ΒΙΟΓΡΑΦΙΚΟ ΣΗΜΕΙΩΜΑ Πτυχίο Βιολογίας, Τµήµα Βιολογίας, Εθνικό και Καποδιστριακό Πανεπιστήµιο Αθηνών.

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1 ΒΙΟΓΡΑΦΙΚΟ ΣΗΜΕΙΩΜΑ Όνοµα Αλέξανδρος Α. Λάβδας Ηµεροµηνία γέννησης 26 / 3 / 1970 Τόπος γέννησης Αθήνα ιεύθυνση Eλληνικό Ινστιτούτο Pasteur, Τµήµα Βιοχηµείας, Εργαστήριο Κυτταρικής και Μοριακής Νευροβιολογίας, Βας Σοφίας 127, 11521, Αθήνα Τηλέφωνο (210) / (694) Ηλεκτρονική διεύθυνση a_lavdas@yahoo.com, alavdas@mail.pasteur.gr ΣΠΟΥ ΕΣ 1997 Ph.D. in Neuroscience (διδακτορικό νευροεπιστηµών), Department of Anatomy and Developmental Biology, University College London, UK M.Sc. in Neuroendocrine Cell Biology (Μάστερ νευροενδοκρινολογίας), Department of Anatomy and Developmental Biology, University College London & Royal Postgraduate Medical School, UK Πτυχίο Βιολογίας, Τµήµα Βιολογίας, Εθνικό και Καποδιστριακό Πανεπιστήµιο Αθηνών (Αύγουστος) Επισκέπτης φοιτητής, Department of Surgery, University of Minnesota, Minneapolis, USA, στον Prof. David Sutherland Πρωτοβάθµια και δευτεροβάθµια εκπαίδευση, Αθήνα. Σεµινάρια τεχνικών: 2007 FACS Aria operator training, 3-7/12/07, Beckton Dickinson Biosciences, Erembodegem, Belgium 2003 Microinjection and Detection of Probes in Cells, EMBL, Heidelberg 1999 Certificate in Professional Photography, New York Institute of Photography 1993 Receptor Localization and analysis. Royal Postgraduate Medical School, Ηammersmith, London.

2 1993 Image analysis & morphometry in Medicine and Biology. Royal Postgraduate Medical School, Ηammersmith, London Immunolabelling for electron microscopy. Royal Postgraduate Medical School, Ηammersmith, London Modern immunocytochemistry. Royal Postgraduate Medical School, Ηammersmith, London Monoclonal antibody techniques. Royal Postgraduate Medical School, Ηammersmith, London. ΠΑΡΟΥΣΑ ΘΕΣΗ (2007-) Ερευνητής Γ (βαθµίδα επικ. Καθηγητή) Ελληνικό Ινστιτούτο Pasteur. Mέλος της Athenian Microsurgical Research Group (AMRG), στα πλαίσια της European Micosurgical Research Association (EMRA) ( EΡΕΥΝΗΤΙΚΗ / ΕΠΑΓΓΕΛΜΑΤΙΚΗ ΕΜΠΕΙΡΙΑ Μεταδιδακτορικός ερευνητής, Ελληνικό Ινστιτούτο Pasteur σήµερα 2004-σήµερα 2004-σήµερα Παραδόσεις µεταπτυχιακού µαθήµατος Νευροβιολογίας (υπεύθυνη καθ Φ Στυλιανοπούλου), Πανεπιστήµιο Αθηνών Παραδόσεις µεταπτυχιακού µαθήµατος Κλινικής Βιοχηµείας/Μοριακής ιαγνωστικής (υπεύθυνη καθ. Ε Λιανίδου), Πανεπιστήµιο Αθηνών. Ασκήσεις συνεστιακής µικροσκοπίας σε σεµινάρια µικροσκοπίας, Ελληνικό Ινστιτούτο Ρasteur (συνεργάτης) Unité de Neurovirologie et Régénération du Système Nerveux, Institute Pasteur, Paris Βιοχηµικό Τµήµα, Γενικό Νοσοκοµείο Κω και Παθολογοανατοµικό τµήµα, 401 ΓΣΝΑ, στα πλαίσια της στρατιωτικής θητείας.

3 Mεταδιδακτορικός ερευνητής, Department of Anatomy and Developmental Biology, University College London, UK (συνεργάτης) Department of Cell Biology, The Scripps Research Institute, La Jolla, California, USA Research Assistant, Department of Anatomy and Developmental Biology, University College London, UK. ΒΡΑΒΕΙΑ- ΙΑΚΡΙΣΕΙΣ-ΥΠΟΤΡΟΦΙΕΣ 2009: Βραβείο προφορικής παρουσίασης (Κ. Κατσαρού) 60ο Πανελλήνιο συνέδριο ΕΕΒΜΒ 2003: Βραβείο εις µνήµη Κώστα Βρεττού του κοινού συνεδρίου Ελληνικών Εταιρειών Επανορθωτικής Χειρουργικής και Χειρουργικής χεριού 2003: Έπαινος «Γεώργιος Πολυκράτης» του πανελλήνιου συνέδριου Πλαστικής, Επανορθωτικής και Αισθητικής Χειρουργικής : Υποτροφία British Council : Υποτροφία Εµπειρίκειου Ιδρύµατος : Υποτροφία ΝΑΤΟ ΕΠΙΣΤΗΜΟΝΙΚΕΣ ΗΜΟΣΙΕΥΣΕΙΣ 2010 Soluble forms of the cell adhesion molecule L1 produced by insect and baculovirus-transduced mammalian cells enhance Schwann cell motility. Alexandros A Lavdas, Rodica Efrose, Vassilis Douris, Maria Gaitanou, Florentia Papastefanaki, Luc Swevers, Dimitra Thomaidou, Kostas Iatrou and Rebecca Matsas. J Neurochem in press 2010 Lentivirus-mediated expression of insulin-like growth factor-i promotes neural stem/precursor cell proliferation and enhances their potential to generate neurons Georgia Kouroupi1, Alexandros A. Lavdas, Maria Gaitanou, Dimitra Thomaidou, Fotini Stylianopoulou and Rebecca Matsas.. J Neurochem Jul 31. [Epub ahead of print]) 2010 Endocytosis of hepatitis C virus non-enveloped capsid-like particles induces MAPK-ERK1/2 signalling events. Konstantina Katsarou, Alexandros Α. Lavdas, Panagiota Tsitoura,

4 Elisavet Serti, Panagiotis Markoulatos, Penelope Mavromara and Urania Georgopoulou. Cell Mol Life Sci Apr Schwann cells engineered to express the cell adhesion molecule L1 accelerate myelination and motor recovery after spinal cord injury. Alexandros A Lavdas, Jian Chen, Florentia Papastefanaki, Suzhen Chen, Melitta Schachner, Rebecca Matsas, Dimitra Thomaidou. Exp Neurol. 221 (2010) Transplantation of embryonic neural stem/ precursor cells overexpressing BM88/Cend1 enhances the generation of neuronal cells in the injured mouse cortex. Georgia Makri, Alexandros A. Lavdas, Lida Katsimpardi, Pierre Charneau, Dimitra Thomaidou and Rebecca Matsas. Stem Cells Nov 12. [Epub ahead of print] 2009 Green fluorescent protein - Tagged HCV nonenveloped capsid like particles: development of a new tool for tracking HCV core uptake. Katsarou K, Serti E, Tsitoura P, Lavdas AA, Varaklioti A, Pickl-Herk AM, Blaas D, Oz-Arslan D, Zhu R, Hinterdorfer P, Mavromara P, Georgopoulou U. Biochimie Jul;91(7): Τowards personalized cell replacement therapies for rain repair. AA Lavdas and R Matsas. Personalized Medicine May 2009, Vol. 6, No. 3, Pages Green fluorescent protein - Tagged HCV nonenveloped capsid like particles: development of a new tool for tracking HCV core uptake. Katsarou K, Serti E, Tsitoura P, Lavdas AA, Varaklioti A, Pickl-Herk AM, Blaas D, Oz-Arslan D, Zhu R, Hinterdorfer P, Mavromara P, Georgopoulou U. Biochimie Jul;91(7): Epub 2009 May Schwann cells: potent vehicles for combined cell and gene therapy of the demyelinated central nervous system? Alexandros A Lavdas, Florentia Papastefanaki, Dimitra Thomaidou, and Rebecca Matsas. Curr Med Chem. 2008;15(2):

5 2008 Deleted in Azoospermia-Like (DAZL) gene expressing cells in human amniotic fluid: a new source for germ cells research? Konstantinos Stefanidis, Dimitris Loutradis, Lemonika Koumbi, Vasiliki Anastasiadou, Vasiliki Dinopoulou, Erasmia Kiapekou, Alexandros A Lavdas, Spiros Mesogitis, Aris Antsaklis. Fertil Steril Sep;90(3): Epub 2007 Nov Grafts of Schwann cells engineered to express PSA-NCAM promote functional recovery after spinal cord injury. Florentia Papastefanaki, Jian Chen, Alexandros A. Lavdas, Dimitra Thomaidou, Melitta Schachner and Rebecca Matsas Brain. Aug;130(Pt 8): Epub 2007 Jul Schwann cells genetically engineered to express PSA show enhanced migratory potential without impairment of their myelinating ability. A. A Lavdas, I. Franceschini, M. Dubois-Dalcq, R. Matsas. Glia Jun; 53(8): Baculovirus infection of mammalian cell lines and primary Schwann cells results in efficient gene transduction but is accompanied by early viral gene expression C Kenoutis, R C Efrose, L Swevers, A A Lavdas, M Gaitanou2, R Matsas, K Iatrou. Journal of Virology Apr;80(8): The effect of genetically modified Schwann cells in end-to-side nerve grafting. A. Gravvanis, A. A. Lavdas, I.Franceschini, A. Papalois, R. Matsas, J. Ioannovich Microsurgery 25(5): Collagen tube lined with genetically modified Schwann cells with increased motility: A new promising bioartificial nerve graft. Gravvanis AI, Lavdas AA, Papalois AE, Tsoutsos DA, Panayotou PN, Chuang DC-C, Franceschini I, Dubois-Dalcq M, Matsas R. Eur Surg 37/4, The use of silicone tubes in end-to-side nerve grafting:an experimental study. A.Gravvanis, M.Karvelas, E.Lykoudis, A.A Lavdas, A.Papalois, C.Petralexis, R.Matsas, C.Stamatopoulos, J.Ioannovich. Eur J Plast Surg 26:

6 2000 The contribution of the ganglionic eminence to the neuronal cell types of the cerebral cortex. Parnavelas JG, Anderson SA, Lavdas AA, Grigoriou M, Pachnis V, Rubenstein JL. Novartis Found Symp. 2000;228: Τhe medial ganglionic eminence gives rise to a population of early neurons in the developing cerebral cortex. A. A. Lavdas, M. Grigoriou, V.Pachnis and J.G.Parnavelas. Journal of Neuroscience, Sept 15, 99(19): Serotonin promotes the differentiation of glutamate neurons in organotypic slice cultures of the developing cerebral cortex. A. A. Lavdas, M. E. Blue, J. Lincoln and J. G. Parnavelas. Journal of Neuroscience, Oct 15, 17(20): Neuronal clones in the cerebral cortex show morphological and neurotransmitter heterogeneity during development. A. A. Lavdas, M. C. Mione and J. G. Parnavelas. Cerebral Cortex, 6: Lineage analysis of neurons by means of betagalactosidase labelling. M. C. Mione, I. S. Pappas, A. A. Lavdas and J. G. Parnavelas. Neuroscience Protocols, , The cell lineage of neuronal subtypes in the mammalian cerebral cortex. J. G. Parnavelas,. M. C. Mione and A. A. Lavdas. Ciba Found Symp. 1995;193:41-58 PROCEEDINGS 2008 Transplantation of genetically modified neural stem cells in a mouse model of acute cortical trauma.: Makri G, Lavdas AA, Katsimpardi L, Charneau P, Matsas R, Thomaidou D FEBS JOURNAL Volume: 275 Pages: Suppl Grafts of transduced Schwann cells with altered expression of adhesion molecules promote functional recovery after spinal cord injury. Papastefanaki F, Lavdas AA, Chen J, Thomaidou

7 D, Schachner M, Matsas R FEBS JOURNAL Volume: 275 Pages: Suppl The beneficial effects of genetically engineered Schwann cells with enhanced motility in peripheral nerve regeneration: review.ai Gravvanis, AA Lavdas, A Papalois, DA Tsoutsos, R Matsas. Acta Neurochir Suppl. 2007;100: Grafts of Schwarm cells engineered to express PSA-NCAM promote functional recovery after spinal cord injury. Papastefanaki F, Chen J, Lavdas AA, Thomaidou D, Schachner M, Matsas R NEURON GLIA BIOLOGY Vol 2 Pages: S119-S119 Suppl Transplantation of Schwann cells over-expressing L1 enhance functional recovery in a mouse spinal cord compression model. Lavdas AA, Chen J, Papastefanaki F, Matsas R, Schachner M, Thomaidou D NEURON GLIA BIOLOGY Volume: 2 Pages: S119-S120 Suppl. 1 ΣΥΜΜΕΤΟΧΗ ΣΕ ΒΙΒΛΙΑ 2010 Εισαγωγή στο βιβλίο Twelve lectures on architecture: Algorithmic Sustainable Design. Nikos Salingaros, Umbau - Verlag, Solingen 2008 Κεφάλαιο Schwann Cell Morphology. A.A. Lavdas and R. Matsas. Στην Encyclopedia of Neuroscience, Larry R. Squire, Editor-in-Chief, Academic Press, Oxford, ΑΝΑΚΟΙΝΩΣΕΙΣ ΣΕ ΕΠΙΣΤΗΜΟΝΙΚΑ ΣΥΝΕ ΡΙΑ 2010 Engineering Schwann Cells for CNS repair: therapeuric applications in neurology. Summer School on Regenerative Medicine, Athens 2009 Engineering Schwann cells for CNS repair. Invited speaker at the Neurotrauma conference, Santa Barbara, California.

8 2009 Εndocytosis of recombinant HCV non-enveloped capsid-like particles produce ERK1/2 - MAPKs signaling events 16th International symposium on hepatitis C virus and related viruses Nice. K. Katsarou, AA. Lavdas, E. Serti, P. Tsitoura, P. Mavromara, U. Georgopoulou 2007 Transplantation of Schwann cells over-expressing L1 enhance functional recovery in a mouse spinal cord compression model Lavdas AA, Chen J, Papastefanaki FC, Matsas R, Schachner M and Thomaidou D, Euroglia meeting, London 2006 Baculovirus infection of Schwann cells results in efficient gene transduction but is accompanied by early viral gene expression.. Lavdas AA, Gaitanou M, Kenoutis C, Efrose RC, Swevers L, Iatrou K and Matsas R FENS meeting, Vienna 2006 Transplantation of Schwann cells expressing PSA-NCAM promotes axonal regrowth and functional recovery after spinal cord injury. Papastefanaki FC, Chen J, Lavdas AA, Franceschini I, Dubois Dalcq M 4, Matsas R, Thomaidou D, and Schachner M. FENS meeting, Vienna 2005 Schwann cells genetically engineered to express PSA show enhanced migratory potential without impairment of their myelinating ability. Lavdas AA, Papastefanaki F, Franceschini I, Dubois- Dalcq M, Matsas R. 57th meeting of Greek Society of Biochemistry and Molecular Biology, Athens 9-11/12/ Gene delivery into mammalian cells using recombinant baculoviruses as transfer vectors Rodica C. Efrose, Christos Kenoutis, Luc Swevers, Alexandros A. Lavdas, Maria Gaitanou, Rebecca Matsas, and Kostas Iatrou. 57th meeting of Greek Society of Biochemistry and Molecular Biology, Athens 9-11/12/ Schwann cells genetically engineered to express PSA show enhanced migratory potential without impairment of their myelinating ability. Lavdas AA, Papastefanaki F, Franceschini I, Dubois- Dalcq M, Matsas R. VIII European Meeting on

9 Glial Cell Function in Health and Disease, Amsterdam 2003 The use of genetically modified Schwann cells for PNS repair. Lavdas AA, Gravvanis A, Franceschini I, Papalois A, Dubois-Dalcq M, Ioannovich J, Matsas R. Sixth European Meeting on Glial Cell Function in Healrth and Disease, Berlin 2003 The effect of genetically modified Schwann cells in end-to-side nerve regeneration. Gravvanis A, Lavdas AA, Franceschini I, Papalois A, Panagiotou P, Dubois-Dalcq M, Μatsas R, Ioannovich I. 6 th Panhellenic Meeting of Plastic, Reconstructive and Aesthetic Surgery, Athens 2003 Genetically engineered Schwann cells as candidates for cell-based therapy in the CNS. Lavdas AA, Franceschini I, Dubois-Dalcq M, Matsas R. Hellenic Society for Neuroscience meeting, Athens 2003 The effect of genetically modified Schwann cells in end-to-side nerve regeneration Gravvanis A, Lavdas AA, Franceschini I, Papalois A, Panagiotou P, Dubois-Dalcq M, Μatsas R, Ioannovich I. Annual common meeting of the Greek Societies of Reconstructive Microsurgery and Hand Surgery, Herakleion 2002 Retrovirus-mediated polysialic acid expression in Schwann cells modulates their migratory behaviour.a.a. Lavdas, I.A. Franceschini, F. Papastefanaki, M. Dubois-Dalcq and R. Matsas. V European Meeting on Glial Cell Function in Health and Disease, Rome 2002 The use of silicone tubes in end-to-side nerve grafting. An experimental study. A.Gravvanis, E.Lykoudis, M. Karvelas, A.A. Lavdas, C.Stamatopoulos, J.Ioannovich. 13 th Annual Meeting of European Association of Plastic Surgeons, Crete, Cellular approaches with genetically modified Schwann cells for the therapy of neurodegenerative CNS and PNS diseases AA Lavdas, F Papastefanaki, I.A.Franceschini,

10 M.Dubois-Dalq, R Matsa.16 th meeting of the Greek Society of Neuroscience Regeneration through nerve conduits sutured onto a perineural window of the intact rat sciatic nerve. Gravvanis A, Karvelas M, Lavdas AA, Petralexis H, Lykoudis E, Papalois A, Sampaziotis D, Stamatopoulos K, Ioannovich I. Annual common meeting of the Greek Societies of Reconstructive Microsurgery and Hand Surgery, Thessaloniki 1998 The medial ganglionic eminence is a source of the early neurons of the developing rat cerebral cortex A. A. Lavdas, M.Grigoriou, V. Pachnis and J. G. Parnavelas. American Society for Neuroscience Abstracts, 1996 Serotonin increases the proportion of glutamatecontaining neurons in organotypic slice cultures of embryonic rat cortex. A. A. Lavdas, J. G. Parnavelas. American Society for Neuroscience Abstracts, 22: Lineage analysis reveals morphological and neurochemical heterogeneity in clonally related neurons during development of the cerebral cortex. A.A. Lavdas, M.C. Mione and J.G. Parnavelas. European Neuroscience Association Meeting, Vienna 1994 The effect of heroin in rat adrenal cells. Katsorhis Th, Mpourntenas P, Lavdas AA, Papalois A, Vamvoukakis I. 16 th Panhellenic meeting of the Greek Society of Biological Sciences, Volos 1991 Thalassaemia in Greece in the ancient times. Papalois A, Lavdas AA, Lymperopoulos I, Zafeiratos D. 4 th Panhellenic meeting of History, Philosophy and Sociology of the Medical Sciences, Nafpaktos. ΗΜΟΣΙΕΥΜΑΤΑ ΣΤΟΝ ΗΜΕΡΗΣΙΟ ΚΑΙ ΠΕΡΙΟ ΙΚΟ ΤΥΠΟ 2010 Η δικτατορία του µοντέρνου (στην αρχιτεκτονική) είναι συντηρητισµός Καθηµερινή, 29 Μαϊου

11 2006 Λουί Παστέρ: Από το κρασί στη δηµιουργία της ζωής. Αλέξανδρος Λάβδας και Ρεβέκκα Μάτσα. Αφιέρωµα «Οι πρωτοπόροι» ΙΣΤΟΡΙΚΑ ΕΛΕΥΘΕΡΟΤΥΠΙΑ 2006, Υπεύθυνος Έκδοσης: Π. Παναγόπουλος Λουί Παστέρ: Τα πρώτα εµβόλια. Ρεβέκκα Μάτσα και Αλέξανδρος Λάβδας. Αφιέρωµα «Οι πρωτοπόροι» ΙΣΤΟΡΙΚΑ ΕΛΕΥΘΕΡΟΤΥΠΙΑ 2006, Υπεύθυνος Έκδοσης: Π. Παναγόπουλος.