Ioannis S. Vizirianakis, Ph.D. Associate Professor in Molecular Pharmacology & Pharmacogenomics

Transcript

1 Minutes Of the meeting of the Seven-Member Special Committee, met in order to vote for the promotion of Associate Professor Ioannis Vizirianakis, to fulfill a position of a Professor (A degree) in the scientific field of Molecular Pharmacology- Pharmacogenomics. Mr I. Vizirianakis, the only candidate, is a faculty member of Pharmacy of the School of Health Sciences of the Aristotle University of Thessaloniki. The proceedings of the Election for the filling of a teaching position of a first degree regular professor in the department of the school of Pharmacy in the scientific field Molecular Pharmacology- Pharmacogenomics (No 498/ ) have been as follows:

2 Ioannis S. Vizirianakis, Ph.D. Associate Professor in Molecular Pharmacology & Pharmacogenomics Detailed Profile-CV-Syllabus Info at: CHRONOLOGICAL AND COMPARATIVE DISTRIBUTION OF MY SCIENTIFIC WORK IN ACADEMIA (RESEARCH-TEACHING-ADMINISTRATION) (For the period up to May 2014). RESEARCH / TOTAL LAST 5-YEAR PERIOD 1 RESEARCH ARTICLES IN PEER-REVIEW JOURNALS (SINCE 2008) IF Range: COMMENTS Lower IF: 1,8 Higher IF: 12,5 BURDEN PER YEAR FOR THE LAST 5-YEAR PERIOD 4.2 (5 additional papers have also been submitted for publication) 2 CHAPTERS IN BOOKS RESEARCH ARTICLES IN Greek Journals and Editions (in Greek language) 4 Presentations in International & National Scientific Conferences 5 Presentations in International & National Scientific Conferences as Invited Speaker (1 additional chapter under preparation) (6 IN INTERNATIONAL MEETINGS) Total N o of Conferences Participation in research and/or educational grant projects 15 1 (as collaborator and/or coordinator) 7 Book editor (in Greek language) (For teaching purposes) 8 BOOK EDITOR (in English language) (4 Educational grant projects) 5 The Simcyp program fulfils both research and education targets nd edition (290 pages; 55 tables; 35 figures) st edition 1560 pages; with 88 Black & white; 48 colored images) URL: om/books/ html 9 THEME EDITOR 1 1 PEER-REVIEW JOURNAL: 2.6 TITLE: Clinical Pharmacokinetics: Basic principles of pharmaceutical care in clinical practice TITLE: Handbook of Personalized Medicine: Advances in Nanotechnology, Drug Delivery, and Therapy Theme issue title: 10 Supervisor as well as member of the 3-member supervising and/or 7- member examination committees in 12 7 (1 as supervisor) ADVANCED DRUG DELIVERY REVIEWS (IF: 12,5) PERSONALIZED NANOMEDICNE 1.4 1

3 Ph.D. thesis projects 11 Supervisor as well as member of the 3-member examination committee in M.Sc. thesis projects 12 Supervisor in diploma theses of undergraduate pharmacy students 13 Supervisor in Erasmus students (Research project) 14 Expert interview- Research project essay 15 Supervisor in M.Sc. projects from other Greek Universities (8 as supervisor) The Graduate Curriculum in the School of Pharmacy has been initiated during the academic year Total number of students enrolled upon the 10-year period in the 2 directions Pharmacology - Therapeutics and Molecular Diagnostics- Biotechnology : The diploma thesis has been introduced in the curriculum during academic year From Spain 1 From Canada 1 1 Faculty of Medicine, University of Thrace 2.4 (My involvement (22 out of 66) in M.Sc. thesis projects accounts for 30% of the total number of students been enrolled) 2.8 (it refers to the 3- year period) 0,2 16 Member of the Organizing Committee in International and National Scientific Conferences 17 Organization of a fully-interactive Continuing Education Program for Pharmacists (Full-in-charge; in contract basis) 18 Introduction of new scientific terms In the scientific literature 19 Member in the Editorial Board in Peer-Review Journals 11 7 (2 International) 1 1 The CE program is available in the following URL: < sfe/default.aspx> Term: pharmacotyping 20 Reviewer in Peer-Review Journals >16 >10 21 Reviewer in various funding bodies/grants (e.g. from the General Secretariat for Research and Technology, State Scholarships Foundation, NASA, University of Patras, Scientific Societies) >12 >8 It was coined on 2004 See the article: Curr Drug Deliv Jan;1(1): The inaugural presentation has been on May 8, 2010 and can be accessed in the following URL: < sfe/sfeparuisiaserres2010. pdf> The term pharmacotyping already appears in the glossary of Cambridge Healthtech Institute (CHI) (URL: aries.com) and also in the Life Science glossary (URL: com/glos/index.php) 2 2 -Frontiers of Pharmacology and pharmacogenetics -World Journal of Pharmacology 1,2 This CE program for Pharmacists has been initiated in supportive collaboration with the use of materials published from the US Pharmacist and Medscape 2

4 Teaching Following, the syllabus of the courses in both the undergraduate and graduate pharmacy curriculum is indicated. TUTOR IOANNIS S. VIZIRIANAKIS, Associate Professor ORGANIZED LAST 5 YEAR-TEACHING COURSE CONTENT Course syllabus for: IN GRADUATE PROGRAM SCHOOL OF PHARMACY, AUTh 1. PHARMACOLOGY 2. PHARMACOLOGY 3. CLINICAL PHARMACOKINETICS AND IN Course syllabus for: POSTGRADUATE PROGRAM SCHOOL OF PHARMACY, AUTh 4. MOLECULAR PHARMACOLOGY & PHARMACOGENETICS 5. DRUG INTERACTIONS THESSALONIKI, MAY

5 1. PHARMACOLOGY Syllabus: PHARMACOLOGY I Code number: MAF54 Cycle: UNDERGRADUATE Semester: 5 th Course type Background/General knowledge X Scientific area (pharmacy) Credit Units (ECTS): Laboratory 2 Course coordinator: Asterios S. Tsiftsoglou Tutors: 1. Asterios S. Tsiftsoglou, Professor 2. Theodore Sklaviadis, Professor 3. Ioannis S. Vizirianakis, Associate Professor Aims of the course: To introduce students into the basic principles of Pharmacology; the pharmacodynamics and pharmacokinetics parameters of drugs; the various pharmacological classes of drugs; the mechanism underlying the actions of the drugs in the body; the factors contributing to pharmacological response; the emergence of adverse drug reactions (ADRs); drug interactions; drug dosage scheme selection upon drug prescription and drug delivery in clinical practice. Skills: Appointment of lectures, tutorials and laboratory tests Teaching methods: Lecture presentations, Computer-Assisted Learning in Pharmacology (PCAL), Tutorials, and Discussion of specific drug-related case studies Contents of the course: Introduction to Pharmacology; Drug-receptor interactions; Mechanisms underlying the emergence of drug resistance; Pharmacogenetics-Pharmacogenomics and drug idiosyncrasy; Pharmacokinetics processes: absorption, distribution, metabolism, excretion (ADME); Drug interactions; Neuron cell types; Synapses; Taxonomy of neuronal receptors; Mechanism of action and structure-activity relationships of neurotransmitters; Autonomous nervous system; Parasympathomimetic drugs acting either in muscarinic or nicotinic receptors; Acetyl-cholinesterase-inhibiting drugs; Parasympatholytic drugs; Autonomic ganglia-blocking drugs; Skeletal muscle relaxant drugs; Sympathomimetic acting on adrenergic alpha- or beta- receptors; Sympatholytic acting on adrenergic alpha- or beta- receptors; Cardiac glycosides and positive inotropic agents; Diuretic drugs; Antihypertensive and anti-angina agents; Antiarrhythmic agents; Histamine and antihistaminic drugs; Ergot alkaloids; Bronchodilators and other agents used for the treatment of asthma; Local anesthetics; Drugs acting in gastrointestinal tract and the liver-bile duct system; Anti-hypercholesterolemia drugs; Hormones of hypothalamus and pituitary gland (hypophysis); Thyroid hormones and related drugs; Adrenal glands hormones and related agents; Estrogens; Androgens; Diabetes, Insulin and related drugs; Vitamins. Proposed literature: Textbooks written in Greek and English as well as pharmaceutical journals Educational activities: Through lectures, tutorials and practical courses Evaluation process and methods: Exams at the end of the semester; essay submission in laboratory tests. PowerPoint slides, computer use, PCAL CD-ROMs, experimental pharmacology animations/modeling, videos. The lectures of Assoc. Prof. I.S. Vizirianakis are available in PDF format to students in e-class AUTh. 4

6 Teaching: A) Lectures. Time 1 st (2hr) 2 nd (1 hr) 3 rd (2 hr) 4 th (1 hr) 5 th (2 hr) 6 th (1 hr) 7 th (1 hr) 8 th (2 hr) Laboratory work Time 1 o 6 groups 2 o 6 groups Title GPCRs - Adrenergic receptors and related drugs : A PCAL related CD-ROM presentation (modeling bindingpharmacological response correlation) Pathophysiology of heart failure Positive inotropic drugs Pathophysiology of hypertension Antihypertensive drugs Clinical pharmacology of antihypertensive drugs Drug selection upon prescription Physiology of urine production (diuresis) and pathophysiology Diuretic drugs Clinical pharmacology of diuretic drugs Drug selection upon prescription Vasodilating agents Anti-angina drugs Pharmacogenomics of cardiovascular disorders drugs Title Genomic DNA isolation from cultured cells and electrophoretic analysis: Study of drug actions Water bath experimental pharmacology animation/modelling program Tutor I.S. Vizirianakis I.S. Vizirianakis I.S. Vizirianakis I.S. Vizirianakis I.S. Vizirianakis I.S. Vizirianakis I.S. Vizirianakis I.S. Vizirianakis Tutor I.S. Vizirianakis I.S. Vizirianakis C) Tutorials Time 1 st (2 hr) Title Pharmacology, Pharmacogenomics and the new drug development era Tutor I.S. Vizirianakis 5

7 2. PHARMACOLOGY Syllabus: PHARMACOLOGY II Code number: MAF64 Cycle: UNDERGRADUATE Semester: 6 th Course type Background/General knowledge X Scientific area (pharmacy) Credit Units (ECTS): Course coordinator: Asterios S. Tsiftsoglou Tutors: 1. Asterios S. Tsiftsoglou, Professor 2. Ioannis S. Vizirianakis, Associate Professor Aims of the course: To introduce undergraduate students of Pharmacy into the basic principles of Pharmacology; the pharmacodynamics and pharmacokinetics parameters of drugs; the various classes of medicines; the mechanism underlying their actions in the human body; the factors contributing to pharmacological response; the emergence of adverse drug reactions (ADRs); possible drug-drug interactions; drug dosage scheme selection upon drug prescription and drug delivery in clinical practice. Emphasis is given on medicines acting on CNS, on chemotherapeutics for microbial, viral infections as well as neoplastic diseases. Part of these courses covers the therapy of hematopoietic and immune disorders as well as several others. Skills: Appointment of lectures, tutorials and laboratory tests Teaching methods: Lecture presentations, Computer-Assisted Learning in Pharmacology (PCAL), Tutorials, and Discussion of specific drug-related case studies Contents of the course: Introduction to Central Nervous System (CNS) pharmacology; Anti-parkinsonism drugs; Opioid analgesics; CNS depressant agents; Barbiturates; Antidepressant drugs; Antianxiety agents; Psychotropics; Anti-psychotropic drugs; Psycho-stimulants; Alcohols; Non-opiod analgesics; NSAIDs; Antigout and anti- hyperuricaemia drugs; Anemias; Iron pharmacology; Vitamin B12; Folic acid; Antiemetic drugs; Expectorant agents; Antacids; Antidiarrhoeals; Laxatives; Antineoplastic agents; Antimicrobial drugs; Antituberculosis drugs; Antifungal drugs; Disinfectants; Antiseptics; Immunosuppressive drugs; Serum; Vaccines; Antibodies; Plasma clot mechanisms; Anticoagulant (anticlotting) agents; Proposed literature: Textbooks written in Greek and English, as well as pharmaceutical journals Educational activities: Through lectures, tutorials and practical courses Evaluation process and methods: Written exams at the end of the semester; essay submission in laboratory tests. PowerPoint slides, computer use, PCAL CD-ROMs, videos. The lectures of Assoc. Prof. I.S. Vizirianakis are available in PDF format to students in e-class AUTh Teaching: A) Lectures Title Tutor Time 1 st Non-opiod analgesics - NSAIDs - Antigout and antihyperuricaemia I.S. Vizirianakis (3 hr) drugs 2 nd Anemias Iron pharmacology Vitamin B12 - Folic acid I.S. Vizirianakis 6

8 (1 hr) 3 rd (2 hr) 4 th (2 hr) 5 th (2 hr) 6 th (1 hr) 7 th (2 hr) 8 th (1 hr) 9 th (1 hr) 10 th (2 hr) 11 th (1 hr) Time 1 o 6 groups) 2 o 6 groups) C) Tutorials Time 1 (2hr) 2 (2hr) Cancer chemotherapy I - Introduction to cancer biology/cancer genome heterogeneity and pharmacological/clinical consequences Cancer Chemotherapy II - Anticancer agents Chemotherapy III - Anticancer molecularly targeted agents and alternative cancer therapies Immunosuppression drugs Plasma clot mechanisms Anticoagulant (anticlotting) agents Pharmacogenomics of anticoagulant agents Antidepressant drugs and antianxiety agents Psychotropics - anticonvulsant drugs Pharmacogenomics of antidepressant and psychotropic drugs Laboratory work Title Evaluation of cytotoxic activity of antineoplastic chemotherapeutic drugs by using leukemic cell cultures Genotyping and mapping analysis of specific DNA fragments for pharmacogenomics applications Cancer pharmacogenomics Title Pharmacovigilance: The case of NSAIDs I.S. Vizirianakis I.S. Vizirianakis I.S. Vizirianakis I.S. Vizirianakis I.S. Vizirianakis I.S. Vizirianakis I.S. Vizirianakis I.S. Vizirianakis I.S. Vizirianakis Tutor I.S. Vizirianakis I.S. Vizirianakis Tutor I.S. Vizirianakis I.S. Vizirianakis 7

9 3. CLINICAL PHARMACOKINETICS Syllabus: CLINICAL PHARMACOKINETICS Code number: 81 Cycle: Undergraduate Semester: 8 th Course type Background/General knowledge X Scientific area (pharmacy) Credit Units (ECTS): Course coordinator: Ioannis Niopas Tutor (s): Ioannis Niopas Ioannis S. Vizirianakis Assisting personnel: Marios Spanakis Aims of the course: Lectures/tutorials by Ioannis S. Vizirianakis: The lectures and tutorials aim to assist pharmacy students in developing their skills to understand and assess clinically relevant drug interactions in a way to finally contribute for minimizing adverse drug interactions (ADRs) in healthcare. To this end, the predictive as well as the assessment capabilities of students for drug interactions and ADRs will be clearly strengthen and an overall benefit for both pharmaceutical care environment and drug delivery outcomes will be achieved. As a matter of fact, students are expected to acquire knowledge and practical skills as practitioners in order to improve drug efficacy and safety profiles in clinical practice. In order these targets to be achieved, specific teaching methodologies are applied: a) lectures focusing on selected pharmacokinetics, pharmacodynamics, pharmacogenomics and personalized medicine concepts; b) discussions of specific clinical drug interaction case studies within the frame of evidence-based medicine; and c) tutorials for specific drug dosage scheme data evaluation by implementing the Simcyp-Population Based Pharmacokinetic Modelling and Simulation» platform (academic license agreement since 2009). Skills: Students assessment capability for drug interactions and ADRs Teaching methods: Presentations, Powerpoint slides, books, drug case-studies discussion Contents of the course: Tutor: Ioannis S. Vizirianakis A) Lectures content Protein binding of drugs, Intestine drug metabolism, Hepatic drug metabolism, Assessment of drug interactions mechanisms, Drug-drug drug-food and drug-herb interactions, Mechanisms involved in the emergence of adverse drug interactions, Pharmacogenomics and adjustment of drug dosage delivery, PK-based drug prescription principles, Pharmacoeconomy issues in drug delivery, Clinical relevance of drug metabolizing enzymes and transporters genetic polymorphism, Individualizing drug delivery dosage schemes in clinical practice, Environmental toxicants and drug delivery. Examples of pharmacokinetic case studies discussed: a) cerivastatin market removal, b) removal of rofecoxib from the market/clinical practice, c) drug-induced QT-elongation and drug cardiotoxicity and d) PK-based methodological improvements applied upon indinavir new drug development. ) Tutorials content Implementation of Simcyp-Population Based Pharmacokinetic Modelling and Simulation platform to predict PK parameters and PD effects of drugs as well as to assess clinically relevant drug interactions for specific populations in an effort to adjust drug delivery dosage schemes either for monotherapy or for polypharmacy». A) Lectures Lecture Title Tutor Time 1 st The role of clinical pharmacokinetics in modern Ioannis S. Vizirianakis therapeutics towards improving new drug development 8

10 (1 hr) era as well as efficacy and safety profiles in clinical practice 2 nd (2 hr) Protein binding and drug distribution: Consequences for drug bioavailability and clinically relevant interactions 3 rd Hepatic function and drug distribution (2 hr) 4 th Drug metabolizing enzymes and transporters: Function, tissue distribution, pharmacokineticspharmacogenomics (3 hr) evaluation and pharmacological assessment 5 th Drug-food interactions: Mechanisms and clinical (2 hr) relevance 6 th Drug-herb interactions: Mechanisms and clinical (2 hr) relevance 7 th Drug-drug interactions: Mechanisms and clinical (2 hr) relevance 8 th Prediction of clinically relevant drug interactions: Pharmacogenomics and pharmacoeconomics (3 hr) evaluation and clinical relevance 9 th Environmental toxicants and drug distribution: clinical (1 hr) evaluation 10 th Pharmacological and pharmacogenomics approaches to improve drug delivery clinical outcomes: (2 hr) Implementation of personalized medicine concepts in drug delivery Ioannis S. Vizirianakis Ioannis S. Vizirianakis Ioannis S. Vizirianakis Ioannis S. Vizirianakis Ioannis S. Vizirianakis Ioannis S. Vizirianakis Ioannis S. Vizirianakis Ioannis S. Vizirianakis Ioannis S. Vizirianakis B) Tutorials Tutorial Title Tutor 1 st (2 hr) Application of population pharmacokinetics platform Simcyp to assess clinically relevant drug interactions: ) Basic principles of population pharmacokinetics and demonstration of Simcyp platform Ioannis S. Vizirianakis, Marios Spanakis 2 nd (2 hr) 3 rd (2 hr) Application of population pharmacokinetics platform Simcyp to assess clinically relevant drug interactions: ) PK/PD evaluation of midazolam administration in various populations Application of population pharmacokinetics platform Simcyp to assess clinically relevant drug interactions: C) PK/PD evaluation upon co-administration of midazolam with ketoconazole in various populations Ioannis S. Vizirianakis, Marios Spanakis Ioannis S. Vizirianakis, Marios Spanakis Referred Books - Handouts - Slides: 1. Ioannis S. Vizirianakis (In Greek). «Clinical Pharmacokinetics: Basic Principles of Pharmaceutical Care in Clinical Practice. 1 st Edition, 2010; Stavros Sartinas Publishing: Thessaloniki, Greece. 2. Ioannis S. Vizirianakis. (In Greek). Course handouts referring to slides/presentations available to students for download in the University e-class Platform of AUTh (slides in total 299) and also the material related to the population pharmacokinetics lessons by the application of Simcyp- Population Based Pharmacokinetic Modelling and Simulation» (academic license agreement since 2009). 3. Population-based Simcyp platform tutorials. Presentation slides available in e-class AUTh. 9

11 4. MOLECULAR PHARMACOLOGY & PHARMACOGENETICS Pharmacy postgraduate curriculum at the School of Pharmacy, AUTh Implementation 1 st year of the program at the School: Tutors: Asterios S. Tsiftsoglou, Professor Ioannis S. Vizirianakis, Associate Professor Course: MOLECULAR PHARMACOLOGY & PHARMACOGENETICS Tutor: Ioannis S. Vizirianakis Title Tutor Time New drug development era: Advancements in molecular I.S. Vizirianakis 3 hr pharmacology, informatics, nanotechnology and genomics Druggability and new pharmacological classes of drugs i.e. antisense RNAs, sirnas, aptamers I.S. Vizirianakis 2 hr Pharmacogenetics/Pharmacogenomics: From pharmacological I.S. Vizirianakis knowledge enrichment to practical clinical utility 2 hr Drug resistance mechanisms and consequences to chemotherapy in I.S. Vizirianakis 2 hr clinical practice Pharmacology and pharmacogenomics of cardiovascular system: I.S. Vizirianakis 2 hr Focus on innovative drug development and drug delivery Assessment of ADRs in clinical practice: Focus on drug interactions I.S. Vizirianakis 2 hr and pharmacogenomics Case study: The development of selective COX-2 inhibitors I.S. Vizirianakis 1 hr Application of MeSHy program to extract unanticipated drug-related I.S. Vizirianakis 1 hr knowledge from Pubmed Personalized medicine and drug prescription I.S. Vizirianakis 2 hr GPCRs: Toward a pharmacological and pharmacogenomics I.S. Vizirianakis 2 hr assessment Development of new innovative molecularly-targeted cancer I.S. Vizirianakis 2 hr therapeutics ANS and cardiovascular system: Pathophysiology - Pharmacology - I.S. Vizirianakis 2 hr Pharmacogenomics Cancer pharmacogenomics / Personalized cancer therapy I.S. Vizirianakis 2 hr Assessment of students work / Presentations I.S. Vizirianakis 6 hr 10

12 5. DRUG INTERACTIONS Pharmacy postgraduate curriculum at the School of Pharmacy, AUTh Implementation 1 st year of the program at the School: Tutor: Ioannis S. Vizirianakis Course: DRUG INTERACTIONS Title Tutor Time Introduction to drug interaction issues and their clinical relevance in modern I.S. Vizirianakis 1 hr therapeutics; Drug interactions assessment methodologies Clinical evaluation of drug-drug, drug-food and drug-herb interactions in routine I.S. Vizirianakis healthcare 2 hr Pharmacovigilance: Eudravigilance and WHO regulatory issues I.S. Vizirianakis 1 hr Pharmacovigilance: Regulatory environment, yellow card scheme, data collection I.S. Vizirianakis and assessment of ADRS in modern therapeutics 2 hr Molecular mechanisms involved in drug interactions: Pharmacology and I.S. Vizirianakis 1 hr pharmacogenomics of drug transporters, metabolizing enzymes and receptors Personalized medicine: Clinical status for individualizing drug prescription dosage I.S. Vizirianakis 2 hr schemes CYP isoenzymes and genetic polymorphism: Clinical consequences in clinical I.S. Vizirianakis 1 hr practice Case study for the cholinesterase inhibitors: Assessment and evaluation of various I.S. Vizirianakis drugs interactions seen in clinical practice 2 hr Induction of CYPs and the role of nuclear receptors I.S. Vizirianakis 1 hr Drug-induced cardiotoxicity: Elongation of QT interval and ICH-E14 guidance I.S. Vizirianakis 2 hr Assessment of pharmacovigilance data from the ADROIT database I.S. Vizirianakis 1 hr Case study for the use of clinical- and genomics-based algorithms to guide I.S. Vizirianakis 2 hr warfarin dose in individual patients (Case study) Simcyp-population based platform: Clinical usefulness and new drug development I.S. Vizirianakis 1 hr capabilities Application of the Simcyp-population based platform toward the prediction of I.S. Vizirianakis 2 hr clinically relevant drug interactions Group work presentation by the students (I) I.S. Vizirianakis 2 hr Drug-induced hepatotoxicity: Molecular pharmacology, pharmacogenomics and clinical evaluation (evidence-based medicine) Group work presentation by the students ((II) I.S. Vizirianakis 2 hr Drug-induced kidney failure: Molecular pharmacology, pharmacogenomics and clinical evaluation (evidence-based medicine) Case study for the consequences of tamoxifen-paroxetine interaction in oncology: I.S. Vizirianakis 2 hr assessment of pharmacological and pharmacogenomics data (specific case study assessment) Practical utility of various sources to predict and evaluate drug interactions in the I.S. Vizirianakis 2 hr clinical settings and minimize the emergence of ADRs Overall assessment of the Simcyp-population based platform I.S. Vizirianakis 1 hr 11

13 I. Administration tasks for I.S. Vizirianakis Member of the General Assembly of the Department of Pharmacology-Pharmacology since 1993 Member of the General Assembly of the School of Pharmacy since 1993 Member of the of the General Assembly of the Departments of Medicinal Chemistry and of the General Assembly of the Department of Pharmacology-Pharmacology ( ) as representative of Ph.D. members Member of the of the Special General Assembly of the School of Pharmacy since 2002 (initiation of the graduate pharmacy curriculum) Coordinator of the Graduate Pharmacy Curriculum in the direction of Pharmacology- Therapeutics since 2012 Member of the Coordinating Committee for the Graduate Pharmacy Curriculum since 2012 Representative of the School of Pharmacy in the Senate of the Aristotle University of Thessaloniki (2 years) Representative of the School of Pharmacy in the Research Committee of the Aristotle University of Thessaloniki (2 years) Member of the Pharmacovigilance Committee of the National Drug Organization Representative of the School of Pharmacy in the Specific Committee of the Aristotle University of Thessaloniki for the procurement of equipment through EU grants for Central Macedonia Member of various administrative committees of the Department of Pharmacology- Pharmacology and the School of Pharmacy (e.g. related to financial, equipment and consumables supply, educational reform/curriculum restructure, etc) since

14 . Regular members:. External members: 1) Ingelman-Sundberg Magnus, 2) Sitaras Nikolaos 3) Papapetropoulos Andreas 4) Gravanis Achilleas, B. AUTH members: 1) Sklaviadis Theodoros 2) Tsiftsoglou Asterios, 3) Niopas Ioannis,. External members: 1) Ingraham Holly 2) Flordellis Christodoulos 3) Sakellaridis Nikolaos 4) Kolios Georgios,. AUTH members: 1) Kouvelas Dimitrios 2) Karakioulakis Georgios 3) Mironidou-Tzouveleki Maria, has appointed you as regular or alternate members of the Seven-Member special Committee -

15 2014 at 12:30 p.m. Teleconference Room - Wednesday 14, May a by two professors or researchers b videoconference, C - Notification: Presidents of Schools/Deans of Faculties After the selection of the electorate Committee, the Dean s office announced to Mr. Vizirianakis (document 1313/ ) the composition of the Committee and asked him to indicate within 5 days in accordance with article 34, paragraph 13 of the Law N. 4115/2013, two Professors or researchers, who are members of AUTH (from the Register of Experts-AUTH) and who will make a written evaluation of this work. The candidate with his letter N , proposed for the written evaluation of his work as a) Prof. Pirmohamed Munir and Prof. Llerena Ruiz Adrian, by the

16 External Evaluators (For Ioannis S. Vizirianakis application regarding promotion to Full Professor) A. Proposed by the Electorate seven-member committee ) Professor Munir Pirmohamed, MB ChB (Hons), PhD, FRCP, FRCP(E), MedSci Professor, David Weatherall Chair of Medicine and NHS Chair of Pharmacogenetics Head of Department of Molecular and Clinical Pharmacology The Wolfson Centre for Personalised Medicine, Institute of Translational Medicine, University of Liverpool, UK ) Professor Adrian Llerena MD PhD Director Clinical Research Center, Extremadura University Hospital and Medical School, Badajoz, Extremadura, Spain B. Proposed by the Candidate III) Professor Michael Murray PhD DSc Professor, Pharmacogenomics and Drug Development Group Discipline of Pharmacology, Sydney Medical School, Australia VI) Professor Shu-Feng Zhou, MD, PhD Associate Vice President for Global Medical Development, Associate Dean for International Research, Professor& Chair of the Department of Pharmaceutical Science, College of Pharmacy, Professor of Department of Internal Medicine, Department of Molecular Medicine & Department of Molecular Pharmacology & Physiology, Morsani College of Medicine, Professor of Moffitt Cancer Center and Research Institute, National Cancer Institute (NCI) Cancer Center, Professor of Department of Global Health, College of Public Health, USF Health, University of South Florida (USF), Tampa, Florida 33612, USA

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26 The invitation for the today session of the special seven-members electorate committee with the N. 2095/ document of the Dean s Office, was send by to the regular members as well us to their alternate ones. The invitation reads as follows: FACULTY OF HEALTH SCIENCES DEANERY Secretariat: Eleni Nalbanti +30 Fa +30 Thessaloniki, : x: /07/2014 emai info@health.aut UR Reference No. : 2095 l: h.gr L: alth Administration Building of School of Medicine To - The regular members of the election Committee: Magnus Ingelman Sundberg, Nikolaos Sitaras, Andreas Papapetropoulos, Achilleas Gravanis, Theodoros Sklaviadis, Asterios Tsiftsoglou, Ioannis Niopas - The substitute members: Holly Ingraham, Dimitrios Kouvelas, Georgios Karakioulakis, Maria Mironidou-Tzouveleki, Georgios Kolios, Christodoulos Flordellis, Nikolaos Sakellaridis.

27 RE: Invitation of the seven member election committee to a repeat convocation for the election process of a Full Professor in the scientific field of Molecular Pharmacology - Pharmacogenomics Candidate: Dr. Ioannis Vizirianakis. Dear Colleagues, We kindly invite you to the rescheduled Meeting of the Special Election Committee, on Tuesday 22 July 2014 at PM (local time) for the election process of a Full Professor in the scientific field of Molecular Pharmacology - Pharmacogenomics, where Dr. Ioannis Vizirianakis is the sole candidate. The meeting, which was originally scheduled for Wednesday 09 July 2014, 11:30-13:00, was postponed by decision of the Committee, after a technical problem in connecting via videoconferencing with a member of the Special Committee and was rescheduled for this particular date. You can participate in the rescheduled Meeting by videoconference (connection details will follow in a separate message from the technical services). For further information, please contact Mr. Ioannis Paspaltsis (tel /997646, /997613, Fax: /997612, info@pharm.auth.gr,). Yours sincerely, The Dean of the Faculty of Health Sciences George Karakiulakis Professor of School of Medicin Continuing the president Prof. A. Tsiftsoglou, underlines that the evaluation of Prof. Zhou Shufeng and Pirmohamed Munir were not received within the legal time. The members of the Seven-memberes Commiitee accepted the above Professors evaluation even they were out of time.

28 2014) which have as follows: /06/ ; Fax: Profile: -mail: ivizir@pharm.auth.gr The candidate Mr. Vizirianakis submitted written opinions (documents 1831/ Syllabus) - revision ) ,

29 / & & Furthermore, the president of the committee stresses to the members of the committee that the results of the student evaluation concerning the teaching ability of Mr. Vizirianakis, show that the teaching ability of the candidate lays above the average and is satisfactory but the students sample was small. The members of the Committee considered the evaluation even the student s sample size was small. The president of the committee Prof. A. Tsiftsoglou at this point gives the floor to the members of the committee: Prof. Asterios Tsiftsoglou (Chairman of the Committee): So, I would say a few things about Dr. Vizirianakis. Dr. Vizirianakis is a graduate of this department. He did his doctorate degree here in the Department of Pharmacology. He has been a longtime colleague of mine in research. He went to America to the University of San Francisco for two years to do his post-doctoral work and he came back. He taught different courses on different disciplines like: Pharmacology I & II, Principles in Pharmacology, Systematic Pharmacology. We did a course together on Pharmacogenetics and Molecular Pharmacology to the graduate students. He teaches

30 Minutes Of the meeting of the Seven-Member Special Committee, met in order to vote for the promotion of Associate Professor Ioannis Vizirianakis, to fulfil a position of a Professor (A degree) in the scientific field of Molecular Pharmacology- Pharmacogenomics. Mr I. Vizirianakis, the only candidate, is a faculty member of Pharmacy of the School of Health Sciences of the Aristotle University of Thessaloniki. The proceedings of the Election for the filling of a teaching position of a first degree regular professor in the department of the school of Pharmacy in the scientific field Molecular Pharmacology- Pharmacogenomics (No 498/ ) have been as follows: The chairman of the Department of Pharmacy Professor Mr. Ch. Panagiotidis opens the session by declaring the following: I would like to inform the Seven-Member Special Committee, that the Dean of the Faculty of the Health Science of AUth has authorized me (Ref. letter 1350/ ) to coordinate and make the arrangements for the election of the president of the seven-member special electing committee. The formentioned president will preside for the rest of the election procedure and at this point I will leave the meeting, because my role is terminated. As a first step, it is certified that the committee for the election of the associate professor Dr Vizirianakis in the position of a regular professor has the necessary number to be in legal session according to the regulation of the University Senate article 77, paragraph 3 of the law N. 4009/2011 for the elections of professors and lecturers of the University of Thessaloniki and thus the election process may begin. Before any discussion on the subject the President of the school certifies the identity of the members of the Seven member electorate committee who are participating via teleconference. He says their names then as well as their position and specialty. After that he welcomes and thanks warmly all the members of the special electorate committee, one by one and especially the members who are participating through teleconference for the participation in the session.

31 We will proceed for the election of the president of the electorate committee, he says and he is mentioning that the up to now procedure is according to the article 34 of the law N. 3848/2010 which has been in the site of the School of Pharmacy. The President, Mr. Panagotidis says: The members of the special seven-members electorate committee, for the filling of the position of the regular professor after consultation, they elect, between the internal members as president of the Committee the member of the committee, Professor Asterios Tsiftsoglou of the School of Pharmacy of A.U.th. At this point the Chairman of the Department of Pharmacy Prof. Panagiotidis leaves the meeting and the session continues with Prof. A. Tsiftsoglou presiding. Mr. Ast. Tsiftsoglou president of the Special electorate committee says: Dr. Vizirianakis was engaged at the level of assistant professor (Government Gazette FEK 352/ band C ). He sworn as assistant Professor and enrolled his duties on 23rd of April The candidate applied for promotion to a full Professor level position on 19th November 2012 (prot. Number 172/ ) within the disciplinary subject Pharmacology Pharmacogenomics with the agreement of the Assembly of the Division Pharmacognosy-Pharmacology (protocoll number 7/ ). The General Assembly of the Department of Pharmacy at the AUTH decided at the meeting 174/ , to declare one (1) position DEP (didactic-research personal) at the Professor level within the disciplinary subject Molecular Pharmacology- Pharmacogenomics. The position was derived by a number of not assigned positions from Schools, which were incorporated into AUTH, according article 14, paragraph 5a law N.2817/2000, published in FEK 1667/ band B (yearly schedule ). with the presidential executive order 743/81 ( FEK 189/ ).

32 The announcement for the position was published in the Government Gazette FEK 498/ band C and the qualifying date for an application was the 19th of August 2013 The candidate submitted the file of his application on the 9th of July 2013 Mr. Ast. Tsiftsoglou president of the Special electorate committee informs the rest of the members for the following subjects: According to the first part of the election procedure I will refer shortly to that part and then I will go on reading the opinions of the evaluators and the students, then each member will express his opinion and discussion will follow between the member of the committee. At the end we will vote. The Department of Pharmacy at its decision N 458/ , created the special seven-members electorate committee according to article 3, paragraph 4 of the law 4076/2012 for the promotion of the associate Professor Mr I. Vizirinakis in the position of a regular professor having the positive opinion of the Dean s Council (Decision 12/ ), in the scientific field of Molecular Pharmacology- Pharmacogenomics This decision of the School of Pharmacy has been announced to the Dean s office of the Faculty of Health by the Document 1034a/ The Dean s office with its document No 1312/ to the selected members of the electorate special Committee let them know the selection and send them the invitation for the first session which took place in the The relevant document reads as follows: ΕΛΛΗΝΙΚΗ ΔΗΜΟΚΡΑΤΙΑ FACULTY OF HEALTH SCIENCES DEANERY ΑΡΙΣΤΟΤΕΛΕΙΟ ΠΑΝΕΠΙΣΤΗΜΙΟ ΘΕΣΣΑΛΟΝΙΚΗΣ Secretariat: Eleni Nalbanti Τηλ.: Fax: Thessaloniki, info@health.auth.gr URL: Reference No. : Κτίριο Administration Building of School of Medicine To the Members of the Seven-Member Special Committee for a position of Professor in scientific field Molecular Pharmacology-Pharmacogenomics. Dear Professors,

33 By acting as Dean of the Faculty of Health Sciences at the Aristotle University of Thessaloniki, I would like to inform you that you have been selected to act as evaluators by vote for the promotion of Associate Professor Ioannis Vizirianakis at the School of Pharmacy. Below you can find the structure of that committee along with instructions of the process to be followed: Ι. Regular members: Α. External members: 1) Ingelman-Sundberg Magnus, Professor of Physiology and Pharmacology & Pharmacogenetics, Karolinska Institute, Stockholm, Sweden 2) Sitaras Nikolaos, Professor of Medicine at the National and Kapodistrian University of Athens 3) Papapetropoulos Andreas, Professor of Pharmacy at the National and Kapodistrian University of Athens 4) Gravanis Achilleas, Professor of Medicine at the University of Creta B. AUTH members: 1) Sklaviadis Theodoros, Professor of Pharmacy at the Aristotle University of Thessaloniki 2) Tsiftsoglou Asterios, Professor of Pharmacy at the Aristotle University of Thessaloniki 3) Niopas Ioannis, Professor of Pharmacy at the Aristotle University of Thessaloniki ΙΙ. Substitute Members Α. External members: 1) Ingraham Holly, Professor of Cellular and Molecular Pharmacology, Univ. of California at San Francisco, USA 2) Flordellis Christodoulos, Professor of Medicine at the University of Patra 3) Sakellaridis Nikolaos, Professor of Medicine at the University of Thessaly 4) Kolios Georgios, Profesor of Medicine at the Democritus University of Thrace Β. AUTH members: 1) Kouvelas Dimitrios, Professor of Medicine at the Aristotle University of Thessaloniki 2) Karakioulakis Georgios, Professor of Medicine at the Aristotle University of Thessaloniki 3) Mironidou-Tzouveleki Maria, Professor of Medicine at the Aristotle University of Thessaloniki We herewith inform you that, the Assembly of the School of Pharmacy, Faculty of Health Sciences of the Aristotle University of Thessaloniki (meeting 458/ ), a) after the consent of the Deanery of the School (meeting 12/ ), b) having considered the relevant application of the candidate Mr. Ioannis Vizirianakis, associate professor, has appointed you as regular or alternate members of the Seven-Member special Committee for the process of election for the vacancy of a position of Professor in the scientific field of Molecular Pharmacology-Pharmacogenomics, as stated in the above mentioned list. This appointment is in accordance with the ordinances of articles 19 and

34 77, paragraphs 3 and 4 of Law 4186/2011, of article 3 paragraph 4 of Law 4076/2012 which replaced paragraph 5e of article 9 of Law 4009/2011, as well as of article 39 paragraph 2 of Law 4186/2013 which replaced paragraph 3 section a3 of article 19 of Law 4009/2011. Thus, a Meeting of the above mentioned Regular Members is called on Wednesday 14, May 2014 at 12:30 p.m. in the Teleconference Room of the Aristotle University of Thessalonikiy, in order to ask for written evaluation(s) of the candidate (a) by two professors or researchers (from the Register of Independent Experts-HQAA) of a foreign academic institution, or, if this is not feasible, by professors or researchers who are Members of the External Registry of the Greek Universities, and (b) by two professors or researchers of the Aristotle University of Thessaloniki indicated by the candidate. You can participate in the above mentioned Convention/Meeting by videoconference, according to G /42/23076/Β2/ MD (Hellenic Government Gazette 433/ , Vol. B) Participation of the members of appointed voting committees by videoconference, in application of par. 5 of article 34 of Law 3848/2010 (Hellenic Government Gazzette 71 Vol. A ). For further information, please send an at ipaspalt@pharm.auth.gr or contact Mr. Ioannis Paspaltsis (phone number ). We would like inform you that the curriculum vitae, as well as a relevant scientific publications of the candidate, Associate Professor, Mr. Ioannis Vizirianakis, are available to the following link: Notification: - Karolinska Institute, Stockholm, Sweden - University of California at San Francisco, USA - Rectors of National Universities Yours sincerely, - Presidents of Schools/Deans of Faculties The Dean of the Faculty of Health Sciences GEORGE KARAKIULAKIS Professor of School of Medicine After the selection of the electorate Committee, the Dean s office announced to Mr. Vizirianakis (document 1313/ ) the composition of the Committee and asked him to indicate within 5 days in accordance with article 34, paragraph 13 of the Law N. 4115/2013, two Professors or researchers, who are members of AUTH (from the Register of Experts-AUTH) and who will make a written evaluation of this work. The candidate with his letter N , proposed for the written evaluation of his work as a) Prof. Pirmohamed Munir and Prof. Llerena Ruiz Adrian, by the

35 Expert 7-Member Committee, b) Prof. Zhou Shufeng and Prof. Murray Michael, by candidate. The document of the Dean s office to the candidate has as follows: ΕΛΛΗΝΙΚΗ ΔΗΜΟΚΡΑΤΙΑ ΣΧΟΛΗ ΕΠΙΣΤΗΜΩΝ ΥΓΕΙΑΣ Κοσμητεία ΑΡΙΣΤΟΤΕΛΕΙΟ ΠΑΝΕΠΙΣΤΗΜΙΟ ΘΕΣΣΑΛΟΝΙΚΗΣ Γραμματειακή Υποστήριξη: Ελένη Ναλμπάντη Τηλ.: Fax: Θεσσαλονίκη, info@health.auth.gr URL: Αριθμ. Πρωτ. : Κτίριο Διοίκησης Τμήματος Ιατρικής, Πανεπιστημιούπολη Προς τον κ.: Ιωάννη Βιζιριανάκη, αναπληρωτή καθηγητή του Τμήματος Φαρμακευτικής της Σχολής Επιστημών Υγείας Σας πληροφορούμε ότι η Συνέλευση του Τμήματος Φαρμακευτικής της Σχολής Επιστημών Υγείας του ΑΠΘ, στη συνεδρίασή της αριθμ. 458/ , μετά από σύμφωνη γνώμη της Κοσμητείας της Σχολής (συνεδρίαση αριθμ. 12/ ), αφού έλαβε υπόψη την από σχετική αίτησή σας, όρισε, σύμφωνα με τις διατάξεις των άρθρων 19 και 77 παρ. 3 και 4 του Ν. 4009/2011, του άρθρου 3 παρ. 4 του Ν. 4076/2012 που αντικατέστησε την παρ. 5 περ. ε του άρθρου 9 του Ν. 4009/2011, και του άρθρου 39 παρ. 2 του Ν. 4186/2013 που αντικατέστησε την παρ. 3 περ. α εδάφιο τρίτο του άρθρου 19 του Ν. 4009/2011, τα μέλη της Ειδικής Επταμελούς Επιτροπής, τακτικά και αναπληρωματικά, όπως αναφέρονται παρακάτω: Τακτικά μέλη: 1) Σκλαβιάδης Θεόδωρος, καθηγητής Φαρμακευτικής του Α.Π.Θ. 2) Τσιφτσόγλου Αστέριος, καθηγητής Φαρμακευτικής του Α.Π.Θ. 3) Νιώπας Ιωάννης, καθηγητής Φαρμακευτικής του Α.Π.Θ. 4) Σιταράς Νικόλαος, καθηγητής Ιατρικής του Ε.Κ.Π.Α. 5) Παπαπετρόπουλος Ανδρέας, καθηγητής Φαρμακευτικής του Ε.Κ.Π.Α. 6) Γραβάνης Αχιλλέας, καθηγητής Ιατρικής του Πανεπιστημίου Κρήτης 7) Ingelman-Sundberg Magnus, Professor of Physiology and Pharmacology & Pharmacogenetics, Karolinska Institute, Stockholm, Sweden Αναπληρωματικά μέλη: 1) Κούβελας Δημήτριος, καθηγητής Ιατρικής του Α.Π.Θ. 2) Καρακιουλάκης Γεώργιος, καθηγητής Ιατρικής του Α.Π.Θ. 3) Μυρωνίδου Τζουβελέκη Μαρία, καθηγήτρια Ιατρικής του Α.Π.Θ.

36 4) Φλωρδέλλης Χριστόδουλος, καθηγητής Ιατρικής του Πανεπιστημίου Πατρών 5) Σακελλαρίδης Νικόλαος, καθηγητής Ιατρικής του Πανεπιστημίου Θεσσαλίας 6) Κολιός Γεώργιος, καθηγητής Ιατρικής του Δ.Π.Θ. 7) Ingraham Holly, Professor of Cellular and Molecular Pharmacology, Univ. of California at San Franscisco, USA Κατόπιν τούτου, σας παρακαλούμε να μας υποδείξετε, εντός πέντε (5) ημερών, δύο καθηγητές ή ερευνητές που θα ανήκουν υποχρεωτικά στο Μητρώο Εσωτερικών και Εξωτερικών Μελών του Ιδρύματος και δεν περιλαμβάνονται στα τακτικά ή αναπληρωματικά μέλη της επιτροπής επιλογής ή εξέλιξης, οι οποίοι θα προβούν σε γραπτή αξιολόγηση του έργου σας, σύμφωνα με την παρ. 8 του άρθρου 3 της Κανονιστικής Απόφασης της Συγκλήτου του ΑΠΘ, όπως τροποποιήθηκε, την παρ. 13 του άρθρου 34 του Ν. 4115/2013 (Α 24) και την παρ. 2 του άρθρου 39 του Ν. 4186/2013. Η Ειδική Επταμελής Επιτροπή θα συνεδριάσει για τον ορισμό των αξιολογητών την Τετάρτη 14 Μαΐου 2014 και ώρα Ο Κοσμήτορας της Σχολής Επιστημών Υγείας ΓΕΩΡΓΙΟΣ ΚΑΡΑΚΙΟΥΛΑΚΗΣ Καθηγητής Τμήματος Ιατρικής

37 The Special seven-members Committee in its 1 st session, decided unanimously after thorough discussion, according to par.3 article 34 Law n 4115/2013 to ask for written evaluation for the work of the candidate Mr. Vizirinakis from the professors or researchers from abroad who are register (in the foreign evaluators register), or if this is not possible by teachers or researchers nominated by the candidate and are mandatory in the records of the Foundation and included in as regular or alternate members of the selection and development Committee. A) Prof. Zhou Shufeng and Prof. Murray Michael, (from the candidate) B) Prof. Pirmohamed Munir and Prof. Llerena Ruiz Adrian (from the Committee) The Dean s office with its decision 1408/ informed the evaluators said that decision of the seven-members special committee which has as follows: ΕΛΛΗΝΙΚΗ ΔΗΜΟΚΡΑΤΙΑ FACULTY OF HEALTH SCIENCES DEANERY ΑΡΙΣΤΟΤΕΛΕΙΟ ΠΑΝΕΠΙΣΤΗΜΙΟ ΘΕΣΣΑΛΟΝΙΚΗΣ Secretariat: Eleni Nalbanti Τηλ.: Fax: Thessaloniki, 16/05/ info@health.auth.gr URL: Reference No. : 1408 Κτίριο Administration Building of School of Medicine To: The EVALUATORS of the academic achievement of Associate Professor Ioannis Vizirianakis, regarding his eligibility for the position of professor in the scientific field of Molecular Pharmacology- Pharmacogenomics 1) Pirmohamed Munir, Professor of Institute of Translational Medicine, University of Liverpool, England. 2) Llerena Ruiz Adrian, Professor of Faculty of Medical School, University of Extremadura, Spain. 3) Murray Michael, Professor of Faculty of Pharmacy, Institute of Pharmaceutical Sciences of Sydney, Australia. 4) Zhou Shufeng, Professor of Department of Pharmaceutical Sciences, College of Pharmacy, Tampa, U.S.A. Subject: Appointment of expert evaluators of the academic achievements of Mr. Ioannis Vizirianakis (Associate Professor), candidate for the position of professor in

38 the field of Molecular Pharmacology-Pharmacogenomics at the School of Pharmacy of the Aristotle University of Thessaloniki. Dear Sirs, In accordance with: 1) the ordinances of articles 19 and 17 of Law 4009/2011, as well as of article 34 of Law 4115/2013, 2) the ordinances of article 3 of the Regulating Decision of the Senate of Aristotle University of Thessaloniki, as in article 77,paragraph 3 of Law 4009/2011 regarding the Election of Faculty Members of the Aristotle University of Thessaloniki (meeting 2842/ , Hellenic Government Gazette 31/ , issue B), 3) the application submitted by associate professor Mr. Ioannis Vizirianakis to the School of Pharmacy of the Aristotle University of Thessaloniki on , 4) the proposal of the General Assembly of the School of Pharmacy of the Faculty of Health Sciences of the Aristotle University (meeting 457/ ) the agreement to this proposal by the Deanery (meeting 12/ ), as well as the meeting 458/ of the General Assembly of the School of Pharmacy, 5) the decision of the Appointed 7-member Committee ( ) for this specific position, you have been appointed as evaluators of the scientific work of Mr. Ioannis Vizirianakis, candidate for the position of professor at the level of professor in the scientific field of Molecular Pharmacology-Pharmacogenomics at the School of Pharmacy of the Aristotle University of Thessaloniki, as follows: Prof. Pirmohamed Munir and Prof. Llerena Ruiz Adrian, by the Expert 7-Member Committee Prof. Zhou Shufeng and Prof. Murray Michael, by candidate (with his document of ). You are kindly requested to submit your written personal evaluation to the Appointed 7- Member Committee within forty (40) days of the announcement of the decision of the committee (Regulating Decision of the Senate of the Aristotle University of Thessaloniki, article 3 paragraph 8). We would like inform you that the curriculum vitae, as well as a relevant scientific publications of the candidate, Associate Professor, Mr. Ioannis Vizirianakis, are available to the following link: The members of the Appointed 7-Member Committee Α. External members: 1) Ingelman-Sundberg Magnus, Professor of Physiology and Pharmacology & Pharmacogenetics at the Karolinska Institute, Stockholm, Sweden 2) Sitaras Nikolaos, Professor of Medicine at the National and Kapodistrian University of Athens 3) Papapetropoulos Andreas, Professor of Pharmacy at the National and Kapodistrian University of Athens 4) Gravanis Achilleas, Professor of Medicine at the University of Creta

39 B. AUTH members: 1) Sklaviadis Theodoros, Professor of Pharmacy at the Aristotle University of Thessaloniki 2) Tsiftsoglou Asterios, Professor of Pharmacy at the Aristotle University of Thessaloniki 3) Niopas Ioannis, Professor of Pharmacy at the Aristotle University of Thessaloniki It should be noted that the evaluators appointed by the 7-Member Committee are Professors or Researchers of foreign educational institutions who are included in the registry of external members, or, when the former is not possible, of Greek educational institutions, who are included in the registry of external members. The evaluators appointed by the candidates are Professors or Researchers who are faculty members at the educational institution of the candidates, and are not among the full or alternate members of the Election Committee deciding upon the election or advancement of the candidates, as required by law. Yours sincerely, The Dean of the Faculty of Health Sciences GEORGE KARAKIULAKIS Professor of School of Medicine

40 Professor Murray Michael submitted his evaluation in time with document No 1691/ , which reads as follows:

41

42

43 Professor Llerena Ruiz Adrian submitted his evaluation in time with document No 1754/ , which reads as follows:

44

45 Professor Zhou Shufeng submitted a late evaluation (overtimed), with document No 2077/ , which reads as follows:

46

47 Prof. Pirmohamed Munir submitted a late evaluation (overtimed), with document No 2145/ , which reads as follows:

48

49 Prof. Mr Tsiftsoglou says: The Dean s Office with documents α) 1692/ , β) 1755/ , c) 2083/ and d) 2147/ , submitted the above evaluation to the candidate Mr. Vizirianakis, stressing that according to the law he can submitted an objection (opinion) within 8 days from the day of official receiving the evaluations, which have as follows: ΕΛΛΗΝΙΚΗ ΔΗΜΟΚΡΑΤΙΑ ΣΧΟΛΗ ΕΠΙΣΤΗΜΩΝ ΥΓΕΙΑΣ Κοσμητεία ΑΡΙΣΤΟΤΕΛΕΙΟ ΠΑΝΕΠΙΣΤΗΜΙΟ ΘΕΣΣΑΛΟΝΙΚΗΣ Γραμματειακή Υποστήριξη: Ελένη Ναλμπάντη Τηλ.: Fax: Θεσσαλονίκη, info@health.auth.gr URL: Αριθμ. Πρωτ. : 1755 Κτίριο Διοίκησης Τμήματος Ιατρικής, Πανεπιστημιούπολη Προς τον κ. Ιωάννη Βιζιριανάκη, Αναπληρωτή Καθηγητή του Τμήματος Φαρμακευτικής της Σχολής Επιστημών Υγείας του ΑΠΘ Θέμα: Κοινοποίηση της αξιολόγησης για την πλήρωση θέσης στη βαθμίδα του Καθηγητή με γνωστικό αντικείμενο «Μοριακή Φαρμακολογία-Φαρμακογονιδιωματική» Σας διαβιβάζουμε τη γραπτή αξιολόγηση που υπέβαλε o κ. Adrian LLerena, Professor of Pharmacology and Clinical Pharmacology, of Clinical Research Center, Extremadura University Hospital and Medical School Badajoz, Extremadura, Spain, ο οποίος ορίστηκε αξιολογητής του έργου σας από την Ειδική Επταμελή Επιτροπή στις , σύμφωνα με τις διατάξεις του άρθρου 34 παρ. 13 του Ν. 4115/2013 (ΦΕΚ 24/ ). Επίσης, σας ενημερώνουμε ότι μπορείτε να υποβάλετε σχετικό υπόμνημα εντός αποκλειστικής προθεσμίας οκτώ (8) ημερών από την κοινοποίηση του εγγράφου αυτού. Ο Κοσμήτορας της Σχολής Επιστημών Υγείας Γεώργιος Καρακιουλάκης

50 Καθηγητής Τμήματος Ιατρικής ΕΛΛΗΝΙΚΗ ΔΗΜΟΚΡΑΤΙΑ ΣΧΟΛΗ ΕΠΙΣΤΗΜΩΝ ΥΓΕΙΑΣ Κοσμητεία ΑΡΙΣΤΟΤΕΛΕΙΟ ΠΑΝΕΠΙΣΤΗΜΙΟ ΘΕΣΣΑΛΟΝΙΚΗΣ Γραμματειακή Υποστήριξη: Ελένη Ναλμπάντη Τηλ.: Fax: Θεσσαλονίκη, URL: Αριθμ. Πρωτ. : 1692 Κτίριο Διοίκησης Τμήματος Ιατρικής, Πανεπιστημιούπολη Προς τον κ. Ιωάννη Βιζιριανάκη, Αναπληρωτή Καθηγητή του Τμήματος Φαρμακευτικής της Σχολής Επιστημών Υγείας του ΑΠΘ Θέμα: Κοινοποίηση της αξιολόγησης για την πλήρωση θέσης στη βαθμίδα του Καθηγητή με γνωστικό αντικείμενο «Μοριακή Φαρμακολογία-Φαρμακογονιδιωματική» Σας διαβιβάζουμε τη γραπτή αξιολόγηση που υπέβαλε ο κ. Michael Murray, Professor of Faculty of Pharmacy, Institute of Pharmaceutical Sciences of Sydney, Australia., ο οποίος ορίστηκε αξιολογητής του έργου σας από την Ειδική Επταμελή Επιτροπή στις , σύμφωνα με τις διατάξεις του άρθρου 34 παρ. 13 του Ν. 4115/2013 (ΦΕΚ 24/ ). Επίσης, σας ενημερώνουμε ότι μπορείτε να υποβάλετε σχετικό υπόμνημα εντός αποκλειστικής προθεσμίας οκτώ (8) ημερών από την κοινοποίηση του εγγράφου αυτού. Ο Κοσμήτορας της Σχολής Επιστημών Υγείας Γεώργιος Καρακιουλάκης Καθηγητής Τμήματος Ιατρικής

51 ΕΛΛΗΝΙΚΗ ΔΗΜΟΚΡΑΤΙΑ ΣΧΟΛΗ ΕΠΙΣΤΗΜΩΝ ΥΓΕΙΑΣ Κοσμητεία ΑΡΙΣΤΟΤΕΛΕΙΟ ΠΑΝΕΠΙΣΤΗΜΙΟ ΘΕΣΣΑΛΟΝΙΚΗΣ Γραμματειακή Υποστήριξη: Ελένη Ναλμπάντη Τηλ.: Fax: Θεσσαλονίκη, URL: Αριθμ. Πρωτ. : 2147 Κτίριο Διοίκησης Τμήματος Ιατρικής, Πανεπιστημιούπολη Προς τον κ. Ιωάννη Βιζιριανάκη, Αναπληρωτή Καθηγητή του Τμήματος Φαρμακευτικής της Σχολής Επιστημών Υγείας του ΑΠΘ Θέμα: Κοινοποίηση της αξιολόγησης για την πλήρωση θέσης στη βαθμίδα του Καθηγητή με γνωστικό αντικείμενο «Μοριακή Φαρμακολογία-Φαρμακογονιδιωματική» Σας διαβιβάζουμε τη γραπτή αξιολόγηση που υπέβαλε o κ. Munir Pirmohamed, Professor of Department of Pharmacology of Institute of Translational Medicine, University of Liverpool, England, ο οποίος ορίστηκε αξιολογητής του έργου σας από την Ειδική Επταμελή Επιτροπή στις , σύμφωνα με τις διατάξεις του άρθρου 34 παρ. 13 του Ν. 4115/2013 (ΦΕΚ 24/ ). Επίσης, σας ενημερώνουμε ότι μπορείτε να υποβάλετε σχετικό υπόμνημα εντός αποκλειστικής προθεσμίας οκτώ (8) ημερών από την κοινοποίηση του εγγράφου αυτού. Ο Κοσμήτορας της Σχολής Επιστημών Υγείας Γεώργιος Καρακιουλάκης Καθηγητής Τμήματος Ιατρικής

52 ΕΛΛΗΝΙΚΗ ΔΗΜΟΚΡΑΤΙΑ ΣΧΟΛΗ ΕΠΙΣΤΗΜΩΝ ΥΓΕΙΑΣ Κοσμητεία ΑΡΙΣΤΟΤΕΛΕΙΟ ΠΑΝΕΠΙΣΤΗΜΙΟ ΘΕΣΣΑΛΟΝΙΚΗΣ Γραμματειακή Υποστήριξη: Ελένη Ναλμπάντη Τηλ.: Fax: Θεσσαλονίκη, URL: Αριθμ. Πρωτ. : 2083 Κτίριο Διοίκησης Τμήματος Ιατρικής, Πανεπιστημιούπολη Προς τον κ. Ιωάννη Βιζιριανάκη, Αναπληρωτή Καθηγητή του Τμήματος Φαρμακευτικής της Σχολής Επιστημών Υγείας του ΑΠΘ Θέμα: Κοινοποίηση της αξιολόγησης για την πλήρωση θέσης στη βαθμίδα του Καθηγητή με γνωστικό αντικείμενο «Μοριακή Φαρμακολογία-Φαρμακογονιδιωματική» Σας διαβιβάζουμε τη γραπτή αξιολόγηση που υπέβαλε o κ. Zhou Shufeng, Professor of Department of Pharmaceutical Sciences, College of Pharmacy, Tampa, U.S.A., ο οποίος ορίστηκε αξιολογητής του έργου σας από την Ειδική Επταμελή Επιτροπή στις , σύμφωνα με τις διατάξεις του άρθρου 34 παρ. 13 του Ν. 4115/2013 (ΦΕΚ 24/ ). Επίσης, σας ενημερώνουμε ότι μπορείτε να υποβάλετε σχετικό υπόμνημα εντός αποκλειστικής προθεσμίας οκτώ (8) ημερών από την κοινοποίηση του εγγράφου αυτού. Ο Κοσμήτορας της Σχολής Επιστημών Υγείας Γεώργιος Καρακιουλάκης Καθηγητής Τμήματος Ιατρικής

53 The above evaluation from the candidate were submitted to all members of the committee (regular and replacements) as well as to the candidate with the documents α) 1927/ ), β) 2078/ , c) 2146/ , which read as follows: ΕΛΛΗΝΙΚΗ ΔΗΜΟΚΡΑΤΙΑ FACULTY OF HEALTH SCIENCES DEANERY ΑΡΙΣΤΟΤΕΛΕΙΟ ΠΑΝΕΠΙΣΤΗΜΙΟ ΘΕΣΣΑΛΟΝΙΚΗΣ Secretariat: Eleni Nalbanti Τηλ.: Fax: Thessaloniki, 14/07/ URL: Reference No. : Κτίριο Administration Building of School of Medicine To -the regular members of the Appointed 7-member Committee: Magnus Ingelman Sundberg, Nikolaos Sitaras, Andreas Papapetropoulos, Achilleas Gravanis,Theodoros Sklaviadis, Asterios Tsiftsoglou, Ioannis Niopas -the substitute members Ingraham Holly, Dimitrios Kouvelas, Georgios Karakioulakis, Maria Mironidou- Tzouveleki, Georgios Kolios, Christodoulos Flordellis, Nikolaos Sakellaridis, for the process of election of Professor in the scientific field of Molecular Pharmacology - Pharmacogenomics Candidate is Mr. Ioannis Vizirianakis. Honorable gentlemen, Further to our letters (ref. no. 1312/ , 1927/ ) and in accordance to Greek laws and by-laws, we hereby forward to you the written evaluation of Pirmohamed Munir, Professor of Institute of Translational Medicine, University of Liverpool, England. Yours sincerely, The Dean of the Faculty of Health Sciences GEORGE KARAKIULAKIS Professor of School of Medicine

54 ΕΛΛΗΝΙΚΗ ΔΗΜΟΚΡΑΤΙΑ FACULTY OF HEALTH SCIENCES DEANERY ΑΡΙΣΤΟΤΕΛΕΙΟ ΠΑΝΕΠΙΣΤΗΜΙΟ ΘΕΣΣΑΛΟΝΙΚΗΣ Secretariat: Eleni Nalbanti Τηλ.: Fax : info@health.auth UR :.gr L: Κτίρι ο Thessaloniki, 08/07/ Reference No. : lth Administration Building of School of Medicine To the regular members of the Appointed 7-member Committee: Magnus Ingelman Sundberg, Nikolaos Sitaras, Andreas Papapetropoulos, Achilleas Gravanis,Theodoros Sklaviadis, Asterios Tsiftsoglou, Ioannis Niopas -the substitute members Ingraham Holly, Dimitrios Kouvelas, Georgios Karakioulakis, Maria Mironidou- Tzouveleki, Georgios Kolios, Christodoulos Flordellis, Nikolaos Sakellaridis, for the process of election of Professor in the scientific field of Molecular Pharmacology - Pharmacogenomics Candidate is Mr. Ioannis Vizirianakis. Honorable gentlemen, Further to our letters (ref. no. 1312/ , 1927/ ) and in accordance to Greek laws and by-laws, we hereby forward to you the written evaluation of Zhou Shufeng, Professor of Department of Pharmaceutical Sciences, College of Pharmacy, Tampa, U.S.A. Yours sincerely, The Dean of the Faculty of Health Sciences George Karakiulakis Professor of School of Medicine

55 ΕΛΛΗΝΙΚΗ ΔΗΜΟΚΡΑΤΙΑ FACULTY OF HEALTH SCIENCES DEANERY ΑΡΙΣΤΟΤΕΛΕΙΟ ΠΑΝΕΠΙΣΤΗΜΙΟ ΘΕΣΣΑΛΟΝΙΚΗΣ Secretariat: Eleni Nalbanti Τηλ.: Fax : info@health.auth UR :.gr L: Κτίρι ο Administration Building of School of Medicine Thessaloniki, 25 /06/2014 Reference No. : lth To the Members of the Appointed 7-member Committee, for the process of election of Professor in the scientific field of Molecular Pharmacology - Pharmacogenomics. Candidate is Mr. Ioannis Vizirianakis. Honorable gentlemen, Further to our letters of 09/05/2014 (ref. no. 1312), and in accordance to Greek laws and bylaws, we hereby forward to you the written evaluation of: Michael Murray, Professor of Human drug metabolism,cytochrome P450 (CYP) pharmacogenetics, Adverse drug reactions, Drugdrug interactions due to inhibition of P450 enzymes caused by reactive drug metabolites, Faculty of Pharmacy, Institute of Pharmaceutical Sciences, Australia, και Adrián LLerena, Professor of Pharmacology, Clinical Pharmacology, Pharmacogenetics, Medical School, University of Extremadura, Spain, which have been submitted for the candidate Mr. Ioannis Vizirianakis and we kindly invite you to the Meeting of the Appointed 7-Member Committee, on 09 July 2014 at for the final evaluation of the candidate Mr. Ioannis Vizirianakis for the position of Professor in the scientific field of Molecular Pharmacology - Pharmacogenomics. The digital format of the Curriculum Vitae and the scientific publications of the above mentioned candidate have already been sent to you by post along with our document numbered (518/ ). You can participate in the above mentioned Meeting by videoconference, as previously mentioned. For further information, please contact Mr. Ioannis Paspaltsis ( /997646, /997613, info@pharm.auth.gr, Fax: /997612). Yours sincerely, The Dean of the Faculty of Health Sciences George Karakiulakis Professor of School of Medicine

56 The evaluation of the undergraduate students based on their electronic application of MODIP, was send to all members of the electorate Committee (regular and replacements) in the same time with the 1 st invitation (Nο invitation 1927/ ). The evaluation of students has as follows:

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75 The invitation for the today session of the special seven-members electorate committee with the N. 2095/ document of the Dean s Office, was send by to the regular members as well us to their alternate ones. The invitation reads as follows: ΕΛΛΗΝΙΚΗ ΔΗΜΟΚΡΑΤΙΑ FACULTY OF HEALTH SCIENCES DEANERY Secretariat: Eleni Nalbanti ΑΡΙΣΤΟΤΕΛΕΙΟ Τηλ. +30 Fa +30 Thessaloniki, ΠΑΝΕΠΙΣΤΗΜΙΟ : x: /07/2014 ΘΕΣΣΑΛΟΝΙΚΗΣ emai info@health.aut UR Reference No. : 2095 l: h.gr L: alth Κτίρ ιο Administration Building of School of Medicine To - The regular members of the election Committee: Magnus Ingelman Sundberg, Nikolaos Sitaras, Andreas Papapetropoulos, Achilleas Gravanis, Theodoros Sklaviadis, Asterios Tsiftsoglou, Ioannis Niopas - The substitute members: Holly Ingraham, Dimitrios Kouvelas, Georgios Karakioulakis, Maria Mironidou-Tzouveleki, Georgios Kolios, Christodoulos Flordellis, Nikolaos Sakellaridis.

76 RE: Invitation of the seven member election committee to a repeat convocation for the election process of a Full Professor in the scientific field of Molecular Pharmacology - Pharmacogenomics Candidate: Dr. Ioannis Vizirianakis. Dear Colleagues, We kindly invite you to the rescheduled Meeting of the Special Election Committee, on Tuesday 22 July 2014 at PM (local time) for the election process of a Full Professor in the scientific field of Molecular Pharmacology - Pharmacogenomics, where Dr. Ioannis Vizirianakis is the sole candidate. The meeting, which was originally scheduled for Wednesday 09 July 2014, 11:30-13:00, was postponed by decision of the Committee, after a technical problem in connecting via videoconferencing with a member of the Special Committee and was rescheduled for this particular date. You can participate in the rescheduled Meeting by videoconference (connection details will follow in a separate message from the technical services). For further information, please contact Mr. Ioannis Paspaltsis (tel /997646, /997613, Fax: /997612, info@pharm.auth.gr,). Yours sincerely, The Dean of the Faculty of Health Sciences George Karakiulakis Professor of School of Medicin Continuing the president Prof. A. Tsiftsoglou, underlines that the evaluation of Prof. Zhou Shufeng and Pirmohamed Munir were not received within the legal time. The members of the Seven-memberes Commiitee accepted the above Professors evaluation even they were out of time.

77 The candidate Mr. Vizirianakis submitted written opinions (documents 1831/ ) which have as follows: Αρ. Πρωτ. 1831/ /06/2014 ΘΕΣΣΑΛΟΝΙΚΗΣ Ημερομηνία: ΙΩΑΝΝΗΣ Σ. ΒΙΖΙΡΙΑΝΑΚΗΣ ΕΡΓΑΣΤΗΡΙΟ ΦΑΡΜΑΚΟΛΟΓΙΑΣ Αναπληρωτής Καθηγητής Μοριακής Φαρμακολογίας ΤΜΗΜΑ ΦΑΡΜΑΚΕΥΤΙΚΗΣ & Φαρμακογονιδιωματικής ΘΕΣΣΑΛΟΝΙΚΗ Tηλ ; Fax: Profile: Ε-mail: Προς την Κοσμητεία Σχολής Επιστημών Υγείας, ΑΠΘ Προς την Κοσμητεία Σχολής Επιστημών Υγείας, ΑΠΘ Θέμα: «Σχετικά με έγγραφο αρ. πρωτ. Κοσμητείας 1755/ & υποβολή υπομνήματος συμπληρωματικών στοιχείων» Αγαπητέ κ. Καρακιουλάκη, Σε συνέχεια του με αρ. πρωτ. Κοσμητείας 1755/ εγγράφου σας σχετικά με την διαβίβαση της αξιολόγησης του καθηγητή Adrian Llerena, σας προωθώ τα συνημμένα τέσσερα PDF αρχεία που αφορούν: 1. Το εκπαιδευτικό έργο σε προπτυχιακό-μεταπτυχιακό στην Ελληνική και Αγγλική (Δελτίο μαθήματος-syllabus) 2. Το τελευταίο ερευνητικό άρθρο που είναι υπό δημοσίευση (ένδειξη στο βιογραφικό «under revision ) 3. Τo CV στην Αγγλική γλώσσα με μερική αναδιοργάνωση των υπαρχόντων στοιχείων Τα παραπάνω αρχεία αποστέλλονται προς κοινοποίηση/ενημέρωση των αξιολογητών και των μελών της 7μελούς εξεταστικής επιτροπής επιθυμώντας να επισημάνω τα παρακάτω: Α. Θεωρώ ότι η συμμετοχή μου σε διοικητικό έργο, - [μέλος Γ.Σ. Τομέα/Τμήματος αρχικά ως εκπρόσωπος των μη διδακτόρων από το 1982 και στη συνέχεια ως μέλος ΔΕΠ από το 1993, μέλος της ΓΣΕΣ του τμήματος από την έναρξη του μεταπτυχιακού προγράμματος το , μέλος της ΣΕΜΣ ως συντονιστής προγράμματος ειδίκευσης από το 2012, εκπρόσωπος του τμήματος σε Σύγκλητο και Επιτροπή Ερευνών, εκπρόσωπος τμήματος στην προμήθεια οργάνων ΠΕΠ, μέλος εξεταστικής επιτροπής πτυχιούχων, μέλος πολλαπλών επιτροπών διοικητικής φύσης του Τμήματος/Πανεπιστημίου/Επιτροπής Ερευνών σχετικά με εκπαιδευτικά θέματα (π.χ.