Effects of PD on IL -6- induced Growth Arrest and Term ina l D ifferen tia tion of M 1 Cells

Σχετικά έγγραφα
ZrO 2, ZrO 2. (M ) W O 3g ( 100% ) SO 4 2- W O 3 M oo 3, SO ( Zr (OH ) 4 ) ( ( 0. 1 mo l. L - 1 A gno 3 ), Zr (OH ) 4 SO (0.

Postna ta l D evelopm en ta l Expression of Phosphoprote in s in Synaptosom e

Ch in. J. B iochem. M o l. B io l. 2000, V o l. 16, N o. 2, K 3 (A 6D )

( , ,

PUR IF ICATION AND CHARACTER IZATION OF EXTRACELL ULAR PROTEASE ECPASE 54 FROM A EROM ONAS H YD RO PH ILA

) V o l. 40 N o. 6 : A : Q ,, W ard [ 1 ] (A v icenn ia m a rina) (K and elia cand el)

Το άτομο του Υδρογόνου

(T rip tery g ium w ilf ord ii Hook) ,Beroza [6 ] 4 W ilfo rine W ilfo rdine W ilfo rgine W il2. Euon ine 1. 0% 1980, 1. 1 ; 1. 0%, ; 0.

6 cm, 1. 2 IAA, NAA, 2. 1

GPS, 0. 5 kg ( In tegrated Fertility Index, IF I) 1. 1 SPSS 10. IF I =

Νόµοςπεριοδικότητας του Moseley:Η χηµική συµπεριφορά (οι ιδιότητες) των στοιχείων είναι περιοδική συνάρτηση του ατοµικού τους αριθµού.

26 3 V o l. 26 N o A cta Eco logiae A n im alis Dom astici M ay ,

F ig. 1 Flow chart of comprehen sive design in the research of com patibil ity. E2m ail: ac. cn

Use of Site-D irected M utagenesis to Investiga te the Properties of Recom binan t H irud in-hv2

Investiga tion on L ipoprote in (a) Receptor in the M em brane of M onkey L iver Cells

Estimation of grain boundary segregation enthalpy and its role in stable nanocrystalline alloy design

G IS N N E E, , km 2, 92% A CTA GEO GRA PH ICA S IN ICA

Appendix B Table of Radionuclides Γ Container 1 Posting Level cm per (mci) mci

ΝΟΜΟΣ ΤΗΣ ΠΕΡΙΟ ΙΚΟΤΗΤΑΣ : Οι ιδιότητες των χηµικών στοιχείων είναι περιοδική συνάρτηση του ατοµικού τους αριθµού.

T IM P-1 cd NA CO S-7. Clon ing of Human T IM P-1 cd NA and its Expression in COS-7 Cells. 21 (tissue in2

D NA , ) SCGE DNA.

ΓΗ ΚΑΙ ΣΥΜΠΑΝ. Εικόνα 1. Φωτογραφία του γαλαξία μας (από αρχείο της NASA)

Study on the M ethod of the Qua lita tive Ana lysis of Phosphoroth ioa te O ligonucleotide Can tide

Ι ΙΟΤΗΤΕΣ ΤΩΝ ΑΤΟΜΩΝ. Παππάς Χρήστος Επίκουρος Καθηγητής

1999, 17 (1): J ourna l of W uhan B otan ica l Resea rch ( ) ( ) 2, 3. (Celosia cristata L. ),

TR IBOLO GY N ov, 2004 , P I2. , 120 M Pa, P I. 6 mm 7 mm 30 mm [7, 8 ] mm,. JSM 25600LV 1. 1 (EDXA ).

rs r r â t át r st tíst Ó P ã t r r r â

ΠΕΡΙΟΔΙΚΟΣ ΠΙΝΑΚΑΣ ΣΤΟΙΧΕΙΩΝ

, ( , (P anax qu inquef olius) ) ; L C2V P series U H PE), M Pa R E252. C18 (5 Λm, 250 mm 4. 6 mm ) ( )

Ch inese Jou rnal of B iochem istry and M o lecu lar B io logy. E, m RNA T IR

Further Study on the Spon taneous Fold ing of Ch icken Apocytochrom e c

Con struction and B ioactiv ity of Cys57 M utan t of Human In testina l Trefo il Factor

CH EM ICAL JOU RNAL O F CH IN ESE UN IV ERS IT IES nm, nm nm,,,. [1, 2 ] :

ΠΕΡΙΟΔΙΚΟ ΣΥΣΤΗΜΑ ΤΩΝ ΣΤΟΙΧΕΙΩΝ (1) Ηλία Σκαλτσά ΠΕ ο Γυμνάσιο Αγ. Παρασκευής

H IV-1 gp160. Ana lysis and Expression of An ti-h IV-1 Id iotyp ic An tibody. H IV 21 gp 160. , 1) Fab. gp 160

Jour. of N o rthw est Sci2T ech U niv. of A gri. and Fo r. (N aṫ Sci. Ed. ) Sep , 1 [7 ] ,, 2 ,, 1 85% [1 4 ], [ ]

P P Ó P. r r t r r r s 1. r r ó t t ó rr r rr r rí st s t s. Pr s t P r s rr. r t r s s s é 3 ñ

Rub isco. Rubisco. R ubisco R ubisco , R ubisco

SUPPLEMENTAL INFORMATION. Fully Automated Total Metals and Chromium Speciation Single Platform Introduction System for ICP-MS

TR IBOLO GY July, %. [1 3 ]. [7, 8 ], , mm mm , 350 # 700 # 900 # 1. 1 PAN. R a = Λm, : ( ).

T. Kaw akam i. B ru ton. , Sf9

M olecular Clon ing of D eletion Br idge Fragm en t of Y unnanese

THE EFFECTS OF SEVERAL 5-HT RECEPTOR ANTAGON ISTS ON THE MOTOR ACTIV ITY IN SCH ISTOSOM A J A PON ICUM

τροχιακά Η στιβάδα καθορίζεται από τον κύριο κβαντικό αριθµό (n) Η υποστιβάδα καθορίζεται από τους δύο πρώτους κβαντικούς αριθµούς (n, l)

ss rt çã r s t Pr r Pós r çã ê t çã st t t ê s 1 t s r s r s r s r q s t r r t çã r str ê t çã r t r r r t r s

T he Op tim al L PM Po rtfo lio M odel of H arlow s and Its So lving M ethod

A (GPA ), (Perco ll) A, Gene Express ion of Erythrocyte M em brane Glycophor in A in N IDDM

: H IV. Screen ing of 1F7 Id iotyp ic An ti-gp160 An tibod ies from Phage An tibody L ibrary

hm 2,, , hm 2, A CTA GEO GRA PH ICA S IN ICA

, 4, 6, 8 m in; 30%, 50%, 70%, 90% 100% 15, 30, 45, 60, s V c

FXR1 FM R FM R P FXR 1. In teraction s between Six FM RP Isoform s and FXR1 Prote in

UPTAKE OF CAROTENO ID S BY INTESTINAL M UCOUS CELL S OF LAY ERS AND GOATS IN V ITRO

acrysta ll iferous stra in Btk BE20

V o l122, N o13 M ay, 2003 PRO GR ESS IN GEO GRA PH Y : (2003) , : TU 984. , (Eco logy fo r evil) [1 ] (R ich Boyer), 2.

(TPP)Co 1. 1 ], [ 1, 2 ] V o l. 3 N o. 4 N ov EL ECTROCH EM ISTR Y ) ) ,, Co V V. (T PP) Co (Py) , - 1.

IL -4 . IL 24, cp IL 42PE38KD EL,.

Fo recasting Stock M arket Q uo tation s via Fuzzy N eu ral N etw o rk Based on T 2S M odel

Ch inese Jou rnal of B iochem istry and M o lecu lar B io logy. (o steoarth ritis, OA )

(H ipp op hae rham noid es L. ) , ; SHB 2g , 1. 0, 2. 0, 3. 0, 4. 0, 5. 0 ml mm. : Y = X - 0.

300071; 3. , ) E2m ail: 263. net CH EM ICAL JOU RNAL O F CH IN ESE UN IV ERS IT IES CH 2CO 2H N H H N

Physique des réacteurs à eau lourde ou légère en cycle thorium : étude par simulation des performances de conversion et de sûreté

(g ) A quanau tics,, , 33. 1%. O , O CH EM ICAL JOU RNAL O F CH IN ESE UN IV ERS IT IES (,,, )

A R, H ilbert2h uang T ran sfo rm and A R M odel

Stem Character istics of W heat w ith Stem L odging and Effects of L odging on Gra in Y ield and Qual ity

Bank A ssetgl iab ility Sheet w ith Em bedded Op tion s

A ( SPA ) Su lfo succin im idyl 62[ 3 2( 22pyridyldith io ) p rop ionam ido ]hexanoate (Su lfo2l C2SPD P) C E2m ail: w

1999, 17 ( 1) : 5 9. ( : N o. 26 ) J ourna l of W uhan B otan ica l Resea rch ( : ) 8, 9

(diam inobenzidine,dab ) ; 0. 5 mmo lgl, : N ac l 8 g, KC l 0. 2 g T ris 3

(classical sw ine fever, CSF) (CSFV ) (O IE) A 15, ,, C2,, , 1. 1 SXZZ), 1. 2

1 B0 C00. nly Difo. r II. on III t o. ly II II. Di XR. Di un 5.8. Di Dinly. Di F/ / Dint. mou. on.3 3 D. 3.5 ird Thi. oun F/2. s m F/3 /3.

Ch in J C lin Tho rac Cardiovasc Surg, A p ril 2008,V o l. 15,No. 2

Αναπληρωτής Καθηγητής Τμήμα Συντήρησης Αρχαιοτήτων και Έργων Τέχνης Πανεπιστήμιο Δυτικής Αττικής - ΣΑΕΤ

D esign and Imp lem en tation of Parallel Genetic A lgo rithm

Expression of Functiona l D oma in g of Ca lpa sta tin in E. coli and Prepara tion of An tiserum Aga in st Pur if ied GST-Ca lpa sta tin

met la disposition du public, via de la documentation technique dont les rιfιrences, marques et logos, sont

Pur if ica tion and Character iza tion of Ang ioten sin Converting Enzym e 3

1998, 18 (1): 1 7. A cta T heriolog ica S inica (,, ) (Grow th layer group s, GL Gs) 168, 42,

Ch in. J. B iochem. M o l. B io l. 2000, V o l. 16, N o. 3, (TA FP) , ; 1) 1, 102phenan th ro line TA FP ;

Expression and Pur if ica tion of W ild and M utan t Type NAD H-Cytochrom e b5 Reducta se in E. coli

ΠΑΡΑΡΤΗΜΑ V. Πρότυπα δυναμικά αναγωγής ( ) ΠΡΟΤΥΠΑ ΔΥΝΑΜΙΚΑ ΑΝΑΓΩΓΗΣ ΣΤΟΥΣ 25 o C. Ημιαντιδράσεις αναγωγής , V. Antimony. Bromine. Arsenic.

IL - 13 /IL - 18 ELISA PCR RT - PCR. IL - 13 IL - 18 mrna. 13 IL - 18 mrna IL - 13 /IL Th1 /Th2

(H yaluronic acid, HA ) , HA,. HA,, HA. N T G (S trep tococcus zooep id em icus J 18), 50 g

Αλληλεπίδραση ακτίνων-χ με την ύλη

DY NAM IC CHANGE OF EP ID ERM AL STEM CELL S IN THE WOUND HEAL ING COURSE OF D IABETIC RATSg

CHEM ICAL JOU RNAL O F CH IN ESE UN IV ERS IT IES , ( ECV 304) (angiogenesis),, :

copula, 5 3 Copula Κ L = lim System s Engineering M ay., 2006 : (2006) ,,, copula Ξ A rch im edean copula (Joe,

1. 1 R x (Strain R x of m arine Pho to syn thetic Bacteria )

ο ο 3 α. 3"* > ω > d καΐ 'Ενορία όλις ή Χώρί ^ 3 < KN < ^ < 13 > ο_ Μ ^~~ > > > > > Ο to X Η > ο_ ο Ο,2 Σχέδι Γλεγμα Ο Σ Ο Ζ < o w *< Χ χ Χ Χ < < < Ο

(CHD ), (Β= , P < 0101) ; P I P I ( IGT ) (T G) (LDL 2C) CHD R R R ,, P < 0101)

(M ed icag o sa tiva L. )

THE CALOR IC VAL UE OF M A IN PLANT SPEC IES AT D INGHUSHAN, GUANGDO NG, CH INA

YU Yong2ting, X IE Yuan2yuan, HUAN G L i2li, KAN G Zhen2sheng

A Study of the O rigin of Comp lex ity in the Science of Comp lex ity

A CTA GEO GRA PH ICA S IN ICA

, ( CO 2+ O 2+ N 2, ], N 2 [ 14, 15 ] O 2. ( 0. 1 ml ) ; (23 Jayasingh h atm ) (2001) [ 7 ]

Con struction and D emon stration of an Index System of Know ledge Amoun t of Po sition

Error ana lysis of P2wave non2hyperbolic m oveout veloc ity in layered media

Human In sulin- like Growth Factorg in M ethylotroph ic Y ea st P. p astoris

CHEM ICAL JOU RNAL O F CH IN ESE UN IV ERS IT IES [1, 2 ]. ., FT IR, , g ( cm - 1 ). H 2O cm - 1. :

, E, PRO GR ESS IN GEO GRA PH Y. V o l122, N o15 Sep t1, 2003 : (2003) , 263, (0 1m ) P93511; P42616

Transcript:

ISSN 100727626 CN 1123870gQ 2001 2 Ch inese Jou rnal of B iochem istry and M o lecu lar B io logy 17 (1): 115 120 PD 098059 IL -6 M 1, 3,,, (, 100850) IL 26 M 1 R asgm A PK, M EK PD 098059 R asgm A PK, PD 098059 IL 26 M 1 PD 098059 M 1, IL 26 M 1 PD 098059 IL 26 M 1 CD 11b, IL 2 6 M 1 R asgm A PK, JA K2STA T s, IL 26 R asgm A PK, PD 098059,, R 392 Effects of PD 098059 on IL -6- induced Growth Arrest and Term ina l D ifferen tia tion of M 1 Cells ZHAN G J i2yan, SH EN Bei2fen 3,L I Yan, SUN Y ing2xun, YU M ing (Institu te of B asic M ed ical S ciences, A cad emy of M ilitary M ed ical S ciences, B eij ing 100850, Ch ina) Abstract To investigate the b io logical ro les of R asgm A PK pathw ay in IL 262induced M 1 leukem ia cells, the con stitu tive and inducib le activation of R asgm A PK pathw ay w as b locked w ith M EK specific inh ib ito r PD 098059 and the effects of PD 098059 on IL 262induced grow th arrest and term inal differen tiation ofm 1 cells w ere determ ined. PD 098059 w as found to inh ib it the grow th of M 1 cells by itself and enhance IL 262induced grow th arrest of M 1 cells. A lthough PD 098059 had little effects on the m o rpho logical changes and CD 11b exp ression of M 1 cells induced by IL 26, it reduced IL 262induced p hagocy t ic act ivity of M 1 cells sign ifican t ly. T hu s the con st itu t ive and inducib le activation of R asgm A PK pathw ay w as im po rtan t in IL 262induced m acrophage differen tiation of M 1 cellṡ Key words R asgm A PK pathw ay, PD 098059, grow th, differen tiation [ 4 R asgm A PK ] STA T 3 RNA, STA T 3 STA T 3, IL 26 M 1 [ 1 ] IL 26 R asgm A PK (ER K1 ER K2) gn F2IL 6 [ 2 ], R asgm A PK IL 26 : 2000203224, : 2000206219 (N o. 39925019) 3 T el: (010) 66931325, Fax: (010) 68159436 IL 26 M 1 R asg M A PK,M 1 IL 26,, 1972 8,, Received:M arch 24, 2000 A ccep ted: June 19, 2000 [ 3 ], Suppo rted by N ational Science Foundation fo r distinguished young IL 26 Scho lars, N o. 39925019 3 Co rresponding autho r T el: (010) 66931325 N akajim a STA T 3 IL 26 M 1 Fax: (010) 68159436,

116 17, IL 26 M 1 R asg m in M A PK IL 26? 116, R asgm A PK, PD 098059 [ 5 ] R asgm A PK (2 lgm l, 0160 m ) 37, 5% CO 2 1 111 M 1 A TCC, 10% FCS21640 112 PD 098059 B io lab s, DM SO, 20 mm o lgl ER K2 San ta C ruz 118 W r ight s F ITC CD 11b [4 ] Imm uno tech rh IL 26 ( 011% BSA PBS ) 10 7 U gm g, rh IL 26 10 m in, PBS 1 RN ase A PM SF g, (20 mm o lgl T ris2c l ph 810, Sigm a, dn T P K lenow P rom ega, [Α2 32 P ]da T P 1% N P240, 1 mm o lgl PM SF, 10 m ggl pep statin, PA GE A, 10 m ggl leupep tin), 4 30 m in 12 000 g 113 (EM SA) rh IL 26 15 m in, 4 2 h, P ro tein A 2agaro se 4 K lenow 5 (20 mm o lgl T ris2c l ph 8. 0, [ Α2 32 P ]da T P (3 000 C igmm o l) 137 mm o lgl N ac l, 10% ) 4 6, (10 20 g ) 10 fm o l (cpm 5 000) 10% SD S2PA GE. 20 m in 4 ER K2, 15%, 0125 TA E (1 TA E 40 mm o lgl T ris2c l ph 7. 8, 1. 1 mm o lgl ED TA, 37 mm o lgl ), : A PR E ( STA T 3) = 5 2 cgat CT TCT GGGAA T TCCTA 23 [ 6 ] ; A T FgN F2IL 6 ( N F2IL 6 ) = 5 2ctgaGA T GA CGTA GT T T T GGCGCT 23 [ 7 ] ;, M A PK (ER K1 ER K2) gn F2IL 6 114 PD 098059, IL 26 STA T 3; R asgm A PK M 1 96, 5 10 3 g PD 098059 1 h rh IL 26; M 1 R asgm A PK 72 h, M T T, 4 h, 10% SD S20101 m o lgl HC l, A 570 115 CD 11b 4 h, Ca 2+ M g 2+ PBS 3, 200 117 70%, 10 6 gm l, 4 18 h, PBS P I P I 50 m ggl, 01002% T riton X2100 100 U gm l RN ase A PBS, 30 m in 119 137 mm o lgl N ac l, 10%, 2 mm o lgl N a3vo 4, 15 m in, ER K2 SD S 10 m in, 2 211 PD 098059 Ra sgm APK IL 26 JA K2STA T s R asg, JA K2STA T s [ 2, IL 26 N F2IL 6 ], M A PK N F2 IL 6 DNA, R asgm A PK, STA T 3 IL 26, 1 g F ITC, STA T 3, M A PK CD 11b 30 N F2IL 6 DNA

1 : PD 098059 IL 26 M 1 117 (F ig. 1, 2), IL 26 JA K2STA T s R asg M A PK, IL 26 STA T 3, N F2IL 6 IL 26 (F ig. 1) F ig. 1 Do se course of nuclear facto rs activated by incubation w ith rh IL 26 fo r 15 m in F ig. 2 Effects of PD 098059 on the tyro sine pho spho rylation of M A PK (A ) and on the DNA binding ability of STA T 3 and N F2IL 6 (B) IP: imm unop recip itation; IB: imm unoblo tting; pt yr: pho spho tyro sine PD 098059 R asgm A PK R asgm A PKgN F2IL 6 M EK, PD 098059 IL 26 M 1 [ 5 M EK M EK ],, IL 26 IL 2 R asgm A PK 6, PD 098059 IL 26, 100 m o lgl PD 098059 ER K2 M A PK (F ig. 2A ) ; EM SA, A 570 100% ) ; IL 26 PD 098059 N F2IL 6 DNA, 100 ggl, PD 098059 IL 26 M 1 STA T 3 DNA (F ig. 2B ),, PD 098059, PD 098059 R asg IL 26 N F2IL 6 M A PKgN F2IL 6, (F ig. 3B ) JA K2STA T s PD 098059 M 1 212 PD 098059 M 1 ( PD 098059 0 ggl IL 26 M 1 M 1 PD 098059 M 1,, 50% S,, (F ig. 3A ), M 1 (< 1% ) 100 m o lgl PD 098059

118 17 F ig. 3 Effects of PD 098059 on the grow th (A ) and IL 262induced grow th arrest (B)of M 1 cells PD 0 mo lgl ; PD 50 mo lgl ; PD 100 mo lgl ; PD 200 mo lgl F ig. 4 Effect of PD 098059 on the cell cycle redistribution of M 1 cells induced by 100 ggl rh IL 26 S, M A PK (F ig. 4, 3 ), M 1 PD 098059 25 m o lgl, R asgm A PK, R asg ( ) F ig. 3 M A PK IL 26 PD 098059, PD 098059 IL 26 213 PD 098059 IL -6 M 1 IL 26, PD 098059 PD 098059 100 M 1 100 ggl IL 26 3 4 d m o lgl, PD 098059 IL 26 PD 098059 IL 26 100 ggl, IL 2 M 1, ; 6 ( ) IL 26 IL 26,, 100 ggl, 100 m o lgl PD 098059, 100 m o lgl PD 098059 IL 26 IL 26 S, (F ig. 5A ), (F ig. 4, ), R asg

1 : PD 098059 IL 26 M 1 119 F ig. 5 Effects of PD 098059 on the mo rpho logical changes (A ) and CD 11b exp ression (B) of M 1 cells induced by 100 ggl rh IL 26 M 1 100 ggl IL 26 3 4 d CD 11b 100 m o lgl PD 098059 M 1 CD 11b, ; 100 ggl IL 26, CD 11b, (F ig. 5B ) 3, 3 t, (t= 1, P > 0105) M 1, IL 26 M 1, 100 ggl IL 26 4 d, 80% M 1 PD 098059 IL 26 M 1,,, R asgm A PK 100 m o lgl PD 098059 M 1 (F ig. 6), F ig. 6 Effect of PD 098059 on the phagocytic activity of M 1 cells

120 17 3 IL 26, IL 26 PD 098059? JA K2STA T s R asgm A PK JA K2STA T s, IL 26 STA T 3, JA K1 STA T 3 N F2IL 6 ino S, IL 26 [ 2 ] PD 098059 M EK STA T 1 STA T 5 STA T N F2IL 6,,, R asgm A PK, IL 26 R asgm A PK (Grb2gSO S R as R af21 M EK M A PK) N F2IL 6 STA T IL 26 R asgm A PK,,, [ 2, 8 R asgm A PK ], STA T 3 c2m yc c2m yb JunB IR F1 P 19 IN K4D P 21WA F1gC IP1, [ 8 ] STA T 3 RNA N akajim a STA T 3 IL 2 [ 4 6 M 1 ] IL 26 M 1 R asg M A PK, IL 26 M 1 R asgm A PK?, R asgm A PK PD 098059 M 1, IL 26 M 1 (F ig. 3, 4), R asgm A PK, STA T 3 ;, R asgm A PK,M 1 IL 26, CD 11b (F ig. 5), (F ig. 6), R asgm A PK, R asgm A PK STA T 3 PD 098059 STA T 3 DNA (F ig. 2), R asgm A PK STA T 3, STA T 3 IL 26 M 1, STA T 3, STA T 3 R asgm A PK R asgm A PK JA K2STA T s, IL 26, N F2IL 6 knock ou t,, ino S,, (References) 1 Sugium R, Toda T, D hut S, Shuntoh H, Kuto T. T he M A PK kinase Pek I acts as a pho spho rylation2dependent mo lecular sw itch. N atu re, 1999, 399 (6735) : 479 482 2 A k ira S. IL 262regulated transcrip tion facto rs. Int J B iochem Cell B iol, 1997, 12: 1401 1408 3,,,. IL 26 M 1. (Zhang J i2yan, Shen Bei2fen, W ang J ian2an, Zhang Xue2m in. A pop to sis of M 1 cells is induced by IL 26 after the cells undergo differentiation and its mo lecular m echanism. Imm unol J ), 2000, 16 (1) : 16 19 4 N akajim a K, Yam anaka Y, N akee K, Ko jim a H, Ich ibam, Kiuch i N, Kitaoka T, Fukada T, H ibi M, H irano T. A central ro le fo r STA T 3 in IL 262induced regulation of grow th and differentiation in M 1 leukem ia cellṡ EM B O J, 1996, 15: 3651 3658 5 Sengup ta T K, T albo t E S, Scherle P A, Ivashk iv L B. Rap id inh ibition of interleuk in26 signaling and Stat3 activation m ediated by m itogen2activated p ro tein k inases. P roc N atl. A cad S ci U SA, 1998, 95: 11107 11112 6 W egenka U M, Buschm ann J, L utticken C, L tticken C, H einri2 ch PC, Ho rn F. A cute2phase responsive facto r, a nuclear facto r binding to acute2phase responsive elem ents, is rap idly activated by interleukin26 at the po sttranslational level. M ol Cell B iol, 1993, 13: 276 288 7 H su W, Kerppo la T K, Chen P L, Curran T, Chen2Kiang S. Fo s and Jun rep ress transcrip tion activation by N F2IL 6 through association at the basic zipper region. M ol Cell B iol, 1994, 14: 268 276 8 H irano T, N akajim a K, H ibi M. Signaling m echanism th rough gp130: a model of the cytokine system. Cy tok ine & G row th f actor R ev, 1997, 8 (4) : 241 252,