products (honey, royal jelly, propolis) from various areas 1 Extraction with various green methods, isolation of ingredients, characterization and efectiveness assesment Encapsulation in nanocarriers (cyclodextrins, liposomes) 2 3

40 Formulation in cosmetic products Objectives 4 5 Evaluation of the efficacy of the products Scale-up 6

41 BeeCosmAge-Target Proof of the uniqueness of Greek bee products Contact with chinese academia & market New series of innovative extracts Βudget: 500, euro (Greek side)

42 BeeCosmAge-Dissemination

43 BeeCosmAge-Dissemination European Biotechnology Congress (May 2015, Bucharest) TOXICITY PROFILING OF PROPOLIS EXTRACTS FROM DIFFERENT GEOGRAPHIC REGIONS OF GREECE AND EVALUATION OF THEIR ANTI- OXIDANT AND ANTI-MUTAGENIC AND ANTI-AGEING PROPERTIES ON HUMAN KERATINOCYTES UNDER UVR EXPOSURE CONDITIONS Voulgaridou Georgia-Persephoni 1,2, Alexis Galanis 1, Sofia Eftaxia 2, Anna Gousia 2, Nektarios Aligiannis 3, Kostantinos Gardikis 4, Panayiotidis Michalis 4 and Pappa Aglaia 1 * 1 Department of Molecular Biology & Genetics, Democritus University of Thrace, Alexandroupolis,Greece 2 Department of Pathology Medical School, University of Ioannina, Ioannina 3 Department of Pharmacy, Division of Pharmacognosy & Natural Products Chemistry, University of Athens Athens, APIVITA SA, Industrial Park, Markopoulo Mesogaias 19003, Markopoulo Attiki, Athens 5 School of Life Sciences, Heriot Watt University, Edinburgh, Scotland

44 BeeCosmAge-Dissemination Polyphenols (June 2015, Malta) APPLICATION OF GREEN EXTRACTION METHODOLOGIES TO DEVELOP PROPOLIS-BASED NATURAL EXTRACTS AS POTENTIAL COSMECEUTCAL AGENTS STAVROPOULOU M.-I. (1), STATHOPOULOU K. (1), KANAKIS H. (1), GARDIKIS K. (2), ALIGIANNIS N. (1) (1) Department of Parmacognosy and Natural Products Chemistry, Faculty of Pharmacy, University of Athens, Athens 15771,Greece (2) Apivita SA Industrial Park of Markopoulo Mesogaias,19003 Markopoulo Attiki,Athens,Greece Propolis is a resinous material collected by honeybees and has various biological activities (antibacterial, antiviral etc.)[1]. It contains phenolics [2], widely recognized as strong antioxidants and suggest that propolis could be applied topically to prevent and treat skin damages [3]. Moreover, safety hazards, high cost of organic solvents and the increased concern for environmental pollution, led to green technologies and innovative extraction procedures [4-6]. This project aims to develop high-quality cosmeceutical agents, based on Greek propolis involving environmentally friendly techniques.

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46 PROPOLIS PATENT CONTROLLED RELEASE Controlled Release Propolis (PATENT METHOD) Cyclodextrin propolis Aqueous core Propolis Polar head

47 PharmaMuds Physicochemical and biological characterization and improvement of natural muds to produce high addedvalue products

48 Core Idea Chemical analysis of mud from various areas of Greece Physicochemical stabilization of mud particles Biological evaluation on skin cells Formulation of face masks

49 Participants Participants Country Dept. Scientist in charge 1 APIVITA S.A Greece Scientific Affairs-R&D Dr. Konstantinos Gardikis 2 University of Patras (UPatras) Greece Chemical Engineering Dr. Ioannis Tsamopoulos 3 University of Athens (UoA) Greece Medical School/Biological Chemistry Dr. Paraskevi Moutsatsou 4 Technion University (Tech) Israel Chemical Engineering Dr. Avi Nir 5 Anna Lotan (AL) Israel R&D Dr. Liping Luo

50 Sample collection (API, AL) Collection of samples from Greek area & Dead Sea Work flow Characterization, Stabilisation, Biological Evaluation (UPatras, UoA, Tech) Analysis of inorganic & organic content Particle modification Additives Anti-inflammatory, antiaging, antimicrobial effect Formulation, Scale up (API, AL) Formulation and QC of new cosmetics based on high quality/tech mud products

51 PharmaMuds-Target Stable raw materials Proof of the efficacy of traditionally used materials New series of face masks Incorporation in products 2018 Βudget: 300, euro (Greek side)

52 MUD AREAS Δείγμα Προιόν Τοποθεσία Έτος συλλογής ΜUD 1 Ιαματική λάσπη Μεσσολογγίου Φοινικιά, μεγάλη αλυκή 2014 ΜUD 2 Ιαματική λάσπη Μεσσολογγίου Τουρλίδα ΜUD 3 Μαύρος θεραπευτικός πηλός σώματος Πικρολίμνη Κιλκίς Ξηροκερατιά 2014 ΜUD 4 Καβάλα Κρηνίδες, Φιλίπποι 2014 ΜUD 5 Ιαματική λάσπη Μεσσολογγίου Αγία Τριάδα 2014 ΜUD 6 Ιαματική λάσπη Μεσσολογγίου Τουρλίδα ΜUD 7 Ιαματική λάσπη Μεσσολογγίου Τουρλίδα ΜUD 8 Κυλλήνη Κάστρο Κυλλήνη 2014 ΜUD 9 Πιερία Πύδνα Κολινδρου 2014 ΜUD 10 Κερκυρα Σιδάρι 2014 ΜUD 11 Ιαματική λάσπη Μεσσολογγίου Φοινικιά/Τουρλίδα ΜUD 12 Λήμνος Κότσινας 2014 MUD 13 Dead Sea Mud ( A) Israel Έτος Αποστολής 2015 ΜUD 14 Ιαματική λάσπη Μεσσολογγίου Τουρλίδα ΜUD 15 Ιαματική λάσπη Μεσσολογγίου Τουρλίδα ΜUD 16 Ιαματική λάσπη Μεσσολογγίου Τουρλίδα

53 MUD ANALYSIS

54 MUD ANALYSIS Mud No Min Size (μm) Max Size (μm) Mean Size (μm) 1 0,7 4,8 1,8 2 3,7 20,3 5,1 3 0,2 6,7 2,0 4 1,4 22,8 5,0 5 0,7 13,1 3,5 6 1,0 6,1 3,0 7 0,7 10,4 3,5 8 0,6 14,3 3,1 9 0,8 12,5 2,9 10 0,3 7,6 1,9 11 0,8 20,5 6,2 12 0,25 54,2 9,1 Α.Α. Δείγματος Συγκέντρωση Ολικών Φαινολών (mg/l) 1 Δεν ήταν δυνατό να μετρηθεί 2 14,3 3 14,3 4 3,7 5 94,7 6 98,3 7 56,5 8 20,4 9 Δεν ήταν δυνατό να μετρηθεί 10* 2,9 11* 1,7 12* 1,2

55 MUD FORMULATION MUD No Stabilized with CODE MUD 5 Sodium hyaluronate 1.2 % MudStab 1 MUD 5 Xanthan gum 0.25 % and Sodium MudStab hyaluronate 2 MUD 5 Xanthan gum 0.5 % and H 2 O MudStab 3 MUD 6 Xanthan gum 0.5 % and H 2 O MudStab 4 MUD 7 Xanthan gum 0.5 % and H 2 O MudStab 5 MUD 6 Xanthan gum 0.25 % and Sodium MudStab hyaluronate 0.2% 6 MUD 11 Xanthan gum 0.35 % and Sodium MudStab hyaluronate 0.2% 7

56 STABILIZED MUD PATENT Stabilized Messologi Mud (PATENT FORMULATION/USE)

57 FRAMEWORK 7

58 AlgaeCom Exploitation of microalgae diversity for the development of novel high added-value cosmeceuticals

59 Core Idea MICROALGAE Bioactive Ingredients Sugars Proteins Ω3 Rhamnose Carageenan

60 Innovation AlgaeCom Ingredients for the Cosmetic Industry Antioxidants Colorants Vitamins Polysacharides

61 Participants Participant Country Dept. Scientist in charge 1 Agricultural University of Athens (AUA) Greece Dept. Agric. Biotechn. Lab. Molec. Biology Dr. Emmanouil Flemetakis 2 Centre National de Rechreches Scientifique (CNRS) France Marine plant and biomolecules Dr. William Helbert 3 APIVITA S.A. Greece Scientific Affairs-R&D Dr. Konstantinos Gardikis 4 FITOPLANCTON MARINO Spain Molecular Biology & Manufacturing Dr. Carlos Unamunzaga

62 Workflow Academic partners (AUA, CNSR) MicroAlgae cultivation (FITOPLANCTON) Development and optimize application-based microalgae culture systems State-of-the-art technologies for the evaluation of microalgae GC-MS / LC-MS Enzymatic studies Studies on the structure and properties of extracellular polysaccharides Testing of microalgae extracts Innovative products development (APIVITA) Development of new natural products and cosmetics based on microalgae extracts, enzymes and polysaccharides

63 ALGAECOM-TARGET Extract(s) with important hydrating/firming/antiageing properties Setup of biochemistry lab Control/proof of effectiveness DNA barcoding Contact with a new world of ingredients Incorporation in products 2016 Βudget: 1,570, euro

64 PRO-ALGAE PATENT Nannochloropsis gaditana extract (1 st time in cosmetics) + Propolis patent

65 ΝΕΟ SUNCARE FACE

66 Research Programs HORIZON 2020

67 1st round: proposals 1st stage success: 11% 2 nd round success: 16% 67

68 Horizon 2020: Algae4a-b Title: Development of Microalgae-based novel high addedvalue products for the Cosmetic and Aquaculture industry Call: H2020-MSCA-RISE-2015 Topic: MSCA-RISE Type of action: Marie-Curie actions Target: New -omic technologies and new strains for the production of high added value cosmeceuticals APIVITA interest: New multifunctional enhanced extracts and isolated enzymes Total Budget: euro APIVITA budget: euro Reimbursement rate: 100% Duration: 48 months Start date: 11/

69 PARTICIPANTS PARTICIPANT PARTICIPANT ORGANIZATION NAME COUNTRY NO 1 (Coordinator) FITOPLANCTON MARINO SPAIN 2 APIVITA GREECE 3 CNRS FRANCE 4 AGRICULTURAL UNIVERSITY OF ATHENS GREECE 5 IFAPA SPAIN 6 CCMAR PORTUGAL 7 LIFESEQUENCING SPAIN 69

70 lgae4a-b structure

71 Algae4A-B in a glance Επιλογή ειδών και στελεχών μικροφυκών ενδημικών στη λεκάνη της Μεσογείου -Nannochloropsis gatitana -Phaeodactylum sp. -Tetraselmis chuii Μεταβολική επαγωγή βιομορίων υψηλής αξίας -Αλατότητα -Έλλειψη αζώτου - Ένταση και ποιότητα φωτισμού Ανάλυση βιομάζας -Γενετική ανάλυση -Ενζυμική ανάλυση -Μεταβολομική ανάλυση Μελέτες βιοδραστικότητας των εκχυλισμάτων με εφαρμογή in vitro συστημάτων Ανάπτυξη τελικών προϊόντων κοσμητολογίας βασισμένων σε εκχυλίσματα μικροφυκών Ανάπτυξη μεθόδων για την παραγωγή υψηλής αξίας εκχυλισμάτων εμπλουτισμένων σε επιθυμητά δραστικά βιομόρια Ανάπτυξη των μεθόδων σε βιομηχανική κλίμακα

72 Ανάπτυξη Πλατφόρμας για την in vitro αξιολόγηση των φυσικών εκχυλισμάτων και βιομορίων In silico αναγνώριση ανθρώπινων γονιδίων που εμπλέκονται σε (>300) Δομή του Δέρματος Γήρανση του Δέρματος Κυτταρικός κύκλος Μηχανισμοί μεταγωγής μοριακών μηνυμάτων Μηχανισμοί αναγέννησης του Δέρματος Ενυδάτωση Προστασία από UV Ανάπτυξη πλατφόρμας μελέτης της επίδρασης των εκχυλισμάτων Table 1. List of selected genes for the study of the transcriptional effects of microalgae extracts or compounds on skin ID Gene Name Gene Physiological Process 1 matrix metallopeptidase 1 MMP1 Breakdown of extracellular matrix, Collagen breakdown 2 matrix metallopeptidase 13 MMP13 Breakdown of extracellular matrix 3 matrix metallopeptidase 3 MMP3 Breakdown of extracellular matrix 4 matrix metallopeptidase 8 MMP8 Breakdown of extracellular matrix 5 collagen, type I, alpha 1 COL1A1 extracellular matrix structure 6 collagen, type IV, alpha 1 COL4A1 extracellular matrix structure 7 collagen, type VI, alpha 1 COL6A1 extracellular matrix structure 8 Tyrosinase TYR Melanogenesis, skin spots 9 Thioredoxin TXN response to intracellular nitric oxide 10 major histocompatibility complex, class II, DR alpha HLA-DRA acne related 11 BTNL2 butyrophilin-like 2 BTNL2 acne related 12 transcobalamin I TCN1 acne related - Vitamin B12 13 B-cell CLL/lymphoma 2 BCL2 anti-apoptosis 14 BCL2-related protein A1 BCL2A1 anti-apoptosis 15 BCL2-like 1 BCL2L1 anti-apoptosis 16 baculoviral IAP repeat containing 3 BIRC3 anti-apoptosis 17 CASP8 and FADD-like apoptosis regulation CFLAR anti-apoptosis 18 Fas cell surface death receptor FAS anti-apoptosis serpin peptidase inhibitor, clade B (ovalbumin), member 2 tumor necrosis factor, alphainduced protein 3 SERPINB2 TNFAIP3 anti-apoptosis anti-apoptosis

73 Horizon 2020: Tascmar Title: Tools And Strategies to access to original bioactive compounds from Cultivation of MARine invertebrates and associated symbionts Call: H2020- Blue Growth Topic: Novel marine derived biomolecules and industrial biomaterials Type of action: Research and Innovation actions Target: Isolation and production of new antioxidant molecules or enhanced extracts from plants of EU seas APIVITA interest: New sustainable and effective raw materials derived with innovative green methods of extraction Total Budget: euro APIVITA budget: euro Reimbursement rate: 100% Duration: 48 months Start date: 3/2015 or 4/

74 Participants

75 Target of the project: Explore the mesophotic aquatic environment Explore marine invertebrates and associated symbionts Discover the chemical weapons of marine organisms Discover bioactive molecules with anti-aging activity Develop new biotechnological solution for cultivations Develop innovative final products

76 Why focusing in the marine environment..?

77 Why focusing in the marine environment..? Described land species ~ 1.5 million (85%) Described marine species ~ 250,000 There are more phyla and classes in the oceans (of 33 animal phyla, 21 exclusively marine, only 1 terrestrial) The exploration of marine ecosystems has only began in the mid 1970 Mar. Drugs 2014, 12, ; doi: /md TYPE OF ECOSYSTEM Deep sea Cold coral reefs Seamounts Pelagic ecosystems Coastal waters Intertidal ecosystems Estuaries

78 Why focusing in the marine mesophotic environment..? Innovation 1

79 Why focusing in invertebrates & marine small molecules? Aciclovir (zovirax) Cryptotethya crypta Ecteinascidia turbinata

80 Why focusing in marine associated organisms..? Innovation 2

81 Why focusing in anti-aging? New drugs New food supplements New cosmetics

82 Why focusing in anti-aging?

83 Why developing new biotechnological solution for invertebrates cultivations? Innovation 5

84 Why developing new biotechnological solution for microorganisms cultivations? Innovation 6

85 Why doing this research now? LC-HRMS NMR HTS Metabolomics Innovation 7

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87 WP3. Bioassay scheme

88 TASCMAR in Brief Microorganisms (Actinomycetes, Fungi) Marine invertebrates Microalgae zooxanthellae Enzymes Extracts - Compounds Cultivation improvements Bio-assays Bio-assays Biocatalysts Industrial developments Industrial equipment Neutraceuticals Pharmaceuticals Cosmeceuticals

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90 TASCMAR Consortium Participant Participant organization name Type of institution Country 1 CNRS CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE RESEARCH ORGANIZATION FRANCE 2 UoA NATIONAL AND KAPODISTRIAN UNIVERSITY OF ATHENS ACADEMIA GREECE 3 TAU TEL AVIV UNIVERSITY ACADEMIA ISRAEL 4 CU CHULALONGKORN UNIVERSITY RESEARCH ORGANIZATION THAILAND 5 UR UNIVERSITE DE LA REUNION ACADEMIA FRANCE 6 CRELUX CRELUX INDUSTRY - SME GERMANY 7 BICT BICT SRL INDUSTRY - SME ITALY 8 PGT PIERRE GUERIN SAS INDUSTRY FRANCE 9 IMARE imare NATURAL SL INDUSTRY - SME SPAIN 10 ASTAREAL ASTAREAL AB INDUSTRY - SME SWEDEN 11 APIVITA APIVITA INDUSTRY - SME GREECE 12 T6ECO T6 Ecosystems SRL CONSULTING - SME ITALY 13 ECOOCEAN ECOOCEAN NGO ISRAEL

91 TASCMAR, who is doing what Group 1. Marine invertebrates Group 2. Microorganisms Group 3. Microalgae Group 4. Chemistry Group 5. Bio-assays Group 6. Tech Equipment Group 7. Enzymes Group 8. Industrial developments Group 9. Socio-Eco-Environ Group 10. Management

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95 TASCMAR is a collaborative European research project funded by the European Union s Horizon 2020 research and innovation programme, under grant agreement N

96 APIVITA SCIENTIFIC SYNERGIES ECOSYSTEM 74 Universities and Research Institutes 23 countries 16 million euro total budget

97 Global presence Ukraine Benelux UK Latvia Croatia Romania Japan USA Spain Italy Greece Hong Kong Cyprus

98 APIVITA Experience Store

99 APIVITA Experience Store

100 Athens International Airport Store

101 Athens Shop in Shop

102 Athens Pharmacy corner

103 SPAIN: INNOVATION APIVITA SPAIN S.A. Key highlights extracton of Greek Propolis for the producton of APIVITA high valued entered raw the material Spanish with market ant-oxidant in 2003, andinitially operating photo-protectve through a distribution and ant-aging agreement actvityactvity. a method with minimum energy consumpton and zero waste In November 2009, APIVITA established a wholly owned subsidiary Products are currently placed in: in 1 order flagship to increase store in stability, Madrid permeability open since March and bioavailability of actve components 2010 Greek 87 EI Royal Corte Jelly Ingles encapsulaton department in liposomes stores offers new 870 and pharmacies enhanced propertes for an-tageing 5 Hotel & SPA

104 SPAIN 1 Store 87 El Corte Ingles 870 Pharmacies

105 Madrid Flagship Store

106 El Corte Ingles, Barcelona

107 JAPAN: INNOVATION APIVITA JAPAN Key highlights extracton of Greek Propolis for the producton APIVITA of high valued entered raw the material market with in 2010, ant-oxidant initially and operated through a distribution agreement photo-protectve and ant-aging actvityactvity. a method with minimum energy consumpton and zero waste In November 2013, APIVITA established a wholly owned subsidiary. Currently, since 2015, in joint venture Products in order are to increase currently stability, placed permeability in: and bioavailability of actve components 10 Greek stores Royal in key Jelly departments encapsulaton stores in liposomes offers new and enhanced propertes for an-tageing

108 Tokyo Flagship Store Jiyugaoka

109 HONG INNOVATION KONG Key highlights extracton of Greek Propolis for the producton of Apivita high valued is the raw market material for 10 with years ant-oxidant and photo-protectve and ant-aging actvityactvity. a method with minimum energy consumpton and zero waste Partnership with IMAGINEX, a leading brand management and distribution company on the luxury market segment of the Great China region, in based order to in Hong increase Kong stability, permeability and bioavailability of actve components Greek Royal Jelly encapsulaton in liposomes offers new 11 shop and enhanced in shop in key propertes departments for an-tageing stores Raised market awareness through key advertising campaigns

110 NEW TOWN PLAZA Shatin

111 Romania INNOVATION Key highlights extracton of Greek Propolis for the producton APIVITA of high valued is in the raw market material for with 6 years ant-oxidant and photo-protectve and ant-aging actvityactvity. a method with minimum energy consumpton and zero Partnership waste with SensiBlu SensiBlu owns 80% of the pharmacy channel in Romania Products are currently placed in: in order to increase stability, permeability and bioavailability 405 pharmacies of actve components full brand 1 Greek flagship Royal store Jelly encapsulaton in liposomes offers new and enhanced propertes for an-tageing 2 shop in shop

112 ROMANIA 405 Pharmacies (53 corners)

113 Romania Pharmacy Corner

114 ROMANIA New Store Bucharest

115 Cyprus INNOVATION Key highlights extracton of Greek Propolis for the producton APIVITA of high valued is in the raw market material for with 20 years ant-oxidant and photo-protectve and ant-aging actvityactvity. a method with minimum energy consumpton and zero Partnership waste with Drogopharma Products are currently placed in: 250 pharmacies in order to increase stability, permeability and bioavailability 1 experience of actve store components open since October 2015 Greek Royal Jelly encapsulaton in liposomes offers new and enhanced propertes for an-tageing

116 CYPRUS New Experience Store

117 CYPRUS International Airport

118 CYPRUS Pharmacy Corner

119 Benelux INNOVATION Key highlights extracton of Greek Propolis for the producton Present of high valued since July raw 2010 material with ant-oxidant and photo-protectve and ant-aging actvityactvity. a method with minimum energy consumpton and zero Products waste are currently placed in: Belgium (100+ pharmacies) Luxembourg The Netherlands ( 1 Apivita store open since November 2015) in order to increase stability, permeability and bioavailability of actve components Greek Royal Jelly encapsulaton in liposomes offers new and enhanced propertes for an-tageing

120 The NETHERLANDS Store New Amsterdam

121 BELGIUM 100 Pharmacies

122 Ukraine INNOVATION Key highlights extracton of Greek Propolis for the producton APIVITA of high valued is in the raw market material for with 4 years ant-oxidant and photo-protectve and ant-aging actvityactvity. a method with minimum energy consumpton and zero Partnership waste with Olfa Products are currently placed in: 250 pharmacies in order to increase stability, permeability and bioavailability 2 Apivita stores of actve components Greek Royal Jelly encapsulaton in liposomes offers new and enhanced propertes for an-tageing

123 UKRAINE 250 Pharmacies

124 Bulgaria INNOVATION Key highlights extracton of Greek Propolis for the producton APIVITA of high valued is in the raw market material for with 2 years ant-oxidant and photo-protectve and ant-aging actvityactvity. a method with minimum energy consumpton and zero Partnership waste with A&D Pharma Products are currently placed in: 60 pharmacies in order to increase stability, permeability and bioavailability Notos Department of actve components Stores Greek Royal Jelly encapsulaton in liposomes offers new and enhanced propertes for an-tageing

125 Six Senses Spa - Elounda, Greece HOTEL & SPA Six Senses Spa - Turkey Me by MELIÁ, Madrid

126 Thank you