1 acid [J ]1 Ch in J M ar D rug s ( (1) :
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1 Ch inese T raditional and H erbal D rugs acid [J ]1 Ch in J M ar D rug s ( ) Table 1 R &D status of mar inespongeder (1) : ived bioactive products [ 3 ] Fan X Yan X J. T he front2line of m arine drugs research abroad and developm ental strategy fo r China [J ]1 Ch in J M ar D rug s ( ) (2) : [ 4 ] T ian C L D eng S Z W u H M. T he research in chem ical m anoalide L uf f ariella varia2 components of m arine sponges Iotrochota rid ley [J ]1 bilis Guang z hou Chem ( ) 1998 (1) : contignatero l P etrosia contig nata [ 5 ] Casapullo A A zella K P razeilla L et al. M akaluvam ine P H ali2 a new cyto toxic pyrro lo im inoquinone from Zy z zy a cf. f u lig i2 ( isohomohalich2 chond ria okad ai nosa [J ]1 J N at P rod R ep (10) : ondrin B) [ 6 ] V o lter K E B laik C J F rank i D et al. T he so lution struc2 spongistatinsgalto2 H y rtios altum tures of calyculin A and depho sphonocalyculin A by NM R hyrtins [J ]1 B ioorg M ed Chem L ett (5) : Dy si2 [ 7 ] Steube K G Jennaka B K Stanlley N et al. A new caly2 (avaro l) d ea avara culin derivative from the sponge T heonella sw inhoei is novel D is2 and po tent inhibito r of tumo r cell p ro liferation [J ]1 A nti2 (discodermo lide) coderm ia d isso2 cancer R es (1A ) : lu te I (hali2 [ 8 ] U ckun F M M ao C Jan S T et al. Spong istatins as tubu2 lin targeting agents [J ]1 Curr P harm D es 2001 (7) : chondrin B) agelasp in A g elas m au ritiana [ 9 ] L uiz C D Paulo R R M. Synthesis of C132C22 fragm ent of II A ra2a (V idara2 C ry 2 bine the m arine sponge po lyketide callystatin A [J ]1 R T etrahed ron ) p teth ia cryp ta L ett (2) : A ra2c (Cytara2 bine [ 10 ] M urakam i N Sugimo to M M o rita M et al. Synthesis and ) evaluation of 42deacetoxyago stero l A as a M DR 2modulato r References: [J ]1 B ioorg M ed Chem L ett (22) : [ 1 ] Zhang X Y Zhao Q Y Xue S et al. B ioactive compounds from m arine sponges and cell culture of m arine sponges [J ]1 [ 11 ] Fusetani N. D rug s f rom the S ea [M ]1 Basel: Karger P ress Ch in J B iotechnol ( ) (1) : [ 12 ] Ronald O Johannes T Rene H W. Cultivation of m arine [ 2 ] H u Z M a R T Yu L J. T he research p rogress in okadaic sponges [J ]1 M ar B iotechnol : Ξ (11 ; ) : 20 ; ; : ; ; : R : A : (2003) Advance in stud ies on chem ica l com ponen ts pharmacolog ica l effect and clin ica l applica tion of L eonu rus j ap on icus RUAN J in2lan 1 2 DU Jun2rong 1 T ZAN G A lexander HC 1 Q IAN Zhong2m ing 1 (1. D evelopm ental Center of TCM based P roducts Hong Kong Po lytechnic U niversity Kow loon Ch ina; 2. Co llege of Pharm acy TonjiM edical Center H uazhong U niversity of Science and T echno logy W uhan Ch ina) Key words: L eonu rus jap on icus Hou tṫ ; chem ical com ponen ts; pharm aco logical effect : : ITRS (G121XX 93A ) : (1952 ) T el: (027) Fax: (027) E2m ail: jinlan5952@ho tm ail. com
![[ 4 ] T ian C L D eng S Z W u H M. T he research in chem ical m anoalide L uf f ariella varia2 components of m arine sponges Iotrochota rid ley [J ]1 bilis Guang z hou Chem ( ) 1998 (1) : 36238.](/docs-images/41/22711086/images/page_1.jpg "contignatero l P etrosia contig nata [ 5 ] Casapullo A A zella K P razeilla L et al. M akaluvam ine P H ali2 a new cyto toxic pyrro lo im inoquinone from Zy z zy a cf.")
2 16 Ch inese T raditional and H erbal D rugs L eonu rus jap onicus Houtṫ cm cm 012 ΛggmL ; ; Α ip L. sibiricus L. L. artem isia (L ou ṙ ) S. Y. H u vaṙ albif lorus (M igo) S. Y. H u L. m acranthus M axim. L. p seu2 d om acrathus K itag. L. g laucescens Bunge [1 4 ] : 0111% 2109% ( leonurine) 0102% 0112% ( stachy2 drine) 0159% 1172% (leonuridine) (leonurinine) 212 : (ap rgennin) (quercetin) (kaempfero l) 213 : (SOD ) (GSH 2Px) ( p reh ispano lone 9Α213R diepoxylabden2142en272one) ( h ispano lone) (p releo2heterin) 214 : 3715% Ca % 3918% ; (fum aric acid) 215 : 0105% 011% : Β2 2Y ( Β2ocim ene2y ) (linaloo l) copaene Β2 (Β2elem ene) Β2 (Β2 bourboene) (cis2caryophyllene) ( trans2caryophyllene) Β2 (Β2cubebene) (hum ulene) allo2arom adendrene Χ2 v2 (v2ca2 diene) 2 (caryphylene oxide) iv 2 h ( ) hexahydro2farnesylacetone (m ethyl palm itate) (palm itic acid) (phyto l) 216 : Zn CuM n Fe N i Pb A s Se Ge [ ] : H 1 Chan % 152 PGF 2Α [ ] : (M DA ) A T P 1 h 1 h R b FeM n Zn R b A l B Po 18 ( m ggml ) Ca M g ( m ggml )
3 Ch inese T raditional and H erbal D rugs KC l(10 mo lgl ) Pang (phenyleph rine) 313 [10 ] : [ T B ] : [ 3 H ]2thym i2 dine T B concanavalin A (Con A ) T AD P Con A 5 8 cam P cgm P PGl2 Con A cam P B PGl2 4 [ ] : 106 [ ] : 35 (P < 0105) 4 ( ) 15 d 9313% 32% (P < 0105) 3 (P < 0105); [ ] : m ggkg 12 h (42 ) (30 ) 3 (u2pa ) (t2pa ) 20 (P < ) (P < 0101) [ ] : (A TN ) (P < 0101) (A FR ) im A TN (P < ) A TN % LA TN 30 im (GM ) A FR GM 52 A FR (P < )
![0105) 4 ( ) 15 d 9313% 32% (P < 0105) 3 (P < 0105); [16 17 412 ] : 16 48 m ggkg 12 h (42 ) (30 ) 3 (u2pa ) (t2pa ) 20 (P < 0105 0101) (P](/docs-images/41/22711086/images/page_3.jpg "< 0101) [12 315 ] : (A TN ) (P < 0101) (A FR ) im A TN (P < 0101 0105) A TN 40 25 10 5 88% LA TN 30 im (GM ) A FR GM 52 A FR (P < 0105")
4 18 Ch inese T raditional and H erbal D rugs [ ] : 417 ABO : 500 g g 180 g 12 g ABO % 2613% (PSS) 55% 0 45% 100% 7 PSS (P < 0105) (P < 0101) PSS [ ] : ( 20 g 10 g 15 g) % 62 (38 ) References: [ 1 ] L uo S R M ai L. A nalysis on alkalo ids constituents of (24 ) L eonu rus jap onicus Houtṫ [J ]1 Ch in J P harm A nal ( 9417% ) (1) : ( [ 2 ] Zheng H Z Dong Z H. She J. M od ern S tudy and A pp lication ) 60 95% of T rad itional Ch inese M ed icine ( ) [M ]1 Beijing: Xueyuan P ress [ 3 ] M iao M S L i Z G. M od ern P ractical Q uality Control T ech2 nology of Ch inese T rad itional M ed icine ( 415 : ( 100 g 50 ) [M ]1 Beijing: Peop le s M edical Publishing House g 10 g 10 g 10 g) 20 [ 4 ] W ang X G Zhu Z Y. Studies on the essential constituents of % 38 th ree p lants from L eonu rus spp. [J ]1 J Ch in M ed M ater ( 2 ) (11) : [ 5 ] Yang M H W ang W Q J in Z H et al. Study on effects (20 ) (18 ) fresh Yim ucao contraction uterus [J ]1 P rim ary J Chin M ater ( ) M ed ( ) (3) : % 4414% [ 6 ] M a Y M Yang D Y T ian Z F et al. Effect of mo therwo rt herb on m yoelectric activity of uterus in rats [J ]1 China J (BUN ) (SC r) Ch in M ater M ed ( ) (6) : (Ccr) 22M G HCT [ 7 ] Chan W C W ong Y C Kong Y C et al. C linical observation (H b) (P < 0101) 60 on the utero tonic effect of l2m u T s ao (L eonu rus artem isia) ( [J ]1 A m J Ch in M ed (124) : [ 8 ] Yin J W ang H L. Effect on blood rheo logy and th rom bo sis ) in rats m yocardial ischem ia by mo therwo rt herb [J ]1 Ch in J 30 T h rom bosis H em ostasis ( ) (1) : (P < [ 9 ] Pang S T such iya S Ho rie S et al. Enhancem ent of phenylephrine2induced contraction in the iso lated rat ao rta 0101) ( w ith endo thelium by H 2O 2extract from an o riental m edicinal ) 36 p lant L eonu ri herba [J ]1 J p n J P harm acol (2) : 8819% [ 10 ] Zhang C F Zhu X M Gong B et al. Study on m echanism of ( anti2p latelet aggregation by mo therwo rt herb [J ]1 Chin J In2 ) % teg rated T rad it W est M ed ( ) 1986 (1) : [ 11 ] L i J M Cui H Zhang Y J. O bserve of mo therwo rt herb in2 jection and stachydrine to influence exsom atize blood speci2 416 : ( 400 g) m en visco sity [J ]1 P ract J Integ rated T rad it W est M ed ( 20 g ) 1992 (7) : [ ] X ia X H Sh i J C Xue Y F et al. Experim ental study of mo therwo rt on p rophylaxsis and treatm ent of acute renal fail2 g ; 120 g 2 h ure induced by gentam ycin in rats [J ]1 Ch in J P athop hy siol ml 15 m in 1 25 ( ) (2) :
![A nalysis on alkalo ids constituents of (24 ) L eonu rus jap onicus Houtṫ [J ]1 Ch in J P harm A nal ( 9417% ) 1986 6 (1) : 47248. ( [ 2 ] Zheng H Z Dong Z H. She J.](/docs-images/41/22711086/images/page_4.jpg "M od ern S tudy and A pp lication ) 60 95% of T rad itional Ch inese M ed icine ( ) [M ]1 Beijing: Xueyuan P ress 1997. [ 3 ] M iao M S L i Z G.")
5 Ch inese T raditional and H erbal D rugs [ 13 ] Xu H M L i Z M H an B M et al. P ro liferation of lympho2 on co ronary heart disease [J ]1 J S hantou U niv M ed Coll ( cytes T and B by p rehispano lone LC25504 of L eonorus ) (1) : hereterop hy llus Sw eet [J ]1 A cta P harm S in ( ) [ 17 ] L i Q Y Zhuo H S. M o therwo rt herb injection treated 40 cas (11) : es frequent ventricular p rem ature beats of co ronary heart dis2 [ 14 ] Zhou Y M. C linical observe on bleeding after drug2abo rtion ease [J ]1 Guang d ong M ed J ( ) (4) : 3502 treated by mo therwo rt herb [J ]1 F uj ian J T rad it Ch in M ed ( ) (4) : [ 18 ] W u G Q Kang C Q W ei Z F. C linical observation on treat2 [ 15 ] W ang R H u Y Q. Yim ucao D rop P reparation and Xue2 ed hypervisco sity of blood by mo therwo rt herb [J ]1 H ebei fuzhuyu O ral So lution fo r reduction of vagina bleeding caused M ed J ( ) 1991 (1) : by m edicine abo rting [J ]1 H eilongj iang M ed P harm ( [ 19 ] Yin T Zhang H T M a S P et al. D ysm eno rrhea 60 cases ) (2) : treated by Zhuyuxueshu D ecoction [J ]1 S haanx i J T rad it [ 16 ] Yan J Z Chen S R Curative effects of L eonu ru heterop hy llus Ch in M ed ( ) (12) : Ξ ( ) : : ; ; : R : A : (2003) Advances in stud ies on pharmacology of plan ts from D end robium Sw. L IN P ing B I Zh i2m ing XU Hong W AN G Zheng2tao XU L uo2shan (D epartm ent of Pharm acogno sy Ch ina Pharm aceutical U niversity N anjing Ch ina) Key words: D end robium Sw. ; pharm aco logical activity; clin ical app lication [1 ] D end robium lod d ig esii Ro lfe D. f im briatum Hook. D. ch ry santhum L indl. D. of f icinale K im ura et M igo (D. cand id um W all. ex L indl. ) D. nobile L indl. (D end robium Sw. ) (O rch idaceae) : L 1210 [2 P388 ] (A 549) (SK2OV 23) (HL 260) 4 72dihy2 droxy222m ethoxy29 102dihydroxyphenanth rene denbi2 Ξ : : ( ) 3 T el: (025)
![hereterop hy llus Sw eet [J ]1 A cta P harm S in ( ) [ 17 ] L i Q Y Zhuo H S. M o therwo rt herb injection treated 40 cas2 1992 (11) : 8122816.](/docs-images/41/22711086/images/page_5.jpg "es frequent ventricular p rem ature beats of co ronary heart dis2 [ 14 ] Zhou Y M.")
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