New Cytotoxic Constituents from the Red Sea Soft Coral Nephthea sp.
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- Θεοφάνια Θεοδωρίδης
- 5 χρόνια πριν
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1 SUPPLEMENTARY MATERIAL New Cytotoxic Constituents from the Red Sea Soft Coral Nephthea sp. Mohamed-Elamir F. Hegazy a,*, Amira M. Gamal-Eldeen b, Tarik A. Mohamed a, Montaser A. Alhammady c, Abuzeid A. Hassanien d, Mohamed A. Shreadah e, Ibrahim I. Abdelgawad d, Eman M. Elkady e, and Paul W. Paré f a Phytochemistry Department and Center of Excellence for Advanced Sciences, National Research Centre, 33 El Bohouth st. (former El Tahrir st.) Dokki, Giza, Egypt, P. O ; b Cancer Biology Lab, Center of Excellence for Advanced Sciences, and Biochemistry Department, National Research Centre, 33 El Bohouth st. (former El Tahrir st.) Dokki, Giza, Egypt, P. O ; c National Institute of Oceanography and Fisheries, Red Sea Branch, Hurghada 84511, Egypt; d Department of Chemistry, Faculty of Science, Suez University, Egypt; e National Institute of Oceanography & Fisheries, Alexandria, Egypt; f Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, TX USA. Abstract: Nephthea species are rich in sesquiterpenoids and steroids. The methylene chloride/methanol (1:1) extract of Nephthea sp. resulted in the isolation of a new steroid (1), as well as previously reported metabolites (2-9). Structures were elucidated by employing extensive NMR and HR-ESI-MS analyses. The total extract, fractions and isolated compounds showed differential cytotoxicity against breast cancer cells MCF-7 cell lines. Keywords: Nephtheasp., Terpenes, Cytotoxicity, Breast cancer cells MCF-7 * Corresponding author. Tel.: ; Fax: ; elamir77@live.com.
2 List of Supplemental Material o Table S1. 1 H (600 MHz) and 13 C (150 MHz) NMR Data for1and2.(page 3). o Table S2. o Full assignment S1. Assignmentof known compounds (2-9) ( 1 H (600 MHz) and 13 C (150 MHz) NMR](page 4-6). o Figure S1. Selected 1 H 1 H COSY ( ) and HMBC ( ) correlations of 1, 2(page 7). o Figure S2. 1 HNMR Spectrum of Compound 1 (page 8). o Figure S3. 13 C NMR Spectrum of Compound 1 (page 9). o Figure S4. 1 HNMR Spectrum of Compound 2 (page 10). o Figure S5. 13 C NMR Spectrum of Compound 2 (page 11). o Figure S6. 1 H-NMR Spectrum of Compound 3 (page 12). o Figure S7. 13 C NMR Spectrum of Compound 3 (page 13). o Figure S8. 1 H-NMR Spectrum of Compound 4 (page 14). o Figure S9. 13 C NMR Spectrum of Compound 4 (page 15). o Figure S10. 1 H-NMR Spectrum of Compound 5 (page 16). o Figure S C NMR Spectrum of Compound 5 (page 17). o Figure S12. 1 H-NMR Spectrum of Compound 6 (page 18). o Figure S C NMR Spectrum of Compound 6 (page 19). o Figure S14. 1 H-NMR Spectrum of Compound 7 (page 20). o Figure S C NMR Spectrum of Compound 7 (page 21). o Figure S16. X-ray spectrum of of Compound 7 (page 22). o Figure S17. 1 H-NMR Spectrum of Compound 8 (page 23). o Figure S C NMR Spectrum of Compound 8 (page 24). o Figure S19. 1 H-NMR Spectrum of Compound 9 (page 25). o Figure S C NMR Spectrum of Compound 9 (page 26).
3 Table S1. 1 H (600 MHz) and 13 C (150 MHz) NMR Data for 1 and C H m, 1.70 m m, 1.75 m m, 1.67 m m, 1.80 m m m m m m m m m, 1.60 m m, 1.80 m m m m m m, 1.65 m m, 180 m m m m m, 1.54 m m, 1.58 m m, m m, 1.90 m m m d (11.7), s d (11.7) s s m m d (6.2) d (6.5) dd (15.1, 8.3) m dd (15.1, 8.3) m m m d (6.2) d (6.5) d (6.8) d (6.5) d (6.8) s, 5.98 s d (6.2) d (6.5) CH acetate C=O acetate C 1 H
4 Table S2: Calculated IC 50 Values of Nephthea extract, fractions and pure compounds with human brest cancer cell lines MCF-7 Sample IC 50 * (µg/ml) N (0.773) N (0.997) N (0.962) N3-4A 146.9(0.772) N (0.982) N (0.814) N (0.898) N (0.896) N (0.986) N (0.883) N (0.823) N (0.996) N (0.925) N (0. 895) N (0.762) N (0.941) *IC 50 values shown with their corresponding goodness of the regression fit (r 2 parentheses. value) given between
5 Full assignment S1. Assignmentof known compounds (2-9) ( 1 H (600 MHz) and 13 C (150 MHz) NMR] Methyl-cholesta-5,24(28)-diene-3β,7β,19-triol (3): Amorphous powder, 1 H-NMR [CD 3 OD] δ H 5.54 (1H, s, H-6), 4.69, 4.63(1H each, br s, H 2-28), 3.83, 3.57 (1H each, d, J = 11.6 Hz, H 2-19), 3.61 (1H, d, J = 7.6 Hz, H-7), 3.55 (1H, m, H-3), 102, 1.01 (6H, d, J = 7.0 Hz, Me-26, 27), 0.93 (3H, d, J= 4.1, Me-21), 0.74 (3H, s, Me-18),. 13 C- NMR [CD 3 OD] δ C (C-24), (C-5), (CH, C-6), (CH 2, C-28), 72.0 (CH, C- 7), 70.7 (CH, C-3), 62.2 (CH 2, C-19), 57.2 (C-14), 55.6 (CH, C-17), 49.0 (CH, C-9), 43.0 (C-13), 41.5 (CH, C-8),41.1 (C-10), 41.1 (CH 2, C-4), 40.1 (CH 2, C-12), 35.7 (CH 2, C-22), 34.8 (CH, C- 20), 33.6 (CH, C-25), 33.1 (CH 2, C-1), 31.3 (CH, C-2), 30.9 (CH 2, C-23), 28.3 (CH 2, C-16) 25.9 (CH 2, C-15), 21.6 (CH 2, C-11), 21.2 (CH 3, C-27), 21.0 (CH 3, C-26), 18.1 (CH 3, C-21), 11.4 (CH 3, C-18) (Bortolotto et al. 1976) β-Acetoxy-24-methyl-cholesta-5,24(28)-diene-3β,19-diol (4): Amorphous powder, 1 H NMR (CD 3 OD): δ H 5.39 (1H, br s, H-6), 4.91 (1H, d, J = 8.2 Hz, H-7), 4.70, 4.63 (1H each, br s, H 2-28), 3.83, 3.58 (1H each, d, J = 11.6 Hz, H 2-19), 3.45 (1H, m, H-3), 2.28, 2.17 (1H each, m, H-4), 1.96 (3H, s, OAc), 1.00 (3H, d, J = 6.5 Hz, CH 3-26), 1.00 (3H, d, J = 6.5 Hz, CH 3-27), 0.99(3H, d, J = 4.14 Hz, CH 3-21), 0.75 (3H, s, CH 3-18). 13 C NMR(CD 3 OD): δ C (C=O acetat), (C-24), (C-5), (CH, C-6), (CH 2, C-28), 75.5 (CH, C-7), 70.6 (CH, C-3), 62.0 (CH 2, C-19), 56.7 (CH, C-14), 55.5 (CH, C-17), 48.8 (CH, C-9), 43.0 (C-13), 41.4 ( C-10), 41.2 (CH 2, C-4), 40.0 (CH 2, C-12), 37.6 (CH, C-8), 35.6 (CH 2, C-22), 34.7 (CH, C-20), 33.6 (CH, C-25), 33.1 (CH 2, C-1), 31.2 (CH 2, C-2), 30.8 (CH 2, C-23), 28.2 (CH 2, C-16), 24.9 (CH 2, C-15), 21.2 (CH 2, C-11), 21.1 (CH 3, C-27), 21.0 (CH 3, C-26), 20.3 (CH 3, CH3-acetat), 18.0 (CH 3, C-21), 11.2 (CH 3, C-18) (Faheem et al. 2012) Methyl-cholesta-5,24(28)-diene-3β-ol (5): Amorphous powder, 1 H NMR (CDCl 3 ) δ H 5.33 (1H, m, H-6), 4.69, 4.63 (1H each, s, H 2-28),
6 3.49 (1H, m, H-3), 1.01(3H, d, J = 3.4 Hz, H-27), 1.00 (3H, br s, H-19), 1.00 (3H, d, J= 3.4 Hz, H-26), 0.93 (3H, d, J= 6.9, H-21), 0.66 (3H, br s, H-18). 13 C NMR (CDCl 3 ) data: δ C (C- 24), (C-5), (CH, C-6), (CH 2, C-28), 71.8 (CH, C-3), 56.8 (CH, C-14), 56.1 (CH, C-17), 50.2 (CH, C-9), 42.4 (C-13), 42.4 (CH 2, C-4), 39.8 (CH 2, C-12), 37.3 (CH 2, C-1), 36.6 (C-10), 35.8 (CH 2, C-22), 34.8 (CH, C-20), 33.9 (CH, C-25), 32.0 (CH, C-8), 31.9 (CH 2, C-7), 31.7 (CH 2, C-2), 31.0 (CH 2, C-23), 28.3 (CH 2, C-16), 24.3 (CH 2, C-15), 22.0 (CH 3, C-26), 21.9 (CH 3, C-27), 21.1 (CH 2, C-11), 19.4 (CH 3, C-19), 18.8 (CH 3, C-21), 11.9 (CH 3, C-18) (Ahmed et al. 2006) α,24R-Dimethyl-5α-cholest-22-en-3β-ol (6): Amorphous powder, 1 H NMR (CDCl 3 ), δ H 5.19 ( 1H, dd, J = 15.1, 7.6, H-23), 5.15 ( 1H, dd, J = 15.1, 7.6, H-22), 3.06 (1H, m, H-3), 0.98 (3H, d, J= 3.4 Hz, H-26), 0.93 (3H, d, J= 6.2, H-21), 0.91(3H, d, J = 7.6 Hz, H-27), 0.89 (3H, d, J = 6.8, H-28), 0.81 (3H, br s, H-19), 0.64 (3H, br s, H-18). 13 C NMR (CDCl 3 ) data: δ C (CH, C-22), (CH, C-23), 76.7 (CH, C-3), 59.0 (CH, C-9), 57.0 (CH, C-17), 56.7 (CH, C-14), 51.0 (CH, C-5), 42.8 (CH, C-20), 42.4 (C-13), 40.0 (CH, C-4), 39.3 (CH 2, C-12), 36.1 (C-10), 36.0 (CH 2, C-1), 34.9 (CH, C-24), 33.1 (CH, C- 25), 32.3 (CH 2, C-7), 31.1 (CH, C-8), 31.1 (CH, C-2), 28.6 (CH 2, C-16), 28.6 (CH 2, C-11), 24.2 (CH 2, C-15), 21.2 (CH 2, C-6), 21.2 (CH 3, C-26), 20.9 (CH 3, C-27), 19.7 (CH 3, C-19), 18.7 (CH 3, C-21), 17.6 (CH 3, C-28), 15.1 (CH 3, C-29), 12.1 (CH 3, C-18) (Kokke et al. 1981) Alismoxide (7): Colorless crystals, 1 H NMR (CDCl 3 ) δ H 5.46 (1H, br s, H-6), 1.23, 1.17 (3H each, s, H-14,15), 0.97, 0.96 (3H each, d, J = 5.5 Hz, H-12, 13). 13 C NMR (CDCl 3 ): δ C 149.6(C-7), (CH, C- 6), 80.3 (C-4), 75.3 (C-10), 50.8 (CH, C-5), 50.4 (CH, C-1), 42.7 (CH 2, C-3), 40.5 (CH 2, C-9), 37.5 (CH, C-11), 25.1 (CH 2, C-8), 22.6 (CH 3, 21.6 (CH 2, C-2), C-15), 21.5 (CH 3, C-13), 21.4 (CH 3, C-12), 21.2 (CH 3, C-14) (Jin et al., 2012) O-Methyl alismoxide(8): Oil, 1 H NMR (200 MHz, CDCl 3 ) δ H 5.45 (1H, br s, H-6), 3.16 (OCH 3 ); 1.18, 1.17 (3H each, s, Me-14, 15), 0.97, 0.96 (3H each, d, J = 4.08 Hz, Me-12, 13). 13 C NMR (CDCl3): δ C (C-7), (CH, C-6), 80.3(C-10), 79.2 (C-4), 50.2 (CH, C-5), 48.8 (OCH3), 48.1 (CH, C-1), 40.6
7 (CH 2, C-9), 37.3 (CH 2, C-3), 35.6 (CH, C-11), 24.6 (CH 2, C-2), 22.5 (CH 3, C-15), 21.8 (CH 3, C- 13), 21.7 (CH 2, C-8), 21.3 (CH 3, C-12), 18.0 (CH 3, C-14). (Jin et al. 2012) Erythro-N-dodecanoyl-docosasphinga-(4E,8E)-dienine (9): 1 H NMR (600 MHz, CDCl3): δ H 5.69 (1H, dd, J = 15.6, 7.6 Hz; H-5), 5.66 (1H, dd, J = 15.6, 7.6 Hz; H-8), 5.46 (1H, dd, J = 15.6,7.6 Hz; H-9), 5.44 (1H, dt, J = 15.6, 7.6 Hz; H-4), 5.40 (1H, br s, NH), 4.02 (1H, t, J = 7.6 Hz; H-3), 3.82 (1H, m, H-2), 3.65 (2H, dd, J = 11.7, 6.9 Hz; 2H-1), 2.18 (2H, t, J = 10.3 Hz; H-2`) 2.05 (2H, m; 2H-6), 2.05 (2H, m; 2H-7), 1.95 (2H, m, 2H-10), 1.57 (4H, m; 2H-3 and 2H-of other position), 1.26 (-(CH 2 ) n ), 0.87 (6H, t, Jvic = 6.84 Hz; Me-22 and Me-16 ). 13 C NMR (100 MHz, CDCl 3 ): δ C (C-1 ), (CH, C-5), (CH, C-8), (CH, C-4), (CH, C-9), 72.3 (CH, C-3), 60.9 (CH 2, C-1), 55.4 (CH, C-2), 36.0 (CH 2, C-2 ), 32.3 (CH 2, C-19), 32.2 (CH 2, C-14), 32.0 (CH 2, C-10), (all CH 2 ), 22.4 (CH 2, C- 20), 22.3 (CH 2, C-15), 13.0 (2CH 3, C-16, C-21) (Bortolotto et al. 1976).
8 Figure S1.Selected 1 H- 1 H COSY ( ) and HMBC ( ) correlations of 1, 2. b HO c d O OH OH a HO HO 1 2
9 Figure S2. 1 H-NMR Spectrum of Compound 1.
10 Figure S3. 13 C NMR Spectrum of Compound 1.
11 Figure S4. 1 H-NMR Spectrum of Compound 2.
12 Figure S5. 13 C NMR Spectrum of Compound 2.
13 Figure S6. 1 H-NMR Spectrum of Compound 3.
14 Figure S7. 13 C NMR Spectrum of Compound 3.
15 Figure S8. 1 H-NMR Spectrum of Compound 4.
16 Figure S9. 13 C NMR Spectrum of Compound 4.
17 Figure S10. 1 H-NMR Spectrum of Compound 5.
18 Figure S C NMR Spectrum of Compound 5.
19 Figure S12. 1 H-NMR Spectrum of Compound 6.
20 Figure S C NMR Spectrum of Compound 6.
21 Figure S14. 1 H-NMR Spectrum of Compound 7.
22
23 Figure S C NMR Spectrum of Compound 7.
24 Figure S16. X-ray spectrum of of Compound 7.
25 Figure S17. 1 H-NMR Spectrum of Compound 8.
26 Figure S C NMR Spectrum of Compound 8.
27 Figure S19. 1 H-NMR Spectrum of Compound 9.
28 Figure S C NMR Spectrum of Compound 9.
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Supporting Information. Copyright Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, 2006
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Supporting Information. Copyright Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, 2006
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