14 HITACHI REAL-TIME ELASTOGRAPHY Novel software (HI-RTE) Red area represents optimal site for aspiration, while blue area represents necrotic tissue (cost euros Germany)
15 ΕΜΒΟΛΟ ΓΙΑ ΕΙΣΑΓΩΓΗ ΝΕΡΟΥ ΣΤΟ ΜΠΑΛΟΝΙ
16 ΣΥΝΔΕΣΗ ΕΜΒΟΛΟΥ ΣΤΟ EBUS
17 BEΛΟΝΑ MEDIGLOBE
18 ΒΕΛΟΝΑ OLYMPUS
21 ΥΠΑΡΧΕΙ ΔΙΑΦΟΡΑ ΜΕΤΑΞΥ DIFFERENCES BETWEEN 21G KAI 22G Comparison of 21-gauge and 22-gauge aspiration needle during endobronchial ultrasound-guided transbronchial needle aspiration. Nakajima T, Yasufuku K, Takahashi R, Shingyoji M, Hirata T, Itami M, Matsui Y, Itakura M, Iizasa T, Kimura H. Respirology Jan;16(1):90-4. doi: /j x. There were no differences in the diagnostic yield between the 21G and 22G needles during EBUS- TBNA. The preserved histological structure of the samples obtained by the Η ΒΕΛΟΝΑ 21G ΕΊΝΑΙ ΑΝΩΤΕΡΗ ΔΙΑΓΝΩΣΤΙΚΑ ΑΠΌ ΤΗΝ ΒΕΛΟΝΑ 22G.
22 H BELONA OLYMPUS EXEI ΠΙΟ ΕΝΙΣΧΥΜΕΝΟ ΣΗΜΑ
23 ΒΕΛΟΝΑ MEDIGLOBE
25 ΥΠΑΡΧΕΙ ΚΑΙ ΛΑΒΙΔΑ ΒΙΟΨΙΑΣ MEDI GLOBE ΓΙΑ EBUS ΠΟΤΕ?
26 ΣΥΝΔΕΤΙΚΟ ΓΙΑ ΦΩΤΕΙΝΗ ΠΗΓΗ ΚΑΙ ΣΥΣΤΗΜΑ ΥΠΕΡΗΧΟΥ
27 HITACHI ULTRASOUND 6500 ΕUB
28 ΦΩΤΕΙΝΗ ΠΗΓΗ PENTAX EPK 1000
29 SUITE SETTING OF EQUIPMENT
30 ΑΣΘΕΝΗΣ ΜΕ ΜΕΘΗ ΚΑΙ ΑΚΑΜΠΤΟ STORZ 12MM
31 ΔΕΝ ΧΡΕΙΑΖΕΤΑΙ ΠΑΝΤΑ ΜΠΑΛΟΝΙ ΓΙΑ ΣΩΣΤΗ ΑΠΟΙΚΟΝΙΣΗ
32 TOΠΟΘΕΣΙΑ ΕΝΔΟΣΚΟΠΙΚΟ Ή ΧΕΙΡΟΥΡΓΙΚΗ ΑΙΘΟΥΣΑ ΕΊΝΑΙ ΤΟ ΙΔΙΟ ΜΕΘΗ-ΔΙΑΣΩΛΗΝΩΣΗ ΑΝΑΛΟΓΑ ΜΕ ΤΟΝ ΧΕΙΡΙΣΤΗ ΚΑΙ ΤΗΝ ΕΝΕΡΓΕΙΑ (ΔΙΑΓΝΩΣΗ- ΣΤΑΔΙΟΠΟΙΗΣΗ) ΛΑΡΥΝΓΓΙΚΗ ΜΑΣΚΑ (ΓΙΑ ΌΧΙ ΠΑΝΩ ΑΠΌ ΛΕΠΤΑ) (ΠΙΟ ΕΥΚΟΛΑ ΠΡΟΣΒΑΣΗΜΕΣ ΟΙ ΘΕΣΕΙΣ 2ΑΡ ΚΑΙ 2ΔΕΞΙΑ ΑΚΑΜΠΤΟ ΤΡΑΧΕΙΟΣΩΛΗΝΑΣ ΝΟ.9
33 ΠΕΡΙΟΧΙΚΗ ΑΝΑΙΣΘΗΣΙΑ ΑΝΤΙ ΓΙΑ ΓΕΝΙΚΗ ΑΝΑΙΣΘΗΣΙΑ
34 ΠΕΡΙΟΧΙΚΗ ΑΝΑΙΣΘΗΣΙΑ ΑΝΤΙ ΓΙΑ ΓΕΝΙΚΗ ΑΝΑΙΣΘΗΣΙΑ SUPERIOR LARYNGEAL BLOCK
35 ΠΕΡΙΟΧΙΚΗ ΑΝΑΙΣΘΗΣΙΑ ΑΝΤΙ ΓΙΑ ΓΕΝΙΚΗ ΑΝΑΙΣΘΗΣΙΑ TRANSTRACHEAL BLOCK
36 ΛΑΡΥΓΓΙΚΟ BLOCK
37 ΛΑΡΥΓΓΙΚΟ BLOCK
38 ΛΑΡΥΓΓΙΚΟ BLOCK
39 ΛΑΡΥΓΓΙΚΟ BLOCK
40 ΠΡΟΥΠΟΘΕΣΕΙΣ ΓΙΑ ΝΑ ΓΙΝΕΙΣ ΧΕΙΡΙΣΤΗΣ EBUS ΠΡΟΕΤΟΙΜΑΣΙΑ ΑΣΘΕΝΟΥΣ ERS/ATS statement on interventional pulmonology. European Respiratory Society/American Thoracic Society. Bolliger CT, Mathur PN, Beamis JF, Becker HD, Cavaliere S, Colt H, Diaz-Jimenez JP, Dumon JF, Edell E, Kovitz KL, Macha HN, Mehta AC, Marel M, Noppen M, Strausz J, Sutedja TG; European Respiratory Society/American Thoracic Society. Eur Respir J Feb;19(2): No abstract available. ΤΟΥΛΑΧΙΣΤΟΝ 50 ΑΣΘΕΝΕΙΣ ΓΙΑ ΕΚΠΑΙΔΕΥΣΗ ΚΑΙ ΤΟΥΛΑΧΙΣΤΟΝ 15 ΓΙΑ ΝΑ ΣΥΝΕΧΙΣΗΣ ΝΑ ΕΙΣΑΙ ΠΡΟΕΤΟΙΜΑΣΙΑ ΑΣΘΕΝΟΥΣ-Η ΙΔΙΑ ΌΠΩΣ ΣΤΗΝ ΒΡΟΓΧΟΣΚΟΠΗΣΗ
41 ΠΡΟΥΠΟΘΕΣΕΙΣ ΓΙΑ ΝΑ ΓΙΝΕΙΣ ΧΕΙΡΙΣΤΗΣ EBUS Respiration. 2014;88(6): doi: / Epub 2014 Nov 12. Training in and experience with endobronchial ultrasound. Bellinger CR 1, Chatterjee AB, Adair N, Houle T, Khan I, Haponik E. BACKGROUND: Diagnosing mediastinal and hilar lymphadenopathy and staging lung cancer with endobronchial ultrasound (EBUS)-guided transbronchial needle aspiration (TBNA) are on the rise, but uncertainty surrounds the optimal number of cases needed to achieve acceptable yields. OBJECTIVES: To determine the threshold at which EBUS-TBNA reaches adequate yields among trainees and skilled bronchoscopists. METHODS: We reviewed all EBUS-TBNAs performed at our medical center since implementing the use of EBUS (n = 222).RESULTS: EBUS-TBNAs were performed in 222 patients (344 nodes). The percentage of adequate specimens sampled (diagnostic specimens or nodal tissue) rose from 66% in 2008 to 90% in 2012 (p < 0.01) and cancer yield improved from 34% in 2008 to 48% in 2012 (p < 0.01). Attending physicians who performed an average of more than 10 procedures per year had higher yields compared to those who performed fewer than 10 procedures per year (86 vs. 68%, p < 0.01). The yield of trainees also improved with every 10 procedures (79, 90 and 95%, p < 0.001) and that of attending physicians with experience (1-25 procedures: 78% yield, procedures: 87% yield and 50+ procedures: 90% yield; p < 0.01). Among trainees, failure rates declined steadily. CONCLUSION: ΕΙΤΕ ΕΜΠΕΙΡΟΣ ΕΙΤΕ ΝΕΟΣ ΧΕΙΡΙΣΤΗΣ ΧΡΕΙΑΖΟΝΤΑΙ ΤΟΥΛΑΧΙΣΤΟΝ ΑΣΘΕΝΕΙΣ ΓΙΑ ΝΑ ΕΞΟΙΚΙΩΘΕΙ ΚΑΠΟΙΟΣ ΜΕ ΤΟ EBUS
42 EBUS ΚΑΙ ΣΑΡΚΟΕΙΔΩΣΗ
43 EBUS ΚΑΙ ΣΑΡΚΟΕΙΔΩΣΗ Chest Mar 1;145(3 Suppl):498A. doi: /chest The Role of EBUS-TBNA for the Diagnosis of Sarcoidosis. Cordovilla R, Torracchi A, Varela Simó G, Gomez MA, González-Ruiz JM, Jiménez López MF, Lanchas M, Barrueco M. CONCLUSIONS: EBUS-TBNA is a useful tool for diagnosis of sarcoidosis and might be the first step in the diagnosis of sarcoidosis if hilar LN are present. The pre-test probability is an important influence in the diagnostic yield of EBUS for the diagnosis of sarcoidosis. CLINICAL IMPLICATIONS: EBUS-TBNA ΠΡΕΠΕΙ ΝΑ ΕΊΝΑΙ Η ΠΡΩΤΗ ΔΙΑΓΝΩΣΤΙΚΗ ΜΕΘΟΔΟΣ ΌΤΑΝ ΥΠΟΤΕΥΟΜΑΣΤΕ ΣΑΡΚΟΕΙΔΩΣΗ
44 EBUS ΚΑΙ ΦΥΜΑΤΙΩΣΗ Ann Thorac Surg Dec;96(6): doi: /j.athoracsur Epub 2013 Sep 12. Endobronchial ultrasound-guided transbronchial needle aspiration in diagnosing intrathoracic tuberculosis. Sun J 1, Teng J, Yang H, Li Z, Zhang J, Zhao H, Garfield DH, Han B. CONCLUSIONS: Η TEXNIKH ΕΒUS EXEI ΗΨΗΛΗ ΔΙΑΓΝΩΣΤΙΚΗ ΑΞΙΑ ΣΤΗ ΔΙΕΡΕΥΝΗΣΗ ΔΙΟΓΚΩΜΕΝΩΝ ΛΕΜΦΑΔΕΝΩΝ ΜΕΣΟΘΩΡΑΚΙΟΥ ΚΑΙ ΌΤΑΝ ΥΠΑΡΧΕΙ ΒΛΑΒΗ ΣΤΟ ΤΟΙΧΩΜΑ ΤΩΝ ΒΡΟΓΧΩΝ.
45 ΥΠΑΡΧΕΙ ΚΑΙ ΛΑΒΙΔΑ ΒΙΟΨΙΑΣ MEDI GLOBE ΓΙΑ EBUS ΠΟΤΕ?
46 EBUS ΚΑΙ ΠΝΕΥΜΟΝΙΚΗ ΙΝΩΣΗ Ann Thorac Med Jan;8(1):33-7. doi: / Interstitial lung diseases in Saudi Arabia: A single-center study. Alhamad EH. A total of 330 cases were included. The mean age was 55.4 ± 14.9 years. There was a slight predominance of females (202; 61.2%), and the male-to-female ratio was 1:1.37. The most frequent disease was connective tissue disease (CTD)-associated ILD (34.8%), followed by idiopathic pulmonary fibrosis (IPF) (23.3%), sarcoidosis (20%), and hypersensitivity pneumonitis (6.3%). Nonclassifiable ILD was present in 1.8% of the total ILD cases. HRCT was performed in 97.3% of the cases, BAL in 17.5%, transbronchial lung biopsy in 21.8%, EBUS-TBNA in 4.5%, and surgical lung biopsy in 22.7% (38.6% of which were performed among the idiopathic interstitial pneumonia cases). EBUS-TBNA ΔΕΙΓΜΑ ΑΠΌ ΒΙΟΨΙΑ ΒΕΛΟΝΑΣ ΔΕΝ ΕΊΝΑΙ ΙΚΑΝΟ ΓΙΑ ΤΗΝ ΔΙΑΓΝΩΣΗ ΠΝΕΥΜΟΝΙΚΗΣ ΙΝΩΣΗΣ
47 EBUS AND OCCUPATIONAL DISEASE Respirology Feb;18(2): doi: /resp Diagnosis of silicotuberculosis by Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration (EBUS-TBNA). Tung AH 1, Ngai JC, Ko FW, Chak BP, Chow L, Hui DS. EBUS-TBNA was used to pinpoint the diagnosis when radiological features were inconclusive of silicosis. As demonstrated in a patho-logical case series, 25% of silicosis was missed in lung biopsies referred for idiopathic pulmonary fibrosis. Monso E, Tura JM, Marsal Met al. Mineralogical microanalysis of idiopathic pulmonary fibrosis. Arch. Environ. Health 1990; 45 : EBUS-TBNA ΒΙΟΨΙΑ ΜΠΟΡΕΙ ΝΑ ΧΡΗΣΙΜΟΠΟΙΗΘΕΙ ΓΙΑ ΤΗΝ ΔΙΑΓΝΩΣΗ ΕΠΑΓΓΕΛΜΑΤΙΚΗΣ ΝΟΣΟΥ ΩΣΤΟΣΟ ΑΚΟΜΑ ΔΕΝ ΕΧΕΙ ΕΝΔΕΙΞΗ ΚΑΙ ΕΧΕΙ ΧΑΜΗΛΗ ΔΙΑΓΝΩΣΤΙΚΗ ΑΞΙΑ
48 EBUS ΩΣ ΔΙΑΓΝΩΣΤΙΚΟ ΕΡΓΑΛΕΙΟ ΓΙΑ ΤΟΝ ΚΑΡΚΙΝΟ ΤΟΥ ΠΝΕΥΜΟΝΑ
49 EBUS ΩΣ ΔΙΑΓΝΩΣΤΙΚΟ ΕΡΓΑΛΕΙΟ ΓΙΑ ΤΟΝ ΚΑΡΚΙΝΟ ΤΟΥ ΠΝΕΥΜΟΝΑ
50 EBUS ΩΣ ΔΙΑΓΝΩΣΤΙΚΟ ΕΡΓΑΛΕΙΟ ΓΙΑ ΤΟΝ ΚΑΡΚΙΝΟ ΤΟΥ ΠΝΕΥΜΟΝΑ
51 EBUS ΩΣ ΔΙΑΓΝΩΣΤΙΚΟ ΕΡΓΑΛΕΙΟ ΓΙΑ ΤΟΝ ΚΑΡΚΙΝΟ ΤΟΥ ΠΝΕΥΜΟΝΑ
52 EBUS ΩΣ ΔΙΑΓΝΩΣΤΙΚΟ ΕΡΓΑΛΕΙΟ ΓΙΑ ΤΟΝ ΚΑΡΚΙΝΟ ΤΟΥ ΠΝΕΥΜΟΝΑ
53 ΔΙΑΓΝΩΣΗ ΘΡΟΜΒΟΥ ΣΕ ΑΓΓΕΙΟ
54 ΤΟ ΕΒUS ΓΙΑ ΔΙΑΓΝΩΣΗ ΘΡΟΜΒΩΝ J Bronchology Interv Pulmonol Jan;22(1): doi: /LBR Use of endobronchial ultrasound to evaluate nonthrombotic endovascular lesions in pulmonary arteries: a systematic review. Al-Saffar F 1, Ibrahim S, Seeram V, Bajwa AA, Shujaat A. BACKGROUND: The finding of a filling defect in a pulmonary artery (PA) sometimes raises the possibility of cancer. Endobronchial ultrasound (EBUS)-guided transbronchial needle aspiration (TBNA) may confirm the underlying nature of the endovascular lesion. However, little is known about the use of this procedure for this purpose. METHODS: We searched PubMed and abstracts of major international conferences. RESULTS: There was a total of 12 cases: 8 female, 3 male, and 1 unknown. The median (range) age was 60 (51 to 79) years. EBUS was performed to evaluate mass-like lesion involving the PA (n=5), persistent or progressive filling defects in the PA despite anticoagulation (n=3), filling defect in the PA with multiple areas of consolidation, air-fluid levels in the lung (n=1), and hilar density (n=1). Moreover, an endovascular lesion was incidentally noted in the PA during EBUS for evaluating lymph nodes (n=2). EBUS-TBNA was diagnostic in 9 of the 10 cases in which it was performed. The final diagnoses were: sarcoma (n=6), lung cancer (n=2), thyroid cancer (n=1), renal cell cancer (n=1), melanoma (n=1), and pulmonary embolism (n=1). The cancer was a recurrence in 6 of the 7 cases with a known history of cancer. CONCLUSIONS: EBUS ΜΠΟΡΕΙ ΝΑ ΧΡΗΣΙΜΟΠΟΙΗΘΕΙ ΓΙΑ ΔΙΑΓΝΩΣΗ ΘΡΟΜΒΩΝ ΑΛΛΑ ΚΑΙ ΜΑΚΡΟΜΕΤΑΣΤΑΣΕΩΝ ΜΕΣΑ ΣΕ ΑΓΓΕΙΑ ΑΠΟ ΚΑΡΚΙΝΟ
55 ΒΛΑΒΗ ΠΙΣΩ ΑΠΌ ΤΟΥΣ ΒΡΟΓΧΟΥΣ ΚΑΙ ΔΙΠΛΑ ΣΤΗΝ ΚΑΤΩ ΚΗΛΗ ΦΛΕΒΑ!
56 ΜΑΖΑ ΑΝΑΜΕΣΑ ΣΤΙΣ ΠΝΕΥΜΟΝΙΚΕΣ
57 ΜΑΖΑ ΔΙΠΛΑ ΣΤΗΝ ΤΡΑΧΕΙΑ ΑΛΛΑ ΌΧΙ ΜΕΣΑ
58 EBUS ΩΣ ΔΙΑΓΝΩΣΤΙΚΟ ΕΡΓΑΛΕΙΟ ΓΙΑ ΤΟΝ ΚΑΡΚΙΝΟ ΤΟΥ ΠΝΕΥΜΟΝΑ
59 EBUS ΩΣ ΔΙΑΓΝΩΣΤΙΚΟ ΕΡΓΑΛΕΙΟ ΓΙΑ ΤΟΝ ΚΑΡΚΙΝΟ ΤΟΥ ΠΝΕΥΜΟΝΑ
60 EBUS KAI ΚΑΡΚΙΝΟΣ ΠΝΕΥΜΟΝΑ Ann Thorac Cardiovasc Surg Feb 15. [Epub ahead of print] The Diagnostic Utility of Real-Time EBUS-TBNA for Hilar and Mediastinal Lymph Nodes in Conventional TBNA Negative Patients. Cetinkaya E 1, Ozgül MA, Tutar N, Ozgül G, Cam E, Bilaçeroglu S. Conclusion: EBUS-TBNA έχει μεγαλύτερη διαγνωστική αξία στην διαγνωστική προσέγγιση λεμφαδένων μεσοθωρακίου και πυλαίων λεμφαδένων από την απλή TBNA και όταν η απλη TNBA είναι αρνητική. (Κατά Κο Pen Wang σταδιοποίηση)
61 EBUS AND OTHER THORACIC MALIGNANCIES Diagnosis and subclassification of thymoma by minimally invasive fine needle aspiration directed by endobronchial ultrasound: a review and discussion of four cases. Moonim MT, Breen R, Gill-Barman B, Santis G. Cytopathology Aug;23(4): doi: /j x. 4 περιπτώσεις θυμώματος από βελόνα βιοψίας EBUS
63 EBUS FOR MOLECULAR TESTING IN ADENOCARCINOMA The efficacy of EBUS-guided transbronchial needle aspiration for molecular testing in lung adenocarcinoma. Jurado J, Saqi A, Maxfield R, Newmark A, Lavelle M, Bacchetta M, Gorenstein L, Dovidio F, Ginsburg ME, Sonett J, Bulman W. Ann Thorac Surg Oct;96(4): doi: /j.athoracsur Epub 2013 Aug 21. ΤΟ ΒΙΟΠΤΙΚΟ ΥΛΙΚΟ ΑΠΌ EBUS-TBNA ΕΊΝΑΙ ΙΚΑΝΟ ΓΙΑ ΝΑ ΑΠΟΚΑΛΥΨΕΙ ΜΕΤΑΛΛΑΞΕΙΣ EGFR, KRAS, ROC1-2 KAI ALK
64 HOW MANY PASSES FOR EFFICIENT Ann Am Thorac Soc Dec;10(6): doi: /AnnalsATS OC. Optimizing endobronchial ultrasound for molecular analysis. How many passes are needed? Yarmus L 1, Akulian J, Gilbert C, Feller-Kopman D, Lee HJ, Zarogoulidis P, Lechtzin N, Ali SZ, Sathiyamoorthy V. CONCLUSIONS: XΡΕΙΑΖΟΝΤΑΙ ΤΟ ΛΙΓΟΤΕΡΟ 4 ΔΕΙΓΜΑΤΑ ΑΠΌ ΤΟΝ ΙΔΙΟ ΛΕΜΦΑΔΕΝΑ ΜΕ 22G ΒΕΛΟΝΑ ΓΙΑ ΝΑ ΔΙΕΡΕΥΝΗΘΟΥΝ EGFR, ALK, KRAS KAI ROC1-2
65 NOVEL APPROACH FOR NON-HOGKIN LYMPHOMA DIAGNOSIS Endoscopic ultrasound fine needle aspiration in the diagnosis of lymphoma. Creemers K, van der Heiden O, Los J, van Esser J, Newhall D, Djamin RS, Aerts JG. J Oncol. 2011;2011: doi: /2011/ ΔΙΑΓΝΩΣΗ follicular non-hodgkin lymphoma, ΜΕ ΤΗΝ ΧΡΗΣΙΜΟΠΟΙΗΣΗ ΥΠΟΛΗΜΜΑΤΟΣ ΔΕΙΓΜΑΤΟΣ ΑΠΌ ΒΕΛΟΝΑ EBUS. (Πρόταση-υπόδειξη καινούργιας μεθόδου διάγνωσης)
66 EBUS AND LYMPHOMA Am J Respir Crit Care Med Nov 15;188(10): doi: /rccm OC. Diagnosis and subtyping of de novo and relapsed mediastinal lymphomas by endobronchial ultrasound needle aspiration. Moonim MT 1, Breen R, Fields PA, Santis G. CONCLUSIONS: ΤΟ EBUS-TBNA ΜΠΟΡΕΙ ΝΑ ΔΙΑΓΝΩΣΗ de novo mediastinal lymphomas ΚΑΙ ΕΠΙΣΗΣ ΜΠΟΡΕΙ ΝΑ ΔΙΑΦΟΡΟΔΙΑΓΝΩΣΗ ΥΠΟΤΡΟΠΗ ΛΕΜΦΩΜΑΤΟΣ ΑΠΌ ΆΛΛΕΣ ΚΑΚΟΗΘΕΙΕΣ ΩΣΤΟΣΟ ΕΧΕΙ ΛΙΓΟΤΕΡΗ ΔΙΑΓΝΩΣΤΙΚΗ ΑΞΙΑ ΣΤΗΝ ΔΙΑΓΝΩΣΗ ΥΠΟΟΜΑΔΩΝ Hodgkin lymphoma.
67 EBUS FOR THE DIAGNOSIS OF LEUKEMIA [Case of precursor T-lymphoblastic lymphoma/leukemia diagnosed by endobronchial ultrasound-guided transbronchial needle aspiration]. Ohkubo R, Izumo T, Ochiai K, Kirishi S, Tamaoki J, Nagai A. Nihon Kokyuki Gakkai Zasshi Dec;48(12): Japanese. ΔΙΑΓΝΩΣΗ T-lymphoblastic lymphoma/leukemia ΜΕ ΤΗΝ ΠΑΡΑΤΗΡΗΣΗ CD3 and terminal transferase (TdT) ΣΕ ΒΙΟΠΤΙΚΟ ΥΛΙΚΟ ΑΠΌ EBUS-TBNA.
68 EBUS FOR FOLICULAR LYMPHOMA Mediastinal follicular lymphoma diagnosed with multidirectional analysis using tissue samples obtained by EBUS-TBNA. Inoue M, Nakajima T, Tsujimura H, Itami M, Sakairi Y, Kimura H, Iizasa T. Intern Med. 2010;49(19): Epub 2010 Oct 1. ΔΙΑΓΝΩΣΗ follicular non-hodgkin lymphoma, ΜΕ ΤΗΝ ΧΡΗΣΙΜΟΠΟΙΗΣΗ ΥΠΟΛΗΜΜΑΤΟΣ ΔΕΙΓΜΑΤΟΣ ΑΠΌ ΒΕΛΟΝΑ EBUS. ΠΡΟΤΕΙΝΕΤΑΙ Η ΧΡΗΣΗ EBUS-TBNA ΓΙΑ ΤΗΝ ΔΙΑΓΝΩΣΗ ΑΙΜΑΤΟΛΟΓΙΚΩΝ ΝΟΣΩΝ ΣΤΟ ΜΕΣΟΘΩΡΑΚΙΟ
69 SHOULD WE PERFORM EBUS FOR LYMPHADENOPATHY; WHAT IF IT IS LYMPHOMA? Endobronchial ultrasound-guided transbronchial needle aspiration for the evaluation of suspected lymphoma. Steinfort DP, Conron M, Tsui A, Pasricha SR, Renwick WE, Antippa P, Irving LB. J Thorac Oncol Jun;5(6): ΤΟ EBUS-TBNA ΠΡΕΠΕΙ ΝΑ ΕΊΝΑΙ Η ΠΡΩΤΗ ΔΙΑΓΝΩΣΤΙΚΗ ΕΞΕΤΑΣΗ ΌΤΑΝ ΥΠΑΡΧΕΙ ΛΕΜΦΑΔΕΝΟΠΑΘΕΙΑ ΜΕΣΟΘΩΡΑΚΙΟΥ ΕΠΕΙΔΗ Η ΕΠΙΔΗΜΙΟΛΟΓΙΑ ΤΟΥ ΛΕΜΦΩΜΑΤΟΣ ΕΊΝΑΙ ΜΙΚΡΟΤΕΡΗ ΑΠΌ ΑΥΤΉ ΤΟΥ ΚΑΡΚΙΝΟΥ ΤΟΥ ΠΝΕΥΜΟΝΑ ΣΤΟ ΘΩΡΑΚΑ
70 IASLC LYMPH NODE MAP
71 ΠΟΙΟΥΣ ΛΕΜΦΑΔΕΝΕΣ ΜΠΟΡΟΥΜΕ ΚΑΝΟΥΜΕ Β NUMBERS 2, 4, 7, 8, 10, 11 ΜΠΟΡΟΥΜΕ ΝΑ ΠΑΡΟΥΜΕ ΔΕΙΓΜΑ ΑΠΌ ΤΙΣ ΘΕΣΕΙΣ 5 ΚΑΙ 6? ΝΑΙ ΕΦΟΣΟΝ ΕΊΝΑΙ ΑΠΟΛΥΤΟΣ ΑΝΑΓΚΑΙΟ
72 LYMPH NODE BIOPSY WITH EBUS
73 LYMPHNODES ACCESIBLE BY EBUS 6 5 8
74 LYMPH NODE BIOPSY WITH EBUS
75 EBUS Η EUS ΌΤΑΝ ΥΠΟΠΤΕΥΟΜΑΣΤΕ ΛΕΜΦΩΜΑ EBUS 21G OR 22G (BRONCHOSCOPE) EUS 22G, 21G AND 19G SAME EFFICIENCY IN PREVIOUSLY DIAGNOSED PATIENTS (RELAPSE) HODGKIN AND T-CELL LYMPHOMA ARE DIFFICULT TO DIAGNOSE WITH CYTOLOGY ALONE (EUS 19G TRUE CUT MAY PROVIDE TISSUE SAMPLE, HOWEVER; NOT ALWAYS EFFICENT FOR THESE LYMPHOMAS IF SUSPICION OF LYMPHOMA IS HIGH AND EBUS/EUS NEGATIVE RESULTS THEN MEDIASTINOSCOPY References Steinfort DP, Conron M, Tsui A, et al. Endobronchial ultrasound-guided transbronchial needle aspiration for the evaluation of suspected lymphoma. J Thorac Oncol 2010;5: Al-Haddad M, Savabi MS, Sherman S, et al. Role of endoscopic ultrasound-guided fine-needle aspiration with flow cytometry to diagnose lymphoma: a single center experience. J Gastroenterol Hepatol 2009;24: Hehn ST, Grogan TM, Miller TP. Utility of fine-needle aspiration as a diagnostic technique in lymphoma. J Clin Oncol 2004;22: Young NA, Al-Saleem TI, Ehya H, et al. Utilization of fine-needle aspiration cytology and flow cytometry in the diagnosis and subclassification of primary and recurrent lymphoma. Cancer 1998;84: Eloubeidi MA, Mehra M, Bean SM. EUS-guided 19-gauge trucut needle biopsy for diagnosis of lymphoma missed by EUS-guided FNA. Gastrointest Endosc 2007;65: Berger LP, Scheffer RC, Weusten BL, et al. The additional value of EUSguided Tru-cut biopsy to EUS-guided FNA in patients with mediastinal lesions. Gastrointest Endosc 2009;69: PENTAX FB-19H FIBER BRONCHOSCOPE WORKING CHANNEL 2.8MM, 19G TRUE CUT
77 EBUS ΚAΙ ΣΤΑΔΙΟΠΟΙΗΣΗ ΤΟΥ ΚΑΡΚΙΝΟΥ ΤΟΥ ΠΝΕΥΜΟΝΑ
78 EBUS AND LUNG CANCER STAGING Cervical mediastinoscopy REVIEW CASES mortality < 0.5 % ΝΟΣΗΡΟΤΗΤΑ 2.5 % ΑΙΜΟΡΡΑΓΙΑ ΠΝΕΥΜΟΘΩΡΑΚΑΣ rare : tear tracheobronchial wall ΔΙΑΤΡΗΣΗ ΟΙΣΟΦΑΓΟΥ, ΕΓΚΕΦΑΛΙΚΟ, ΕΜΒΟΛΟ ΑΕΡΑ, ΧΥΛΟΘΩΡΑΚΑΣ Kirschner P. Chest Surg Clin North Am 1996; 6 : 1-2
79 EBUS AND LUNG CANCER STAGING
80 LYMPH NODE BIOPSY WITH MEDIASTINOSCOPY
81 LYMPH NODE BIOPSY WITH MEDIASTINOSCOPY
82 EBUS AND LUNG CANCER STAGING Intern Med. 2015;54(1):43-8. doi: /internalmedicine Epub 2015 Jan 1. Endobronchial Ultrasound-guided Transbronchial Needle Aspiration in a Patient with Pericardial Mesothelioma. Ashinuma H 1, Shingyoji M, Yoshida Y, Itakura M, Ishibashi F, Tamura H, Moriya Y, Itami M, Tatsumi K, Iizasa T. Pericardial mesothelioma is a very rare pericardial tumor. Diagnosing pericardial disease can be challenging, and obtaining an antemortem diagnosis of pericardial mesothelioma is particularly difficult. We herein report the case of a 60-year-old man with pericardial mesothelioma diagnosed on endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA). Chest computed tomography showed a mass surrounding the pericardium, and EBUS-TBNA of the right inferior paratracheal and subcarinal stations was consequently performed. No uptake was noted on (18)F-fluorodeoxy glucose positron emission tomography, other than in the pericardial mass. The results of histological and immunohistochemical examinations indicated the features of malignant mesothelioma. ΕΓΙΝΕ ΔΙΑΓΝΩΣΗ ΠΕΡΙΚΑΡΔΙΑΚΟΥ ΜΑΣΟΘΗΛΙΩΜΑΤΟΣ ΜΕ ΒΙΟΨΙΑ ΠΕΡΙΚΑΡΔΙΑΚΗΣ ΜΑΖΑΣ. ΜΕ ΤΟ EBUS ΕΓΙΝΕ ΚΑΙ ΑΦΑΙΡΕΣΗ ΠΕΡΙΚΑΡΔΙΑΚΟΥ ΥΓΡΟΥ!!!
83 EBUS AND INTRALESION THERAPY WITH CISPLATIN Ann Am Thorac Soc Jan;12(1): doi: /AnnalsATS BC. Endobronchial ultrasound-guided transbronchial needle injection for local control of recurrent non-small cell lung cancer. Khan F 1, Anker CJ, Garrison G, Kinsey CM. RATIONALE: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is an established technique for the diagnosis of thoracic malignancies. Non-ultrasound-guided transbronchial needle injection has been used previously to deliver chemotherapeutic agents. OBJECTIVES: To use endobronchial ultrasound-guided transbronchial needle injection (EBUS-TBNI) to achieve local control of recurrent early-stage lung cancer. METHODS: A 63-year-old man presented with recurrent early stage non-small cell lung carcinoma after chemotherapy and external beam radiation. We used EBUS-TBNI to deliver cisplatin into the tumor located outside the airway. This procedure was performed on three separate occasions without complication. MEASUREMENTS AND MAIN RESULTS: EBUS-TBNI resulted in resolution of fluorodeoxyglucose avidity, measured by positron emission tomography-computed tomography, in the region at 4 weeks. However, at 5 months, there was evidence of distal recurrence.conclusions: This is the first description of EBUS- TBNI to treat local recurrence of lung cancer and one of the first reports of the use of EBUS for intratumoral therapy. Additional research is warranted to determine the clinical usefulness and safety of this therapeutic approach.
84 EBUS AND INTRALESION THERAPY WITH CISPLATIN Drug Des Devel Ther Jul 18;7: doi: /DDDT.S Print Intratumoral chemotherapy for lung cancer: re-challenge current targeted therapies. Hohenforst-Schmidt W 1, Zarogoulidis P, Darwiche K, Vogl T, Goldberg EP, Huang H, Simoff M, Li Q, Browning R, Turner FJ, Le Pivert P, Spyratos D, Zarogoulidis K, Celikoglu SI, Celikoglu F, Brachmann J. Strategies to enhance the already established doublet chemotherapy regimen for lung cancer have been investigated for more than 20 years. Initially, the concept was to administer chemotherapy drugs locally to the tumor site for efficient diffusion through passive transport within the tumor. Recent advances have enhanced the diffusion of pharmaceuticals through active transport by using pharmaceuticals designed to target the genome of tumors. In the present study, five patients with non-small cell lung cancer epidermal growth factor receptor (EGFR) negative stage IIIa-IV International Union Against Cancer 7 (UICC-7), and with Eastern Cooperative Oncology Group (ECOG) 2 scores were administered platinum-based doublet chemotherapy using combined intratumoral-regional and intravenous route of administration. Cisplatin analogues were injected at 0.5%-1% concentration within the tumor lesion and proven malignant lymph nodes according to pretreatment histological/cytological results and the concentration of systemic infusion was decreased to 70% of a standard protocol. This combined intravenous plus intratumoral-regional chemotherapy is used as a first line therapy on this short series of patients. To the best of our knowledge this is the first report of direct treatment of involved lymph nodes with cisplatin by endobronchial ultrasound drug delivery with a needle without any adverse effects. The initial overall survival and local response are suggestive of a better efficacy compared to established doublet cisplatin-based systemic chemotherapy in (higher) standard concentrations alone according to the UICC 7 database expected survival. An extensive search of the literature was performed to gather information of previously published literature of intratumoral chemo-drug administration and formulation for this treatment modality. Our study shows a favorable local response, more than a 50% reduction, for a massive tumor mass after administration of five sessions of intratumoral chemotherapy plus two cycles of low-dose intravenous chemotherapy according to our protocol. These encouraging results (even in very sick ECOG 2 patients with central obstructive non-small cell lung cancer having a worse prognosis and quality of life than a non-small cell lung cancer in ECOG 0 of the same tumor node metastasis [TNM]-stage without central obstruction) for a chemotherapy-only protocol that differs from conventional cisplatin-based doublet chemotherapy by the route, target site, and dose paves the way for broader applications of this technique. Finally, future perspectives of this treatment and pharmaceutical design for intratumoral administration are presented.
85 TBNA VS EBUS TBNA Mol Clin Oncol Jan;2(1): Epub 2013 Oct 23. Endobronchial ultrasound guided-transbronchial needle aspiration vs. conventional transbronchial needle aspiration in the diagnosis of mediastinal masses: A metaanalysis. Zhu T 1, Zhang X 2, Xu J 3, Tian J 4, Li H 2, Liu D 1, Chen R 1, Li Q 1, Bai C 1. Whether an endobronchial ultrasound (EBUS) is required for transbronchial needle aspiration (TBNA) in the diagnosis of mediastinal masses is currently a disputed subject. Previous studies have demonstrated that EBUS-TBNA performs better compared to conventional TBNA as it is capable of sampling in real-time compared with conventional TBNA. However, some clinicians consider conventional TBNA to be sufficient for diagnosis. In this meta-analysis, we evaluated these two methods according to diagnostic yield. A search was conducted through PubMed, Embase and the proceedings of major conferences, for studies comparing TBNA with EBUS-TBNA in the diagnosis of mediastinal masses. The identified studies were evaluated for publication bias and heterogeneity. The primary outcome was diagnostic yield. Pooled odds ratio (OR) estimated with 95% confidence intervals (CIs) was calculated using the fixed-effects model. Five studies, including a total of 407 patients, were included in the meta-analysis. The EBUS-TBNA arm was associated with a significantly higher OR compared to that of the TBNA arm in terms of diagnostic yield (OR=2.72, 95% CI: , P<0.001). There was no evidence of heterogeneity (I 2 =0%, P=0.540) or publication bias (Egger's test, P=0.568; Begg-Mazumdar test, P=0.806). OTAN ΣΥΓΚΡΙΝΟΥΜΕ TBNA VS EBUS TBNA (ΜΟΝΟ ΓΙΑ ΥΠΟΤΡΟΠΙΔΙΚΟ ΚΑΙ ΠΥΛΑΟΥΣ ΝΟΥΜΕΡΟ 7 ΚΑΙ 10) ΤΟΤΕ Η EBUS-TBNA ΕΧΕΙ ΜΙΚΡΟΤΕΡΟ ΧΡΟΝΟ ΑΝΑΡΡΟΦΗΣΗΣ ΚΑΙ ΜΕΓΑΛΥΤΕΡΗ ΕΥΑΙΣΘΗΣΙΑ.
86 TBNA VS EBUS TBNA Chest Sep;146(3): doi: /chest Endobronchial ultrasound-guided transbronchial needle aspiration vs conventional transbronchial needle aspiration in the diagnosis of sarcoidosis. Gupta D, Dadhwal DS, Agarwal R, Gupta N, Bal A, Aggarwal AN. BACKGROUND: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is superior to conventional transbronchial needle aspiration (ctbna) in the staging of lung cancer. However, its efficiency in diagnosis of sarcoidosis when combined with endobronchial biopsy (EBB) and transbronchial lung biopsy (TBLB) has not been studied. This randomized controlled trial compares diagnostic yield of EBUS-TBNA vs ctbna in combination with EBB and TBLB. METHODS: Patients with clinical diagnosis of sarcoidosis were randomized 1:1 to EBUS-TBNA or ctbna. All patients underwent TBLB and EBB. The primary outcome was detection of granulomas. The secondary end points were the individual and cumulative yields of various procedures, serious adverse events, and procedure time.results: Of the 130 patients, sarcoidosis was diagnosed in 117 (62 ctbna, 55 EBUS-TBNA). The two groups were similar at baseline. Granulomas were demonstrated in 104 (53 ctbna, 51 EBUS-TBNA) patients and were similar in two groups (85.5% vs 92.7%, P =.34). Individually, EBUS-TBNA had the highest yield (41 of 55, 74.5%), which was better than ctbna (30 of 62, 48.4%, P =.004) or EBB (40 of 111, 36.3%, P <.0001) but not TBLB (78 of 112, 69.6%, P =.54). Adding EBB/TBLB to ctbna led to an increase in granuloma detection, whereas the addition of TBLB (but not EBB) significantly enhanced the yield of EBUS-TBNA. The procedure time was significantly longer with EBUS-TBNA. No major adverse events occurred. CONCLUSIONS: Η EBUS-TBNA ΕΧΕΙ ΚΑΛΥΤΕΡΑ ΑΠΟΤΕΛΕΣΜΑΤΑ ΑΠΟ ΤΗΝ TBNA ΑΛΛΑ ΕΧΕΙ ΑΚΟΜΑ ΚΑΛΥΤΕΡΑ ΑΝ ΓΙΝΕΙ ΒΙΟΨΙΑ ΜΕ ΜΕΓΑΛΥΤΕΡΗ ΒΕΛΟΝΑ (19G). TRIAL REGISTRY: ClinicalTrials.gov; No.: NCT ; URL:
87 TBNA VS EBUS TBNA South Med J Dec;105(12): doi: /SMJ.0b013e318273a749. Conventional and endobronchial ultrasound-guided transbronchial needle aspiration: complementary procedures. Bellinger CR 1, Chatterjee AB, Chin R Jr, Conforti J, Adair N, Haponik E. OBJECTIVE: The diagnosis of mediastinal and hilar lymphadenopathy and staging lung cancer with endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) are on the rise. Most reports have demonstrated high yields with EBUS-TBNA and superiority of this procedure over conventional TBNA (ctbna), but the relative roles of these procedures remain undefined. We present a comprehensive comparison of EBUS-TBNA to ctbna. METHODS: We reviewed all of the bronchoscopies performed at our medical center from January 2009 through December We collected data on 82 EBUS-TBNAs and 209 ctbnas performed. A cost analysis was subsequently performed.results: EBUS-TBNA was performed more often in patients with known prior cancer and suspicion of recurrence or staging compared with ctbna (42% vs 18%, P < 0.001). ctbna was more likely to be performed in patients suspected of having malignancy and needing diagnostic specimens (70% vs 46%, P = 0.009). The overall yield in which a diagnostic specimen or lymphoid tissue was obtained was not different in each group: EBUS 84% vs ctbna 86% (P = 0.75). The cancer yield was 57% in ctbnas compared with 44% in EBUS-TBNAs (P < ), with EBUS- TBNA more often targeting smaller nodes (mean 15 ± 7 mm vs 21 ± 11 mm; P < ) and paratracheal sites (67% vs 49%, P = 0.003). Per-procedure cost using a Medicare scale was higher for EBUS than it was for ctbna ($1195 vs $808; P < 0.001).CONCLUSIONS: H BEΛΟΝΑ ΕΒUS-TBNA EINAI ΠΙΟ ΑΚΡΙΒΗ ΑΠΟ ΤΗΝ ΑΠΛΗ TBNA ΚΑΙ ΓΙΑ ΑΥΤΟ ΠΡΕΠΕΙ ΝΑ ΕΠΙΛΕΓΕΤΑΙ Η ΚΑΤΑΛΛΗΛΗ ΜΕΘΟΔΟΣ ΑΝΑΛΟΓΑ ΜΕ ΤΗ ΘΕΣΗ ΤΗΣ ΒΛΑΒΗΣ ΚΑΙ ΤΟ ΚΟΣΤΟΣ-ΟΦΕΛΟΣ
88 TBNA VS EBUS TBNA Tuberk Toraks. 2011;59(2): Conventional vs. endobronchial ultrasound-guided transbronchial needle aspiration in the diagnosis of mediastinal lymphadenopathies. Arslan Z 1, Ilgazli A, Bakir M, Yildiz K, Topçu S. The aim of this study was to determine whether or not radial probe endobronchial ultrasound (EBUS)- guided transbronchial needle aspiration (TBNA) is superior to conventional TBNA in the diagnosis of mediastinal lymphadenopathies in routine clinical practice. Consecutive patients, who were referred for TBNA, were randomized to conventional TBNA and EBUS-guided TBNA groups. Patients were also grouped according to the anatomic location of the pathologic lymph nodes to evaluate if there was a difference in the diagnostic yield with respect to lymph node station. Patients with subcarinal lymph nodes were designated as group A and patients with lymph nodes at station 2 (upper paratracheal), 3 (prevascular and retrotracheal), and 4 (lower paratracheal) were designated as group B. A 21-G aspiration needle was used during the procedure. Sixty patients with a mean age of ± years were included in the study. Thirty patients each underwent EBUS-TBNA and conventional TBNA. The overall diagnostic yield of conventional TBNA was 33.3% (10/30), while EBUS-TBNA had a yield of 66.7% (20/30; p= 0.010). In patients with subcarinal lymph nodes, the yield of conventional TBNA was 33.3% (4/12) compared to 62.5% (5/8) in the EBUS-guided group (p= 0.362). ΕΒUS-ΤΒΝΑ ΠΡΕΠΕΙ ΝΑ ΠΡΟΤΙΜΑΤΕ ΕΝΑΝΤΙ ΤΗΣ ΑΠΛΗΣ TBNA ΓΙΑ ΟΠΟΙΑΔΗΠΟΤΕ ΑΛΛΗ ΘΕΣΗ ΠΕΡΑΝ ΤΟΥ ΛΕΜΦΑΔΕΝΑ ΝΟΥΜΕΡΟ 7.
89 TBNA VS EBUS TBNA Ann Thorac Surg Jun;85(6): doi: /j.athoracsur Endobronchial ultrasound-guided miniforceps biopsy in the biopsy of subcarinal masses in patients with low likelihood of non-small cell lung cancer. Herth FJ 1, Morgan RK, Eberhardt R, Ernst A. BACKGROUND: Transbronchial needle aspiration (TBNA) is used to sample mediastinal masses, but the value may be limited by the small specimen size obtained. In benign diseases and hematologic malignancies, the sample size from TBNA is often considered insufficient for diagnosis. We evaluated the safety and efficacy of obtaining histologic specimens from subcarinal masses using a 1.15-mm miniforceps under endobronchial ultrasound (EBUS) guidance and compared the diagnostic yield with TBNA alone.methods: Patients being evaluated for subcarinal lesions exceeding 2.5 cm (short axis) and without known or suspected non-small cell lung cancer were included. Bronchoscopy was performed, and EBUS-guided BNA of the lesion was performed first with a 22-gauge needle, followed by the 19-gauge needle. The miniforceps was then passed through the airway into the lesion (three to five passes) under real-time EBUS guidance. Three biopsy specimens were obtained. RESULTS: The study enrolled 75 patients (41 men; mean age, 51.5 years). Specimens were acquired from each patient using the three techniques and processed separately. A specific diagnosis was made in 36% of patients with the 22-gauge needle, 49% with the 19-gauge needle, and in 88% with the miniforceps. The increase in diagnostic yield with miniforceps was most significant in patients with sarcoidosis (88% vs 36% for TBNA, p = 0.001) or lymphoma (81% vs 35%, p = 0.038). No complications occurred.conclusions: MINIFORCEPS ΜΕ ΚΑΘΟΔΙΓΗΣΗ EBUS ΚΑΛΥΤΕΡΑ ΑΠΟΤΕΛΕΣΜΑΤΑ ΓΙΑ ΜΑΖΕΣ ΜΕΣΟΘΩΡΑΚΙΟΥ- ΛΕΜΦΑΔΕΝΙΚΑ ΜΠΛΟΚ ΑΠΟ ΟΤΙ Η EBUS-TBNA Η ΤΒΝΑ
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