CHLORPYRIFOS 50 g/kg GR

Transcript

1 . 72C/ A Page 1 17 SAFETY DATA SHEET CHLORPYRIFOS 50 g/kg GR :. 1: / CHLORPYRIFOS 50 g/kg GR maleic anhydride CHEMINOVA A/S P.O. Box 9 Denmark sds@cheminova.dk (+30) (24 ; ) TMHMA 2: 2.1. CLP 1272/2008 DPD. 1999/45/EC 16 R-. - : 1 ( 317) : 1 (H400) 1 (H410) N;R50/53 WHO II:., Chlorpyrifos ( )..., chlorpyrifos,,.

2 Page / Chlorpyrifos50 g/kggr maleic anhydride (GHS07, GHS09)... H H EUH P P P P P P P302+P P : SP /45/EC...,,,. A :. (. ). N

3 Page 3 17 Chlorpyriphos R- R50/53... S- S60... S ,. /. maleic anhydride PBT vpvb. 3: / , R-. Chlorpyrifos... CAS... : 6% Phosphorothioic acid, O,O-diethyl O-(3,5,6-trichloro-2-pyridinyl) ester CAS IUPAC... O,O-Diethyl O-3,5,6-trichloro-2-pyridyl phosphorothioate ISO... Chlorpyrifos EC EU index no.... CLP DSD : 3 (H301) : 1 (H400) 1 (H410) T;R25 N;R50/53

4 Page 4 17 (% / ) CAS no. EC no. (EINECS no.) DSD CLP Quartz max (2-Butoxyethoxy)ethanol Reg. nr Xi;R36. 2 (H319) Maleic anhydride Reg. no Xn;R22 C;R34 R42/43. 4 (H302). 1B (H314). 1B (H334)... 1A (H317) 4: ,,. :.. :.,..,, ,... :,,,,,,,,,,,,,.

5 Page chlorpyriphos,,.., atropine sulphate.... Cholinesterase inhibition treatment Chlorpyrifos. ( ),.,. : ( 4.2), atropine sulphate,,, mg, , obidoxime chloride (Toxogonin) pralidoxime chloride (2-PAM),,, , 5: ,. 5.2.,,,,,,,,,,

6 Page , : 6.1.,.. ( 10 ): 1., 8 2., ,,,, , GHS (Annex 4, 6).,....,,,

7 Page , ,., 8....,., ,..,,,,...,,.,.

8 Page ( ).... 8: / 8.1. Year Chlorpyrifos ACGIH (USA) TLV 2014 TWA 0.1 mg/m 3,. ; BEI OSHA (USA) PEL EU, 2000/39/EC Germany, MAK ; BAT HSE (UK) WEL h TWA 0.2 mg/m 3 STEL 0.6 mg/m 3 ; 15- Crystalline ACGIH (USA) TLV 2014 TWA mg/m 3, silica (quartz) OSHA (USA) PEL 2014 TWA : 30 mg/m 3 % SiO : 250 mppcf 10 mg/m 3 EU, 2000/39/EC Germany, MAK HSE (UK) WEL 2009 % SiO % SiO hr TWA: 0.1 mg/m 3,,.... Chlorpyrifos DNEL,... PNEC,....,,, mg/kg../ ng/l ,.,.,.,,.

9 Page ,..,.....,, PE. PE. 9: ( )...,... ph... / ( / )... /... Chlorpyrifos : 2.7 x 10-3 Pa 25 C 1.8 x 10-2 Pa 35 C : g/cm 3 ( )... Chlorpyrifos : toluene ethyl acetate 774 g/l hexane 20 C 290 g/l methanol 20 C 0.94 mg/l 25 C n- octanol/... Chlorpyrifos : log K ow = (, 10.2.)

10 Page : , Chlorpyrifos 160 C, , ( ) : * =,... ( ) - LD 50, oral, rat: > 2000 mg/kg. *.,, : - LD 50, dermal, rat: > 4000 mg/kg - LC 50, inhalation, rat: > 5.0 mg/l/4 h /... /..... ( ; method US EPA 81-5). * ( ; method US EPA 81-4). * ( ; method US EPA 81-6).

11 Page ,.*,. :,,,,,,,,,,,,, Chlorpyrifos,... Chlorpyriphos : ( ) - LD 50, oral, rat: mg/kg (method FIFRA 81.01) - LD 50, dermal, rat: > 2000 mg/kg (method FIFRA 81.02) * - LC 50, inhalation, rat: not available /... (method FIFRA 81.05). * /.. (method FIFRA 81.04). *... (method FIFRA 81.06). *... Chlorpyrifos (23 ). *... Chlorpyrifosl. (5 ). *... chlorpyrifos (3 ). chlorpyrifos ( ) 15 mg/kg/ ( ) (2 ). * STOT... STOT chlorpyrifos 50 mg/kg.. * : ( ). LOAEL: 1 mg/kg../ 90.,. (LOEL). * Quartz (crystalline silica).... *... crystalline silica.

12 Page STOT... STOT-. crystalline silica mg/m 3.. *,. * 2-(2-Butoxy-ethoxy)ethanol, (2-butoxyethoxy)acetic acid *. : ( ) - LD 50, oral, rat ( ): 5080 mg/kg - LD 50, dermal, rabbit: 2764 mg/kg ( OECD 402) - LC 50, inhalation, rat:, 2 (29 ppm 0.25 mg/l). /... / STOT... STOT-... ( ). * ( ). ( OECD 409* Chinese hamster. ( OECD ). *.. ( ). ( OECD 414). *. * : ( ) LOAEL: mg/kg../ 90-day. ( OECD 408). *. * Maleic anhydride,, maleic anhydride

13 Page : ( ) - LD50, oral, rat: 1090 mg/kg (method OECD 401) - LD50, dermal, rabbit: 2620 mg/kg (method OECD 402) * - LC50, inhalation, rat: / / STOT... STOT-... ( OECD 404).. Maleic anhydride. * Maleic anhydride OECD 451. * ( OECD 416). (OECD 414). *.. * NOEL,, 40 mg/kg../ 90 ( OECD 408) NOAEC,, 3.3 mg/m3 (0.8 ppm) 6 ( OECD 413) /. *. * 12: , - chlorpyrifos : - Rainbow trout (Salmo gairdneri) h-lc 50 : 3 µg/l 21-day NOEC: 1.8 µg/l - Daphnids (Daphnia magna) h-ec 50 : 1.7 µg/l

14 Page day NOEC: µg/l - Green algae (Scenedesmus subspicatus) h IC 50 : 0.48 mg/l - Bobwhite quail (Colinus virginianus)... LD 50 : 13.3 mg/kg Mallard duck (Anas platyrhynchos)... LD 50 : 75.6 mg/kg - Honey bees (Apis mellifera)... LD 50, : 0.36 µg/ LD 50, : µg/ Chlorpyrifos mg/l.. chlorpyrifos ph. ph Chlorpyrifos ( 2-3 ). chlorpyrifos 1375 (rainbow trout) Chlorpyrifos PBT vpvb PBT vpvb : (2008/98/EC),.,,,. Chlorpyrifos ph > 8.0.

15 Page , ( ) ,,., 14: ADR/RID/IMDG/IATA/ICAO UN number UN...,, n.o.s. (chlorpyrifos) III II MARPOL 73/78 IBC. 15: /, Seveso I 2,. 96/82/EC: : ACGIH American Conference of Governmental Industrial Hygienists BAT Biologische Arbeitsstoff-Toleranzwert BEI Biological Exposure Index CAS Chemical Abstracts Service CLP Classification, Labelling and Packaging; refers to EU

16 Page regulation 1272/2008 as amended Dir. Directive DNEL Derived No Effect Level DPD Dangerous Preparation Directive; refers to Dir. 1999/45/EC as amended DSD Dangerous Substance Directive; refers to Dir. 67/548/EEC as amended EC European Community EC 50 50% Effect Concentration EINECS European Inventory of Existing Commercial Chemical Substances FIFRA Federal Insecticide, Fungicide and Rodenticide Act GHS Globally Harmonized classification and labelling System of chemicals, Fourth revised edition 2011 GR Granule HSE Health & Safety Executive, UK IBC International Bulk Chemical code IC 50 50% Inhibition Concentration ISO International Organisation for Standardisation IUPAC International Union of Pure and Applied Chemistry LC 50 50% Lethal Concentration LD 50 50% Lethal Dose LOAEL Lowest Observed Adverse Effect Level LOEL Lowest Observed Effect Level MAK Maximale Arbeitspaltz-Konzentration MARPOL Set of rules from the International Maritime Organisation (IMO) for prevention of sea pollution Mppcf Million particles per cubic foot NOEC No Observed Effect Concentration NOEL No Observed Effect Level N.o.s. Not otherwise specified OSHA Occupational Safety and Health Administration PBT Persistent, Bioaccumulative, Toxic PE Polyethylene PEL Personal Exposure Limit PNEC Predicted No Effect Concentration Reg. Regulation R-phrase Risk phrase S-phrase Safety phrase STEL Short-Term Exposure Limit STOT Specific Target Organ Toxicity TLV Threshold Limit Value TWA Time Weighed Average US EPA Environmental Protection Agency USA vpvb very Persistent, very Bioaccumulative WEL Workplace Exposure Limit WHO World Health Organisation CLP H301.

17 Page H H H400 H EUH401 R-... R22 R25. R34 R36. R42/43 R50/53,....., Cheminova A/S.. : Cheminova A/S Safety, Health, Environment & Quality Department / GHB