Superficial fungal infection and allergic dermatitis

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1 n = 173 n = P < P < P > % % 5. 22% 6. 72% P > R 756 R A Superficial fungal infection and allergic dermatitis LIU Fang SANG Hong HU Wen-xing KONG Qing-tao WANG Xue-lian WANG Gao-feng ZHANG Min DENG De-quan XIE Qi-mei Department of Dermatology Nanjing General Hospital of Nanjing Military Command Medical School of Nanjing University Nanjing China Abstract Objective To investigate superficial fungal infection in the etiology of allergic dermatitis by comparing the sensitivities of fungal allergens and unfungal allergens among allergic dermatitis patients with or without tineaand the identification of pathogens. Methods Totally 353 patients with chronic urticariaeczema or atopic dermatitis were divided into two groups classified by direct microscopic examinationthe group with superficial fungal infection n = 173and the contral group without superficial fungal infection n = 180. Skin prick tests were performed in all subjectsbut fungal culture were administered only in the patients with superficial fungal infection. Results Positive rates to Trichophyton Specific Penicillium Curvularia lunata and Aspergillus fumigatus in experiment group were higher than those in control group P < Positive rate to Trichophyton in experiment group was higher than that in control group P < There were no statistically significant differences among other fungal allergens and unfungal allergens P > T. rubrum % T. mentagrophytes % Epidermophyton floccosum 5. 22% and Candida 6. 72% were cultured in 134 cases of skin allergic diseases with superficial fungal infection. The positive rates were not statistically significant between Trichophyton and dermatophytes P > Conclusions Patients with chronic urticaria or eczema who present immediate hypersensitivity to Trichophyton always have dermatophyte infection. Superficial fungal infections seem to be an important factort in the subjects with chronic urticaria or eczema. Key words fungusinfectionallergic diseasesskin Chin J Mycol liufangndyx@ hotmail. com sanghong@ nju. edu. cn

2 345 Allergic diseases 0. 1% 1936 Wise Sulzberger 1 skin prick test SPT 1 2 cm 15 ~ 20 min SPT > 1 /4 + 1 / ~ SPSS Williams 4 ± d x 珋 ± s M 3 25% ~ 75% 4 χ 2 5 χ 2 P < P < ± % KOH a II > a 1 1 ~ 5 a ± ~ 5a % 33% Serpula lacrymans 5% < 5 a 29.

3 346 6% 5 a 70. 4% % % % P < % P > % 83. 0% P < % % 16. 7% P > SPT + Tab. 1 Prevalence of inhalant allergens among 353 cases n = 173 n = 112 n = 61 n = 180 n = 130 n = 44 n = % % % % % % II % % % % % % % % % % % % % % % % % % % % % % % % % % % % % % P = % % % Dermatophytes % % % % χ 2 =

4 347 Tab. 2 2 SPT Percentage of positive skin tests in groups of chronic urticaria and eczema n = 112 n = 130 χ 2 P n = 61 n = 44 χ 2 P % % % % % % % % % % II % % % % % % % % % % % % % % % % % % % % % % % % % % % % % % % % % % % % % % % % % % % % % % % % % % % % % % % % IH IgE Wilson Ward 9 immediate hypersensitivity IH IgE 100 mg /d 11 Hürlimann / IH 2 IgE

5 348 IgE T IgE 4 5 a 70. 4% / / 1 Wise FSulzberger MB. Urticaria and hay fever due to Trichophyton J. JAMA Mungan J. Platts M. 4. Trichophyton asthma Matsuoka IgE 4 Williams HCBurney PGJPembroke ACet al. Validation of the U. K. diagnostic criteria for atopic dermatitis in apopulation setting J. Br J Dermatol Sevin CM Peebles RS Jr. Infections and asthmanew insights 80. 4% % into old ideas J. Clin Exp Allergy Wilson BBDeuell BPlatts-Mills TA. Atopic dermatitis associated with dermatophyte infection and Trichophyton hypersensitivity J. Cutis Hürlimann AFh J. Asthmarhinitis and dermatitis triggered by fungal infectiontherapeutic effects of terbinafine J. Dermatology Woodfolk JA. Allergy and dermatophytesj. Clin Microbiol sensitization of bronchi and upper airways to dermatophyte anti- Rev gen J. Lancet late-onset asthma with fluconazole J Pt IgE 11. J Ward GW JrKarlsson GRose Get al. Trichophyton asthma 10Ward GW JrWoodfolk JAHayden MLet al. Treatment of. J Allergy Clin Immunol IgE 12Mungan DBavbek SPeksari Vet al. Trichophyton sensitivi-

6 349 ty in allergic and nonallergic asthmaj. Allergy Platts-Mills TA Woodfolk JA. Trichophyton asthmaj. Chest Matsuoka HNiimi AMatsumoto Het al. Specific IgE response to trichophyton and asthma severityj. Chest Duek LKaufman GUlman Yet al. The pathogenesis of dermatophyte infections in human skin sectionsj. J Infect Alonso APionetti CHMouchián Ket al. Hypersensitivity to Trichophyton rubrum antigens in atopic and non-atopic podiatrists J. Allergol Immunopathol latory gene cassette spatzle / toll / cactus controls the potent anti- TLR2 fungal response in drosophila adults J TLR albicans J. Med Mycol 2010 TLR2 Candida albicans infectionsj Knapp S Wieland CWFlorguin S 1 Netea MG Sutmuller R Hermann C et al. Toll-like receptor 2 suppresses immunity against Candida albicans through induction of IL-10 and regulatory T cellsj. J Immunol Villamon E Gozaibo D Roig Pet al. Toll-like receptor 2 is dispensable for acquired host immune resistance to Candida albicans in a murine model of disseminated candidiasisj. Microbes Infect Selsted MESzklarek DGanz T et al. Activity of rabbit leukocyte peptides against Candida albicans J. Infect Immun J Wistar. 14Netea MGGow NAMunro CAet al. Immune sensing of 5 van der Graaf CA Netea MG Verschueren I et al. Differential cytokine production and Toll-Like receptor signaling pathways by Candida albicans blastoconidia and hyphaej. Infect Immun St Johnston D Nusslein-Volhard C. The origin of pattern and polarity in the drosophila embryo J. Cell Lemaitre BNicolas EMichaut L et al. The dorsoventral regu- 8 Tessarolli VGasparoto THLima HR et al. Absence of TLR2 influences survival of neutrophils after infection with Candida Gil MLGozalbo D. Role of Toll-like receptors in systemic. Cell Front Biosci et al. Differential roles of CD14 and Toll-like receptors4 and 2 in murine acinetobacter pneumonia J. Am J Respir Crit Care Med Alves-Filho JCFreitasa A Souto FO et al. Regulation of chemokine receptor by Toll-like receptor 2 is critical to neutrophil migration and resistance to polymicrobial sepsisj. Proc Natl Acad Sci USA Netea MG Van der Meer JWKullberg BJ. Toll-like receptors as an escape mechanism from the host defense J. Trends Microbiol Ferreira KSBastos KRRusso Met al. Interaction between Paracocciioides brasiliensis and Pulmonary dendritic cells induces interleukin-10 production and Toll-like receptor-2 expressionpossible mechanisms of susceptibility J. Infect Dis Candida albicans requires cooperative recognition of mannans and glucans by lectin and Toll-like receptorsj. J Clin Invest Li X Qin J. Modulation of Toll-interleukin 1 receptor mediated signaling J. J Mol Med

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