SYNkinase Catalogue. September Kinase Inhibitor Library Arrays. 1 Multi-Target Arrays. 2 Pathway and Family Specific Arrays

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SYNkinase Catalogue September 2014 Kinase Inhibitor Library Arrays Pre-made Inhibitor Array Options 1 Multi-Target Arrays 2 Pathway and Family Specific Arrays 9 Custom Array Options 16

Abl Kinase Inhibitor Library Arrays High quality, research relevant kinase inhibitor library arrays. SYNkinase multi-target inhibitor libraries are available in either 100 μl of 10mM or 100 μl of 20mM DMSO inhibitor solution per well. SYNkinase pathway specific inhibitor arrays are available as 100 μl of 10mM DMSO inhibitor solution per well. These arrays are available with to six wells per inhibitor on each plate. SYNkinase Library Arrays Abl PYK2, FAK PYK2, FAK Half-Plate Library (47 Inhibitors) BTK BTK FAK, PYK2 JAK1,3 Src, Abl Syk FAK, PYK2 JAK1,3 Src, Abl Syk Single Plate Library (95 Inhibitors),1 LCK, RAF TYK2,1 LCK, RAF TYK2 Double Plate Library (190 Inhibitors) PI3K Array (11 Inhibitors) SYNkinase libraries are made in REMP plates with individually foil sealed wells. Thermo Matrix plates are available for an additional fee. PI3K Pathway Array (9 Inhibitors) Cytoplasmic PTK Panel (11 Inhibitors) RTK Panel (13 Inhibitors) Ser/Thr Kinase Array (16 Inhibitors) Ras-Raf Panel (9 Inhibitors) JAK-STAT Family Array (12 Inhibitors) JAK-STAT Array (8 Inhibitors) 1

47 Kinase Inhibitor Library SYN-2104 Plate Wells by Target CHK1 PI3K, p110 α/β/δ/γ S6K c-met, Flt-1/3/4, Tie2, 2, AXL, Ret, Kit Akt1,, PKA EGFR c-kit PI3Kδ TRK Bcr-Abl, Src, c-kit Akt1/2/3 (p38map), p38α/β Pim TrkA 1/2/3 ALK FAK MEK1/2 PLK TYK2 BCR-ABL, 2, FGFR1, Src, PDGFRα Aurora A FGFR1 c-met PYK2 1/2/3, c-kit B-RAF, -2, Raf-1 Bcl-2 FLT3, FMS, ckit, PDGFR B-RAF 1/2/3,FGFR, c-fms VEGF, FGFR1 BCR-ABL GSK-3 PDK1 ROCK c-kit, PDGFRβ, 1/2/3 c-kit, PDGFRβ, 2 (Flk-1) PERK RSK BCR-Abl, Src FLT3, PDGFR 2

47 Kinase Inhibitor Library Inhibitor name, Catalog and CAS # SYN-1174 PF0477736 1-A3 SYN-1104 TG101348 1-A5 SYN-1200 BKM120 1-A7 SYN-1177 PF-04708671 1-A9 SYN-1138 Cabozantinib 1-A11 SYN-1110 A-674563 1-B1 SYN-1042 Gefitinib 1-B3 SYN-1053 Masatinib 1-B5 SYN-1045 IC87114 1-B7 SYN-1183 GNF-5837 1-B9 SYN-1036 Dasatinib 1-B11 SYN-1162 MK-2206 1-C1 SYN-1052 Lapatinib 1-C3 SYN-1073 SB202190 1-C5 SYN-1113 SMI-4a 1-C7 SYN-1044 GW441756 1-C9 SYN-1055 Motesanib 1-C11 SYN-1199 LDK378 1-D1 SYN-1064 PF-562271 1-D3 SYN-1031 CI-1040 1-D5 SYN-1019 (R)-BI-2536 1-D7 SYN-1198 GDC-046 1-D9 SYN-1116 Ponatinib 1-D11 SYN-1092 Tozasertib 1-E1 SYN-1176 PD-0173074 1-E3 SYN-1060 PF04217903 1-E5 SYN-1063 PF431396 1-E7 SYN-1013 Tivozanib 1-E9 SYN-1082 Sorafenib 1-E11 SYN-1001 ABT-737 1-F1 SYN-1003 Quizartinib 1-F3 SYN-1181 PP242 1-F5 SYN-1161 PLX4032 1-F7 SYN-1058 Pazopanib 1-F9 SYN-1085 SU-6668 1-F11 SYN-1046 Imatinib mesylat 1-G1 SYN-1075 SB-216763 1-G3 SYN-1026 BX795 1-G5 SYN-1071 GSK429286A 1-G7 SYN-1014 Axitinib 1-G9 SYN-1086 Sunitinib 1-G11 SYN-1070 Purvalanol B 1-H1 SYN-1112 Mubritinib 1-H3 SYN-1201 GSK2606414 1-H5 SYN-1020 BI-D1870 1-H7 SYN-1025 Bosutinib 1-H9 SYN-1088 Tandutinib 1-H11 3

95 Kinase Inhibitor Library SYN-2103 Plate Wells by Target Control AXL FGFR1/2/3 JAK3 (p38map), p38α PI3Kα/δ PLK TRK c-kit, PDGFRβ, 1/2/3 c-met, FGFR1/2/3, PDGFRβ Akt1,, PKA Bcl-2 FGFR1 JNK MEK1/2 PI3Kδ PYK2 TrkA BCR-Abl, Src 1/2/3 Akt1/2/3 BCR-ABL CHK1 FLT3, FMS, ckit, PDGFR c-kit MEK1/2 PI3K, p110α B-RAF TYK2 c-met, Flt-1/3/4, Tie2, 2, AXL, Ret, Kit BCR-ABL, 2, FGFR1, Src, PDGFRα ALK BTK CK2 GSK-3 Lck MEK1 PDK1 PI3Kα/γ/δ ROCK 1/2/3, c-kit Bcr-Abl, Src, c-kit 1/2/3, PDGFRβ, KIT, RET, Raf-1 ASK c-src EGFR LIMK c-met PERK PI3K, p110β RSK 2 FGFR1/3, FLT3, FMS, 1-4 B-RAF, -2, Raf-1 Aurora A/B 1/2/4/6 (p38map) 1c-MET PI3Kγ PIK fyve S6K 3 2, 3 (Flt-4) VEGF, FGFR1 Aurora A/B/C Aurora A 1/2/4/6/9 4/6 FAK FGFR1, 2 JAK1/2 (p38map), p38α/β (p38map) c-met, Mps1, TTK PI3K, p110α/β/δ/γ PI3Kα/δ/γ Pim PKC Syk TIE-2 1/2/3, FGFR, c-fms Flt3, KIT, PDGFRα 1/2/3, FGFR1/2/3, PDGFRα/β Flt-1/3, PDGFRβ, 2, CSF-1R c-kit, PDGFRβ, 2 (Flk-1) FLT3, PDGFR 4

95 Kinase Inhibitor Library Inhibitor name, Catalog and CAS # SYN-1183 GNF-5837 1-A10 SYN-1014 Axitinib 1-A11 SYN-1149 MK-2461 1-A12 SYN-1131 R428 1-A2 SYN-1070 Purvalanol B 1-A3 SYN-1152 NVP-BGJ398 1-A4 SYN-1032 Tofacitinib 1-A5 SYN-1087 TAK-715 1-A6 SYN-1181 PP242 1-A7 SYN-1041 GDC-0941 1-A8 SYN-1019 (R)-BI-2536 1-A9 SYN-1110 A-674563 1-B1 SYN-1044 GW441756 1-B10 SYN-1025 Bosutinib 1-B11 SYN-1055 Motesanib 1-B12 SYN-1001 ABT-737 1-B2 SYN-1080 BMS387032 1-B3 SYN-1176 PD-0173074 1-B4 SYN-1028 CC-401 1-B5 SYN-1190 AS703026 1-B6 SYN-1185 Rapamycin 1-B7 SYN-1045 IC87114 1-B8 SYN-1063 PF431396 1-B9 SYN-1162 MK-2206 1-C1 SYN-1198 GDC-046 1-C10 SYN-1138 Cabozantinib 1-C11 SYN-1116 Ponatinib 1-C12 SYN-1046 Imatinib mesylate 1-C2 SYN-1174 PF0477736 1-C3 SYN-1003 Quizartinib 1-C4 SYN-1053 Masatinib 1-C5 SYN-1031 CI-1040 1-C6 SYN-1186 XL388 1-C7 SYN-1067 PIK-75 1-C8 SYN-1161 PLX4032 1-C9 SYN-1199 LDK378 1-D1 SYN-1013 Tivozanib 1-D10 SYN-1036 Dasatinib 1-D11 SYN-1169 Regorafenib 1-D12 SYN-1164 GCI1746 1-D2 SYN-1109 CX-4945 1-D3 SYN-1075 SB-216763 1-D4 SYN-1007 AMG-47a 1-D5 SYN-1016 Selumetinib 1-D6 SYN-1026 BX795 1-D7 SYN-1068 PIK-90 1-D8 SYN-1071 GSK429286A 1-D9 SYN-1119 S-99 1-E1 SYN-1133 JNJ-38158471 1-E10 SYN-1029 CHIR-258 1-E11 SYN-1082 Sorafenib 1-E12 SYN-1062 PD173955-Analog1 1-E2 SYN-1042 Gefitinib 1-E3 SYN-1112 Mubritinib 1-E4 SYN-1024 BMS-5 1-E5 SYN-1139 Crizotinib 1-E6 SYN-1201 GSK2606414 1-E7 SYN-1089 TGX221 1-E8 SYN-1020 BI-D1870 1-E9 SYN-1034 CYC116 1-F1 SYN-1165 SAR131675 1-F10 SYN-1038 E7080 1-F11 SYN-1085 SU-6668 1-F12 SYN-1040 Alvocidib 1-F2 SYN-1052 Lapatinib 1-F3 SYN-1196 LY2784544 1-F4 SYN-1072 RWJ-67657 1-F5 SYN-1060 PF04217903 1-F6 SYN-1009 AS-252424 1-F7 SYN-1094 YM201636 1-F8 SYN-1177 PF-04708671 1-F9 SYN-1081 SNS-314 1-G1 SYN-1058 Pazopanib 1-G10 SYN-1091 Intedanib 1-G11 SYN-1086 Sunitinib 1-G12 SYN-1010 AT-7519 1-G2 SYN-1064 PF-562271 1-G3 SYN-1035 Momelotinib 1-G4 SYN-1073 SB202190 1-G5 SYN-1129 Foretinib 1-G6 SYN-1200 BKM120 1-G7 SYN-1113 SMI-4a 1-G8 SYN-1121 R406 1-G9 SYN-1092 Tozasertib 1-H1 SYN-1056 Amuvatinib 1-H10 SYN-1002 Linifanib 1-H11 SYN-1088 Tandutinib 1-H12 SYN-1180A Palbociclib Isethionate 1-H2 SYN-1134 BMS-540215 1-H3 SYN-1104 TG101348 1-H4 SYN-1079 SD169 1-H5 SYN-1187 MPI0479605 1-H6 SYN-1202 GDC-0032 1-H7 SYN-1021 Bisindoylmaleimide X 1-H8 SYN-1008 AMG-Tie2-1 1-H9 5

Control Control SYN-2102 Plate Wells by Target Akt1,, PKA Akt Akt Akt Akt1/2/3 Akt1/2/3 ALK ALK ASK Aurora A/B, /3, Abl Aurora A/B Aurora A/B/C, Abl,TrkA, c-ret, FGFR1 Aurora A/B, 1/2 Aurora A/B/C Aurora A AXL Bcl-2 Bcr-Abl, Lyn BCR-ABL BCR-ABL, c-src BCR-ABL BTK c-src 1/2/4/6 1/2/4/6/9 4/6 4/6 CHK1/2 CHK1 CHK1 CHK1 CK2 EGFR EGFR EGFR ErbB2, FAK FGFR1, 2 2 FGFR 1/2/3 FGFR1 FGFR, FLT3, FMS, ckit, PDGFR c-fms FMS GSK-3 JAK1/2 FMS JAK1 JAK1/2 JAK1/2 JAK3 JNK-1 JNK c-kit c-kit Lck LIMK LIMK (p38map) MEK1/2 MEK1/2 MEK1/2 MEK1/2 MEK MEK (p38map) (p38map) (p38map) (p38map) (p38map) (p38map) (p38map), p38α (p38map), p38α MEK1 c-met, RON c-met c-met c-met c-met c-met c-met c-met c-met, Mps1, TTK C 1/2 PDK1 PDK1 PERK PIK fyve Pim Pim1, FLT3 Pim PKC PKC PKCβ PLK PYK2 PYK2 B-RAF B-RAF B-RAF ROCK ROCK ROCK-II RSK S6K S6K Syk Syk TIE-2 TRK TrkA TYK TYK2 TYK 1/2/3, c-kit -2 2, RAF 3 1/2/3, FGFR, c-fms 1/2/4, FGFR, c-fms Flt3, KIT, PDGFRα c-kit, PDGFRβ, 1/2/3 BCR-Abl, Src c-met, Flt-1/3/4, Tie2, 2, AXL,Ret, Kit Bcr-Abl, Src, c-kit 2 (KDR)/ 3 (Flt-4) 1/2/3, FGFR1/2/3, PDGFRα/β Flt-1/3, PDGFRβ, 2(KDR), CSF-1R c-met, FGFR1/2/3, DGFRβ 1/2/3 BCR-ABL, 2, FGFR1, Src, PDGFRα 1/2/3, PDGFRβ, KIT, RET, Raf-1 PI3Kα PI3Kα PI3Kα/δ PI3Kα/δ/γ PI3Kα/δ/β PI3Kδ PI3Kδ PI3K δ/γ PI3Kγ PI3Kγ/δ PI3Kα/δ/γ PI3Kα/γ/δ pan-pi3k pan-pi3k pan-pi3k PI3K, p110 α/β/δ/γ PI3K, p 110δ PI3K, p110β PI3K, p110α p110 α/β/δ/γ PI3K p110 α/γ/δ/β, p110 α/β/δ/γ, C1/2 PI3K α/β/δ/γ, PI3Kα/β/γ, PI3Kα/β/γ, PI3K, PI3K, PI3K, 190 Kinase Inhibitor Library 6

190 Kinase Inhibitor Library (Plate #1) Inhibitor name, Catalog and CAS # SYN-1159 TAE684 1-A2 SYN-1131 R428 1-A3 SYN-1040 Alvocidib 1-A4 SYN-1173 SCH 900776 1-A5 SYN-1012 AV-412 1-A6 SYN-1033 CP-724714 1-A7 SYN-1154 JNJ-28312141 1-A8 SYN-1120 Ruxolitinib 1-A9 SYN-1191 XL019 1-A10 SYN-1024 BMS-5 1-A11 SYN-1087 TAK-715 1-A12 SYN-1110 A-674563 1-B1 SYN-1119 S-99 1-B2 SYN-1001 ABT-737 1-B3 SYN-1010 AT-7519 1-B4 SYN-1189 SAR020106 1-B5 SYN-1100 Afatinib 1-B6 SYN-1064 PF-562271 1-B7 SYN-1049 Ki20227 1-B8 SYN-1196 LY2784544 1-B9 SYN-1032 Tofacitinib 1-B10 SYN-1101 R1487 1-B11 SYN-1123 VX745 1-B12 SYN-1005 Akt-I-1 1-C1 SYN-1011 AT9283 1-C2 SYN-1057 Nilotinib 1-C3 SYN-1151 BS194 1-C4 SYN-1174 PF0477736 1-C5 SYN-1142 BMS-599626 1-C6 SYN-1176 PD-0173074 1-C7 SYN-1003 Quizartinib 1-C8 SYN-1015 AZ-960 1-C9 SYN-1147 Bentamapimod 1-C10 SYN-1072 RWJ-67657 1-C11 SYN-1190 AS703026 1-C12 SYN-1006 Akt-I-2 1-D1 SYN-1034 CYC116 1-D2 SYN-1046 Imatinib mesylate 1-D3 SYN-1180 Palbociclib HCl 1-D4 SYN-1017 AZD7762 1-D5 SYN-1052 Lapatinib 1-D6 SYN-1152 NVP-BGJ398 1-D7 SYN-1075 SB-216763 1-D8 SYN-1156 CEP-33779 1-D9 SYN-1028 CC-401 1-D10 SYN-1073 SB202190 1-D11 SYN-1195 AZD8330 1-D12 SYN-1160 AZD-26 1-E1 SYN-1081 SNS-314 1-E2 SYN-1061 PD173955 1-E3 SYN-1180A Palbociclib Isethionate 1-E4 SYN-1109 CX-4945 1-E5 SYN-1140 Neratinib 1-E6 SYN-1135 Brivanib 1-E7 SYN-1112 Mubritinib 1-E8 SYN-1136 NVP-BSK805 1-E9 SYN-1125 AMG-25 1-E10 SYN-1073A SB202190 HCl 1-E11 SYN-1170 GSK1120212 1-E12 SYN-1043 GSK-690693 1-F1 SYN-1048 JNJ-7706621 1-F2 SYN-1179 Bafetinib 1-F3 SYN-1097 PHA690509 1-F4 SYN-1042 Gefitinib 1-F5 SYN-1141 Pelitinib 1-F6 SYN-1084 SU-5402 1-F7 SYN-1158 GPLG0634 1-F8 SYN-1107 TG-89 1-F9 SYN-1053 Masatinib 1-F10 SYN-1076 SB-242235 1-F11 SYN-1031 CI-1040 1-F12 SYN-1162 MK-2206 1-G1 SYN-1095 Danusertib 1-G2 SYN-1164 GCI1746 1-G3 SYN-1070 Purvalanol B 1-G4 SYN-1030 Canertinib 1-G5 SYN-1153 TAK-285 1-G6 SYN-1134 BMS-540215 1-G7 SYN-1117 Baricitinib 1-G8 SYN-1103 TG101209 1-G9 SYN-1007 AMG-47a 1-G10 SYN-1078 SD-06 1-G11 SYN-1188 CH4987655 1-G12 SYN-1199 LDK378 1-H1 SYN-1092 Tozasertib 1-H2 SYN-1062 PD173955-Analog1 1-H3 SYN-1080 BMS387032 1-H4 SYN-1039 Erlotinib 1-H5 SYN-1090 Vandetanib 1-H6 SYN-1197 BLZ-945 1-H7 SYN-1035 Momelotinib 1-H8 SYN-1104 TG101348 1-H9 SYN-1023 BMS-3 1-H10 SYN-1079 SD169 1-H11 SYN-1059 PD0325901 1-H12 7

190 Kinase Inhibitor Library (Plate #2) Inhibitor name, Catalog and CAS # 8 SYN-1060 PF04217903 2-A2 SYN-1181 PP242 2-A3 SYN-1041 GDC-0941 2-A4 SYN-1127 XL147 2-A5 SYN-1067 PIK-75 2-A6 SYN-1137 XL765 2-A7 SYN-1172 Ruboxistaurin 2-A8 SYN-1071 GSK429286A 2-A9 SYN-1183 GNF-5837 2-A10 SYN-1013 Tivozanib 2-A11 SYN-1036 Dasatinib 2-A12 SYN-1016 Selumetinib 2-B1 SYN-1143 AMG-1 2-B2 SYN-1185 Rapamycin 2-B3 SYN-1202 GDC-0032 2-B4 SYN-1068 PIK-90 2-B5 SYN-1065 PI103 2-B6 SYN-1194 PF-04979064 2-B7 SYN-1019 (R)-BI-2536 2-B8 SYN-1083 SR3677 2-B9 SYN-1044 GW441756 2-B10 SYN-1168 Takeda-6d 2-B11 SYN-1038 E7080 2-B12 SYN-1155 SGX523 2-C1 SYN-1129 Foretinib 2-C2 SYN-1050 KU0063794 2-C3 SYN-1009 AS-252424 2-C4 SYN-1114 GNE-490 2-C5 SYN-1018 BEZ-235 2-C6 SYN-1094 YM201636 2-C7 SYN-1063 PF431396 2-C8 SYN-1020 BI-D1870 2-C9 SYN-1130 Bayer-18 2-C10 SYN-1058 Pazopanib 2-C11 SYN-1091 Intedanib 2-C12 SYN-1111 AMG-51 2-D1 SYN-1187 MPI0479605 2-D2 SYN-1026 BX795 2-D3 SYN-1099 ZSTK474 2-D4 SYN-1115 GNE-493 2-D5 SYN-1126 GSK2126458 2-D6 SYN-1182 CX6258 2-D7 SYN-1163 PF4618433 2-D8 SYN-1177 PF-04708671 2-D9 SYN-1198 GDC-046 2-D10 SYN-1056 Amuvatinib 2-D11 SYN-1002 Linifanib 2-D12 SYN-1144 AMG-458 2-E1 SYN-1167 AZD2014 2-E2 SYN-1027 BX912 2-E3 SYN-1175 IPI 145 2-E4 SYN-1145 NIBR-17 2-E5 SYN-1150 RG7422 2-E6 SYN-1113 SMI-4a 2-E7 SYN-1069 PLX4720 2-E8 SYN-1132 S6K-18 2-E9 SYN-1128 RO495 2-E10 SYN-1058A Pazopanib HCl 2-E11 SYN-1149 MK-2461 2-E12 SYN-1022 BMS-2 2-F1 SYN-1166 AZD8055 2-F2 SYN-1201 GSK2606414 2-F3 SYN-1045 IC87114 2-F4 SYN-1200 BKM120 2-F5 SYN-1178 BGT-226 2-F6 SYN-1193 SGI-1776 2-F7 SYN-1077 SB590885 2-F8 SYN-1121 R406 2-F9 SYN-1004 AG13958 2-F10 SYN-1014 Axitinib 2-F11 SYN-1055 Motesanib 2-F12 SYN-1139 Crizotinib 2-G1 SYN-1157 MLN0128 2-G2 SYN-1146 CH5132799 2-G3 SYN-1108 LY294002 2-G4 SYN-1089 TGX221 2-G5 SYN-1178A BGT-226 free base 2-G6 SYN-1021 Bisindoylmaleimide X 2-G7 SYN-1161 PLX4032 2-G8 SYN-1122 Tamatinib fosdium 2-G9 SYN-1133 JNJ-38158471 2-G10 SYN-1025 Bosutinib 2-G11 SYN-1116 Ponatinib 2-G12 SYN-1047 JNJ38877605 2-H1 SYN-1186 XL388 2-H2 SYN-1066 PIK-93 2-H3 SYN-1105 TG100115 2-H4 SYN-1098 PIK-294 2-H5 SYN-1148 GNE 477 2-H6 SYN-1037 Dianilinopyrimidine_01 2-H7 SYN-1124 GSK-25 2-H8 SYN-1008 AMG-Tie2-1 2-H9 SYN-1165 SAR131675 2-H10 SYN-1138 Cabozantinib 2-H11 SYN-1169 Regorafenib 2-H12

PI3K Pathway Array SYN-2155 AKT (allosteric) GSK690693 (SYN-1043) [937174-76-0] p110γ TG100115 (SYN-1105) [677297-51-7] AKT1 (kinase) A-674563 (SYN- 1110) [552325-73-2] pan PI3K GSK2126458 (SYN-1126) [1086062-66-9] GSK3 SB216763 (SYN-1075) [280744-09-4] pan-akt (kinase) MK-2206 dihydrochloride (SYN-1162) [1032350-13-2] KU0063794 (SYN-1050) [938440-64-3] p110δ NIBR-17 (SYN-1145) [944396-88-7] p110α NVP-BGT226 (SYN-1178) [1245537-68-1] 9

Cytoplasmic PTK Panel SYN-2156 Abl PD173074 (SYN-1176) [219580-11-7] PYK2, FAK Tofacitinib (SYN-1032) [477600-75-2] BTK FAK, PYK2 PF4618433 (SYN-1163) [1166393-85-6 ] CGI1746 (SYN-1164) [910232-84-7] Src, Abl R406 (SYN-1121) [841290-80-0] Momelotinib (SYN-1035) [1056634-68-4] JAK1,3 Bosutinib (SYN-1025) [380843-75-4] Syk GDC046 (SYN-1198) [1258292-64-6],1 CGI1746 (SYN-1164) [910232-84-7] TYK2 AMG-47a (SYN-1007) [882663-88-9] LCK, RAF Dasatinib (SYN-1036) [302962-49-8] 10

Ras-Raf Panel SYN-2153 B-raf PLX4720 (SYN-1069) [918505-84-7] MEK1,2,5 - MKK3,4,6,7 AS703026 (SYN-1190) [1236699-92-5] c-raf/lck AMG-47a (SYN-1007) [882663-88-9] RSK SR3677 (SYN-1083) [1072959-67-1] EGFR Lapatinib (SYN-1052) [231277-92-2] S6K PF-04708671 (SYN-1177) [1255517-76-0] GSK3 SB216763 (SYN-1075) [280744-09-4] MEK1,2,5 PD0325901 (SYN-1059) [391210-10-9] R1487 (SYN-1101) [449808-64-4] 11

Ser/Thr Kinase Array SYN-2157 ASK S-99 (SYN-1119) [1124381-69-6] GSK3 SB216763 (SYN-1075) [280744-09-4] RSK SR3677 (SYN-1083) [1072959-67-1] PKCα CX6258 (SYN-1182) [1202916-90-2] LIMK1/2 BMS-3 (SYN-1023) [1338247-30-5] S6K1 PF-04708671 (SYN-1177) [1255517-76-0] AURK Tozasertib (SYN-1092) [639089-54-6] R1487 (SYN-1101) [449808-64-4] TBK1 BX795 (SYN- 1026) [702675-74-9] B-Raf PLX4720 (SYN-1069) [918505-84-7] MEK1,2,5 - MKK3,4,6,7 Crizotinib (SYN-1139) [877399-52-5] CHK2 CX-4945 (SYN-1109) [1009820-21-6] (family) BS194 (SYN- 1151) [1092443-55-4] PKC LY333531 Hydrochloride (SYN-1172) [169939-93-9] c-raf AMG-47a (SYN-1007) [882663-88-9] CHK1 XL388 (SYN-1186) [1251156-08-7] 12

RTK Panel SYN-2152 AXL R428 (SYN-1131) [1037624-75-1] FGFR MK-2461 (SYN-1149) [917879-39-1] ALK NVP-TAE684 (SYN-1159) [761439-42-3] Tie-2 AMG-Tie2-1 (SYN-1008) [870223-96-4] EGFR Lapatinib (SYN-1052) [231277-92-2] TRK GNF-5837 (SYN-1183) [1033769-28-6] c-fms Ki20227 (SYN-1049) [623142-96-1] TrkA GW441756 (SYN-1044) [504433-23-2] c-met Ki20227 (SYN-1049) [623142-96-1] Regorafenib (SYN-1169) [835621-08-4] c-kit, PDGFR FGFR3 Masitinib (SYN-1053) [790299-79-5] -2 JNJ-38158471 (SYN-1133) [951151-97-6] -3 SAR131675 (SYN-1165) [1092539-44-0 ] 13

JAK-STAT Family Array SYN-2150 JAK1/3 Tofacitinib (SYN-1032) [477600-75-2] BI-D1870 (SYN-1020) [501437-28-1] Bayer-18 (SYN-1130) [1251752-12-1] JAK1/2 GPLG0634 (SYN-1158) [1206161-97-8] TYK2 GDC046 (SYN-1198) [1258292-64-6] LY2784544 (SYN-1196) [1229236-86-5] RO495 (SYN- 1128) [1258296-60-4] NVP-BSK805 (SYN-1136) [1092499-93-8] Pan JAK Baricitinib phosphate salt (SYN-1117) [1187595-84-1] XL019 (SYN-1191) [945750-13-0] /1 Momelotinib (SYN-1035) [1056634-68-4] AZ-960 (SYN-1015) [905586-69-8] 14

JAK-STAT Array (small) SYN-2151 Pan JAK Baricitinib phosphate salt (SYN-1117) [1187595-84-1] /1 JAK1/2 Momelotinib (SYN-1035) [1056634-68-4] BI-D1870 (SYN-1020) [501437-28-1] JAK1/3 Tofacitinib (SYN-1032) [477600-75-2] TYK2 NVP-BSK805 (SYN-1136) [1092499-93-8] AZ-960 (SYN-1015) [905586-69-8] Bayer-18 (SYN-1130) [1251752-12-1] GDC046 (SYN-1198) [1258292-64-6] 15

Custom Libraries SYNkinase s partnership with a state of the art robotics facility means we can manufacture custom arrays with a lead time as short as three days. Select from over 200 high purity kinase inhibitors to design the perfect array for your research. You pick the inhibitors, their positions and concentrations, then we ll take care of the rest. Just look for the Array Ready* compounds on pages X-Y. All SYNkinase library arrays are manufactured using REMP 96 well plates with individually foil sealed wells to minimize any chance of cross contamination during use. For more information on custom libraries, or to start building your own right away, visit us at SYNkinase.com Custom Dilutions Anything You Can Imagine Pixel Art 16

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