1. ΒΙΟΓΡΑΦΙΚΟ ΣΗΜΕΙΩΜΑ

1. ΒΙΟΓΡΑΦΙΚΟ ΣΗΜΕΙΩΜΑ Ονοματεπώνυμο ΒΙΟΛΕΤΤΑ ΚΩΝΣΤΑΝΤΙΝΟΥ-ΚΟΚΟΤΟΥ Ημερομηνία γέννησης 7-7-1955 Τόπος γέννησης Αθήνα-Ελλάδα Σπουδές α) Πτυχίο Χημείας Πανεπιστήμιο Αθηνών, Απρίλιος 1979. Βαθμός Λίαν καλώς (8.13) β) ιδακτορικό ίπλωμα, Γενικό Τμήμα, Γεωργικό Πανεπιστημίο Αθηνών, Ιανουάριος 1990. Βαθμός Αριστα (10) Μεταδιδακτορικές σπουδές και έρευνα σε ερευνητικά κέντρα του εξωτερικού Ξένες Γλώσσες Θέση και διεύθυνση εργασίας α) Τμήμα Φαρμακευτικής και Βιολογικής Χημείας του Πανεπιστημίου του Λονδίνου. Εκπαίδευση στις σύγχρονες μεθόδους φαματοσκοπίας ΝΜR και καθαρισμού με ΗΡLC οργανικών ενώσεων (Ιούλιος - Σεπτέμβριος 1990, Νοέμβριος- εκέμβριος 1990). β) School of Pharmacy, University of London (1991, 1993, 1994, 1995) γ) Τμήμα Χημείας και Βιοχημείας, University of California, San Diego (2000, 2003) δ) Τμήμα Βιολογίας, Norwegian University of Science and Technology, 2009. Αγγλικά, Γαλλικά Ιανουάριος 2005- σήμερα, Καθηγήτρια Οργανικής Χημείας, Εργαστήριο Χημείας, Τμήμα Γενικό, ΓΕΩΠΟΝΙΚΟ ΠΑΝΕΠΙΣΤΗΜΙΟ ΑΘΗΝΩΝ, Ιερά οδός 75, Αθήνα 11855 2009-, Πρόεδρος Γενικού Τμήματος ΓΠΑ 2012- ιεθύντρια Τομέα Μαθηματικών και Πληροφορικής Γενικού Τμήματος ΓΠΑ 2012- ιεθύντρια Τομέα Γεωλογικού Περιβάλλοντος και Μετεωρολογίας Γενικού Τμήματος ΓΠΑ 2006-2009, ιεθύντρια Τομέα Φυσικών και Χημικών Επιστημών Γενικού Τμήματος ΓΠΑ 2004-σήμερα, Συντονίστρια του μεταπτυχιακού προγράμματος σπουδών του κλαδου ΙΙΙ (Αξιοποίησης Φυσικών προιόντων) του Γενικού Τμήματος ΓΠΑ 1999-2005, Αναπληρώτρια Καθηγήτρια ΓΠΑ 1995-1999, Επίκουρη Καθηγήτρια ΓΠΑ 1991-1995, Λέκτορας ΓΠΑ 1981-1991, Επιστημονικός Συνεργάτης ΓΠΑ Επικοινωνία Τηλ εργασίας: 210 5294261 e-mail: vikon@aua.gr FAX: 210 5294265 Οικογενειακή Κατάσταση Παντρεμένη και μητέρα δυο παιδιών 2. ΕΡΕΥΝΗΤΙΚΗ ΡΑΣΤΗΡΙΟΤΗΤΑ ιδακτορική διατριβή ΠΟΡΕΙΕΣ ΣΥΝΘΕΣΕΩΣ ΚΑΙ ΗΜΙΣΥΝΘΕΣΕΩΣ ΝΕΩΝ ΑΝΤΙΒΙΟΤΙΚΩΝ Η ΑΝΑΛΟΓΩΝ ΤΟΥΣ Β. Κωνσταντίνου-Κόκοτου, ιδακτορική ιατριβή, Γεωργικό Πανεπιστήμιο Αθηνών, Αθήνα 1989. 2A. ιπλώματα ευρεσιτεχνίας (PATENT) 1. COMPOSITIONS AND METHODS FOR INHIBITION OF PHOSPHOLIPASE A 2 MEDIATED INFLAMMATION E.A. Dennis, T. Yaksh, K. K. Lucas, C. Svensson, D.A. Six, G. Kokotos, V. Constantinou-Kokotos, WO 03/076389 A1, 2003-09-18. 2. MONOESTERS AND MONOETHERS OF 2-AMINO-GLYCEROL CONTAINING LONG CHAINS AND STRUCTURALLY RELATED COMPOUNDS: PREPARATION AND USE G. Kokotos and V. Constantinou-Kokotou, GR 20050100169 A, 2006-11- 23. 3. SYSTEMIC AND INTRATHECAL EFFECTS OF A NOVEL SERIES OF PHOSPHOLIPASE A 2 INHIBITORS ON HYPERALGESIA AND SPINAL PGE 2 RELEASE E.A. Dennis, T. Yaksh, G. Kokotos, V. Constantinou-Kokotou, WO 2007/022443 A2. 4. PERFLUOROKETONE COMPOUNDS AND USES THEREOF S. David, A. Kalyvas, R. Lopez-Vales, G. Kokotos, V. Constantinou-Kokotou, C. Baskakis, C.G. Kokotos, E.A. Dennis, D. Stephens WO 2008122119 A1, 2008-10-16.

2 5. PHOSPHOLIPASE A 2 INHIBITORS AND THEIR USE IN TREATING NEUROLOGICAL INJURY AND DISEASE E.A. Dennis, D. Stephens, S. David, R. Lopez-Vales, A. Kalyvas, G. Kokotos, V. Constantinou-Kokotou. E. Barbayianni, V. Magrioti, WO 2009009449 A2, 2009-01-15. 6. AMIDES AS INHIBITORS OF HUMAN SECRETED PHOSPHOLIPASE A 2 G. Kokotos, V. Constantinou-Kokotou, E. A. Dennis, S. David, US Provisional Patent Application. 7. 2-OXOAMIDE INHIBITORS OF PLA2 ACTIVITY AND CELLULAR ARACHIDONATE RELEASEBASED ON DIPEPTIDES AND PSEUDOPEPTIDES, E. Dennis, G. Kokotos, V. Constantinou-Kokotou 2Β. Πρωτότυπες επιστημονικές δημοσιεύσεις σε διεθνή περιοδικά Β1.- SYNTHESIS OF AMINO ACID DERIVATIVES OF NEAMINE AND 2-DEOXYSTREPTAMINE TO BE USED AS MUTASYNTHONS M. Georgiadis, V. Constantinou-Kokotou, G. Kokotos, J. Carbohydrate Chem. 10, 739-748 (1991). Β2.- RESOLUTION OF 2,3-DIDEOXY-DL-2-ENOPYRANOS-4-ULOSES VIA CHROMATOGRAPHIC SEPARATION OF THEIR DIASTEREOMERIC O-TERT-BUTYLOXYCARBONYL-L-ALANYL ESTERS. A CONVENIENT SYNTHESIS OF L- AND D-ACULOSE V. Constantinou-Kokotou, E. Couladouros, M. Georgiadis, G. Kokotos, J. Carbohydrate Chem. 10, 749-756 (1991). Β3.- SYNTHESIS OF 6-ACYLOXY AND 6-ALKOXY DERIVATIVES OF 2H-PYRAN-3(6H)-ONES V. Constantinou-Kokotou, G. Kokotos, M. Georgiadis, Liebigs Ann. Chem. 151-154 (1991). Β4.- TOTAL SYNTHESIS OF 4-(D-ALANYLAMINO)-2-AMINO-2,3,4-TRIDEOXY-DL-THREO-PENTOSE (3-DEOXY-DL- PRUMYCIN) V. Constantinou-Kokotou, E. Couladouros, M. Georgiadis, G. Kokotos, T. Georgiadis, Carbohydr. Res. 222, 163-172 (1991). Β5.- MODIFIED AMINO ACIDS AND PEPTIDES. PART 2. A CONVENIENT CONVERSION OF AMINO AND PEPTIDE ALCOHOLS INTO AMINES G. Kokotos, V. Constantinou-Kokotou, J. Chem. Research. (S) 391 (1992) and J. Chem. Research. (M) 3117-3132 (1992). Β6.- CONVERSION OF RACEMIC LIPIDIC AMINO ACIDS INTO SPHINGOSINE AND CERAMIDE ANALOGUES AND 1,2- DIAMINES G. Kokotos, V. Constantinou-Kokotou, E. Del Olmo Fernandez, I. Toth, W. A. Gibbons, Liebigs Ann. Chem. 961-964 (1992). Β7.- A SYNTHESIS IN ONE REACTION VESSEL OF 2,4-DIAMINOSUGAR PERCURSORS FROM 2,3-DIDEOXY-2- ENOPYRANOS-4-ULOSES E. Couladouros, V. Constantinou-Kokotou, M. Georgiadis, G. Kokotos, Carbohydr. Res. 254, 317-324 (1994). Β8.- SYNTHESIS AND ANTIFUNGAL ACTIVITY OF 3-DEOXY-DL-PRUMYCIN ANALOGUES. V. Constantinou-Kokotou, G. Kokotos, E. Couladouros, M. Chrysayi-Toukousbalides, M. P. Georgiadis, Liebigs Ann. Chem. 847-850. (1994). Β9.- SYNTHESIS OF 1,3-DIAMINES V. Constantinou-Kokotou, G. Kokotos, Organic Prep. Proced. Int. 26, 599-602 (1994). Β10.- NMR LIPID PROFILES OF CELLS TISSUES AND BODY FLUIDS. PROTON NMR ANALYSIS OF HUMAN BLOOD LIPIDS. R. Adosraku, G. Choi, V. Constantinou-Kokotou, M. Anderson, W. Gibbons J. Lipid Res. 35, 1925-1931 (1994). Β11.- SYNTHESIS AND ANTIMICROBIAL AND TOXICOLOGICAL STUDIES OF AMINO ACID AND PEPTIDE DERIVATIVES OF KANAMYCIN A AND NETILMICIN S. Kotretsou, M. Mingeot-Leclerq, V. Constantinou-Kokotou, P. Tulkens, M. P. Georgiadis, J. Med. Chem. 38, 4710-4719 (1995). Β12.- SYNTHESIS OF CHIRAL TRIAMINES AND DIAMINES FROM AMINO ACIDS G. Kokotos, T. Markidis, V. Constantinou- Kokotou, Synthesis 1223-1226 (1996). Β13.- SYNTHESIS OF MEDICINALLY USEFUL LIPIDIC -AMINO ACIDS, 2-AMINO ALCOHOLS AND DIAMINES G. Kokotos, V. Martin, V. Constantinou-Kokotou and W.A. Gibbons, Amino Acids 11, 329-343 (1996). Β14. SYNTHESIS OF LIPIDIC AMINO ACID AND DIPEPTIDE INHIBITORS OF HUMAN PLATELET PHOSPHOLIPASE A 2 G. Kokotos, V. Constantinou-Kokotou, C. Noula, A. Nicolaou, W. Gibbons, Int. J. Peptide Protein Res. 48, 160-166 (1996). Β15.- SYNTHESIS AND PROPERTIES OF NOVEL LIPOPEPTIDES AND LIPID MIMETICS. A. Nicolaou, G. Kokotos, V. Constantinou-Kokotou, C. Charitos, C. Noula, R. Verger and W.A. Gibbons, J. Peptide Science 3, 291-298 (1997). Β16.- AN HPLC METHOD FOR THE MEASUREMENT OF POLYAMINES AND LIPIDIC AMINES BINDING TO DNA G. Karikas, V. Constantinou-Kokotou and G. Kokotos, J. Liq. Chrom. & Rel. Technol. 20, 1789-1796 (1997). Β17.- SYNTHESIS AND IN VITRO CYTOTOXICITY OF LIPOPHILIC PLATINUM(II) COMPLEXES G. Kokotos, V. Theodorou, V. Constantinou-Kokotou, W. Gibbons, Bioorg. Med. Chem. Lett. 8, 1525-1530 (1998). Β18.- SYNTHESIS AND IN VITRO CYTOTOXICITY OF LIPIDIC ALCOHOLS AND AMINES V. Constantinou-Kokotou, G. Kokotos, C. Roussakis, Anticancer Research 18, 3439-3442 (1998). Β19.- MASS SPECTROMETRIC STUDIES ON THE FRAGMENTATION AND STRUCTURAL CHARACTERIZATION OF AMINOACYL DERIVATIVES OF KANAMYCIN A S. Kotretsou, V. Constantinou-Kokotou, Carbohyd. Res. 310, 121-127 (1998).

3 Β20.- FAST ATOM BOMBARDMENT MASS SPECTROMETRY OF NETILMICIN AND 6 -Ν DERIVATIVES S. Kotretsou, V. Constantinou-Kokotou, Europ. Mass spectrometry,. 4, 265-268 (1998). Β21.- SYNTHESIS OF OPTICALLY ACTIVE LIPIDIC -AMINO ACIDS AND LIPIDIC 2-AMINO ALCOHOLS G. Kokotos, V. Constantinou-Kokotou, Amino Acids 16, 273-286 (1999). Β22.- SYNTHESIS OF N-PROTECTED 2-AMINOHEXANESULPHONIC ACID V. Constantinou-Kokotou, Org. Prep. Proced. Int., 31, 237-239 (1999). Β23. SYNTHESIS, IN VITRO CYTOTOXICITY AND IN VIVO ANTI-INFLAMMATORY ACTIVITY OF LONG CHAIN 3-AMINO- 1,2-DIOLS J.M. Padron, V. Martin, D. Hadjipavlou-Litina, C. Noula, V. Constantinou-Kokotou, G.Peters, G. Kokotos, Bioorg. Med. Chem. Lett., 9, 821-826 (1999). B24. SYNTHETIC ROUTES TO LIPIDIC DIAMINES AND AMINOALCOHOLS: A CLASS OF POTENTIAL ANTI- INFLAMMATORY AGENTS G. Kokotos, V. Constantinou-Kokotou, C. Noula, D. Hadjipavlou-Litina, Lipids, 34, 307-311 (1999). B25. SYNTHESIS AND STUDY OF A LIPOPHILIC -KETO AMIDE INHIBITOR OF PANCREATIC LIPASE A.Chiou, T. Markidis, V. Constantinou-Kokotou, R. Verger, G. Kokotos, Organic Lett., 2, 347-350 (2000). Β26. INHIBITION OF LIPOPROTEIN LIPASE BY ALKANESULFONYL FLUORIDES G.Kokotos, S. Kotsovolou, V. Constantinou-Kokotou, W. Gengshu, G. Olivecrona, Bioorg. Med. Chem. Lett., 10, 2803-2806 (2000). B27. "STUDY OF DNA INTERACTIONS WITH MELPHALAN, BUSULPHAN AND ANALOGUES USING AN HPLC METHOD, G.A. Karikas, V. Constantinou-Kokotou, V. Magrioti, G. Kokotos, J. Liq. Chrom., 23, 1859-1864 (2000). B28. "SYNTHESIS AND IN VITRO CYTOTOXICITY OF NOVEL LONG CHAIN BUSULPHAN ANALOGUES", G. Kokotos, V. Constantinou-Kokotou, J.M. Padron, G.J. Peters, Bioorg. Med. Chem. Let. 11, 861-863 (2001). B29. "STUDY OF AMINOGLYCOSIDE-NUCLEIC ACID INTERACTIONS BY AN HPLC METHOD", V. Constantinou-Kokotou, G. Karikas, G. Kokotos, Bioorg. Med. Chem. Lett., 11, 1015-1018 (2001). B30. SYNTHESIS OF ENANTIOPURE NON-NATURAL α-amino ACIDS USING tert-butyl (2S)-2-[BIS-(tert- BUTYLOXYCARBONYL)AMINO]-5-OXO-PENTANOATE AS KEY INTERMEDIATE: THE FIRST SYNTHESIS OF (S)-2-AMINO OLEIC ACID, V. Constantinou-Kokotou, V. Magrioti, T. Markidis, G. Kokotos, J. Pept. Res., 58, 325-331 (2001). B31. SYNTHESIS OF (S)-α-AMINO OLEIC ACID, V. Magrioti, V. Constantinou-Kokotou, Lipids, 37, 223-228 (2002). B32. SYNTHESIS AND BIOLOGICAL ACTIVITIES OF LONG CHAIN 2-AMINO ALCOHOLS V. Constantinou-Kokotou, Lett. Pep. Sience 9, 143-152 (2002) B33. NOVEL 2-OXO-AMIDE INHIBITORS OF HUMAN GROUP IVA PHOSPHOLIPASE A2, G.Kokotos, S. Kotsovolou, D. Six, V. Constantinou-Kokotou, C. Beltzner, E. Dennis, J. Med. Chem., 45, 2891-2893 (2002). B34. SYNTHESIS AND USE OF N,N-DI BOC GLUTAMATE γ-semialdehydes AND RELATED ALDEHYDES, V. Constantinou- Kokotou, V. Magrioti, Amino Acids, 24, 231-243 (2003). B35. SYNTHESIS AND IN VIVO ANTI-INFLAMMATORY ACTIVITY OF LONG CHAIN 2-AMINO-ALCOHOLS, V. Magrioti, D. Hadjipavlou-Litina, V. Constantinou-Kokotou, Bioorg. Med. Chem. Lett., 13, 375-377 (2003). B36. TRIACYLGLYCEROLS BASED ON 2-(N-tert-BUTOXYCARBONYLAMINO)-OLEIC ACID AS POTENT INHIBITORS OF PANCREATIC LIPASE, V Magrioti, R. Verger, V. Constantinou-Kokotou, J. Med. Chem., 47, 288-291 (2004). B37. STERICALLY HINDERED TRIACYLGLYCEROL ANALOGUES AS POTENT INHIBITORS OF HUMAN DIGESTIVE LIPASES V. Constantinou-Kokotou, V. Magrioti, R. Verger, Chemistry Eur. J., 10, 1133-1140 (2004). Β38. INHIBITION OF GROUP IV CYTOSOLIC PHOSPHOLIPASE A 2 BY NOVEL 2-OXOAMIDES in vitro, in cells AND in vivo G. Kokotos, D. Six, V. Loukas, T. Smith, V. Constantinou-Kokotou, D. Hadjipavlou-Litina, S. Kotsovolou, A. Chiou, C. Belzner, E. Dennis, J. Med. Chem. 47, 3615-3628 (2004). B39 MICROWAVE ASSISTED NiCl 2 PROMOTED ACYLATION OF ALCOHOLS V. Constantinou-Kokotou, A. Peristeraki, Synthetic Commun. 34, 4227-4232 (2004). B40. SYNTHESIS AND ACTIVITY OF 2-OXOAMIDES CONTAINING LONG CHAIN β-amino ACIDS V. Constantinou- Kokotou, A. Peristeraki, C. G. Kokotos, D. Six, E.A. Dennis, J. Peptide Sci 11, 431-435 (2005). B41. PHASE TRANSITIONS IN CRYSTALS OF RACEMIC LONG CHAIN 2-AMINO ALCOHOLS P. Xynogalas, A. Kanapitsas, V. Constantinou-Kokotou, P. Pissis, K. Viras, Chem. Phys. Lipids 135, 83-92 (2005). Β42. ENZYMATIC REMOVAL OF CARBOXYL PROTECTING GROUPS. 1. CLEAVAGE OF THE tert- BUTYL MOIETY M. Schmidt. E. Barbayianni, I. Fotakopoulou, M. Hohne, V. Constantinou-Kokotou, U. Bornscheuer, G. Kokotos, J. Org. Chem. 70, 3737-3740 (2005).

4 Β43. ENZYMATIC REMOVAL OF CARBOXYL PROTECTING GROUPS. 2. CLEAVAGE OF THE BENZYL AND METHYL MOIETY. E. Barbayianni, I. Fotakopoulou, M. Schmidt, V. Constantinou-Kokotou, U. Bornscheuer, G. Kokotos, J. Org. Chem. 70, 8730-8733 (2005). B44. DIFFERENTIAL INHIBITION OF GROUP IV A PHOSPHOLIPASES A 2 by 2-OXOAMIDES. D. Stephens, E. Barbayianni, V. Constantinou-Kokotou, A. Peristeraki, D. Six, J. Cooper, R. Harkiewicz, R. Deems, E. Dennis, G. Kokotos, J. Med. Chem. 49, 2821-2828 (2006). Β45. ENZYMATIC REMOVAL OF CARBOXYL PROTECTING GROUPS III. FAST REMOVAL OF ALLYL AND CHLOROETHYL ESTERS BY BACCILUS SUBTILIS ESTERASE. I. Fotakopoulou, E. Barbayianni, V. Constantinou-Kokotou, U. Bornscheuer, G. Kokotos, J. Org. Chem. 72, 782-786 (2007). B46. STRUCTURE-ACTIVITY RELATIONCHIP OF 2-OXOAMIDE INHIBITION OF GROUP IV A CYTOSOLIC PHOSPHOLIPASE A 2 AND GROUP V SECRETED PHOSPHOLIPASE A 2 D. Six, E. Barbayianni, V. Loukas, V. Constantinou-Kokotou, D. Hadjipavlou- Litina, D. Stephens, A. Wong, V. Magrioti, P Moutevelis-Minakakis, S Baker, E. Dennis, G. Kokotos, J. Med. Chem. 50, 4222-4235 (2007). B47. INTRACELLULAR PHOSPHOLIPASE A 2 GROUP IVA AND GROUP VIA PLAY IMPORTANT ROLES IN WALLERIAN DEGENERATION AND AXON REGENERATION AFTER PERIPHERAL NERVE INJURY R.Lopez-Vales, X. Navarro. T. Shimizu, C. Baskakis, G. Kokotos, V. Constantinou-Kokotou, D. Stephens, S. David, Brain. 131, 2620-2631 (2008). B48. SYNTHESIS OF 2-OXOAMIDES BASED ON SULFONAMIDE ANALOGS OF γ-amino ACIDS AND THEIR ACTIVITY ON PHOSPHOLIPASE A 2 G. Antonopoulou, V. Magrioti, D. Stephens, V. Constantinou-Kokotou, E.A. Dennis, G. Kokotos, J. Peptide Sci. 14, 1111-1120 (2008). B49. STRUCTURE-ACTIVITY RELATIONCHIPS OF NATURAL AND NON-NATURAL AMINO ACID-BASED AMIDE AND 2- OXOAMIDE INHIBITORS OF HUMAN PHOSPHOLIPASE A 2 ENZYMES G. Antonopoulou, E. Barbayianni, V. Magrioti, N. Cotton, D. Stephens, V. Constantinou-Kokotou, E.A. Dennis, G. Kokotos, Bioorg. Med. Chem. 16, 10257-10269 (2008). B50. SYNTHESIS OF POLYFLUORO KETONES FOR SELECTIVE INHIBITION OF HUMAN PHOSPHOLIPASE A 2 ENZYMES C. Baskakis, V. Magrioti, N. Cotton, D. Stephens, V. Constantinou-Kokotou, E. Dennis, G. Kokotos, J. Med. Chem. 51, 8027-8037 (2008). B51. DIFFERENT PHOSPHOLIPASE A 2 s AFFECT DISTINCT PHASES OF CNS AUTOIMMUNE DISEASE EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS A. Kalyvas, C. Baskakis, V. Magrioti, V. Constantinou-Kokotou, D. Stephens, E. A. Dennis, G. Kokotos and S. David Brain, 132, 1221-1235 (2009). B52. SYNTHESIS OF HOMOPROLINE ANALOGUES CONTAINING HETEROCYCLIC RINGS AND THEIR ACTIVITY AS ORGANOCATALYSTS FOR MICHAEL REACTION E. Barbayianni, P. Bouzi, V. Constantinou-Kokotou, V. Ragoussis, and G. Kokotos, Heterocycles, 78, 1243-1252 (2009). Β53. REMOVAL OF ALLYL ESTERS BY CANDIDA ANTARCTICA LIPASE B (CAL-B) AND PIG LIVER ESTERASE (PLE) K. Thodi, E. Barbayianni, I. Fotakopoulou, U. T. Bornscheuer, V. Constantinou-Kokotou, P. Moutevelis-Minakakis, G. Kokotos, J. Mol. Catal. B: Enzymatic, 61, 241-246 (2009). Β54. RESOLYTION OF N-PROTECTED AMINO ALCOHOLS BY PORCINE PANCREATIC LIPASE V.Magrioti, I.Fotakopoulou, N. Athinaios, P. Anastasopoulou, V. Constantinou-Kokotou, G. Kokotos, Letters in Org Chem., 7, 159-162 (2010). Β55. PHOSPHOLIPASE A 2 SUPERFAMILY MEMBERS PLAY DIVERGENT ROLES AFTER SPINAL CORD INJURY R. Lopez- Vales, N. Ghasemlou, A. Redensek, B. Kerr, E. Barbayianni, G. Antonopoulou, C. Baskakis, K. Rathore, V. Constantinou-Kokotou, D. Stephens, T. Shimizu, E. A. Dennis, G. Kokotos and S. David FASEB J., 23, 4240-4252 (2011). Β56. BINDING CONFORMATION OF 2-OXOAMIDE INHIBITORS TO GROUP IV CYTOSOLIC PHOSPHOLIPASE A2 DETERMINRD BY MOLECULAR DOCKING COMBINED WITH MOLECULAR DYNAMICS V. Mouchlis, V. Michopoulou, V. Constantinou-Kokotou, T. Mavromoustakos, E. Dennis, G. Kokotos, J. Chem. Inf. and Mod. 52, 243-254 (2012). 2Γ. ημοσιεύσεις σε βιβλία περιοδικέςδιεθνείς εκδόσεις που περιέχονται στο citation index Γ1.- AMINO ACID AND PEPTIDE ANALOGS OF 3-DEOXY-DL-PRUMYCIN: SYNTHESIS AND ANTIFUNGAL ACTIVITY G. Kokotos, V. Constantinou-Kokotou, M. Chrysayi, E. Couladouros, M, Georgiadis (1991) in " Peptides 1990 " (E. Giralt and D Andreu, eds), p.p. 412-413, ESCOM, Leiden. Γ2.- A CONVENIENT CONVERSION OF N- PROTECTED AMINO ACIDS AND PEPTIDES INTO ALCOHOLS AND AMINES G. Kokotos, V. Constantinou-Kokotou (1991) in " Peptides 1990 " (E. Giralt and D Andreu, eds), p.p. 23-24, ESCOM, Leiden. Γ3.- CONVENIENT CONVERSION OF N-PROTECTED AMINO ALCOHOLS INTO 1,3-DIAMINES G. Kokotos, V. Constantinou-Kokotou, (1993) in " Peptides 1992 " (C. Scneider and A. Eberle eds), p.p. 179-180, ESCOM, Leiden. Γ4.- SYNTHESIS OF AMINO ACID AND PEPTIDE DERIVATIVES OF AMINOGLYCOSIDES TARGETED AGAINST RESISTANCE OF BACTERIA S. Kotretsou, V. Constantinou-Kokotou, M. Georgiadis, in Properties and Chemistry of Biomolecular Systems (N. Russo et al Eds) p.p. 277-280 (1994), Kluwer, Netherlands.

5 Γ5.- HYBRID ANTIBIOTICS: AMINOGLYCOSIDE 3-QUINOLONE OR -LACTAM AMIDES S. Kotretsou, V. Constantinou- Kokotou, M. Georgiadis, in Properties and Chemistry of Biomolecular Systems (N. Russo et al Eds) p.p. 267-270 (1994), Kluwer, Netherlands. Γ6.- LIPIDIC MIMETICS AS INHIBITORS OF PANCREATIC PHOSPHOLIPASE A 2 A. Nicolaou, G. Kokotos, V. Constantinou- Kokotou, J. York, W. Gibbons, Biochem. Soc. Trans. 23, 614S (1995). Γ7.- LIPID MIMETICS AS INHIBITORS OF HUMAN PLATELET PHOSPHOLIPASE A 2 C. Noula, V. Constantinou-Kokotou, A. Nicolaou, G. Kokotos, W. Gibbons, Biochem. Soc. Trans. 24, 303S (1996). Γ8.- THE INHIBITION OF PANCREATIC LIPASE AND PHOSPHOLIPASE A 2 BY LIPID MIMETICS AND LIPOPEPTIDES A. Nicolaou, G. Kokotos, V. Constantinou-Kokotou, S. Ransac, R. Verger, W. Gibbons (1998) in " Peptides 1996" (R. Ramage and R. Epton eds), p.p. 679-680, Mayflower Scientific Ltd.. Γ9.- AMINO ACID AND PEPTIDE DERIVATIVES OF AMINOCYCLITOLS: AN APPROACH TO LESS TOXIC ANTIBIOTICS V. Constantinou-Kokotou, S. Kotretsou, M. P. Mingeot-Leclercq, Hellenic Forum on Bioactive Peptides (1997) 89-97. Γ.10- SYNTHESIS AND BIOLOGICAL ACTIVITY OF LIPIDIC α-amino ACIDS, LIPIDIC PEPTIDES AND LIPID MIMETICS G. Kokotos, V. Constantinou-kokotou, W. Gibbons, Hellenic Forum on Bioactive Peptides (1997) (P. Cordopatis, Ed.), Crete University Press, 63-73. Γ.11- LIPIDIC AMINO ACIDS AND LIPOPEPTIDES: CHEMISTRY AND MEDICAL ASPECTS V. Constantinou, G. Kokotos, in Bioactive Peptides in Drug Discovery and Design: Medical Aspects (J. Matsoukas, Ed.) (1999), IOS Press, Biomed. Health, Res. (1999) 22, 121-136. Γ.12- SYNTHESIS OF LIPOPHILIC α-keto AMIDES AND STUDY OF THEIR INHIBITION EFFECT ON PANCREATIC AND GASTRIC LIPASES A. Chiou, T. Markidis, V. Constantinou-Kokotou, R. Verger. G. Kokotos, Lipases and Lipids: Structure, function and Biotechnological applications (G. Kokotos and V. Constantinou-Kokotou, Eds) Crete University Press, Heraklion, (2000), 215-232. Γ.13- D-GLUTAMIC ACID BASED SYNTHESIS OF A LIPOPHILIC α-keto AMIDE INHIBITOR OF PANCREATIC LIPASE A. Chiou, T. Markidis, V. Constantinou-Kokotou, R. Verger. G. Kokotos, in 2nd Hellenic Forum on Bioactive Peptides (2001) (ed. P. A. Cordopatis) Typorama, Patra, 253-258. Γ.14- "SYNTHESIS OF ENANTIOPURE NON-NATURAL α-amino ACIDS USING tert-butyl (S)-2-[DI-(tert- BUTYLOXYCARBONYL)AMINO]-5-OXO-PENTANOATE AS KEY INTERMEDIATE", V. Magrioti, T. Markidis, V. Constantinou- Kokotou and G. Kokotos, in "2 nd Hellenic Forum on Bioactive Peptides" (ed. P. A. Cordopatis) (2001), p.p. 259-263, Τyporama, Patra. Γ.15- SYNTHESIS OF (S)-2-AMINO OLEIC ACID AND OTHER BIOACTIVE MOLECULES THROUGH GLUTAMATE ALDEHYDES V. Constantinou-Kokotou, V. Magrioti, T. Markidis, G. Kokotos, Drug Discovery and Design: Medical Aspects (J. Matsoukas and T. Mavromoustakos, Eds) IOS Press (2002) 76-82. Γ.16- SYNTHESIS AND in vivo ANTIINFLAMMATORY ACTIVITY OF LONG CHAIN 2-AMINOALCOHOLS Constantinou- Kokotou, V. Magrioti, D. Hadjipavlou-Litina, (2002) in " Peptides 2002" (E. Benedetti and C. Pedone eds), p.p. 74-75, Edizioni Ziino, Napoli Italy. Γ.17- SYNTHESIS OF BIOACTIVE DERIVATIVES OF 2-AMINO OLEIC ACID V. Magrioti, V. Constantinou-Kokotou, 3nd Hellenic Forum on Bioactive Peptides " (ed. P. A. Cordopatis) (2003), pp 177-186. Γ.18- "SYNTHESIS OF 2-OXOAMIDES BASED ON -AMINO ACIDS AND STUDY OF THEIR ACTIVITY ON HUMAN GIVA PHOSPHOLIPASE A2 V. Loukas, D. A. Six, V. Constantinou-Kokotou, P. Moutevelis-Minakakis, E.A. Dennis and G. Kokotos, in Peptides 2004 (ed. M. Flegel, M. Fridkin, C. Gilon and J. Slaninova), Kenes International, Geneva, 615-616, 2005. Γ.19- "2-OXOAMIDES BASED ON -AMINO ACIDS INHIBIT HUMAN GIVA PHOSPHOLIPASE A2 AND PRESENT IN VIVO ANTI-INFLAMMATORY ACTIVITY G. Kokotos, V. Loukas, D. A. Six, D. Hadjipavlou-Litina, S. Kotsovolou, V. Constantinou-Kokotou and E. A. Dennis, in Peptides 2004 (ed. M. Flegel, M. Fridkin, C. Gilon and J. Slaninova), Kenes International, Geneva, 643-644, 2005. Γ.20.- STUDIES ON A REVERSE TURN SCAFFOLD CONTAINING A THIOUREA FUNCTIONALITY M. Zervou, K. Paschalidou, S. Fotaras, V. Constantinou-Kokotou, G. Kokotos, in Peptides 2012 (ed. G. Kokotos, Flegel, V. Constantinou-kokotou and J. Matsoukas), EKPA, Athens, Greece 2012, pp 380-382. 2. ημοσιεύσεις σε συνέδρια διεθνή και ελληνικά 1.- ΣΥΝΘΕΣΗ ΠΑΡΑΓΩΓΩΝ ΤΗΣ 2- ΕΟΞΥΣΤΡΕΠΤΑΜΙΝΗΣ ΚΑΙ ΝΕΑΜΙΝΗΣ ΚΑΤΑΛΛΗΛΩΝ ΓΙΑ ΜΟΥΤΑΣΥΝΘΕΣΗ. M. Γεωργιάδης, Β. Κωνσταντίνου, Γ. Κόκοτος, Chimica Chronika, New Series, p.p. 26-29 (1986). 2.- TOTAL SYNTHESIS OF 3-DEOXYPRUMYCIN FROM 2H-PYRAN-3(6H)-ONE V. Constantinou, E. Couladouros, M. Georgiadis, G. Kokotos. Xth International Symposium on Medicinal Chemistry, Budapest (1988), Abstracts p. 166. 3.- SYNTHESIS AND USEFULNESS OF DIASTEREOMERIC AMINO ACID AND PEPTIDE DERIVATIVES OF 6-HYDROXY- 2H-PYRAN-3(6H)-ONES " G. Kokotos, V. Constantinou, M. Georgiadis. 4th Meeting on Bioorganic Chemistry of Peptides, Abstracts p. 27, Prague 1989.

6 4.- SYNTHESIS AND CONFORMATIONAL STUDIES OF 2,4-DIAMINOSUGAR PRECURSORS V. Constantinou, E. Couladouros, M. Georgiadis, G.Kokotos. XI International Symposium on Medicinal Chemistry, Ierusalem (1990), Abstracts p. 33. 5.- A CONVENIENT CONVERSION OF N-PROTECTED AMINO ACIDS AND PEPTIDES INTO ALCOHOLS AND AMINES G. Kokotos and V. Constantinou-Kokotou, 21 European Peptide Symposium, Platja d Aro, 1990 Abstacts P1 6.- AMINO ACID AND PEPTIDE ANALOGUES OF 3-DEOXYPRUMYCIN: SYNTHESIS AND ANTIFUNGAL ACTIVITY G. Kokotos, V. Constantinou-Kokotou, M. Chrysayi, E. Couladouros, and M.Georgiadis, 21 European Peptide Symposium, Platja d Aro, 1990 Abstacts P5. 7.- SYNTHESIS OF N-PROTECTED LIPIDIC 1,2-AMINO ALCOHOLS AND MONOPROTECTED 1,2-DIAMINES G. Kokotos, V. Constantinou, I. Toth, E. Del Olmo Fernandez, W. A. Gibbons, 7 th European Symposium on Organic Chemistry, Namur-Belgium (1991), Abstracts p. 192. 8.- CONVENIENT CONVERSION OF N-PROTECTED AMINO ALCOHOLS I NTO 1,3-DIAMINES G. Kokotos and V. Constantinou-Kokotou, 22 European Peptide Symposium, Interlaken (1992) Abstracts, P10. 9.- PHOSPHOLIPASE A 2 INHIBITION BY LONG CHAIN UNSATURATED AMINO ACID AMIDES AND PEPTIDES A. Nicolaou, C Charitos, V. Constantinou, C. Noula, G. Kokotos, W. Gibbons 1st Australian Peptide Conference, Daydream Island 1994, Australia 10.- LIPIDIC AMINO ACID AND PEPTIDE INHIBITORS OF PHOSPHOLIPASE A 2 G. Kokotos, A. Nicolaou, K. Noula, A. Anastasiou, V. Constantinou, 23rd European Peptide Symposium, Braga, Portugal 1994, Abstracts p. 3-66. 11.- CONVESION OF LIPIDIC AMINO ACIDS INTO LIPIDIC 1,3-DIAMINES and TAURINES V. Constantinou, G. Kokotos, Amino Acids 9, 66-67 (1995). 12.- SYNTHESIS OF CHIRAL TRIAMINES AND DIAMINES FROM AMINO ACIDS G. Kokotos, T. Markidis, V. Constantinou, Amino Acids 9, 71 (1995). 13.- LIPIDIC MIMETICS AS INHIBITORS OF PANCREATIC PLA 2 A. Nicolaou, G. Kokotos, V. Constantinou, J. York, W. Gibbons, in 655th Biochemical Society Meeting, University of Manchester, p. 70 (1995). 14.- INHIBITION OF PANCREATIC LIPASE BY LIPIDIC AMINES AND ALCOHOLS A. Nicolaou, G. Kokotos, V. Constantinou, C. Noula, W. Gibbons, in Perspectives on Protein Engineering, Montpellier 1996, Abstracts p. 35. 15.- INHIBITION OF PANCREATIC PHOSPHOLIPASE A 2 BY LIPIDIC AMINES V. Constantinou, C. Noula, A. Nicolaou, G. Kokotos, W. Gibbons, in Perspectives on Protein Engineering, Montpellier 1996, Abstracts p. 35. 16. INHIBITION OF PANCREATIC PHOSPHOLIPASE A 2 BY LIPIDIC 3-AMINO 1,2-DIOLS G. Kokotos, C. Noula, J.-M. Padron, A. Nicolaou, V. Constantinou, V. Martin, W. Gibbons, in Perspectives on Protein Engineering, Montpellier 1996, Abstracts p. 35. 17.- THE INHIBITION OF PANCREATIC LIPASE AND PHOSPHOLIPASE A 2 BY LIPID MIMETICS AND LIPOPEPTIDES A. Nicolaou, G. Kokotos, V. Constantinou, R. Verger, W. Gibbons, 24th European Peptide Symposium, 1996, Abstracts p. 367. 18.- ΠΡΟΣ ΙΟΡΙΣΜΟΣ ΤΗΣ ΟΠΤΙΚΗΣ ΚΑΘΑΡΟΤΗΤΑΣ ΑΜΙΝΟΑΛΚΟΟΛΩΝ Θ. Μαρκίδης, Β. Κωνσταντίνου, Γ. Κόκοτος, Πρακτικά 17ου Πανελλήνιου Συνέδριου Χημείας, 1996, σελ. 160-163. 19.- ΧΡΩΜΑΤΟΓΡΑΦΙΚΗ ΜΕΘΟ ΟΣ ΠΡΟΣ ΙΟΡΙΣΜΟΥ ΤΗΣ ΑΛΛΗΛΕΠΙ ΡΑΣΗΣ ΠΟΛΥΑΜΙΝΩΝ ΚΑΙ ΛΙΠΙ ΙΚΩΝ ΑΜΙΝΩΝ ΜΕ ΤΟ DNA Γ. Καρίκας, Β. Κωνσταντίνου, Γ. Κόκοτος, Πρακτικά 17ου Πανελλήνιου Συνέδριου Χημείας, 1996, σελ. 262-265. 20.- CONVERSION OF CHIRAL UNSATURATED LIPIDIC AMINO ACIDS INTO SPHINGOSINE ANALOGS AND DIAMINES. T. Markidis, J. M. Padron, V. Constantinou, T. Martin, V. Martin and G. Kokotos, Amino Acids, 13, 32, 1997. 21.- ANTI-INFLAMMATORY ACTIVITY OF LIPID MIMETICS DERIVED FROM LIPIDIC AMINO ACIDS. G. Kokotos, D. Hadjipavlou-Litina, V. Constantinou, C. Noula and W.A. Gibbons, Amino Acids 13, 36, 1997. 22.- SYNTHESIS AND IN VITRO CYTOTOXICITY OF LIPIDIC ALCOHOLS AND AMINES. G.Kokotos, V. Constantinou, C. Charitos and C.Roussakis, Anticancer Research 17, 4081, 1997. 23.- ΦΥΣΙΚΟΧΗΜΙΚΕΣ Ι ΙΟΤΗΤΕΣ ΛΙΠΙ ΙΚΩΝ ΑΜΙΝΟΑΛΚΟΟΛΩΝ Ι. Μαραγκού, Π. Ξυνογαλάς, Β. Κωνσταντίνου, Γ. Κόκοτος, Κ. Βύρας 4ο Πανελλήνιο Συνέδριο Πολυμερών,Πάτρα 1997, σελ. 71-74. 24.- STUDY OF DNA-BUSULPHAN ANALOGUES CROSSLINKS BY AN HPLC REVERSED PHASE METHOD G. Karikas, V. Magrioti, C. Terzakou, V. Constantinou, G. Kokotos, 1st International Conference on Chemical Sciences and Industry, Chalkidiki, Greece 1998, P 209. 25.- INHIBITION OF PANCREATIC LIPASE BY ALKANESULPHONYL HALIDES G. Kokotos, S. Kotsovolou, A. Chiou, V. Constantinou, R. Verger, 1st International Conference on Chemical Sciences and Industry, Chalkidiki, Greece 1998, P 211.

7 26.- STUDY OF THE POLYMORPHISM OF LIPIDIC AMINO ACID DERIVATIVES BY DIFFERENTIAL SCANNING CALORIMETRY, OPTICAL MICROSCOPY AND RAMAN SPECTROSCOPY C. Grammatikaki, A. Mitakos, M. Soubakas, P. Xynogalas, V. Constantinou, G. Kokotos, K. Viras, 1st International Conference on Chemical Sciences and Industry, Chalkidiki, Greece 1998, P 305. 27.- IN VITRO CYTOTOXICITY OF SYNTHETIC LIPOPHILIC BUSULPHAN ANALOGUES. CORRELATION OF THEIR ACTIVITY WITH THEIR DNA CROSS-LINKING ABILITY. J. M. Padron, V. Constantinou-Kokotou, G. Karikas, G. J. Peters and G. Kokotos, Anticancer Res., 18, 4900, 1998. 28.- INHIBITION OF LIPOPROTEIN LIPASE BY ALKANESULFONYL FLUORIDES. G. Kokotos, S. Kotsovolou, V. Constantinou-Kokotou, G. Wu and G. Olivecrona, LIPASES AND LIPIDS: Structure, Function and Biotechnological Applications, Santorini, 1999, Abstracts 78. 29.- SYNTHETIC ROUTES TO BIOACTIVE LIPIDS AND LIPASES INHIBITORS. V. Constantinou-Kokotou, T. Markidis, A. Chiou and G. Kokotos, LIPASES AND LIPIDS: Structure, Function and Biotechnological Applications, Santorini, 1999, Abstracts 99. 30.- "SYNTHESIS OF ENANTIOPURE NON-NATURAL α-amino ACIDS USING tert-butyl (S)-2-[DI-(tert- BUTYLOXYCARBONYL)AMINO]-5-OXO-PENTANOATE AS KEY INTERMEDIATE", V. Magrioti, T. Markidis, V. Constantinou- Kokotou and G. Kokotos, 2 nd Hellenic Forum on Bioactive Peptides, Patras, 2000, P04. 31.- "D-GLUTAMIC ACID BASED SYNTHESIS OF A LIPOPHILIC α-keto AMIDE INHIBITOR OF PANCREATIC LIPASE", A. Chiou, T. Markidis, V. Constantinou-Kokotou, R. Verger and G. Kokotos, 2 nd Hellenic Forum on Bioactive Peptides, Patras, 2000, P03. 32 ΜΕΛΕΤΗ ΤΗΣ ΑΛΛΗΛΕΠΙ ΡΑΣΗΣ ΕΝΩΣΕΩΝ ΦΑΡΜΑΚΟΛΟΓΙΚΟΥ ΕΝ ΙΑΦΕΡΟΝΤΟΣ ΜΕ ΝΟΥΚΛΕΙΝΙΚΑ ΟΞΕΑ ΜΕ ΤΗ ΧΡΗΣΗ ΥΓΡΗΣ ΧΡΩΜΑΤΟΓΡΑΦΙΑΣ ΥΨΗΛΗΣ ΑΠΟ ΟΣΗΣ» Γ. Καρίκας, Β. Κωνσταντίνου-Κοκοτου, Β. Μαγκριώτη, Γ. Κόκοτος, 9 ο Πανελλήνιο Συμπόσιο Φαρμακοχημείας, Αθήνα (2000), σελ 102. 33.- SYNTHESIS OF (S)- α-amino OLEIC ACID V. Magrioti, and V. Constantinou-Kokotou, 1st NIAF Merinos Meeting, Houffalize, 2001, Abstracts, MO 06. 34.- SYNTHESIS AND IN VITRO ANTI INFLAMMATORY ACTIVITY OF LONG CHAIN 2-AMINO ALCOHOLS V. Constantinou, V. Magrioti, D. Hadjipavlou-Litina, 27 th European Peptide Symposium, Sorrento, Italy, 2002 J. Peptιde Sci. S97..35.- SYNTHESIS OF 2-OXOAMIDES BASED ON LONG CHAIN β-amino ACIDS V. Constantinou-Kokotou, A. Peristeraki, C. Kokotos, D. Six and E. Dennis, 4 th Hellenic Forum on Bioactive Peptides, Patras, 2004, J. Peptιde Sci. 10, H45. 36.- RESOLUTION OF Boc-PROTECTED 2-AMINO ALCOHOLS BY PORCINE PANCREATIC LIPASE V. Magrioti, I. Fotakopoulou, V. Constantinou-Kokotou, 4 th Hellenic Forum on Bioactive Peptides, Patras, 2004, J. Peptιde Sci. 10, H46. 37.- SYNTHESIS OF 2-OXOAMIDES BASED on δ-amino ACIDS AND STUDY OF THEIR ACTIVITY ON HUMAN GIVA PLA2 V. Lukas, D. Six, V. Constantinou-Kokotou, P. Moutavelis, E. Dennis, G. Kokotos, 28 EPS, Πράγα, Σεπτέμβριος 2004, J. Peptιde Sci. 10, P323 page 205 (2004). 38.- SYNTHESIS OF 2-OXOAMIDES BASED on γ-amino ACIDS AND THEIR ACTIVITY ON HUMAN GIVA PLA2 G. Kokotos, V. Lukas, D. Six, D. Hadjipavlou, S. Kotsovolou, V. Constantinou-Kokotou, E. Dennis,, 28 EPS, Πράγα, Σεπτέμβριος 2004, J. Peptιde Sci. 10, P343 page 210 (2004). 39.- TRIACYLGLYCEROLS BASED ON 2-Boc-AMINO OLEIC ACID ARE POTENT INHIBITORS OF PANCREATIC LIPASE V. Constantinou-Kokotou, V. Magrioti, A. Peristeraki, R. Verger. 28 EPS, Πράγα, Σεπτέμβριος 2004, J. Peptιde Sci. 10, P347 page 211 (2004). 40. STERICALLY HINDERED TRIACYLGLYCEROLS: POTENT INHIBITORS OF HUMAN PANCREATIC LIPASE V. Magrioti, R. Verger, V. Constantinou-Kokotou. 1 st Hellenic Symposium in Organic Chemistry, Athens 2004, Abstract L05, page 35. 41. STUDIES ON THE ENZYMATIC CLEAVAGE OF tert-butyl ESTER PROTECTING GROUP E. Barbayianni, M. Schmidt, I. Fotakopoulou, V. Constantinou-Kokotou, U. Bornscheuer, G. Kokotos. 1 st Hellenic Symposium in Organic Chemistry, Athens 2004, Abstract P31, page 93. 42. PORCINE PANCREATIC LIPASE MEDIATED RESOLUTION OF 2-AMINO ALCOHOLS PROTECTED BY URETHANE-TYPE GROUP I. Fotakopoulou, N. Athinaios, P. Anastasopoulou, V. Magrioti, V. Constantinou-Kokotou, G. Kokotos. 1 st Hellenic Symposium in Organic Chemistry, Athens 2004, Abstract P32, page 94. 43. MICROWAVE ASSISTED ACYLATION OF ALCOHOLS A. Peristeraki, V. Constantinou-Kokotou. 1 st Hellenic Symposium in Organic Chemistry, Athens 2004, Abstract P34, page 96. 44. SYNTHESIS OF 2-OXOAMIDES CONTAINING A SULFONAMIDE GROUP AND STUDY OF THEIR ACTIVITY AGAINST HUMAN GIVA PHOSPHOLIPASE A2 G. Antonopoulou, T. Markidis, D. Stephens, V. Constantinou-Kokotou, E. Dennis, G. Kokotos. 1 st Hellenic Symposium in Organic Chemistry, Athens 2004, Abstract P41, page 103. 45.- ISOLATION AND NMR STUDY OF LIPID COMPOSITION IN SARDINE J. Yioyios, K. Konstantinou, E. Mikros, V. Constantinou-Kokotou. 1 st Hellenic Symposium in Organic Chemistry, Athens 2004, Abstract P67, page 129.

8 46. SYNTHESIS AND IN VIVO ANTI-INFLAMMATORY ACTIVITY OF O-MONOAYL 2-AMINO-GLYCEROLS V. Constantinou- Kokotou, I. Fotakopoulou, A. Peristeraki, D. Hadjipavlou-Litina, G. Kokotos. 14 th European Symposium on Organic Chemistry, Helsinki 2005, Abstract P134, page 263. 47. ENZYMATIC REMOVAL OF CARBOXYL PROTECTING GROUPS. CLEAVAGE OF tert-butyl MOIETY E. Barbayianni, M. Schmidt, I. Fotakopoulou, V. Constantinou-Kokotou, U. Bornscheuer, G. Kokotos. 14 th European Symposium on Organic Chemistry, Helsinki 2005, Abstract P218, page 347. 48. DESIGN, SYNTHESIS AND ANTI-INFLAMMATORY ACTIVITY OF 2-OXOAMIDES INHIBITORS OF PHOSPHOLIPASE A2 G. Kokotos, E. Barbayianni, D. Stephens, G. Antonopoulou, V. Magrioti, A. Peristeraki, D. Stephens, D. Hadjipavlou-Litina, J. Cooper, V. Constantinou-Kokotou, E. Dennis. 14 th European Symposium on Organic Chemistry, Helsinki 2005, Abstract O60, page 113. 49.- ΑΠΟΜΟΝΩΣΗ ΚΑΙ ΜΕΜΕΤΗ ΜΕ NMR ΤΩΝ ΠΟΛΥΑΚΟΡΕΣΤΩΝ ΛΙΠΑΡΩΝ ΟΞΕΩΝ ΤΩΝ ΛΙΠΙ ΙΩΝ ΤΩΝ ΙΧΘΥΩΝ, V. Constantinou-Kokotou. Greek Lipid Forum, Athens 2005, Abstract O-12. 50.- ΠΟΛΥΑΚΟΡΕΣΤΑ ΛΙΠΑΡΑ ΟΞΕΑ. ΜΕΛΕΤΗ ΙΧΘΥΕΛΑΙΩΝ ΜΕ ΦΑΣΜΑΤΟΣΚΟΠΙΑ NMR ΚΑΙ ΕΜΠΛΟΥΤΙΣΜΟΣ ΤΟΥΣ ΣΕ ω-3 ΛΙΠΑΡΑ ΟΞΕΑ, Β. Κωνσταντίνου- Κόκοτου, Γ. Αντωνοπούλου, Ε. Φωτακοπούλου, Ε. Μικρός 7ο Συνέδριο Ιατρικής Χημείας, Πάτρα 2006, Abstract L-25, page 46. 51.- NMR STUDY OF THE LIPASE-ASSISTED HYDROLYSIS PRODUCTS OF SARDINE LIPIDS V. Constantinou-Kokotou, G. Antonopoulou, I. Fotakopoulou, E. Mikros, 7 th Tethrahedron Symposium,Kyoto Japan 2006, Abstract P102, page 158. 52.- SYNTHESIS OF 2-PYRROLIDINEMETHANESULFONIC ACID ANS SULFONAMIDES BASED ON HOMO-PROLINE AND THEIR ACTIVITY AS ORGANOCATALYSTS FOR MICHAEL REACTION G. Kokotos, S. Kousidou, P. Bouzi, V. Constantinou- Kokotou, Seventh Tetrahedron Symposium Challenges in Organic Chemistry, Japan 2006, P103. 53.- ΛΙΠΑΣΕΣ ΚΑΙ ΙΧΘΥΕΛΑΙΑ: ΜΕΛΕΤΗ ΜΕ ΦΑΣΜΑΤΟΣΚΟΠΙΑ NMR ΤΩΝ ΕΜΠΛΟΥΤΙΣΜΕΝΩΝ ΣΕ ΠΟΛΥΑΚΟΡΕΣΤΑ ΛΙΠΑΡΑ ΟΞΕΑ ΕΚΧΥΛΙΣΜΑΤΩΝ Η Οργανική Χημεία στην Ελλάδα των αρχών του 21 ου αιώνα: Τάσεις και προοπτικές, Θεσσαλονίκη Μάρτιος 2006, Abstract σελ. 9. 54.- SYNTHESIS OF SPHINGOSINE ANALOGUES FROM SERINE V. Constantinou-Kokotou, A. Peristeraki, I. Fotakopoulou, 5 th Hellenic Forum on Bioactive Peptides, Patras, 2006, Abstract P-01, page 45. 55.- ENZYMATIC REMOVAL OF METHYL AND BENZYL ESTERS FROM AMINO ACIDS AND DIPEPTIDES BY CANDIDA ANTARTICA LIPASE A I. Fotakopoulou, E. Barbayianni, M. Schmidt, V. Constantinou-Kokotou, U. Bornscheuer, G. Kokotos. 5 th Hellenic Forum on Bioactive Peptides, Patras, 2006, Abstract P-12, page 50. 56.- FAST REMOVAL OF ALLYL ESTERS BY BACILLUS SUBTILIS ESTERASE I. Fotakopoulou, V. Constantinou-Kokotou, U. Bornscheuer, G. Kokotos. International Symposium on Chemistry, Biology and Medicine, Cyprus 2006, Abstract P, page. 57.- INHIBITION OF GROUP IVA AND GROUP VIA PHOSPHOLIPASE A 2 AND ANTIHYPERALGESIC ACTIVITY OF 2- OXOAMIDE ESTERS G. Kokotos, E. Barbayianni, V. Magrioti, D. Stephens, V. Constantinou-Kokotou, T. L. Yaksh, E. A. Dennis International Symposium on Chemistry, Biology and Medicine, Cyprus 2006, P47. 58.- REMOVAL OF CARBOXYL PROTECTING GROUP BY ESTERASES AND LIPASES CONTAINING THE GGG(A)X MOTIF G. Kokotos, I. Fotakopoulou, E. Barbayianni, M. Schmidt, V. Constantinou-Kokotou, U. T. Bornscheuer Protein Design and Evolution for Biocatalysis, Germany 2006, Abstracts 35. 59.- 41.- ΑΠΟΜΟΝΩΣΗ ΜΕΜΕΤΗ KAI ΒΙΟΤΕΧΝΟΛΟΓΙΚΟΣ ΕΜΠΛΟΥΤΙΣΜΟΣ ΤΩΝ ΙΧΘΥΕΛΑΙΩΝ ΣΕ ω-3 ΚΑΙ ω-6 ΠΟΛΥΑΚΟΡΕΣΤΑ ΛΙΠΑΡΑ ΟΞΕΑ, Βιολέττα Κωνσταντίνου- Κόκοτου, Ημερίδα ΕΠΕΑΕΚ, ΠΥΘΑΓΟΡΑΣ 1, Αθήνα 2007, Abstract σελ.25. 60.- SYNTHESIS OF PROLINE DERIVATIVES CONTAINING 5-THIOXO-1,2,4-OXADIAZOLE AND 2-OXO-1,2,3,5- OXATHIODIAZOLE RINGS AND THEIR ACTIVITY AS ORGANOCATALYSTS FOR MICHAEL REACTION P. Bouzi, V. Constantinou-Kokotou, G. Kokotos, 2nd Hellenic Symposium Organic Synthesis from Chemistry to Biology, Medicine and Materials Science, Athens, 2007, P7. 61.- SULFONAMIDES OF HOMOPROLINE AND γ-proline AS ORGANOCATALYSTS FOR MICHAEL REACTION S. Kousidou, V. Constantinou-Kokotou, G. Kokotos, 2nd Hellenic Symposium Organic Synthesis from Chemistry to Biology, Medicine and Materials Science, Athens, 2007, P8. 61.- NMR STUDY OF ALKYL AND ACYLGLYCEROLS OBTAINED FROM FISH OILS V. Constantinou-Kokotou, G. Antonopoulou, 15 th European Symposium on Organic Chemistry, Dublin 2007, Abstract P58, page 122. 62.- DESIGN AND SYNTHESIS OF 2-OXOAMIDE PHOSPHOLIPASE A 2 INHIBITORS FOR THE TREATMENT OF HYPERALGESIA G. Kokotos, G. Antonopoulou, C. G. Kokotos, C. Baskakis, E. Barbayianni, V. Magrioti, D. Stephens, D. Hadjipavlou-Litina, V. Constantinou-Kokotou, T. L. Yaksh, E. A. Dennis, 3 rd International Conference on Phospholipases A 2 and Lipid Mediators, Italy 2007, Abstracts 186. 63.- SYNTHESIS OF OPTICALLY ACTIVE 2-(NITROMETHYL)-4-OXOACIDS VIA AN ORGANOCATALYTIC MICHAEL REACTION E. Brabayianni, P. Bouzi, S. Kousidou, V. Constantinou-Kokotou, V. Ragoussis, G. Kokotos, 15 th European Symposium on Organic Chemistry, Ireland 2007, P161.

9 64.- SELECTIVE INHIBITION OF SECRETED PHOSPHOLIPASE A 2 BY 2-OXOAMIDES BASED ON α- OR β-amino ACID ESTERS G. Kokotos, E. Barbayianni, V. Magrioti, D. Stephens, V. Constaninou-Kokotou, E. A. Dennis, 10 th International Conference: Bioactive lipids in Cancer, Inflammation, and Related Diseases, Montreal 2007, Abstracts 10. 65.- FAST AND SELECTIVE REMOVAL OF PROPYL AND BUTYL ESTERS BY BACILLUS SUBTILIS ESTERASE E. Barbayianni, C. Drakou, E. Fotakopoulou, V. Constantinou-Kokotou, U. Bornscheuer, G. Kokotos. International Symposium on Catalysis and Fine Chemicals, Singapore 2007, Abstract BC-A0126, pagea010. 66.- BIOACTIVE LIPIDS: STUDY OF ETHER LIPIDS FROM FOOD SUPPLEMENTS BY NMR SPECTROSCOPY P. Dolatzas, V. Constantinou-Kokotou, E. Mikros, G. Kokotos, 13 th Hellenic Symposium on Medicinal Chemistry, Athens, March 2008, p165. 67.- SYNTHESIS OF 2-OXOAMIDES BASED ON SULFONAMIDE ANALOGUES OF γ-amino ACIDS AND THEIR ACTIVITY ON HUMAN PHOSPHOLIPASE A 2 ISOFORMS G. Antonopoulou, V. Magrioti, D. Stephens, V. Constantinou-Kokotou, E. A. Dennis, G. Kokotos, 6 th Hellenic Forum on Bioactive Peptides, Patras, 2008, P7. 68.- SELECTIVE INHIBITION OF HUMAN INTRACELLULAR AND EXTRACELLULAR PHOSPHOLIPASES A 2 BY SYNTHETIC 2- OXOAMIDES AND PERFLUOROKETONES, V. Magrioti, G. Antonopoulou, C. Baskakis, C. G. Kokotos, E. Barbayianni, N. Cotton, D. Stephens, V. Constantinou-Kokotou, E. A. Dennis, G. Kokotos, 6 th Euro Fed Lipid Congress, Athens, 2008, p. 195. 69.- SYNTHETIC ROUTES TO 2-OXO-THIAZOLES, M. Tsakos, V. Magrioti, C. Baskakis, V. Constantinou-Kokotou, G. Kokotos, 3rd Hellenic Symposium Organic Synthesis from Chemistry to Biology, Medicine and Materials Science, P29, Athens 2009, p. 89. 70.- MOLECULAR MODELLING STUDIES OF SECRETED PHOSPHOLIPASE A2 INHIBITION BY NATURAL PRODUCTS, V. Mouchlis, M. Kokotou, F. Symboura, T. Mavromoustakos, V. Constantinou-Kokotou, 3rd Hellenic Symposium Organic Synthesis from Chemistry to Biology, Medicine and Materials Science, P62, Athens 2009, p. 122. 71.- MOLECULAR MODELLING STUDIES OF SECRETED PHOSPHOLIPASE A2 INHIBITION BY OLEUROPEIN, M. Kokotou, V. Mouchlis, T. Mavromoustakos, V. Constantinou-Kokotou, 14 ο Πανελλήνιο Συμπόσιο Φαρμακοχημείας, Θεσσαλονίκη 2010, p. 127. 72.- 1,1,1-Trifluoro-6-(napthalen-2-yl)hexan-2-one: A new potent inhibitor of Ca-independent phospholipase A2 ICMedchem 2010, V. Magrioti, C. Baskakis, Y-H. Hsu, J. Burke, V. Constantinou-Kokotou, E. Dennis, G. Kokotos, Beijin, China 2010, p 179. 73.- POTENT AND SELECTIVE INHIBITION OF HUMAN Ca INDEPENDENT PLA2 BY FLUOROKETONES A. Smyrniotou, A. Nicolaou, V. Magrioti, M. Creason, I. Shah, V. Constantinou-Kokotou, E. Dennis, G. Kokotos, 17 th European Symposium on Organic Chemistry, Crete-Greece 2011, P1.224. 74.- INHIBITION OF Ca INDEPENDENT PLA2 BY 2-OXOAMIDE BASED ON DIPEPTIDES AND ETHER PSEUDODIPEPTIDES A. Smyrniotou, E. Barbayianni, I. Shah, V. Constantinou-Kokotou, E. Dennis, G. Kokotos, 17 th European Symposium on Organic Chemistry, Crete-Greece 2011, P1.325. 75.- STRUCTURE _ACTIVITY RELATIONSHIP STUDIES FOR THE INHIBITION OF HUMAN Ca -INDEPENDENT PLA2 BY FLUOROKETONES A. Smyrniotou, V. Magrioti, A. Nicolaou, V. Magrioti, M. Creason, I. Shah,, E. Dennis, G. Kokotos, V. Constantinou-Kokotou 43 rd IUPAC World Chemistry Congress, San Jouan-Puerto Ricco 2011,P.275 76.- STUDIES ON A REVERSE TURN SCAFFOLD CONTAINING A THIOUREA FUNCTIONALITY M. Zervou, K. Paschalidou, S. Fotaras, V. Constantinou-Kokotou, G. Kokotos, 32 European Peptide Symposium, Athens, Greece 2012, P182, J. Peptide Sci. 2012, 18, S124 3Α. ιδασκαλία 3. ΕΚΠΑΙ ΕΥΤΙΚΗ ΡΑΣΤΗΡΙΟΤΗΤΑ Εργαστήρια. A) Από το 1980 ως σήμερα συμμετέχω στην οργάνωση και διεξαγωγή του εργαστηριακού μαθήματος Γενικής και Ανόργανης Χημείας 1ου εξαμήνου που απευθύνεται στους φοιτητές όλων των τμημάτων του Γ.Π.Α.. B) Από το 1980 ως σήμερα συμμετέχω στην οργάνωση και διεξαγωγή του εργαστηριακού μαθήματος Οργανικής Χημείας του 2ου εξαμήνου που απευθύνεται στους φοιτητές όλων των τμημάτων του Γ.Π.Α.. Προπτυχιακά Μαθήματα. Α) Από το 1990 ως σήμερα διδάσκω με ανάθεση το μάθημα Γενική και Ανόργανη Χημεία 1ου εξαμήνου που απευθύνεται στους φοιτητές όλων των τμημάτων του Γ.Π.Α.. Β) Από το 1990 ως σήμερα διδάσκω με ανάθεση κεφάλαια το μάθημα Οργανική Χημεία 2ου εξαμήνου που απευθύνεται στους φοιτητές όλων των τμημάτων του Γ.Π.Α.. Γ) Από το 1992 ως το 1994 δίδαξα με ανάθεση κεφάλαια του μαθήματος Αναλυτική Χημεία 4ου εξαμήνου που απευθύνεται στους φοιτητές του τμήματος των Γεωργικών Βιομηχανιών του Γ.Π.Α.. Μεταπτυχιακά Μαθήματα Α) Από το 2002 στα μεταπτυχιακά προγράμματα του Τμήματος της Φυτικής Παραγωγής του ΓΠΑ, στο μάθημα «Φασματοσκοπικές Μέθοδοι Ανάλυσης Φυτών» το κεφάλαιο των τερπενίων

10 Β) Από το Φεβρουάριο 2003 στο μεταπτυχιακό του Τμήματος Χημείας του Πανεπιστημίου Αθηνών, «Οργανική σύνθεση και εφαρμογές στη χημική βιομηχανία» στο μάθημα των σακχάρων. Γ) Από το Σεπτέμβριο του 2004, στο μεταπτυχιακό του Γενικού Τμήματος του ΓΠΑ, «Φυσικά Προιόντα», «Απομόνωση, Καθαρισμός, Αναγνώριση, Πιστοποιήση Φυσικών Προιόντων», «Νανοτεχνολογία-Υπερμοριακή Χημεία» 3Β. Συγγραφικό εκπαιδευτικό υλικό Για τις ανάγκες των εργαστηριακών ασκήσεων έχω συγγράψει από το 1982 με τον. Καθηγητή Η. Κουλαδούρο το εργαστηριακό βοήθημα με τίτλο Πρακτικά και Θεωρητικά Θέματα Χημείας προσαρμοσμένο στις ιδιαιτερότητες των τμημάτων του Γ.Π.Α.. Για τις ανάγκες του ιαπανεπιστημιακού Μεταπτυχιακού προγράμματος σπουδών «ΟΡΓΑΝΙΚΗ ΣΥΝΘΕΣΗ» που συντονίζει το Τμήμα Χημείας του Πανεπιστημίου Αθηνών, έχω γράψει σημειώσεις για προχωρημένα μαθήματα στις αντιδράσεις των σακχάρων Για τις ανάγκες του μεταπτυχιακού προγράμματος του Γενικού Τμήματος του ΓΠΑ σημειώσεις των μαθημάτων «Απομόνωση, Καθαρισμός Αναγνώριση, Πιστοποιήση Λιπιδίων και τερπενίων», «Τερπένια», «Μοριακές Μηχανές». 3Γ. Επιστημονικός Υπεύθυνος διδακτορικών διατριβών και μεταπτυχιακών διπλωμάτων ειδίκευσης Μέχρι σήμερα εχουν περατωθεί με εμένα ως επιστημονική υπεύθυνο 3 διδακτορικές διατριβές [Μαγκριώτη B (2003), Περιστεράκη A (2006), Φωτακοπούλου E. (2007)] και 6 μεταπτυχιακά διπλώματα ειδίκευσης [Αντωνοπούλου Γ. (2005), Γιογιός Γ. (2005), Μπούζη Π. (2006), Κοσμάτος Α. (2006), Γεωργαλά Ι. (2007), Nτόλατζας Π. (2008), Σύμπουρα Φ (2010)]. Επισης έχω συμμετάσχει ως μέλος πολλών συμβουλευτικών επιτροπών διδακτορικών διατριβών και διπλωμάτων ειδίκευσης. 3. Εισηγήτρια θεμάτων Χημείας, Θετικής Κατεύθυνσης στις Πανελλαδικές Εξετάσεις Νυκτερινών Λυκείων το 2005. 3Ε. Μέλος της Κεντρικής Επιτροπής Εξετάσεων Νυκτερινών Λυκείων το 2007 και συντονίστρια στις εξετάσεις των μαθημάτων «Χημεία» και «Χημεία-Βιοχημεία». 3ΣΤ. Βαθμολόγηση του μαθήματος «ιδακτική της Χημείας» στις εξετάσεις του ΑΣΕΠ για την πρόσληψη προσωπικού τα έτη, 2005 και 2007. 3Ζ. Κριτής Βιβλίων Χημείας Τεχνικών Λυκείων για τη δευτεροβάθμια εκπαίδευση. 4. ΙΕΘΝΗΣ ΑΝΑΓΝΩΡΙΣΗ Αναφορές στις δημοσιεύσεις από τη διεθνή βιβλιογραφία Αναφέρονται πάνω από 500 στις βάσεις δεδομένων, όπως web of science- science citation index, USA patents. Οργανωτικές επιτροπές συνεδρίων α) Οργάνωση διεθνούς συνεδρίου χρηματοδοτούμενου από Ευρωπαική κοινότητα, Υπουργείο Αιγαίου, Γ.Γ.Ε.Τ από κοινού με το Πανεπιστήμιο Αθηνών. Ο τίτλος του συνεδρίου ήταν Lipases and Lipids: Structure, Function and Biotechnological Applications. Πραγματοποιήθηκε στη Σαντορίνη το 1999. β) Πρόεδρος συνεδρίας στο 4 ο Hellenic Forum of Bioactive Peptides. γ) Μέλος της οργανωτικής επιτροπής του 1 ου, 2 ου και 3 ου Ελληνικού συμποσίου «ΟΡΓΑΝΙΚΗ ΣΥΝΘΕΣΗ ΑΠΟ ΤΗ ΧΗΜΕΙΑ ΣΤΗ ΒΙΟΛΟΓΙΑ, ΤΗΝ ΙΑΤΡΙΚΗ ΚΑΙ ΤΗΝ ΕΠΙΣΤΗΜΗ ΤΩΝ ΥΛΙΚΩΝ» το 2005, 2007, 2009. δ) Συνδιοργανώτρια του 32 ου European Peptide Symposium, στην Αθήνα, Μέγαρο Μουσικής 2-7 Σεπτεμβρίου 2012 Κριτής ερευνητικών εργασιών σε διεθνή περιοδικά 1. Biochimica et Biophysica Acta 2. Chemical Research in Toxicology 3. Molecules 4. Biomacromolecules 5. Journal of Organic Chemistry 6. Journal of Medicinal Chemistry Εκδότης περιοδικής έκδοσης Peptides 2012 (Εds, G Kokotos, V. Constantinou-Kokotou, J. Matsoukas) Proccedings 32d European Peptide Symposium