Supporting Information. Discovery and Characterization of (8S, 9R)-5-Fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-
|
|
|
- Καλλίστρατος Ελευθεριάδης
- 6 χρόνια πριν
- Προβολές:
Transcript
1 Supporting Information Discovery and Characterization of (8S, 9R)-5-Fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H- 1,2,4-triazol-5-yl)-2,7,8,9-tetrahydro-3H-pyrido[4,3,2-de]phthalazin-3-one (BMN 673, talazoparib), a Novel, Highly Potent, and Orally Efficacious Poly(ADP-ribose) Polymerase- 1/2 Inhibitor as an Anticancer Agent Bing Wang,* Daniel Chu, Ying Feng, Yuqiao Shen, Mika Aoyagi-Scharber, Leonard E. Post BioMarin Pharmaceutical Inc., 105 Digital Drive, Novato, California Contents: NMR Spectra of Compound (8S,9R) S2-S5 H-NMR spectrum... S2 C13-NMR spectrum... S3 HMBC-NMR spectrum... S4 HSQC-NMR spectrum... S5 Optical Rotation Measurement for Compound (8S,9R)-47 and (8R, 9S) S6-S7 Single-crystal Structure of Compound (8S,9R) S8-S10 Single-crystal Structure of Compound (2S,3R)-60a... S11-S13 Smiles Strings..... S14-S15 Enantiomeric Purity Analysis of the Compounds in Table S16-S18 Mouse Body Weight in Xenograft Model Studies..... S19-S20 S1
2 PPM nmrb601, DMSO, F1: F2: SW1: 8224 OF1: USER: nmrb DATE: Wed Oct 28 13:19: PTS1d: EX: zg30 PW: 13.8 usec PD: 1.0 sec NA: 8 LB: 0.0 Nuts - $pdata S2
3 PPM nmrb601, DMSO, F1: F2: SW1: OF1: USER: nmrb DATE: Sun Dec 06 18:25: PTS1d: EX: zgpg30 PW: 8.1 usec PD: 2.0 sec NA: 5000 LB: 0.0 Nuts - $pdata S3
4 ppm NAME CP HMBC-DMSO T31 EXPNO 10 PROCNO 1 Date_ Time INSTRUM nmrb601 PROBHD 5 mm PABBO BB- PULPROG hmbcgpndqf TD 4096 SOLVENT DMSO NS 16 DS 16 SWH Hz FIDRES Hz AQ sec RG 203 DW usec DE 6.50 usec TE K CNST D sec D sec D sec D sec IN sec ======== CHANNEL f1 ======== NUC1 1H P usec P usec PL db PL1W W SFO MHz ======== CHANNEL f2 ======== NUC2 13C P usec PL db PL2W W SFO MHz ====== GRADIENT CHANNEL ===== GPNAM1 SINE.100 GPNAM2 SINE.100 GPNAM3 SINE.100 GPZ % GPZ % GPZ % P usec ND0 2 TD 128 SFO MHz FIDRES Hz SW ppm FnMODE QF SI 1024 SF MHz WDW SINE SSB 0 LB 0.00 Hz GB 0 PC 1.40 SI 1024 MC2 QF SF MHz WDW SINE SSB 0 LB 0.00 Hz GB ppm S4
5 ppm ppm S NAME CP HSQC-DMSO T31 EXPNO 10 PROCNO 1 Date_ Time INSTRUM nmrb601 PROBHD 5 mm PABBO BB- PULPROG hsqcedetgp TD 1024 SOLVENT DMSO NS 16 DS 16 SWH Hz FIDRES Hz AQ sec RG 203 DW usec DE 6.50 usec TE K CNST D sec D sec D sec D sec D sec D sec D sec IN sec ZGOPTNS ======== CHANNEL f1 ======== NUC1 1H P usec P usec P usec PL db PL1W W SFO MHz ======== CHANNEL f2 ======== CPDPRG2 garp NUC2 13C P usec P usec PCPD usec PL db PL db PL2W W PL12W W SFO MHz ====== GRADIENT CHANNEL ===== GPNAM1 SINE.100 GPNAM2 SINE.100 GPZ % GPZ % P usec ND0 2 TD 256 SFO MHz FIDRES Hz SW ppm FnMODE Echo-Antiecho SI 1024 SF MHz WDW QSINE SSB 2 LB 0.00 Hz GB 0 PC 1.40 SI 1024 MC2 echo-antiecho SF MHz WDW QSINE SSB 2 LB 0.00 Hz GB 0
6 Optical Rotation of (8S,9R)-47 Report No.: ROA_ L04 Project Code: L04 Sample ID: Remark Rotation Wavelength Cell Path 589 nm 100 mm Specific Rotation Temperature 20 MeOH:CAN:DMF=0.5:0.5: Solvent 1 Instrument RUDOLPH (AUTOPOL V) Automatic Polarimeter Concentration 0.667g/100ml (6.67mg/ml) S6
7 Optical Rotation of (8R,9S)-47 Report No.: ROA_ L04 Project Code: L04 Sample ID: Remark Rotation Wavelength Cell Path 589 nm 100 mm Specific Rotation Temperature 20 MeOH:ACN:DMF=0.5:0.5: Solvent 1 Instrument RUDOLPH (AUTOPOL V) Automatic Polarimeter Concentration 0.667g/100ml (6.67mg/ml) S7
8 ORTEP drawing of (8S,9R)-47 Tosylate (LIMS no ). Atoms are represented by 50% probability anisotropic thermal ellipsoids. S8
9 I. Crystal Data and Data Collection Parameters for (8S,9R)-47 Tosylate formula C 26H 22F 2N 6O 4S formula weight space group P2 1 (No. 4) a, Å (11) b, Å (9) c, Å (10) β, deg (6) V, Å (2) Z 2 d calc, g cm crystal dimensions, mm 0.20 x 0.18 x 0.01 temperature, K 150. radiation (wavelength, Å) Cu K α ( ) monochromator graphite linear abs coef, mm absorption correction applied empirical a transmission factors: min, max 0.643, diffractometer Rigaku Rapid II h, k, l range -14 to 14-7 to to 14 2θ range, deg mosaicity, deg 0.84 programs used SHELXTL F weighting 1/[σ 2 (F o2 )+(0.0293P) P] where P=( F o2 +2F c2 )/3 data collected unique data 4037 R int data used in refinement 4037 cutoff used in R-factor calculations F o2 >2.0σ(F o2 ) data with I>2.0σ(I) 2384 refined extinction coef number of variables 428 largest shift/esd in final cycle 0.00 R(F o) R w(f o2 ) goodness of fit absolute structure determination Flack parameter b (0.04(2)) Hooft parameter c (0.056(19)) Friedel Coverage 82% a CrystalClear: An Integrated Program for the Collection and Processing of Area Detector Data, Rigaku Corporation, b Flack,H. D. Acta Cryst., 1983 A39, 876. c Hooft,R.W.W., Straver,L.H., and Spek, A.L. J. Appl. Cryst., 2008, 41, S9
10 Positional Parameters and Their Estimated Standard Deviations for (8S,9R)-47 Tosylate Atom x y z U(Å 2 ) S (10) (15) (9) (4) F (19) (3) (18) (8) F (2) (3) (2) (11) O (2) (4) (2) (12) O (2) (4) (2) (10) O (3) (4) (3) (10) O (2) (4) (2) (9) N (3) (5) (3) (12) N (3) (5) (3) (14) N (3) (5) (3) (12) N (3) (5) (3) (12) N (3) (6) (3) (12) N (4) (5) (3) (14) C (4) (7) (3) (16) C (4) (7) (3) (16) C (4) (6) (3) (14) C (4) (6) (4) (16) C (4) (6) (4) (17) C (4) (6) (4) (16) C (4) (6) (3) (14) C (4) (6) (4) (16) C (3) (6) (3) (16) C (3) (5) (3) (10)* C (4) (6) (3) (14) C (5) (7) (4) (19) C (4) (7) (4) (19) C (4) (7) (4) (17) C (5) (7) (4) 0.045(2) C (4) (6) (3) (16) C (4) (6) (3) (16) C (5) (6) (4) (19) C (5) (7) (5) 0.052(2) C (5) (8) (5) 0.059(2) C (5) (9) (5) 0.060(2) C (5) (7) (4) 0.047(2) C (7) (19) (9) 0.095(4) C (4) (7) (3) (16) C (5) (6) (5) 0.052(2) C (4) (7) (4) (17) H (3) 0.456(5) 0.294(3) 0.032(14)* H (3) 0.146(5) 0.388(3) 0.029(12)* H (3) 0.308(5) 0.511(3) 0.039(13)* H (3) 0.352(4) 0.498(3) 0.023(11)* H (3) 0.348(6) 0.193(3) 0.056(15)* Starred atoms were refined isotropically U eq = (1/3)Σ iσ j U ija * ia * ja i.a j Hydrogen atoms are included in calculation of structure factors but not refined S10
11 ORTEP drawing of (2S,3R)-60a. Atoms are represented by 50% probability anisotropic thermal ellipsoids. S11
12 Crystal Data and Data Collection Parameters for Compound (2S,3R)-60a formula C 20H 16F 2N 4O 3 formula weight space group P (No. 96) a, Å (2) c, Å (3) V, Å (3) Z 8 d calc, g cm crystal dimensions, mm 0.20 x 0.20 x 0.04 temperature, K 150. radiation (wavelength, Å) Cu K α ( ) monochromator graphite linear abs coef, mm absorption correction applied empirical a transmission factors: min, max 0.769, diffractometer Rigaku Rapid II h, k, l range -9 to 8-6 to to 55 2θ range, deg mosaicity, deg 2.87 programs used SHELXTL F weighting 1/[σ 2 (F o2 )+(0.0461P) P] where P=( F o2 +2F c2 )/3 data collected unique data 3252 R int data used in refinement 3252 cutoff used in R-factor calculations F o2 >2.0σ(F o2 ) data with I>2.0σ(I) 2691 refined extinction coef number of variables 327 largest shift/esd in final cycle 0.00 R(F o) R w(f o2 ) goodness of fit absolute structure determination Flack parameter b (-0.1(2)) Hooft parameter c (-0.08(11)) Friedel Coverage 100% a CrystalClear: An Integrated Program for the Collection and Processing of Area Detector Data, Rigaku Corporation, b Flack,H. D. Acta Cryst., 1983 A39, 876. c Hooft,R.W.W., Straver,L.H., and Spek, A.L. J. Appl. Cryst., 2008, 41, S12
13 Positional Parameters and Estimated Standard Deviations for Compound (2S,3R)-60a Atom x y z U(Å 2 ) F (19) (19) (3) (5) F (19) (19) (3) (5) O (2) (2) (3) (6) O (2) (2) (4) (6) O (2) (2) (4) (6) N (3) (3) (4) (7) N (3) (3) (4) (6) N (3) (3) (5) (8) N (3) (3) (4) (7) C (3) (3) (5) (8) C (3) (4) (5) (8) C (3) (3) (5) (8) C (3) (3) (5) (7) C (3) (3) (5) (7) C (3) (3) (5) (7) C (3) (3) (5) (7) C (3) (3) (5) (8) C (3) (3) (5) (8) C (5) (4) (9) (10) C (3) (3) (6) (8) C (3) (3) (5) (7) C (4) (4) (6) (9) C (5) (4) (8) (12) C (3) (3) (5) (7) C (3) (3) (5) (8) C (4) (3) (6) (8) C (3) (3) (5) (8) C (3) (3) (6) (9) C (3) (3) (5) (8) H (4) 0.783(5) (7) 0.091(13)* H (3) 0.785(3) (5) 0.038(8)* H (3) 0.687(3) (5) 0.023(7)* H (3) 0.414(3) (5) 0.035(8)* H (3) 0.500(3) (6) 0.045(8)* H (4) 0.424(3) (6) 0.068(10)* H (3) 0.826(3) (6) 0.052(9)* H (4) 0.879(4) (6) 0.061(10)* H (4) 0.593(4) (6) 0.061(10)* H (4) 0.536(4) (5) 0.054(9)* H10A 1.058(4) 0.159(4) (7) 0.071(11)* H10B 1.185(4) 0.243(4) (6) 0.061(10)* H10C 1.068(4) 0.142(4) (7) 0.071(12)* H14A 0.770(5) 0.080(5) (9) 0.116(16)* H14B 0.739(5) 0.103(5) (8) 0.106(15)* H14C 0.625(6) 0.184(6) (9) 0.131(19)* Starred atoms were refined isotropically U eq = (1/3)Σ iσ j U ija * ia * ja i.a j Hydrogen atoms are included in calculation of structure factors but not refined S13
14 Compound Smiles PARP-1 Enzyme Cellular PAR TMZ Chemosensitizationᵈ Capan-1 rlm IC₅₀ (nm)ᵃ inhibition GI₅₀ (µm)ᵇ (BRCA2 mutant) T1/2 EC₅₀ (nm)ᵇ EC₅₀ (µm)ᵇ (min)ᵃ 13 O=C1NN=C2C(C3=CC=CC=C3)C(C4=CC=CC=C4)NC5=CC=CC1=C O=C1NN=C2C(C3=CC=C(CN(C)C)C=C3)C(C4=CC=CC=C4)NC5=CC=CC1=C O=C1NN=C2C(C3=CC=CC=C3)C(C4=CC=C(CN(C)C)C=C4)NC5=CC=CC1=C O=C1NN=C2C(C3=CC=CC(CN(C)C)=C3)C(C4=CC=CC=C4)NC5=CC=CC1=C O=C1NN=C2C(C3=CC=CC=C3)C(C4=CC(CN(C)C)=CC=C4)NC5=CC=CC1=C O=C1NN=C2C(C3=CC=C(CN(C)C)C=C3)C(C4=CC=C(CN(C)C)C=C4)NC5=CC=CC1=C > O=C1NN=C2C(C3=CC=C(C(C)C)C=C3)C(C4=CC=C(CN(C)C)C=C4)NC5=CC=CC1=C O=C1NN=C2C(C3=CC=C(C)C=C3)C(C4=CC=C(CN(C)C)C=C4)NC5=CC=CC1=C O=C1NN=C2C(C3=CC=C(C(F) (F)F)C=C3)C(C4=CC=C(CN(C)C)C=C4)NC5=CC=CC1=C O=C1NN=C2C(C3=CC=C(F)C=C3)C(C4=CC=C(CN(C)C)C=C4)NC5=CC=CC1=C O=C1NN=C2C(C3=CC=CC=C3)C(C4=CC=C(CN(C)C)C=C4)NC5=CC(F)=CC1=C O=C1NN=C2C(C3=CC=C(F)C=C3)C(C4=CC=C(CN(C)C)C=C4)NC5=CC(F)=CC1=C O=C1NN=C2C(C3=CC=CC=C3)C(C4=CC=C(CN5CCN(C)CC5)C=C4)NC6=CC=CC1=C O=C1NN=C2C(C3=CC=CC=C3)C(C4=CC=C(CN5CCCC5)C=C4)NC6=CC=CC1=C O=C1NN=C2C(C3=CC=CC=C3)C(C4=CC=C(CN5CCC5)C=C4)NC6=CC=CC1=C O=C1NN=C2C(C3=CC=C(F)C=C3)C(C4=CC=C(CN5CCCC5)C=C4)NC6=CC=CC1=C O=C1NN=C2C(C3=CC=C(F)C=C3)C(C4=CC=C(CN5CCC5)C=C4)NC6=CC=CC1=C O=C1NN=C2C(C3=CC=NC=C3)C(C4=CC=NC=C4)NC5=CC=CC1=C > O=C1NN=C2C(C3=CC=CC=N3)C(C4=CC=CC=N4)NC5=CC=CC1=C O=C1NN=C2C(C3=CC=CN=C3)C(C4=CN=CC=C4)NC5=CC=CC1=C O=C1NN=C2C(C3=NC=CN3C)C(C4=NC=CN4C)NC5=CC=CC1=C O=C1NN=C2C(C3CCCNC3)C(C4=CN=CC=C4)NC5=CC=CC1=C O=C1NN=C2C(C(C)C)C(C3=CC=CC=C3)NC4=CC=CC1=C O=C1NN=C2C(C3=CC=CC=C3)C(C4=NC=CN4C)NC5=CC=CC1=C > O=C1NN=C2C(C3=NC=CN3C)C(C4=CC=CC=C4)NC5=CC=CC1=C O=C1NN=C2C(C3=NC=CN3C)C(C4=CC=C(F)C=C4)NC5=CC=CC1=C > O=C1NN=C2C(C3=NC=CN3C)C(C4=CC=CC=C4)NC5=CC(F)=CC1=C O=C1NN=C2C(C3=NC=CS3)C(C4=CC=C(F)C=C4)NC5=CC=CC1=C O=C1NN=C2C(C3=CC=NN3C)C(C4=CC=C(F)C=C4)NC5=CC=CC1=C > O=C1NN=C2C(C3=NC=CN3C)C(C4=CC=C(C(F)(F)F)C=C4)NC5=CC=CC1=C O=C1NN=C2C(C3=NC=CN3C)C(C4=CC=CC=C4)NC5=CC(Cl)=CC1=C O=C1NN=C2C(C3=NC=CN3C)C(C4=CC=C(F)C=C4)NC5=CC(F)=CC1=C O=C1NN=C2C(C3=NC=NN3C)C(C4=CC=CC=C4)NC5=CC=CC1=C > O=C1NN=C2C(C3=NC=NN3C)C(C4=CC=CC=C4)NC5=CC(F)=CC1=C O=C1NN=C2C(C3=NN=CN3C)C(C4=CC=CC=C4)NC5=CC=CC1=C > O=C1NN=C2C(C3=NC=NN3C)C(C4=CC=C(F)C=C4)NC5=CC=CC1=C > O=C1NN=C2C(C3=NC=NN3C)C(C4=CC=C(F)C=C4)NC5=CC(F)=CC1=C O=C1NN=C2C(C3=NC=NN3C)C(C4=CC=C(NC(C)=O)C=C4)NC5=CC(F)=CC1=C > O=C1NN=C2C(C3=NC=NN3C)C(C4=CN=CN=C4)NC5=CC(F)=CC1=C O=C1NN=C2C(C3=NC=NN3C)C(C4=CC=NN4C)NC5=CC(F)=CC1=C O=C1NN=C2C(C3=NC=NN3C)C(C4=CC=C(C#N)C=C4)NC5=CC(F)=CC1=C (Rucaparib) FC1=CC2=C3C(NC(C4=CC=C(CNC)C=C4)=C3CCNC2=O)=C ᵃ Mean of duplicate determinations. ᵇ Mean of triplicate determinations. ᵈ TMZ sensitization condition: the concentration (µm) of TMZ that kills 50% of the treated cells (GI50) in the presence of 0.4 µm of PARP inhibitors S14
15 Compound Smiles PARP-1 Cellular PAR TMZ Chemo- Capan-1 Enzyme inhibition sensitizationᵈ (BRCA2 deficient) IC₅₀ (nm)ᵃ EC₅₀ (nm)ᵇ GI₅₀ (µm)ᵇ EC₅₀ (nm)ᵇ (8R,9S) > 10, (8S,9R) (8R,9S) (8S,9R) (8S,9R) (8R,9S) (8S,9R) (8R,9S) (8S,9R) (8R,9S)-47 O=C1NN=C2[C@@H](C3=NC=NN3C)[C@H](C4=CC=C(F)C=C4)NC5=CC(F)=CC1=C ᵃ Mean of duplicate determinations. ᵇ Mean of triplicate determinations. ᵈ TMZ sensitization condition: the concentration (nm) of a PARP inhibitor that kills 50% of the treated cells (GI50) in the presence of 200 µm of TMZ is reported. S15
16 Enantiomeric Purity Analysis of the Compounds in Table 3 S16
17 Enantiomeric Purity Analysis of the Compounds in Table 3 (cont d) S17
18 Enantiomeric Purity Analysis of the Compounds in Table 3 (cont d) S18
19 S19
20 S20
Supporting Information. Route to benzo- and pyrido-fused 1,2,4-triazinyl radicals via N'-(het)aryl- N'-[2-nitro(het)aryl]hydrazides
![Supporting Information. Route to benzo- and pyrido-fused 1,2,4-triazinyl radicals via N'-(het)aryl- N'-[2-nitro(het)aryl]hydrazides](/thumbs/93/112488784.jpg "Supporting Information. Route to benzo- and pyrido-fused 1,2,4-triazinyl radicals via N'-(het)aryl- N'-[2-nitro(het)aryl]hydrazides")
Supporting Information Route to benzo- and pyrido-fused 1,2,4-triazinyl radicals via N'-(het)aryl- N'-[2-nitro(het)aryl]hydrazides Andrey A. Berezin, Georgia Zissimou, Christos P. Constantinides, Yassine
IV. ANHANG 179. Anhang 178
Anhang 178 IV. ANHANG 179 1. Röntgenstrukturanalysen (Tabellen) 179 1.1. Diastereomer A (Diplomarbeit) 179 1.2. Diastereomer B (Diplomarbeit) 186 1.3. Aldoladdukt 5A 193 1.4. Aldoladdukt 13A 200 1.5. Aldoladdukt
Enantioselective Synthesis of the Anti-inflammatory Agent ( )-Acanthoic Acid
Enantioselective Synthesis of the Anti-inflammatory Agent ( )-Acanthoic Acid Taotao Ling, a Chinmay Chowdhury, a Bryan A. Kramer, a Binh G. Vong, a Michael A. Palladino b and Emmanuel A. Theodorakis a
Supporting Information
Supporting Information Vinylogous elimination/heck coupling/allylation domino reactions: access to 2- substituted 2,3-dihydrobenzofurans and indolines Jianguo Yang, *, Hanjie Mo, Xiuxiu Jin, Dongdong Cao,
Antioxidant Activities of Chemical Constituents Isolated from Echinops orientalis Trauv.
Supporting Information Rec. Nat. Prod. :1 (014) 3-36 Antioxidant Activities of Chemical Constituents Isolated from Echinops orientalis Trauv. Ramazan Erenler 1, SakineYilmaz 1, useyin Aksit 1, zkan Sen
Nickel and Platinum PCP Pincer Complexes Incorporating an Acyclic Diaminoalkyl Central Moiety Connecting Imidazole or Pyrazole Rings
ickel and Platinum PCP Pincer Complexes Incorporating an Acyclic Diaminoalkyl Central Moiety Connecting Imidazole or Pyrazole Rings Braulio M. Puerta Lombardi, Rudy M. Braun, Chris Gendy, Chia Yun Chang,
Fischer Indole Synthesis in Low Melting Mixtures
Fischer Indole Synthesis in Low Melting Mixtures Sangram Gore, a,b Sundarababu Baskaran* a and Burkhard König* b Supporting Information Table of Contents: General Information General Procedure for the
Enantioselective Organocatalytic Michael Addition of Isorhodanines. to α, β-unsaturated Aldehydes
Electronic Supplementary Material (ESI) for Organic & Biomolecular Chemistry. This journal is The Royal Society of Chemistry 2016 Enantioselective Organocatalytic Michael Addition of Isorhodanines to α,
Cycloaddition of Homochiral Dihydroimidazoles: A 1,3-Dipolar Cycloaddition Route to Optically Active Pyrrolo[1,2-a]imidazoles
![Cycloaddition of Homochiral Dihydroimidazoles: A 1,3-Dipolar Cycloaddition Route to Optically Active Pyrrolo[1,2-a]imidazoles](/thumbs/89/100111450.jpg "Cycloaddition of Homochiral Dihydroimidazoles: A 1,3-Dipolar Cycloaddition Route to Optically Active Pyrrolo[1,2-a]imidazoles")
X-Ray crystallographic data tables for paper: Supplementary Material (ESI) for Organic & Biomolecular Chemistry Cycloaddition of Homochiral Dihydroimidazoles: A 1,3-Dipolar Cycloaddition Route to Optically
Supporting Information
One-Pot, Three-Component Assembly of Indoloquinolines: Total Synthesis of Isocryptolepine Alexander V. Aksenov,* Dmitrii A. Aksenov, Naila A. Orazova, Nicolai A. Aksenov, Georgii D. Griaznov, Annelise
Supporting Information. Research Center for Marine Drugs, Department of Pharmacy, State Key Laboratory
Supporting Information Dysiherbols A C and Dysideanone E, Cytotoxic and NF-κB Inhibitory Tetracyclic Meroterpenes from a Dysidea sp. Marine Sponge Wei-Hua Jiao,, Guo-Hua Shi,, Ting-Ting Xu,, Guo-Dong Chen,
Patrycja Miszczyk, Dorota Wieczorek, Joanna Gałęzowska, Błażej Dziuk, Joanna Wietrzyk and Ewa Chmielewska. 1. Spectroscopic Data.
; doi:10.3390/molecules22020254 S1 of S23 Supplementary Materials: Reaction of 3-Amino-1,2,4-Triazole with Diethyl Phosphite and Triethyl Orthoformate: Acid-Base Properties and Antiosteoporotic Activities
Pyrrolo[2,3-d:5,4-d']bisthiazoles: Alternate Synthetic Routes and a Comparative Study to Analogous Fused-ring Bithiophenes
![Pyrrolo[2,3-d:5,4-d']bisthiazoles: Alternate Synthetic Routes and a Comparative Study to Analogous Fused-ring Bithiophenes](/thumbs/92/108867714.jpg "Pyrrolo[2,3-d:5,4-d']bisthiazoles: Alternate Synthetic Routes and a Comparative Study to Analogous Fused-ring Bithiophenes")
SUPPORTING INFORMATION Pyrrolo[2,3-d:5,4-d']bisthiazoles: Alternate Synthetic Routes and a Comparative Study to Analogous Fused-ring Bithiophenes Eric J. Uzelac, Casey B. McCausland, and Seth C. Rasmussen*
Supporting Information File 2. Crystallographic data of syn-bis-quinoxaline, 16c CH 3 CO 2 C 2 H 5 ;
Supporting Information File 2 Crystallographic data of syn-bis-quinoxaline, 16c CH 3 CO 2 C 2 H 5 ; Preparation, structures and host guest chemistry of fluorinated syn-bisquinoxaline molecular tweezers
Supplementary Information. Living Ring-Opening Polymerization of Lactones by N-Heterocyclic Olefin/Al(C 6 F 5 ) 3
Supplementary Information Living Ring-Opening Polymerization of Lactones by N-Heterocyclic Olefin/Al(C 6 F 5 ) 3 Lewis Pairs: Structures of Intermediates, Kinetics, and Mechanism Qianyi Wang, Wuchao Zhao,
chlorostibine Iou-Sheng Ke and François P. Gabbai Department of Chemistry, Texas A&M University, College Station, TX
σ-donor/acceptor confused ligands: The case of a chlorostibine Iou-Sheng Ke and François P. Gabbai Department of Chemistry, Texas A&M University, College Station, TX 77843-3255. *To whom correspondence
Electronic Supplementary Information (ESI)
Electronic Supplementary Material (ESI) for RSC Advances. This journal is The Royal Society of Chemistry 2016 Electronic Supplementary Information (ESI) Cyclopentadienyl iron dicarbonyl (CpFe(CO) 2 ) derivatives
Supplementary information
Electronic Supplementary Material (ESI) for rganic & Biomolecular Chemistry. This journal is The Royal Society of Chemistry 2015 Supplementary information Hybrids of acylated homoserine lactone and nitric
Photo-Induced Self-Assembly of Pt(II)-Linked Rings and Cages via the Photolabilization of a Pt(II) Pyridine Bond
Photo-Induced Self-Assembly of Pt(II)-Linked Rings and Cages via the Photolabilization of a Pt(II) Pyridine Bond Ken-ichi Yamashita, Kei-ichi Sato, Masaki Kawano and Makoto Fujita* Contents; Figure S1.
Multifunctinality and Crystal Dynamics of Highly Stable Porous Metal-Organic Framework [Zn 4 O(NTB) 2 ]
![Multifunctinality and Crystal Dynamics of Highly Stable Porous Metal-Organic Framework [Zn 4 O(NTB) 2 ]](/thumbs/92/109256432.jpg "Multifunctinality and Crystal Dynamics of Highly Stable Porous Metal-Organic Framework [Zn 4 O(NTB) 2 ]")
Supporting Information Multifunctinality and Crystal Dynamics of Highly Stable Porous Metal-Organic Framework [Zn 4 O(NTB) 2 ] Eun Young Lee, Seung Yeon Jang, and Myunghyun Paik Suh* School of Chemistry,
Single Crystal X-Ray Structure Determination of Compounds 8a, 8b and 11a
Single Crystal X-Ray Structure Determination of Compounds 8a, 8b and 11a General: Preliminary examination and data collection were carried out on an area detecting system (Kappa-CCD; Nonius) using graphite-monochromated
Supporting Information. Palladium Complexes with Bulky Diphosphine. Synthesis of (Bio-) Adipic Acid from Pentenoic. Acid Mixtures.
Supporting Information Palladium Complexes with Bulky Diphosphine Ligands as Highly Selective Catalysts for the Synthesis of (Bio-) Adipic Acid from Pentenoic Acid Mixtures. Choon Heng Low, James D. Nobbs,*
Experimental. Crystal data
organic compounds Acta Crystallographica Section E Structure Reports Online ISSN 1600-5368 Terephthalic acid 2,2 0 -dimethyl-1,1 0 - (butane-1,4-diyl)dibenzimidazole (2/3) Hui Jiang and Xian-Wu Dong* Department
Synthesis of N-Aryl and N-Alkyl Anthranilic Acids via S N Ar Reaction of Unprotected 2-Fluoro and 2- Methoxybenzoic Acids by Lithioamides
Synthesis of N-Aryl and N-Alkyl Anthranilic Acids via S N Ar Reaction of Unprotected 2-Fluoro and 2- Methoxybenzoic Acids by Lithioamides SUPPORTING INFORMATION Mickaël Belaud-Rotureau, Tin Thanh Le, Thi
Electronic supplementary information (ESI) Bodipy functionalized ortho-carborane dyads for low-energy photosensitization
Electronic Supplementary Material (ESI) for Dalton Transactions. This journal is The Royal Society of Chemistry 2014 Electronic supplementary information (ESI) Bodipy functionalized ortho-carborane dyads
Stereochemistry and mechanistic insight in the [2 k +2 i +2 i ] annulations of ketenes and imines
![Stereochemistry and mechanistic insight in the [2 k +2 i +2 i ] annulations of ketenes and imines](/thumbs/83/87678994.jpg "Stereochemistry and mechanistic insight in the [2 k +2 i +2 i ] annulations of ketenes and imines")
Stereochemistry and mechanistic insight in the [2 k +2 i +2 i ] annulations of ketenes and imines Zhanhui Yang, Wei He, Baoxiang Cheng and Jiaxi Xu* State Key Laboratory of Chemical Resource Engineering,
Supporting Information
Supporting Information 1,3,5-Triazapentadienes by Nucleophilic Addition to 1,3- and 1,4-Dinitriles - Sterically Constrained Examples by Incorporation into Cyclic Peripheries: Synthesis, Aggregation and
SUPPLEMENTARY MATERIAL. A Facile and Convenient Approach for the Synthesis of Novel Sesamol-Oxazine and Quinoline- Oxazine Hybrids
10.1071/CH17272_AC CSIRO 2017 Australian Journal of Chemistry 2017, 70(12), 1285-1290 SUPPLEMENTARY MATERIAL A Facile and Convenient Approach for the Synthesis of Novel Sesamol-Oxazine and Quinoline- Oxazine
NH-Type of chiral Ni(II) complexes of glycine Schiff base: design, structural evaluation, reactivity and synthetic applications
Supporting Information NH-Type of chiral Ni(II) complexes of glycine Schiff base: design, structural evaluation, reactivity and synthetic applications Mackenzie Bergagnini, a Kazunobu Fukushi, b Jianlin
Synthesis and Biological Evaluation of Novel Acyclic and Cyclic Glyoxamide derivatives as Bacterial Quorum Sensing and Biofilm Inhibitors
Electronic Supplementary Material (ESI) for Organic & Biomolecular Chemistry. This journal is The Royal Society of Chemistry 2017 Synthesis and Biological Evaluation of Novel Acyclic and Cyclic Glyoxamide
Supporting Information
Supporting Information Chloroyttrium 2-(1-(arylimino)alkyl)quinolin-8-olate Complexes: Synthesis, Characterization, and Catalysis of the Ring-Opening Polymerization (ROP) of ε- Caprolactone (ε-cl) Wenjuan
C H Activation of Cp* Ligand Coordinated to Ruthenium. Center: Synthesis and Reactivity of a Thiolate-Bridged
Supporting Information C H Activation of Cp* Ligand Coordinated to Ruthenium Center: Synthesis and Reactivity of a Thiolate-Bridged Diruthenium Complex Featuring Fulvene-like Cp* Ligand Xiaoxiao Ji, Dawei
Synthesis, Crystal Structure and Supramolecular Understanding of 1,3,5-Tris(1-phenyl-1H-pyrazol-5- yl)benzenes
Supplementary information Synthesis, Crystal Structure and Supramolecular Understanding of 1,3,5-Tris(1-phenyl-1H-pyrazol-5- yl)benzenes Marcos A. P. Martins 1 *, Alexandre R. Meyer 1, Paulo R. S. Salbego
Supplementary Material
Supplementary Material Synthesis of bis-oxathiaaza[3.3.3]propellanes via nucleophilic addition of (1,ω-alkanediyl)bis(N'-organylthioureas) on dicyanomethylene-1,3-indanedione Alaa A. Hassan, a * Kamal
Electronic Supplementary Information (ESI)
Electronic Supplementary Material (ESI) for Dalton Transactions. This journal is The Royal Society of Chemistry 2016 Electronic Supplementary Information (ESI) CPh 3 as a functional group in P-heterocyclic
Supporting Information for. Catalytic C H α-trifluoromethylation of α,β-unsaturated Carbonyl Compounds
Supporting Information for Catalytic C H α-trifluoromethylation of α,β-unsaturated Carbonyl Compounds Zhongxue Fang, a Yongquan Ning, a Pengbing Mi, a Peiqiu Liao, a Xihe Bi* a,b a Department of Chemistry,
Electronic Supporting Information. 3-Aminothiophenecarboxylic acid (3-Atc)-induced folding in peptides
Electronic Supplementary Material (ESI for New Journal of Chemistry. This journal is The Royal Society of Chemistry and the Centre National de la Recherche Scientifique 2016 Electronic Supporting Information
metal-organic compounds
metal-organic compounds Acta Crystallographica Section E Structure Reports Online ISSN 1600-5368 [1,2-Bis(1H-benzimidazol-2-yl-jN 3 )- ethane]dichloridozinc(ii) Yan-Ling Zhou, a Ming-Hua Zeng a and Seik
Supporting Information. Pd(0)-Catalyzed Decarboxylative Coupling and Tandem C H Arylation/Decarboxylation for the. Synthesis of Heteroaromatic Biaryls
Supporting Information Pd()-Catalyzed Decarboxylative Coupling and Tandem C H Arylation/Decarboxylation for the Synthesis of Heteroaromatic Biaryls Debkumar andi, Yang-Ming Jhou, Jhen-Yi Lee, Bing-Chiuan
Table S1. Summary of data collections and structure refinements for crystals 1Rb-1h, 1Rb-2h, and 1Rb-4h.
Supporting Information [NH 3 CH 3 ] [In SbS 9 SH]: A novel methylamine-directed indium thioantimonate with Rb + ion-exchange property Kai-Yao Wang a,b, Mei-Ling Feng a, Jian-Rong Li a and Xiao-Ying Huang
Experimental. Crystal data. C 37 H 38 N 4 O 6 M r = Monoclinic, P2 1 a = (2) Å b = (7) Å c = (2) Å = 112.
organic compounds Acta Crystallographica Section E Structure Reports Online ISSN 1600-5368 Pheophorbide b ethyl ester from a chlorella vulgaris dietary supplement Experimental Crystal data C 37 H 38 N
ANNEXE 2 : SPECTRES DE RÉSONANCE MAGNÉTIQUE NUCLÉAIRE
ANNEXE 2 : SPECTRES DE RÉSONANCE MAGNÉTIQUE NUCLÉAIRE 175 4-Oxopentyl acetate (1-9) 27.56 17.91 63.49 39.76 29.86 22.66 2.82 2. 1.97 2.91 2.96 2.9 4. 3.98 3.96 2.47 2.44 2.42 2.7 1.95 1.86 1.84 1.82 1.79
Synthesis of New Heteroscorpionate Iridium(I) and Iridium(III) Complexes
Electronic Supplementary Material (ESI) for Dalton Transactions. This journal is The Royal Society of Chemistry 2015 ELECTRONIC SUPPORTING INFORMATION For Synthesis of New Heteroscorpionate Iridium(I)
SUPPORTING INFORMATION. Diastereoselective synthesis of nitroso acetals from (S,E)- -aminated
SUPPORTING INFORMATION for Diastereoselective synthesis of nitroso acetals from (S,E)- -aminated nitroalkenes via multicomponent [4 + 2]/[3 + 2] cycloadditions promoted by LiCl or LiClO 4 Leandro Lara
Supporting Information for Substituent Effects on the Properties of Borafluorenes
Supporting Information for Substituent Effects on the Properties of Borafluorenes Mallory F. Smith, S. Joel Cassidy, Ian A. Adams, Monica Vasiliu, Deidra L. Gerlach, David Dixon*, Paul A. Rupar* Department
Zebra reaction or the recipe for heterodimeric zinc complexes synthesis
Electronic Supplementary Material (ESI) for Dalton Transactions. This journal is The Royal Society of Chemistry 05 Supporting Information Zebra reaction or the recipe for heterodimeric zinc complexes synthesis
Fused Bis-Benzothiadiazoles as Electron Acceptors
Fused Bis-Benzothiadiazoles as Electron Acceptors Debin Xia, a,b Xiao-Ye Wang, b Xin Guo, c Martin Baumgarten,*,b Mengmeng Li, b and Klaus Müllen*,b a MIIT Key Laboratory of ritical Materials Technology
Supporting Information
Electronic Supplementary Material (ESI) for Dalton Transactions. This journal is The Royal Society of Chemistry 2016 Supporting Information Abnormal N-Heterocyclic Carbene Based Nickel Complex for Catalytic
Supporting Information
Supporting Information for Pyrene nucleobase conjugates: synthesis, oligonucleotide binding and confocal bioimaging studies Artur Jabłoński 1, Yannic Fritz 2, Hans-Achim Wagenknecht 2, Rafał Czerwieniec
Supporting Information. Copyright Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, 2008
Supporting Information Copyright Wiley-VC Verlag Gmb & Co. KGaA, 69451 Weinheim, 2008 Copper Complexes of Mono- and Ditopic [(Methylthio)methyl]borates: Missing Links and Linked Systems En Route to Copper
Supporting Information
Supporting Information Montmorillonite KSF-Catalyzed One-pot, Three-component, Aza-Diels- Alder Reactions of Methylenecyclopropanes With Arylaldehydes and Aromatic Amines Li-Xiong Shao and Min Shi* General
data reports 2-(4-Methylphenyl)-2-oxoethyl 3,4-dimethoxybenzoate Structure description Synthesis and crystallization Refinement
2-(4-Methylphenyl)-2-oxoethyl 3,4-dimethoxybenzoate ISSN 2414-3146 Shamantha Kumar, a Chandra, b B. M. Rajesh, c M. Mahendra b and B. H. Doreswamy a * Received 27 December 2016 Accepted 2 February 2017
SUPPORTING INFORMATION. Pyramidanes: The Covalent Form of the Ionic Compounds
SUPPORTING INFORMATION Pyramidanes: The Covalent Form of the Ionic Compounds Vladimir Ya. Lee, 1 * Olga A. Gapurenko, 2 Yuki Ito, 1 Takahiko Meguro, 1 Haruka Sugasawa, 1 Akira Sekiguchi, 1 *, Ruslan M.
Supporting Information
Electronic Supplementary Material (ESI) for Organic & Biomolecular Chemistry. This journal is The Royal Society of Chemistry 2017 Supporting Information Domino reaction of cyclic sulfamidate imines with
Triclinic, P1 a = (2) Å b = (3) Å c = (4) Å = (1) = (1) = (1) Data collection.
organic compounds Acta Crystallographica Section E Structure Reports Online ISSN 1600-5368 Benzyl N 0 -(4,6-dimethoxy-2-methyl-3- phenyl-1h-indol-7-ylmethylene)- hydrazinecarbodithioate Hamid Khaldei,
Bloco A, Cidade Universitária, Ilha do Fundão, Rio de Janeiro, RJ, Brazil. Contents Pages
Electronic Supplementary Material (ESI) for Organic & Biomolecular Chemistry. This journal is The Royal Society of Chemistry 2016 Supporting Information Copper(II) Catalyzed Synthesis of Novel Helical
Supporting Information
Supporting Information Wiley-VCH 27 69451 Weinheim, Germany Supplementary Figure 1. Synthetic results as detected by XRD (Cu-Kα). Simulation pattern of MCM-68 Relative Intensity / a.u. YNU-2P Conventional
Supporting information. An unusual bifunctional Tb-MOF for highly sensing of Ba 2+ ions and remarkable selectivities of CO 2 /N 2 and CO 2 /CH 4
Electronic Supplementary Material (ESI) for Journal of Materials Chemistry A. This journal is The Royal Society of Chemistry 2015 Supporting information An unusual bifunctional Tb-MOF for highly sensing
Supporting Information
Supporting Information Aluminum Complexes of N 2 O 2 3 Formazanate Ligands Supported by Phosphine Oxide Donors Ryan R. Maar, Amir Rabiee Kenaree, Ruizhong Zhang, Yichen Tao, Benjamin D. Katzman, Viktor
Supporting Information-B. A Facile Iterative Synthesis of 2,5-Terpyrimidinylenes as Non-peptidic α-helical Mimics
Supporting Information-B A Facile Iterative Synthesis of 2,5-Terpyrimidinylenes as on-peptidic α-helical Mimics Laura Anderson, 1,2 Mingzhou Zhou, 1,2 Vasudha Sharma, 2 Jillian M. McLaughlin, 2 Daniel.
Supporting Information
Electronic Supplementary Material (ESI) for Organic & Biomolecular Chemistry. This journal is The Royal Society of Chemistry 2018 Supporting Information Crotonols A and B, Two Rare Tigliane Diterpenoid
Nitric oxide (NO) reactivity studies on mononuclear Iron(II) complexes supported by a tetradentate Schiff base Ligand
Electronic Supplementary Material (ESI) for RSC Advances. This journal is The Royal Society of Chemistry 2016 Nitric oxide (NO) reactivity studies on mononuclear Iron(II) complexes supported by a tetradentate
metal-organic compounds
metal-organic compounds Acta Crystallographica Section E Structure Reports Online ISSN 1600-5368 2,2 0 -Biimidazolium hexaaquamanganese(ii) bis(sulfate) Mukhtar A. Kurawa, Christopher J. Adams and A. Guy
College of Life Science, Dalian Nationalities University, Dalian , PR China.
Electronic Supplementary Material (ESI) for New Journal of Chemistry. This journal is The Royal Society of Chemistry and the Centre National de la Recherche Scientifique 2018 Postsynthetic modification
Table of Contents 1 Supplementary Data MCD
Electronic Supplementary Material (ESI) for Dalton Transactions. This journal is The Royal Society of Chemistry 2017 Supporting Information for Magnetic circular dichroism and density functional theory
Supporting Information
Electronic Supplementary Material (ESI) for Dalton Transactions. This journal is The Royal Society of Chemistry 2017 Supporting Information Phosphorescent Pt(II) complexes bearing a monoanionic C^N^N luminophore
Supporting Information for: Intramolecular Hydrogen Bonding-Assisted Cyclocondensation of. 1,2,3-Triazole Synthesis
Supporting Information for: Intramolecular Hydrogen Bonding-Assisted Cyclocondensation of α-diazoketones with Various Amines: A Strategy for Catalytic Wolff 1,2,3-Triazole Synthesis Zikun Wang, a Xihe
Supporting Information
Supporting Information Molecular Cage Impregnated Palladium Nanoparticles: Efficient, Additive-Free Heterogeneous Catalysts for Cyanation of Aryl Halides. Bijnaneswar Mondal, Koushik Acharyya, Prodip Howlader
Tunable Ligand Emission of Napthylsalophen Triple-Decker Dinuclear Lanthanide (III) Sandwich Complexes
Electronic Supplementary Material (ESI) for Dalton Transactions. This journal is The Royal Society of Chemistry 2017 Supplemental Information Tunable Ligand Emission of Napthylsalophen Triple-Decker Dinuclear
2. Experimental Crystal data. C 22 H 29 F 3 O 5 S M r = Orthorhombic, P a = (10) Å b = (12) Å c = 27.
data reports ISSN 2056-9890 Crystal structure of 3b-acetoxyandrosta- 5,16-dien-17-yl trifluoromethanesulfonate Shengjun Zhou, a Huaqi Huang, b Ting Zhang, b Dangfeng Wang b and Rongbin Huang b * a Hangzhou
SUPPORTING INFORMATION
SUPPORTING INFORMATION Heronamides A C, new polyketide macrolactams from an Australian marine-derived Streptomyces sp. A biosynthetic case for synchronized tandem electrocyclization. Ritesh Raju, Andrew
Total Synthesis of (+) Vicenin-2
Supporting Information Total Synthesis of (+) Vicenin-2 Thanh C. Ho, Haruki Kamimura, Ken Ohmori,* and Keisuke Suzuki* Department of Chemistry, Tokyo Institute of Technology, O-okayama, Meguro-ku, Tokyo
Supplementary Materials for. Kinetic and Computational Studies on Pd(I) Dimer- Mediated Halogen Exchange of Aryl Iodides
Supplementary Materials for Kinetic and Computational Studies on Pd(I) Dimer- Mediated Halogen Exchange of Aryl Iodides Indrek Kalvet, a Karl J. Bonney, a and Franziska Schoenebeck a * a Institute of Organic
organic papers 7,8-Dihydroxy-3-methyl-10-oxo-1H,10Hpyrano[4,3-b]chromene-9-carboxylic
![organic papers 7,8-Dihydroxy-3-methyl-10-oxo-1H,10Hpyrano[4,3-b]chromene-9-carboxylic](/thumbs/91/105777620.jpg "organic papers 7,8-Dihydroxy-3-methyl-10-oxo-1H,10Hpyrano[4,3-b]chromene-9-carboxylic")
organic papers Acta Crystallographica Section E Structure Reports Online ISSN 1600-5368 7,8-Dihydroxy-3-methyl-10-oxo-1H,10Hpyrano[4,3-b]chromene-9-carboxylic acid Jian-Feng Wang, a * Yong-Jie Zhang, b
Supporting Information. Experimental section
Electronic Supplementary Material (ESI) for RSC Advances. This journal is The Royal Society of Chemistry 2014 Supporting Information Experimental section General. Proton nuclear magnetic resonance ( 1
Palladium-Catalyzed Direct ortho-sulfonylation of. Azobenzenes with Arylsulfonyl Chlorides via C H. Table of Contents
Electronic upplementary Material (EI) for RC Advances. This journal is The Royal ociety of Chemistry 205 upporting Information Palladium-Catalyzed Direct ortho-ulfonylation of Azobenzenes with Arylsulfonyl
Four- and Five-membered Cobaltacycles by Regioselective Cyclometalation. of Benzylsulfide Derivatives via Co(V) intermediates
Electronic Supplementary Information for Dalton Transactions This journal is The Royal Society of Chemistry 2008 Supporting Information for: Four- and Five-membered Cobaltacycles by Regioselective Cyclometalation
Mandelamide-Zinc Catalyzed Alkyne Addition to Heteroaromatic Aldehydes
1 Mandelamide-Zinc Catalyzed Alkyne Addition to Heteroaromatic Aldehydes Gonzalo Blay, Isabel Fernández, Alícia Marco-Aleixandre, and José R. Pedro Departament de Química Orgànica, Facultat de Química,
Synthetic Control of Excited States in Cyclometalated Ir(III) Complexes using Ancillary Ligands
Synthetic Control of Excited States in Cyclometalated Ir(III) Complexes using Ancillary Ligands Jian Li, (a) Peter I. Djurovich, (a) Bert D. Alleyne, (a) Muhammed Yousufuddin, (a) Nam N. Ho, (a) J. Christopher
difluoroboranyls derived from amides carrying donor group Supporting Information
The influence of the π-conjugated spacer on photophysical properties of difluoroboranyls derived from amides carrying donor group Supporting Information Anna Maria Grabarz a Adèle D. Laurent b, Beata Jędrzejewska
A new ent-kaurane diterpene from Euphorbia stracheyi Boiss
SUPPLEMENTARY MATERIAL A new ent-kaurane diterpene from Euphorbia stracheyi Boiss Tie Liu a, Qian Liang a,b, Na-Na Xiong a, Lin-Feng Dai a, Jun-Ming Wang a,b, Xiao-Hui Ji c, Wen-Hui Xu a, * a Key Laboratory
SUPPLEMENTARY MATERIAL. In Situ Spectroelectrochemical Investigations of Ru II Complexes with Bispyrazolyl Methane Triarylamine Ligands
10.1071/CH16555_AC CSIRO 2017 Australian Journal of Chemistry 2017, 70(5), 546-555 SUPPLEMENTARY MATERIAL In Situ Spectroelectrochemical Investigations of Ru II Complexes with Bispyrazolyl Methane Triarylamine
Supporting Information
Supporting Information Gold-catalyzed Cycloisomerization of 1,6-Diyne-4-en-3-ols to form Naphthyl Ketone Derivatives. Jian-Jou Lian and Rai-Shung Liu* Department of Chemistry, National Tsing-Hua University,
Supporting Information. Introduction of a α,β-unsaturated carbonyl conjugated pyrene-lactose hybrid
Electronic Supplementary Material (ESI) for RSC Advances. This journal is The Royal Society of Chemistry 16 Supporting Information Introduction of a α,β-unsaturated carbonyl conjugated pyrene-lactose hybrid
Supporting Information
Chloromethylhalicyclamine B, a Marine-Derived Protein Kinase CK1δ/ε Inhibitor Germana Esposito, Marie-Lise Bourguet-Kondracki, * Linh H. Mai, Arlette Longeon, Roberta Teta, Laurent Meijer, Rob Van Soest,
Supporting Information
SUPPORTING INFORMATION FOR: Trialkylstibine complexes of boron, aluminium, gallium and indium trihalides: synthesis, properties and bonding Victoria K. Greenacre, William Levason and Gillian Reid Chemistry,
Heavier chalcogenone complexes of bismuth(iii)trihalides: Potential catalysts for acylative cleavage of cyclic ethers. Supporting Information
Electronic Supplementary Material (ESI) for RSC Advances. This journal is The Royal Society of Chemistry 2015 Heavier chalcogenone complexes of bismuth(iii)trihalides: Potential catalysts for acylative
metal-organic compounds
metal-organic compounds Acta Crystallographica Section E Structure Reports Online ISSN 1600-5368 Pentakis(2-oxo-2,3-dihydropyrimidin-1- ium) di-l 3 -chlorido-tri-l 2 -chlorido-hexachloridotricadmate(ii)
Supporting information
Electronic Supplementary Material (ESI) for Green Chemistry. This journal is The Royal Society of Chemistry 204 Supporting information Palladium nanoparticles supported on triazine functionalised mesoporous
Discovery of multi-target receptor tyrosine kinase inhibitors as novel anti-angiogenesis agents
Discovery of multi-target receptor tyrosine kinase inhibitors as novel anti-angiogenesis agents Jinfeng Wang, Lin Zhang, Xiaoyan Pan, Bingling Dai, Ying Sun, Chuansheng Li, Jie Zhang School of Pharmacy,
A strategy for the identification of combinatorial bioactive compounds. contributing to the holistic effect of herbal medicines
1 2 Supplementary information 3 4 A strategy for the identification of combinatorial bioactive compounds contributing to the holistic effect of herbal medicines 5 6 Fang Long 1, Hua Yang 1, Yanmin Xu,
Highly enantioselective cascade synthesis of spiropyrazolones. Supporting Information. NMR spectra and HPLC traces
Highly enantioselective cascade synthesis of spiropyrazolones Alex Zea a, Andrea-Nekane R. Alba a, Andrea Mazzanti b, Albert Moyano a and Ramon Rios a,c * Supporting Information NMR spectra and HPLC traces
Supporting Information for
Supporting Information for An atom-economic route to densely functionalized thiophenes via base-catalyzed rearrangement of 5-propargyl-2H-thiopyran-4(3H)-ones Chunlin Tang a, Jian Qin b, Xingqi Li *a a
Aluminum Electrolytic Capacitors
Aluminum Electrolytic Capacitors Snap-In, Mini., 105 C, High Ripple APS TS-NH ECE-S (G) Series: TS-NH Features Long life: 105 C 2,000 hours; high ripple current handling ability Wide CV value range (47
Supporting Information. for
Supporting Information for Enantioselective Synthesis of -(Hetero)aryl Piperidines Through Asymmetric Hydrogenation of Pyridinium Salts and Its Mechanistic Insights Bo Qu,* Hari P. R. Mangunuru, Sergei
Supporting Information
Supporting Information For A Highly Sensitive ESIPT Based Ratiometric Fluorescence Sensor for Selective Detection of Al 3+ Sanghamitra Sinha, Bijit Chowdhury and Pradyut Ghosh* Department of Inorganic
Aluminum Electrolytic Capacitors (Large Can Type)
Aluminum Electrolytic Capacitors (Large Can Type) Snap-In, 85 C TS-U ECE-S (U) Series: TS-U Features General purpose Wide CV value range (33 ~ 47,000 µf/16 4V) Various case sizes Top vent construction
Experimental. Crystal data. C 23 H 27 ClN 2 O M r = Triclinic, P1 a = (3) Å b = (6) Å c = (7) Å = (4) = 80.
organic compounds Acta Crystallographica Section E Structure Reports Online ISSN 1600-5368 8-{(E)-[(4-Chlorophenyl)imino]methyl}- 1,1,7,7-tetramethyl-1,2,3,5,6,7-hexahydropyrido[3,2,1-ij]quinolin-9-ol
Malgorzata Korycka-Machala, Marcin Nowosielski, Aneta Kuron, Sebastian Rykowski, Agnieszka Olejniczak, Marcin Hoffmann and Jaroslaw Dziadek
Molecules 2017, 21, 154; doi:10.3390/molecules22010154 Supplementary Materials: Naphthalimides Selectively Inhibit the Activity of Bacterial, Replicative DNA Ligases and Display Bactericidal Effect against
Synthesis, Characterization, and Computational Study of Three-Coordinate SNS-Copper(I) Complexes Based on Bis-Thione Precursors
For Synthesis, Characterization, and Computational Study of Three-Coordinate SNS-Copper(I) Complexes Based on Bis-Thione Precursors John R. Miecznikowski a *; Matthew A. Lynn b ; Jerry P. Jasinski c ;