Elevated free fatty acid uptake via CD36 promotes epithelial-mesenchymal transition in. and *Christina Chan
|
|
|
- Δάμων Παπαδάκης
- 5 χρόνια πριν
- Προβολές:
Transcript
1 Elevated free fatty acid uptake via CD36 promotes epithelial-mesenchymal transition in hepatocellular carcinoma Aritro Nath 1, Irene Li 2, Lewis R. Roberts 3 1, 2, 4 and *Christina Chan 1 Genetics Program, Michigan State University, 567 Wilson Road, Rm 2240E, East Lansing, Michigan 48824, USA 2 Department of Microbiology and Molecular Genetics, Michigan State University, 567 Wilson Road, Rm 2215, East Lansing, Michigan 48824, USA 3 Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, 200 First St. SW, Rochester, Minnesota 55905, USA 4 Department of Chemical Engineering and Materials Science, Michigan State University, 428 South Shaw Lane, Rm 2527, East Lansing, Michigan 48824, USA *Corresponding author krischan@egr.msu.edu
2 Supplementary Figure 1: Differential effects of FFAs on migration. A & B. Scratch-wound healing assays. HepG2 cells were grown to 80% confluence in regular medium, and a scratch was introduced on the monolayer. The cells were then cultured in regular media containing either
3 BSA (control), PA (0.4mM), OL (0.4mM), LA (0.4mM), PA (0.2mM) + LA (0.2mM) or OL (0.2mM) + LA (0.2mM). The migration of the wound front was monitored over a 10-day period to establish an empirical time-frame within which the cell front acquired the ability to migrate across the wound. Phase contrast images were recorded at 40X magnification (scale bar=50µm) C & D. Bar graph showing the open wound area in treated cells calculated using the T-scratch package at different time points normalized to open wound area at 0 hr. P-values indicate significance levels (n=3) determined by Student s t-test (two tailed).
4 Supplementary Figure 2 mrna expression levels of Hedgehog ligand SHH and downstream transcription factor GLI1in PA vs. BSA treated HepG2 cells. Bar graphs showing fold-change in GAPDH normalized expression levels of SHH and GLI1in PA vs. BSA treated HepG2 cells. P- value indicates comparison of average delta Ct values between PA and BSA using two tailed Student s t-test.
5 Supplementary Figure 3 CD36 HighBMI CD36 Low BMI
6 VIM HighBMI VIM Low BMI
7 CDH1 HighBMI CDH1 Low BMI
8 40 SNAIL Low BMI SNAIL HighBMI 30 20
9 PORCN HighBMI PORCN Low BMI
10 DSP HighBMI DSP Low BMI
11 TGFB Low BMI TGFB HighBMI
12 ZEB1 HighBMI ZEB1 Low BMI
13 ZEB2 Low BMI ZEB2 HighBMI
14 GAPDH HighBMI GAPDH Low BMI
15 Supplementary Figure 4 +SSO -SSO PA BSA PA BSA VIM
16 BSA -SSO PA CDH1 CDH1 PA BSA +SSO
17 BSA -SSO PA GAPDH GAPDH PA BSA +SSO
18 Supplementary Figure 5 A B C
19 Supplementary Figure 5: A. (From left to right) Panels showing unstained control to set gating threshold Zombie Violet stained cells and GAPDH-Alexa488 stained cells. This gating was used for the subsequent marker assessment. The plot distributions show the signal intensity distributions for B. DSP and C. CDH1 from BSA (BLUE) or PA (RED) treated cells. The overlap images show that the DSP peak in the PA treated cells is clearly shifted towards the left, indicating a population of cells with reduced DSP expression in PA treated condition. The CDH1 plots show a distinct bimodal distribution, where the low-intensity peak (lower CDH expression) is higher in the PA treated cells, while the high-intensity peak (higher CDH expression) is higher in the control cells, and is suggestive of sub-population of cells.
20 Sample_ID CD36 FABP1 FABP4 FABP5 SLC27A2 SLC27A5 CDH2 FN1 SNAI1 SNAI2 TWIST1 TWIST2 VIM ZEB1 ZEB2 CDH1 CLDN4 CLDN7 MUC1 TJP3 EMTSCR Age Gender Gender_bin Height Weight BMI Pathologic M Pathologic N Pathologic T Pathologic_T_bin Pathologic Stage TCGA-BC FEMALE 0 M0 N0 T3 1 Stage IIIA TCGA-BC MALE 1 MX N0 T3 1 Stage IIIA TCGA-BC-A10Q FEMALE 0 MX NX T2 0 TCGA-BC-A10R FEMALE 0 MX NX T3 1 TCGA-BC-A10S MALE 1 74 MX NX T3 1 TCGA-BC-A10T MALE 1 86 MX NX T4 1 TCGA-BC-A10U MALE 1 MX NX T2 0 TCGA-BC-A10W MALE 1 71 MX NX T4 1 TCGA-BC-A10X FEMALE 0 65 MX N0 T3a 1 Stage IIIA TCGA-BC-A10Y MALE MX NX T4 1 TCGA-BC-A10Z FEMALE 0 79 MX N0 T1 0 Stage I TCGA-BC-A FEMALE MX NX T1 0 TCGA-BC-A MALE MX NX T3 1 TCGA-BC-A FEMALE M0 NX T3 1 Stage IIIA TCGA-BC-A FEMALE M0 NX T2 0 Stage II TCGA-BC-A3KF FEMALE M0 NX T1 0 Stage I TCGA-BC-A3KG FEMALE M0 N0 T2 0 Stage II TCGA-BC-A5W MALE M0 NX T3a 1 Stage IIIA TCGA-BC-A69H MALE M0 NX T2 0 Stage II TCGA-BC-A69I MALE M0 N0 T1 0 Stage I TCGA-BD-A2L MALE MX NX T2 0 TCGA-BD-A3EP FEMALE M0 N0 T1 0 Stage I TCGA-BD-A3ER MALE MX NX T2 0 Stage II TCGA-BW-A5NO MALE 1 MX NX T3a 1 Stage IIIA TCGA-BW-A5NP FEMALE 0 M1 N0 T2 0 Stage IV TCGA-BW-A5NQ MALE 1 MX NX T1 0 Stage I TCGA-CC MALE 1 55 M0 N0 T2 0 Stage II TCGA-CC FEMALE M0 N0 T4 1 Stage IIIC TCGA-CC FEMALE M0 N0 T4 1 Stage IIIC TCGA-CC MALE M0 N0 T2 0 Stage II TCGA-CC MALE M0 N0 T4 1 Stage IIIC TCGA-CC MALE M0 N0 T3 1 Stage IIIA TCGA-CC MALE M0 N0 T3 1 Stage IIIA TCGA-CC-A1HT MALE M0 N0 T3 1 Stage IIIA TCGA-CC-A3M MALE M0 N0 T3 1 Stage IIIA TCGA-CC-A3MA MALE M0 N0 T3 1 Stage IIIA TCGA-CC-A3MB MALE M0 N0 T3 1 Stage IIIA TCGA-CC-A3MC MALE M0 N0 T3 1 Stage IIIA TCGA-CC-A5UC MALE M0 N0 T3 1 Stage IIIA TCGA-CC-A5UD MALE M0 N0 T3 1 Stage IIIA TCGA-CC-A5UE MALE M0 N0 T4 1 Stage IIIB TCGA-CC-A7IF MALE M0 N0 T3 1 Stage IIIA TCGA-CC-A7IG MALE M0 N0 T2 0 Stage II TCGA-CC-A7IH MALE M0 N0 T3 1 Stage IIIA TCGA-CC-A7II MALE M0 N0 T3 1 Stage IIIA TCGA-CC-A7IJ MALE M0 N0 T2 0 Stage II TCGA-CC-A7IK MALE M0 N0 T3 1 Stage IIIA TCGA-CC-A7IL MALE M0 N0 T3 1 Stage IIIA TCGA-DD-A FEMALE M0 N0 T2 0 Stage II TCGA-DD-A MALE M0 T2 0 Stage II TCGA-DD-A MALE M0 N0 T3 1 Stage IIIA TCGA-DD-A MALE M0 N0 T3 1 Stage IIIA TCGA-DD-A FEMALE M0 N0 T2 0 Stage II TCGA-DD-A MALE M1 N0 T3a 1 Stage IV TCGA-DD-A11A MALE M0 N0 T1 0 Stage I TCGA-DD-A11B MALE M0 N0 T1 0 Stage I TCGA-DD-A11C MALE M0 N0 T1 0 Stage I TCGA-DD-A11D FEMALE M0 N0 T1 0 Stage I TCGA-DD-A1EA MALE M0 N0 T2 0 Stage II TCGA-DD-A1EB FEMALE M0 N0 T1 0 Stage I TCGA-DD-A1EC FEMALE M0 N0 T1 0 Stage I TCGA-DD-A1ED MALE M0 N0 T1 0 Stage I TCGA-DD-A1EE MALE M0 N0 T3 1 Stage IIIA TCGA-DD-A1EF FEMALE M0 N0 T1 0 Stage I TCGA-DD-A1EG MALE M0 N0 T1 0 Stage I TCGA-DD-A1EH MALE M0 N0 T3 1 Stage III TCGA-DD-A1EI MALE M0 N0 T1 0 Stage I TCGA-DD-A1EJ FEMALE M0 N1 T1 0 Stage IIIC TCGA-DD-A1EK FEMALE M1 N0 T4 1 Stage IVB TCGA-DD-A1EL MALE M0 N0 T2 0 Stage II TCGA-DD-A39V MALE M0 NX T2 0 Stage II TCGA-DD-A39W FEMALE M0 N0 T3 1 Stage III TCGA-DD-A39X FEMALE M0 NX T1 0 Stage I TCGA-DD-A39Y MALE M0 NX T1 0 Stage I TCGA-DD-A39Z FEMALE M0 NX T2 0 Stage II TCGA-DD-A3A MALE M0 N0 T3b 1 Stage IIIA TCGA-DD-A3A FEMALE M0 N0 T1 0 Stage I TCGA-DD-A3A MALE M0 N0 T1 0 Stage I TCGA-DD-A3A MALE M0 N0 T3 1 Stage IIIA TCGA-DD-A3A FEMALE M0 N0 T3 1 Stage III TCGA-DD-A3A FEMALE M0 N0 T2 0 Stage II TCGA-DD-A3A MALE M0 N0 T3b 1 Stage IIIB TCGA-DD-A3A MALE M0 N0 T2 0 Stage II TCGA-DD-A3A FEMALE M1 N0 T4 1 Stage IVB TCGA-DD-A4NA FEMALE M0 N1 T2 0 Stage IIIC TCGA-DD-A4NB MALE M0 N0 T1 0 Stage I TCGA-DD-A4ND FEMALE M0 N0 T1 0 Stage I TCGA-DD-A4NE FEMALE M0 N0 T3a 1 Stage IIIA TCGA-DD-A4NF MALE M0 N0 T1 0 Stage I TCGA-DD-A4NG MALE M0 NX T3a 1 Stage IIIA TCGA-DD-A4NH FEMALE M0 N0 T3b 1 Stage IIIB TCGA-DD-A4NI MALE M0 NX T2 0 Stage II TCGA-DD-A4NJ FEMALE M0 N0 T2 0 Stage II TCGA-DD-A4NK FEMALE 0 84 M0 N0 T3 1 Stage IIIA TCGA-DD-A4NL MALE M0 N0 T1 0 Stage I TCGA-DD-A4NN FEMALE M0 N0 T1 0 Stage I TCGA-DD-A4NO MALE M0 N0 T1 0 Stage I TCGA-DD-A4NP MALE M0 N0 T1 0 Stage I TCGA-DD-A4NQ MALE M0 N0 T2 0 Stage II TCGA-DD-A4NR FEMALE M0 N0 T1 0 Stage I TCGA-DD-A4NS FEMALE M0 N0 T1 0 Stage I TCGA-DD-A4NV MALE M0 N0 T3 1 Stage IIIA TCGA-DD-A73A MALE M0 N0 T1 0 Stage I TCGA-DD-A73B FEMALE M0 N0 T1 0 Stage I TCGA-DD-A73C FEMALE M0 N0 T3a 1 Stage IIIA TCGA-DD-A73D FEMALE MX NX T2 0 Stage II TCGA-DD-A73E MALE M0 N0 T1 0 Stage I TCGA-DD-A73F FEMALE M0 N0 T1 0 Stage I TCGA-DD-A73G FEMALE M0 N0 T1 0 Stage I TCGA-ED-A MALE M0 N0 T2 0 Stage II TCGA-ED-A4XI MALE M0 N0 T2 0 Stage II TCGA-ED-A5KG FEMALE M0 N0 T2 0 Stage II TCGA-ED-A MALE M0 NX T1 0 Stage I TCGA-ED-A66X MALE M0 N0 T3a 1 Stage IIIA TCGA-ED-A66Y FEMALE M0 N0 T3a 1 Stage IIIA TCGA-ED-A7PY FEMALE M0 NX T2 0 Stage II TCGA-ED-A7PZ MALE M0 NX T2 0 Stage II TCGA-EP-A12J MALE MX NX T1 0 Stage I TCGA-EP-A26S MALE MX N0 T1 0 Stage I TCGA-EP-A2KA FEMALE MX NX T3a 1 Stage IIIA TCGA-EP-A2KB FEMALE MX NX T1 0 Stage I TCGA-EP-A2KC MALE MX NX T1 0 Stage I TCGA-EP-A3JL MALE MX NX T1 0 Stage I TCGA-EP-A3RK MALE MX NX T3a 1 Stage IIIA TCGA-ES-A2HS MALE MX NX T1 0 Stage I TCGA-ES-A2HT MALE MX NX T1 0 Stage I TCGA-FV-A23B FEMALE 0 M0 N0 T2 0 Stage II TCGA-FV-A2QQ MALE 1 MX N1 T1 0 Stage IVA TCGA-FV-A2QR MALE 1 M0 N0 T1 0 Stage I TCGA-FV-A3I FEMALE 0 M0 NX T2 0 Stage II TCGA-FV-A3I FEMALE 0 MX N0 T2 0 Stage II TCGA-FV-A3R MALE 1 75 MX NX T1 0 Stage I TCGA-FV-A3R FEMALE MX NX T1 0 Stage I TCGA-FV-A FEMALE M0 NX T2 0 Stage II TCGA-FV-A FEMALE M0 NX T1 0 Stage I TCGA-FV-A4ZP MALE M0 NX T3 1 Stage IIIA TCGA-FV-A4ZQ MALE 1 M0 NX T1 0 Stage I TCGA-G3-A25S MALE M0 N0 T1 0 Stage I TCGA-G3-A25T FEMALE M0 N0 T3 1 Stage IIIA TCGA-G3-A25U FEMALE M0 N0 T1 0 Stage I TCGA-G3-A25V MALE M0 N0 T1 0 Stage I TCGA-G3-A25X MALE M0 N0 T2 0 Stage II TCGA-G3-A25Y FEMALE M0 N0 T1 0 Stage I TCGA-G3-A25Z MALE M0 N0 T1 0 Stage I TCGA-G3-A3CG MALE M0 N0 T1 0 Stage I TCGA-G3-A3CH MALE M0 N0 T3a 1 Stage IIIA TCGA-G3-A3CI MALE M0 N0 T1 0 Stage I TCGA-G3-A3CJ MALE M0 N0 T2 0 Stage II TCGA-G3-A3CK MALE M0 N0 T1 0 Stage I TCGA-G3-A5SI MALE M0 N0 T2 0 Stage II TCGA-G3-A5SJ MALE M0 NX T1 0 Stage I TCGA-G3-A5SK MALE M0 NX T1 0 Stage I TCGA-G3-A5SL MALE M0 NX T2 0 Stage II TCGA-G3-A5SM MALE M0 NX T2 0 Stage II TCGA-G3-A6UC MALE M0 N0 T3b 1 Stage IIIB TCGA-G3-A7M MALE MX NX T1 0 Stage I TCGA-G3-A7M FEMALE MX NX T1 0 Stage I TCGA-G3-A7M MALE 1 MX NX T1 0 Stage I TCGA-GJ-A6C FEMALE MX NX T2 0 Stage II TCGA-HP-A5MZ MALE M0 NX T1 0 Stage I TCGA-HP-A5N FEMALE M0 NX TX TCGA-K7-A5RF MALE MX NX T1 0 Stage I TCGA-K7-A5RG MALE MX NX T1 0 Stage I TCGA-K7-A6G MALE MX N0 T1 0 Stage I TCGA-KR-A7K MALE M0 N0 T1 0 Stage I TCGA-KR-A7K MALE M0 N0 T1 0 Stage I TCGA-KR-A7K FEMALE M0 N0 T2 0 Stage II TCGA-KR-A7K MALE M0 N0 T1 0 Stage I TCGA-LG-A6GG FEMALE M0 NX T2 0 Stage II TCGA-MI-A75C MALE M0 N0 T1 0 Stage I TCGA-MI-A75E MALE M0 N0 T4 1 Stage IIIC TCGA-MI-A75G MALE M0 N0 T2 0 Stage II TCGA-MI-A75H MALE MX NX TCGA-MI-A75I MALE MX NX T2 0 TCGA-MR-A TCGA-NI-A4U MALE MX NX T3 1 Stage IIIA TCGA-O8-A75V MALE MX NX T1 0 Stage I TCGA-PD-A5DF FEMALE M0 N0 T4 1 Stage IIIB TCGA-QA-A7B MALE MX NX T2 0 Stage II TCGA-RC-A6M TCGA-RC-A6M TCGA-RC-A6M TCGA-RC-A6M TCGA-RC-A7S FEMALE M0 N0 T1 0 Stage I TCGA-RG-A7D MALE M0 N0 T2 0 Stage II TCGA-T1-A6J MALE M0 NX T1 0 TCGA-UB-A7MA FEMALE M0 N0 T2b 0 Stage II TCGA-UB-A7MB MALE MX NX T2 0 Stage II TCGA-UB-A7MC MALE MX N0 T3a 1 Stage IIIA TCGA-UB-A7ME MALE MX NX T1 0 Stage I TCGA-UB-A7MF MALE MX NX T3a 1 Stage IIIA Supplementary Table 1
21 Supplementary Table 2 EMT Score CD36 FABP1 FABP4 FABP5 SLC27A2 SLC27A5 BMI BMI_Log2 Pearson correlation P-value (two-tailed) BMI_Log2 EMT SCR CD36 FABP1 FABP4 FABP5 SLC27A2 SLC27A5 BMI Pearson correlation P-value (two-tailed) BMI_Log2 CDH2 FN1 SNAI1 SNAI2 TWIST1 TWIST2 VIM ZEB1 ZEB2 CDH1 CLDN4 CLDN7 MUC1 TJP3 EMT SCR BMI Pearson correlation P-value (two-tailed) Bonferroni corrected p-value
22 Supplementary Table 3 Patient clinical information Western Blot quantification TSS ID BMI SEX Grade T N M STAGE CD36 VIM ZEB1 ZEB2 TGFB PORCN CDH DSP SNAIL Patient Key: M II Patient Key: F III Patient Key: F I Patient Key: M III Patient Key: M 3 3A 0 1 IV Patient Key: M I Patient Key: F II Patient Key: M IIIA Patient Key: SW F IIIA Patient Key: M 2 3A X 0 X Patient Key: F 1 2 X X X Patient Key: M I Patient Key: M I Patient Key: SW M IIIA Patient Key: F IIIC Patient Key: M X X TSS ID Hx of disease Patient Key:6680 chronic HBV; dx with HCC 6/2/2009; HCC recurrence on 12/3/2009; Patient Key: 3993 dx with HCC 7/23/1996; recurrence on 10/15/1996 Patient Key:2604 extreme smoking until 1996, dx with HCC w/o Cirrhosis 5/7/2001, recurrence 10/1/2002, recurrence 05/14/2003 Patient Key:5828 Chronic HBV; dx with HCC 05/29/2008; Metastatic HCC to lung 4/8/2009 Patient Key:3167 Chronic HBV; dx with HCC 4/8/2003; Patient Key:5858 Chronic HBV: dx with cirrhosis in 2000, dx with HCC 6/13/2008; Patient Key:2613 Smoking history for 45 yrs; occasional alcohol consumption; dx with HCC 2006; recurrence of HCC 2010; Patient Key:3013 Chronic HCV; dx with HCC 1/18/2002; Metastatic HCC to sternum 10/19/2004 Patient Key: SW1 dx with HCC 2/9/2004 Patient Key: 8118 remote alcohol history; dx with HCC 1/10/2011 Patient Key: Chronic HCV; advance fibrosis; dx with HCC in 2012; reccurent HCC 5/6/2014; HCC with Cirrhosis 5/7/2014 Patient Key:4068 dx with HCC 2/27/2006 Patient Key:3423 nonalcoholic steatohepatitis with cirrhosis; dx with HCC 5/31/2005 Patient Key: SW14 dx with HCC 2007 Patient Key: 6796 dx with CCA 6/11/2009 then determined to be HCC 6/27/2009; Patient Key: 3070 Heavy alcohol use; dx with HCC 6/25/2002; TSS ID Treatment history Patient Key:6680 resection in 6/22/2009; Patient Key: 3993 resection in 7/23/1996; alcohol ablation in 10/17/1996; Chemoembolization 4/9/1997 Patient Key:2604 hepatectomy in 5/14/2001; alcohol ablation 10/2/2002; alcohol ablation 05/15/2003 embolization 6/4/2008; treated with entecavir for HBV 5/52/2008; right hepatectomy & left portal vein thrombectomy 7/1/2008; Radiofrequency ablation 11/4/2008; Sorafenib Patient Key:5828 6/24/2009, Sorafenib+doxorubicin 1/5/2010, Sorafenib only 6/22/2010; MC0812 Chemotherapy (Cisplatin, gemcitabine, and everolimus) 11/11/2010; Cisplatin & Gemcitabine only 3/3/2011; Pazopanib & everolimus 7/24/2012 Patient Key:3167 embolization right portal vein 4/14/2003; Hepatectomy, right adrenalectomy, & cholecystectomy 5/6/2003 Patient Key:5858 portal embolization on the right hepatic lobe 6/17/2008 Patient Key:2613 Patient Key:3013 resection 2006 & 2010; laser ablation 10/14/2011, 6/7/2012, 9/20/2012, 10/4/2012, & 7/24/2013; Radiofrequency 10/28/2013; MR guided liver cyroablation 6/25/2014; MR cyroablation 1/7/2015; Lamivudine 1/18/2002; resection 1/21/2002; Epivir 5/28/2002; Patient Key: SW1 right hepatectomy 2/26/2004; TheraSphere treatment 8/31/2006; Hospice care 3/21/2007 Patient Key: 8118 resection 1/14/2011; Patient Key: resection 9/2012; ethanol ablation 5/13/2014 Patient Key:4068 right hepatectomy 3/3/2006 Patient Key:3423 resection 6/7/2005 Patient Key: SW14 resection 6/2007 Patient Key: 6796 resection 6/24/2009 Patient Key: 3070 resection 7/8/2002
23 HepG2 PA vs. BSA foldchange Transcriptional regulation by TGFβ Supplementary Table 4 Transcriptional regulation by WNT/β-catenin Hep3B PA vs. BSA foldchange Transcriptional regulation by TGF-β Transcriptional regulation by WNT/β-catenin AHNAK x IL1RN Genes used for KEGG pathway enrichment analysis COL5A x MST1R WNT5B x TGFB x WNT SNAI BMP TGFB IL1RN IGFBP x PPPDE ZEB NODAL BMP FOXC x NUDT SOX SMAD TSPAN TCF x x STEAP RGS TGFB x CDH x CDH x COL3A x CALD x SPP MST1R ESR x WNT5A x CALD x KRT CTNNB x VIM GSK3B x COL3A x ILK MSN TSPAN ZEB PTP4A MMP FGFBP KRT VCAN SPARC GNG MMP GSC BMP TWIST COL1A MAP1B GNG ZEB GSC PDGFRB TWIST SIP PDGFRB BMP MMP F11R IGFBP EGFR VCAN ITGAV TMEM132A PTK OCLN OCLN TFPI COL1A SNAI COL5A TCF KRT MAP1B KRT ILK TIMP PTK SOX RGS ITGA NUDT PPPDE FGFBP RAC BMP STEAP CTNNB MSN STAT STAT AKT ITGB F11R ERBB ERBB MMP VPS13A JAG KRT AKT SIP VPS13A TIMP NOTCH PLEK DSP ITGA TCF GSK3B SNAI TMEFF MMP ITGB VIM SPP TFPI TCF BMP SMAD FN CDH DSC PTP4A WNT5B ESR NODAL FZD TMEM132A ZEB CAV SNAI CAMK2N DSC TGFB RAC SPARC JAG PLEK DSP CDH TGFB TMEFF SERPINE SNAI FN FZD CAMK2N KRT NOTCH WNT5A ITGAV FOXC CAV MMP TGFB WNT SNAI SERPINE EGFR AHNAK
24 Supplementary Table 5 CD36 vs TGFB signaling (KEGG) CD36 vs WNT signaling (KEGG) CD36 vs PPAR/TFs Pearson's Pearson's Pearson's Gene P-value FDR (BH) Gene P-value FDR (BH) Gene P-value FDR (BH) Correlation Correlation Correlation CD CD CD BMP NKD PPARD ROCK AXIN NFKB BMPR1B CTNNB NR1I AMH TCF PPARA COMP DAAM HIF1A THBS ROCK FOS DCN PRKCA NR1H BMP8B SFRP PPARG TGFB WNT9A JUN INHBE PLCB STAT BMP8A WNT ID FZD LEFTY MMP SMAD WNT7B GDF WNT10A SMAD FZD TGFBR WNT ID NKD SKP NFAT TGFB PPP3R NODAL CSNK1A INHBB WNT10B CUL DKK CREBBP TCF7L ZFYVE CTBP E2F PRKX RPS6KB BTRC RBX NFATC AMHR SMAD MAPK CER PPP2CA FRAT ACVR1C FRAT LEFTY LEF NOG FZD SMAD PRKACB GDF PPP2R5A ZFYVE SKP LTBP WNT2B BMP DAAM TGFB PRICKLE PPP2R1A PPP2R5C SMURF CCND TNF NFATC THBS SFRP ACVR2A CTNNBIP RBL WIF SMAD VANGL THBS CUL PITX WNT5B ID AXIN PPP2R1B CREBBP SMAD DKK RPS6KB RBX BMP CAMK2B BMPR CCND ID MAP3K THBS SFRP BMP CSNK2A SMAD PPP2CA RHOA RAC INHBA TBL1X SMAD MAPK MYC PPP2R5B ACVR SENP RBL CHP SMURF DVL ROCK DKK ACVR2B MAPK SP WNT ACVRL CSNK2A FST FZD INHBC PPP2R1A BMPR1A FOSL CHRD FBXW GDF TCF7L PPP2CB PPARD EP DVL MAPK JUN CDKN2B FZD E2F WNT3A TGFBR APC IFNG FZD BMP PPP2R5D TFDP PLCB SMAD MAPK GSK3B VANGL CACYBP PPP2R1B LRP CAMK2D TP DVL CHP SMAD SFRP PSEN NLK CSNK1A1L RAC PRKCB FZD PLCB PPP3CA FZD PRKACA CHD NFATC CAMK2A TBL1XR APC FZD RHOA PPP3R RUVBL SMAD WNT8A WNT7A WNT NFATC PRKACG SOX MYC RAC PPP3CC ROCK PRICKLE CCND PPP2CB WNT9B LRP PORCN PRKCG FZD EP CAMK2G WNT5A WNT8B CSNK2B CXXC SIAH CTBP PPP3CB WNT PLCB WNT PPP2R5E WNT
Supplemental Table S1. Tumor specific networks are enriched with somatically mutated genes (taken from the database COSMIC)
Additional file 1 Supplemental Table S1. Tumor specific networks are enriched with somatically mutated genes (taken from the database COSMIC) COSMIC genes in tumor network COSMIC genes not in tumor network
Electronic Supplementary Information
Electronic Supplementary Information The preferred all-gauche conformations in 3-fluoro-1,2-propanediol Laize A. F. Andrade, a Josué M. Silla, a Claudimar J. Duarte, b Roberto Rittner, b Matheus P. Freitas*,a
Parts Manual. Trio Mobile Surgery Platform. Model 1033
Trio Mobile Surgery Platform Model 1033 Parts Manual For parts or technical assistance: Pour pièces de service ou assistance technique : Für Teile oder technische Unterstützung Anruf: Voor delen of technische
Nature Medicine doi: /nm.2457
ature Medicine doi:10.1038/nm.2457 ature Medicine doi:10.1038/nm.2457 ature Medicine doi:10.1038/nm.2457 ature Medicine doi:10.1038/nm.2457 ature Medicine doi:10.1038/nm.2457 Table S1 - Candidate genes
Heterobimetallic Pd-Sn Catalysis: Michael Addition. Reaction with C-, N-, O-, S- Nucleophiles and In-situ. Diagnostics
Supporting Information (SI) Heterobimetallic Pd-Sn Catalysis: Michael Addition Reaction with C-, N-, -, S- Nucleophiles and In-situ Diagnostics Debjit Das, a Sanjay Pratihar a,b and Sujit Roy c * a rganometallics
TFDP2 TFDP1 SUMO1 SERTAD1 RPA3 RBBP8 RAD9A RAD17 RAD1 NBN MRE11A MNAT1 KPNA2 KNTC1 HUS1 HERC5 GTSE1 GTF2H1 GADD45A E2F4 DNM2 DDX11 CUL3 SKP2 RBL1 RB1
-8-6 -4-2 CHEK2 MKI67 RB1 RBL1 SKP2 Fold-Change Fold-Change -3-2 -1 CCND1 CCNE1 CDK4 CDK5R1 5 1 15 ATM ATR BAX BCCIP BRCA1 BRCA2 BL1AT ABL1A ABL1 CCNG1 CCNG2 CCNH CCNT1 CCNT2 CDC2 CDC34 CDKN1A CDKN1B CDKN2A
Math 6 SL Probability Distributions Practice Test Mark Scheme
Math 6 SL Probability Distributions Practice Test Mark Scheme. (a) Note: Award A for vertical line to right of mean, A for shading to right of their vertical line. AA N (b) evidence of recognizing symmetry
Η ΥΠΕΡΕΚΦΡΑΣΗ ΤΟΥ SMAD7 ΠΡΟΣΤΑΤΕΥΕΙ ΤΟ ΗΠΑΡ ΑΠΟ ΤΗΝ TGF-Β/SMAD ΜΕΣΟΛΑΒΟΥΜΕΝΗ ΙΝΟΓΕΝΕΣΗ
Η ΥΠΕΡΕΚΦΡΑΣΗ ΤΟΥ SMAD7 ΠΡΟΣΤΑΤΕΥΕΙ ΤΟ ΗΠΑΡ ΑΠΟ ΤΗΝ TGF-Β/SMAD ΜΕΣΟΛΑΒΟΥΜΕΝΗ ΙΝΟΓΕΝΕΣΗ OVEREXPRESSION OF SMAD7 PROTECTS LIVER FROM TGF-B/SMAD-MEDIATED FIBROGENESIS Γ. Γερμανίδης(1), Ν. Αργέντου(2), Ε.
Group 2 Methotrexate 7.5 mg/week, increased to 15 mg/week after 4 weeks. Methotrexate 7.5 mg/week, increased to 15 mg/week after 4 weeks
Group 1 Methotrexate 7.5 mg/week, increased to 15 mg/week after 4 weeks Group 2 Methotrexate 7.5 mg/week, increased to 15 mg/week after 4 weeks Sulfasalazine 2000-3000 mg/day Leflunomide 20 mg/day Infliximab
NES: normalized enrichment score (analyzed using KEGG pathway gene sets in the GSEA software); FDR:
Supplementary table1. List of gene sets with simultaneously altered the enrichment upon SAP18 overexpression and knockdown. Gene sets enriched by SAP18 and reduced by shsap18 SAP18 against LacZ shsap18
Quantum dot sensitized solar cells with efficiency over 12% based on tetraethyl orthosilicate additive in polysulfide electrolyte
Electronic Supplementary Material (ESI) for Journal of Materials Chemistry A. This journal is The Royal Society of Chemistry 2017 Supplementary Information (SI) Quantum dot sensitized solar cells with
A strategy for the identification of combinatorial bioactive compounds. contributing to the holistic effect of herbal medicines
1 2 Supplementary information 3 4 A strategy for the identification of combinatorial bioactive compounds contributing to the holistic effect of herbal medicines 5 6 Fang Long 1, Hua Yang 1, Yanmin Xu,
Electronic Supplementary Information
Electronic Supplementary Information NbCl 3 -catalyzed [2+2+2] intermolecular cycloaddition of alkynes and alkenes to 1,3-cyclohexadiene derivatives Yasushi Obora,* Keisuke Takeshita and Yasutaka Ishii*
Synthesis of Imines from Amines in Aliphatic Alcohols on Pd/ZrO 2 Catalyst at Ambient Conditions
This journal is The Royal Society of Chemistry 213 Synthesis of Imines from Amines in Aliphatic Alcohols on Pd/ZrO 2 Catalyst at Ambient Conditions Wenjing Cui, a Bao Zhaorigetu,* a Meilin Jia, a and Wulan
Supplementary Information. Living Ring-Opening Polymerization of Lactones by N-Heterocyclic Olefin/Al(C 6 F 5 ) 3
Supplementary Information Living Ring-Opening Polymerization of Lactones by N-Heterocyclic Olefin/Al(C 6 F 5 ) 3 Lewis Pairs: Structures of Intermediates, Kinetics, and Mechanism Qianyi Wang, Wuchao Zhao,
RFA : HCC. percutaneous acetic acid injection therapy: PAIT 3 percutaneous hot water injection therapy: PHot 4 HCC HCV HCC
89 Vol. 33, pp. 89 97, 2005 radiofrequency ablation therapy RFA : 17 6 14 HCC 3 HCC B HBV C HCV HCV HCC 8 HCC HCV 7 8 high risk group HCC HCC i ii iii HCC HCC radiofrequency ablation therapy: RFA 1980
VBA Microsoft Excel. J. Comput. Chem. Jpn., Vol. 5, No. 1, pp (2006)
J. Comput. Chem. Jpn., Vol. 5, No. 1, pp. 29 38 (2006) Microsoft Excel, 184-8588 2-24-16 e-mail: yosimura@cc.tuat.ac.jp (Received: July 28, 2005; Accepted for publication: October 24, 2005; Published on
Supporting Information
Electronic Supplementary Material (ESI) for Organic & Biomolecular Chemistry. This journal is The Royal Society of Chemistry 2018 Supporting Information Crotonols A and B, Two Rare Tigliane Diterpenoid
Η γενετική πολυπλοκότητα του καρκίνου του παγκρέατος
Η γενετική πολυπλοκότητα του καρκίνου του παγκρέατος Δρ Αθανάσιος Αθανασιάδης Αθανάσιος Αθανασιάδης Δεν έχω αντικρουόμενα συμφέροντα προς γνωστοποίηση Καρκίνος παγκρέατος Θνητότης Επίπτωση Καθυστερημένη
encouraged to use the Version of Record that, when published, will replace this version. The most /BCJ
Biochemical Journal: this is an Accepted Manuscript, not the final Version of Record. You are encouraged to use the Version of Record that, when published, will replace this version. The most up-to-date
Aquinas College. Edexcel Mathematical formulae and statistics tables DO NOT WRITE ON THIS BOOKLET
Aquinas College Edexcel Mathematical formulae and statistics tables DO NOT WRITE ON THIS BOOKLET Pearson Edexcel Level 3 Advanced Subsidiary and Advanced GCE in Mathematics and Further Mathematics Mathematical
The effect of curcumin on the stability of Aβ. dimers
The effect of curcumin on the stability of Aβ dimers Li Na Zhao, See-Wing Chiu, Jérôme Benoit, Lock Yue Chew,, and Yuguang Mu, School of Physical and Mathematical Sciences, Nanyang Technological University,
Pyrrolo[2,3-d:5,4-d']bisthiazoles: Alternate Synthetic Routes and a Comparative Study to Analogous Fused-ring Bithiophenes
![Pyrrolo[2,3-d:5,4-d']bisthiazoles: Alternate Synthetic Routes and a Comparative Study to Analogous Fused-ring Bithiophenes](/thumbs/92/108867714.jpg "Pyrrolo[2,3-d:5,4-d']bisthiazoles: Alternate Synthetic Routes and a Comparative Study to Analogous Fused-ring Bithiophenes")
SUPPORTING INFORMATION Pyrrolo[2,3-d:5,4-d']bisthiazoles: Alternate Synthetic Routes and a Comparative Study to Analogous Fused-ring Bithiophenes Eric J. Uzelac, Casey B. McCausland, and Seth C. Rasmussen*
Μελέτη της έκφρασης του ογκοκατασταλτικού γονιδίου Cyld στον καρκίνο του μαστού
Σχολή Θετικών Επιστημών Τμήμα Βιολογίας Πρόγραμμα Μεταπτυχιακών Σπουδών Κατεύθυνση: Εφαρμοσμένη γενετική και βιοτεχνολογία ΜΕΤΑΠΤΥΧΙΑΚΗ ΔΙΠΛΩΜΑΤΙΚΗ ΕΡΓΑΣΙΑ Μελέτη της έκφρασης του ογκοκατασταλτικού γονιδίου
Electronic Supplementary Information (ESI)
Electronic Supplementary Material (ESI) for RSC Advances. This journal is The Royal Society of Chemistry 2016 Electronic Supplementary Information (ESI) Cyclopentadienyl iron dicarbonyl (CpFe(CO) 2 ) derivatives
Supplementary Appendix
Supplementary Appendix Measuring crisis risk using conditional copulas: An empirical analysis of the 2008 shipping crisis Sebastian Opitz, Henry Seidel and Alexander Szimayer Model specification Table
Supporting Information
Electronic Supplementary Material (ESI) for ChemComm. This journal is The Royal Society of Chemistry 2015 Synthesis of 3-omosubstituted Pyrroles via Palladium- Catalyzed Intermolecular Oxidative Cyclization
Cellular Physiology and Biochemistry
Original Paper 2016 The Author(s). 2016 Published The Author(s) by S. Karger AG, Basel Published online: November 25, 2016 www.karger.com/cpb Published by S. Karger AG, Basel 486 www.karger.com/cpb Accepted:
SABiosciences PCR Array Catalog #: PAHS-021 SA+ SCF 4h stimulaton AVG(Ct) Position Unigene Refseq Symbol Description shcontr shcontr-4h shgskβ A01
SABiosciences PCR Array Catalog #: PAHS-021 SA+ SCF 4h stimulaton AVG(Ct) Position Unigene Refseq Symbol Description shcontr shcontr-4h shgskβ A01 Hs.1274 NM_006129 BMP1 Bone morphogenetic protein 1 25.25
Matrices and Determinants
Matrices and Determinants SUBJECTIVE PROBLEMS: Q 1. For what value of k do the following system of equations possess a non-trivial (i.e., not all zero) solution over the set of rationals Q? x + ky + 3z
Comparison of carbon-sulfur and carbon-amine bond in therapeutic drug: -S-aromatic heterocyclic podophyllum derivatives display antitumor activity
Comparison of carbon-sulfur and carbon-amine bond in therapeutic drug: -S-aromatic heterocyclic podophyllum derivatives display antitumor activity Jian-Long Li 1,a, Wei Zhao 1,a, Chen Zhou 1,a, Ya-Xuan
Pax8 and Pax2 are specifically required at different steps of Xenopus pronephros development
Pax8 and Pax2 are specifically required at different steps of Xenopus pronephros development Isabelle Buisson, Ronan Le Bouffant, Mélinée Futel, Jean-François Riou, Muriel Umbhauer To cite this version:
Example Sheet 3 Solutions
Example Sheet 3 Solutions. i Regular Sturm-Liouville. ii Singular Sturm-Liouville mixed boundary conditions. iii Not Sturm-Liouville ODE is not in Sturm-Liouville form. iv Regular Sturm-Liouville note
Parts Manual. Wide Transport Stretcher Model 738
Wide Transport Stretcher Model 738 Modèle 738 De Civière Large Pour Le Transport Breites Transport-Bahre-Modell 738 Breed Model 738 van de Brancard van het Vervoer Modello Largo 738 Della Barella Di Trasporto
Supplementary figures
A Supplementary figures a) DMT.BG2 0.87 0.87 0.72 20 40 60 80 100 DMT.EG2 0.93 0.85 20 40 60 80 EMT.MG3 0.85 0 20 40 60 80 20 40 60 80 100 20 40 60 80 100 20 40 60 80 EMT.G6 DMT/EMT b) EG2 0.92 0.85 5
Supporting Information
Supporting Information Mitochondria-Targeting Polydopamine Nanocomposites as Chemophotothermal Therapeutics for Cancer Zhuo Wang *,, Yuzhi Chen, Hui Zhang, Yawen Li, Yufan Ma, Jia Huang, Xiaolei Liu, Fang
Supplementary Materials for. Kinetic and Computational Studies on Pd(I) Dimer- Mediated Halogen Exchange of Aryl Iodides
Supplementary Materials for Kinetic and Computational Studies on Pd(I) Dimer- Mediated Halogen Exchange of Aryl Iodides Indrek Kalvet, a Karl J. Bonney, a and Franziska Schoenebeck a * a Institute of Organic
ΚΕΡΚΙΔΙΚΗ ΚΑΙ ΜΗΡΙΑΙΑ ΠΡΟΣΠΕΛΑΣΗ ΣΕ ΣΤΕΦΑΝΙΟΓΡΑΦΙΕΣ ΚΑΙ ΑΓΓΕΙΟΠΛΑΣΤΙΚΕΣ. ΜΙΑ ΣΥΓΚΡΙΤΙΚΗ ΜΕΛΕΤΗ
ΚΕΡΚΙΔΙΚΗ ΚΑΙ ΜΗΡΙΑΙΑ ΠΡΟΣΠΕΛΑΣΗ ΣΕ ΣΤΕΦΑΝΙΟΓΡΑΦΙΕΣ ΚΑΙ ΑΓΓΕΙΟΠΛΑΣΤΙΚΕΣ. ΜΙΑ ΣΥΓΚΡΙΤΙΚΗ ΜΕΛΕΤΗ Μαυρόγιαννη Γεωργία 1, Καραντζούλα Ευαγγελία 2, Τουλιά Γεωργία 3, Κυριακόπουλος Βασίλης 4, Καδδά Όλγα 5 EΡΕΥΝΑ
상대론적고에너지중이온충돌에서 제트입자와관련된제동복사 박가영 인하대학교 윤진희교수님, 권민정교수님
상대론적고에너지중이온충돌에서 제트입자와관련된제동복사 박가영 인하대학교 윤진희교수님, 권민정교수님 Motivation Bremsstrahlung is a major rocess losing energies while jet articles get through the medium. BUT it should be quite different from low energy
Supporting information. An unusual bifunctional Tb-MOF for highly sensing of Ba 2+ ions and remarkable selectivities of CO 2 /N 2 and CO 2 /CH 4
Electronic Supplementary Material (ESI) for Journal of Materials Chemistry A. This journal is The Royal Society of Chemistry 2015 Supporting information An unusual bifunctional Tb-MOF for highly sensing
Supporting Information
Supporting Information Aluminum Complexes of N 2 O 2 3 Formazanate Ligands Supported by Phosphine Oxide Donors Ryan R. Maar, Amir Rabiee Kenaree, Ruizhong Zhang, Yichen Tao, Benjamin D. Katzman, Viktor
Τα ηπατικά επίπεδα του FOXP3 mrna στη χρόνια ηπατίτιδα Β εξαρτώνται από την έκφραση των οδών Fas/FasL και PD-1/PD-L1
Τα ηπατικά επίπεδα του FOXP3 mrna στη χρόνια ηπατίτιδα Β εξαρτώνται από την έκφραση των οδών Fas/FasL και PD-1/PD-L1 Γ. Γερμανίδης, Ν. Αργέντου, Θ. Βασιλειάδης, Κ. Πατσιαούρα, Κ. Μαντζούκης, A. Θεοχαρίδου,
IL - 13 /IL - 18 ELISA PCR RT - PCR. IL - 13 IL - 18 mrna. 13 IL - 18 mrna IL - 13 /IL Th1 /Th2
344 IL - 13 /IL - 18 1 2 1 2 1 2 1 2 1 2 3 1 2 13 18 IL - 13 /IL - 18 10% / OVA /AL OH 3 5% 16 ~ 43 d 44 d ELISA BALF IL - 13 IL - 18 PCR RT - PCR IL - 13 IL - 18 mrna IL - 13 mrna 0. 01 IL - 18 mrna 0.
Jesse Maassen and Mark Lundstrom Purdue University November 25, 2013
Notes on Average Scattering imes and Hall Factors Jesse Maassen and Mar Lundstrom Purdue University November 5, 13 I. Introduction 1 II. Solution of the BE 1 III. Exercises: Woring out average scattering
Supplementary Table 1. Primers used for RT-qPCR analysis of striatal and nigral tissue.
Supplementary Table 1. Primers used for RT-qPCR analysis of striatal and nigral tissue. Gene Forward Primer (5-3 ) Reverse Primer (5-3 ) Dopaminergic Markers TH CTG GCC ATT GAT GTA CTG GA ACA CAC ATG GGA
Homework 8 Model Solution Section
MATH 004 Homework Solution Homework 8 Model Solution Section 14.5 14.6. 14.5. Use the Chain Rule to find dz where z cosx + 4y), x 5t 4, y 1 t. dz dx + dy y sinx + 4y)0t + 4) sinx + 4y) 1t ) 0t + 4t ) sinx
!"#!"!"# $ "# '()!* '+!*, -"*!" $ "#. /01 023 43 56789:3 4 ;8< = 7 >/? 44= 7 @ 90A 98BB8: ;4B0C BD :0 E D:84F3 B8: ;4BG H ;8
Table S1: Inpatient Diet Composition
Table S1: Inpatient Diet Composition Diet Components (% of Energy) Inpatient Period Baseline Intervention Protein 15.1 ± 0.0 15.0 ± 0.1 Total fat 30.0 ± 0.0 30.0 ± 0.1 Saturated fat 8.6 ± 0.8 8.4 ± 0.9
< (0.999) Graft (0.698) (0.483) <0.001 (0.698) (<0.001) (<0.001) 3 months (0.999) (0.483) (<0.001) 6 months (<0.
Supplementary table 1. Correlation of endothelial cell density among graft, 3, 6, and 12 months after Descemet s automated stripping endothelial keratoplasty. Graft 3 months 6 months 12 months Graft
Metal-free Oxidative Coupling of Amines with Sodium Sulfinates: A Mild Access to Sulfonamides
Electronic Supplementary Material (ESI) for RSC Advances. This journal is The Royal Society of Chemistry 2014 Supporting information for Metal-free Oxidative Coupling of Amines with Sodium Sulfinates:
Supplementary Materials: Development of Amyloseand β-cyclodextrin-based Chiral Fluorescent Sensors Bearing Terthienyl Pendants
S1 of S12 Supplementary Materials: Development of Amyloseand β-cyclodextrin-based Chiral Fluorescent Sensors Bearing Terthienyl Pendants Tomoyuki Ikai, Changsik Yun, Yutaka Kojima, Daisuke Suzuki, Katsuhiro
Review Test 3. MULTIPLE CHOICE. Choose the one alternative that best completes the statement or answers the question.
Review Test MULTIPLE CHOICE. Choose the one alternative that best completes the statement or answers the question. Find the exact value of the expression. 1) sin - 11π 1 1) + - + - - ) sin 11π 1 ) ( -
Second Order RLC Filters
ECEN 60 Circuits/Electronics Spring 007-0-07 P. Mathys Second Order RLC Filters RLC Lowpass Filter A passive RLC lowpass filter (LPF) circuit is shown in the following schematic. R L C v O (t) Using phasor
Supporting Information. Introduction of a α,β-unsaturated carbonyl conjugated pyrene-lactose hybrid
Electronic Supplementary Material (ESI) for RSC Advances. This journal is The Royal Society of Chemistry 16 Supporting Information Introduction of a α,β-unsaturated carbonyl conjugated pyrene-lactose hybrid
w o = R 1 p. (1) R = p =. = 1
Πανεπιστήµιο Κρήτης - Τµήµα Επιστήµης Υπολογιστών ΗΥ-570: Στατιστική Επεξεργασία Σήµατος 205 ιδάσκων : Α. Μουχτάρης Τριτη Σειρά Ασκήσεων Λύσεις Ασκηση 3. 5.2 (a) From the Wiener-Hopf equation we have:
Enzymatic Synthesis of Dithiolopyrrolone Antibiotics Using Cell-Free Extract of Saccharothrix
Enzymatic Synthesis of Dithiolopyrrolone Antibiotics Using Cell-Free Extract of Saccharothrix algeriensis NRRL B-24137 and Biochemical Characterization of Two Pyrrothine N-Acyltransferases in This Extract.
ΑΡΙΣΤΟΤΕΛΕΙΟ ΠΑΝΕΠΙΣΤΗΜΙΟ ΘΕΣΣΑΛΟΝΙΚΗΣ ΤΜΗΜΑ ΟΔΟΝΤΙΑΤΡΙΚΗΣ ΕΡΓΑΣΤΗΡΙΟ ΟΔΟΝΤΙΚΗΣ ΚΑΙ ΑΝΩΤΕΡΑΣ ΠΡΟΣΘΕΤΙΚΗΣ
ΑΡΙΣΤΟΤΕΛΕΙΟ ΠΑΝΕΠΙΣΤΗΜΙΟ ΘΕΣΣΑΛΟΝΙΚΗΣ ΤΜΗΜΑ ΟΔΟΝΤΙΑΤΡΙΚΗΣ ΕΡΓΑΣΤΗΡΙΟ ΟΔΟΝΤΙΚΗΣ ΚΑΙ ΑΝΩΤΕΡΑΣ ΠΡΟΣΘΕΤΙΚΗΣ ΣΥΓΚΡΙΤΙΚΗ ΜΕΛΕΤΗ ΤΗΣ ΣΥΓΚΡΑΤΗΤΙΚΗΣ ΙΚΑΝΟΤΗΤΑΣ ΟΡΙΣΜΕΝΩΝ ΠΡΟΚΑΤΑΣΚΕΥΑΣΜΕΝΩΝ ΣΥΝΔΕΣΜΩΝ ΑΚΡΙΒΕΙΑΣ
ΓΕΩΠΟΝΙΚΟ ΠΑΝΕΠΙΣΤΗΜΙO ΑΘΗΝΩΝ ΤΜΗΜΑ ΑΞΙΟΠΟΙΗΣΗΣ ΦΥΣΙΚΩΝ ΠΟΡΩΝ & ΓΕΩΡΓΙΚΗΣ ΜΗΧΑΝΙΚΗΣ
ΓΕΩΠΟΝΙΚΟ ΠΑΝΕΠΙΣΤΗΜΙO ΑΘΗΝΩΝ ΤΜΗΜΑ ΑΞΙΟΠΟΙΗΣΗΣ ΦΥΣΙΚΩΝ ΠΟΡΩΝ & ΓΕΩΡΓΙΚΗΣ ΜΗΧΑΝΙΚΗΣ ΠΡΟΓΡΑΜΜΑ ΜΕΤΑΠΤΥΧΙΑΚΩΝ ΣΠΟΥΔΩΝ «ΕΦΑΡΜΟΓΕΣ ΤΗΣ ΓΕΩΠΛΗΡΟΦΟΡΙΚΗΣ ΣΤΟΥΣ ΦΥΣΙΚΟΥΣ ΠΟΡΟΥΣ» «Χωρικά μοντέλα πρόβλεψης αναβλάστησης
Supplementary Materials: A Preliminary Link between Hydroxylated Metabolites of Polychlorinated Biphenyls and Free Thyroxin in Humans
S1 of S11 Supplementary Materials: A Preliminary Link between Hydroxylated Metabolites of Polychlorinated Biphenyls and Free Thyroxin in Humans Eveline Dirinck, Alin C. Dirtu, Govindan Malarvannan, Adrian
J. Dairy Sci. 93: doi: /jds American Dairy Science Association, 2010.
Supplementary Table 1. Primers and PCR conditions used for the amplification of the goat SCD1 cdna (PCR1 to PCR6) and three SCD1 polymorphic regions (PCR7 to PCR9) PCR Primers Sequence Position 1 Thermal
Supporting Information
Supporting Information rigin of the Regio- and Stereoselectivity of Allylic Substitution of rganocopper Reagents Naohiko Yoshikai, Song-Lin Zhang, and Eiichi Nakamura* Department of Chemistry, The University
ΠΡΟΓΡΑΜΜΑ ΕΚΠΟΝΗΣΗΣ ΜΕΛΕΤΩΝ ΚΑΙ ΧΡΟΝΟΔΙΑΓΡΑΜΜΑ
ΕΛΛΗΝΙΚΗ ΔΗΜOΚΡΑΤΙΑ ΥΠΟΥΡΓΕΙΟ ΠΕΡΙΒΑΛΛΟΝΤΟΣ ΚΑΙ ΕΝΕΡΓΕΙΑΣ Γ.Γ. Χωρικού Σχεδιασμού & Αστικού Περιβάλλοντος Γεν. Δ/νση Χωρικού Σχεδιασμού Δ/νση Χωροταξικού Σχεδιασμού ΜΕΛΕΤΗ: ΧΡΗΜ/ΤΗΣΗ: Αξιολόγηση και αναθεώρηση
... 5 A.. RS-232C ( ) RS-232C ( ) RS-232C-LK & RS-232C-MK RS-232C-JK & RS-232C-KK
RS-3C WIWM050 014.1.9 P1 :8... 1... 014.0.1 1 A... 014.0. 1... RS-3C()...01.08.03 A.. RS-3C()...01.08.03 3... RS-3C()... 003.11.5 4... RS-3C ()... 00.10.01 5... RS-3C().008.07.16 5 A.. RS-3C().0 1.08.
the total number of electrons passing through the lamp.
1. A 12 V 36 W lamp is lit to normal brightness using a 12 V car battery of negligible internal resistance. The lamp is switched on for one hour (3600 s). For the time of 1 hour, calculate (i) the energy
CRASH COURSE IN PRECALCULUS
CRASH COURSE IN PRECALCULUS Shiah-Sen Wang The graphs are prepared by Chien-Lun Lai Based on : Precalculus: Mathematics for Calculus by J. Stuwart, L. Redin & S. Watson, 6th edition, 01, Brooks/Cole Chapter
Supplementary Information
Electronic upplementary Material (EI) for Photochemical & Photobiological ciences. This journal is The Royal ociety of Chemistry and wner ocieties 214 upplementary Information elective and sensitive fluorescence-shift
High order interpolation function for surface contact problem
3 016 5 Journal of East China Normal University Natural Science No 3 May 016 : 1000-564101603-0009-1 1 1 1 00444; E- 00030 : Lagrange Lobatto Matlab : ; Lagrange; : O41 : A DOI: 103969/jissn1000-56410160300
Best of Uro-oncology Kidney Cancer 2016
Best of Uro-oncology Kidney Cancer 2016 Ιάσων Κυριαζής, MD, MSc, FEBU Κλινικά εντοπισμένη νόσος 417 PN patients all techniques: Long term oncological outcomes. Only tumor stage was associated with recurrence.
MSM Men who have Sex with Men HIV -
,**, The Japanese Society for AIDS Research The Journal of AIDS Research HIV,0 + + + + +,,, +, : HIV : +322,*** HIV,0,, :., n,0,,. + 2 2, CD. +3-ml n,, AIDS 3 ARC 3 +* 1. A, MSM Men who have Sex with Men
of the methanol-dimethylamine complex
Electronic Supplementary Information for: Fundamental and overtone virational spectroscopy, enthalpy of hydrogen ond formation and equilirium constant determination of the methanol-dimethylamine complex
Contents Part I Psychoneuroimmunology and Systems Biology Mechanisms 1 From Psychoneuroimmunology to Personalized, Systems, and Dynamical Medicine
Contents Part I Psychoneuroimmunology and Systems Biology Mechanisms 1 From Psychoneuroimmunology to Personalized, Systems, and Dynamical Medicine... 3 1.1 Psychoneuroimmunology (PNI) and Systems Biology...
EE101: Resonance in RLC circuits
EE11: Resonance in RLC circuits M. B. Patil mbatil@ee.iitb.ac.in www.ee.iitb.ac.in/~sequel Deartment of Electrical Engineering Indian Institute of Technology Bombay I V R V L V C I = I m = R + jωl + 1/jωC
Malgorzata Korycka-Machala, Marcin Nowosielski, Aneta Kuron, Sebastian Rykowski, Agnieszka Olejniczak, Marcin Hoffmann and Jaroslaw Dziadek
Molecules 2017, 21, 154; doi:10.3390/molecules22010154 Supplementary Materials: Naphthalimides Selectively Inhibit the Activity of Bacterial, Replicative DNA Ligases and Display Bactericidal Effect against
Supplemental file 3. All 306 mapped IDs collected by IPA program. Supplemental file 6. The functions and main focused genes in each network.
LIST OF SUPPLEMENTAL FILES Supplemental file 1. Primer sets used for qrt-pcr. Supplemental file 2. All 1305 differentially expressed genes. Supplemental file 3. All 306 mapped IDs collected by IPA program.
Calculating the propagation delay of coaxial cable
Your source for quality GNSS Networking Solutions and Design Services! Page 1 of 5 Calculating the propagation delay of coaxial cable The delay of a cable or velocity factor is determined by the dielectric
Supplementary Table 1. Primer sequences used for RT-qPCR validation of the microarray data. Primer. direction. Forward
Supplementary Table 1. Primer sequences used for RT-qPCR validation of the microarray data Gene Glyceraldehyde 3-phosphate dehydrogenase (Gapdh) Cell death-inducing DFFAlike effector a (Cidea) Peroxisome
Mandelamide-Zinc Catalyzed Alkyne Addition to Heteroaromatic Aldehydes
1 Mandelamide-Zinc Catalyzed Alkyne Addition to Heteroaromatic Aldehydes Gonzalo Blay, Isabel Fernández, Alícia Marco-Aleixandre, and José R. Pedro Departament de Química Orgànica, Facultat de Química,
Οι επιδόσεις Ελλήνων στο Mini Mental State Examination με βάση την ηλικία και τη νοητική κατάσταση από την παιδική στην τρίτη ηλικία.
CLINICAL TRIALS ΚΛΙΝΙΚΕΣ ΜΕΛΕΤΕΣ 25 Οι επιδόσεις Ελλήνων στο Mini Mental State Examination με βάση την ηλικία και τη νοητική κατάσταση από την παιδική στην τρίτη ηλικία. Τσάνταλη, Ε. 1,2,3, Οικονομίδης,
Supplemental tables and figures
Supplemental tables and figures Supplemental Table S1. Demographic and clinical parameters by quartiles of white Variables blood cell count. WBC quartiles( 1 9 cells/l) Q1(.6-5.3, n=2587) Q2(5.4-6.3, n=263)
HIV HIV HIV HIV AIDS 3 :.1 /-,**1 +332
,**1 The Japanese Society for AIDS Research The Journal of AIDS Research +,, +,, +,, + -. / 0 1 +, -. / 0 1 : :,**- +,**. 1..+ - : +** 22 HIV AIDS HIV HIV AIDS : HIV AIDS HIV :HIV AIDS 3 :.1 /-,**1 HIV
PHOS π 0 analysis, for production, R AA, and Flow analysis, LHC11h
PHOS π, ask PHOS π analysis, for production, R AA, and Flow analysis, Henrik Qvigstad henrik.qvigstad@fys.uio.no University of Oslo --5 PHOS π, ask ask he task we use, AliaskPiFlow was written prior, for
Math221: HW# 1 solutions
Math: HW# solutions Andy Royston October, 5 7.5.7, 3 rd Ed. We have a n = b n = a = fxdx = xdx =, x cos nxdx = x sin nx n sin nxdx n = cos nx n = n n, x sin nxdx = x cos nx n + cos nxdx n cos n = + sin
(1) Describe the process by which mercury atoms become excited in a fluorescent tube (3)
Q1. (a) A fluorescent tube is filled with mercury vapour at low pressure. In order to emit electromagnetic radiation the mercury atoms must first be excited. (i) What is meant by an excited atom? (1) (ii)
Selecting Critical Properties of Terpenes and Terpenoids through Group-Contribution Methods and Equations of State
Supporting Information Selecting Critical Properties of Terpenes and Terpenoids through Group-Contribution Methods and Equations of State Mónia A. R. Martins, 1,2 Pedro J. Carvalho, 1 André M. Palma, 1
CONSULTING Engineering Calculation Sheet
E N G I N E E R S Consulting Engineers jxxx 1 Structure Design - EQ Load Definition and EQ Effects v20 EQ Response Spectra in Direction X, Y, Z X-Dir Y-Dir Z-Dir Fundamental period of building, T 1 5.00
Supplementary information:
Supplementary information: Monitoring changes of docosahexaenoic acid-containing lipids during the recovery process of traumatic brain injury in rat using mass spectrometry imaging Shuai Guo 1, Dan Zhou
SUPPORTING INFORMATION
SUPPRTING INFRMATIN Per(-guanidino--deoxy)cyclodextrins: Synthesis, characterisation and binding behaviour toward selected small molecules and DNA. Nikolaos Mourtzis, a Kyriaki Eliadou, a Chrysie Aggelidou,
Supplementary Information for
Supplentary Information for Aggregation induced blue-shifted ission molecular picture from QM/MM study Qunyan Wu, a Tian Zhang, a Qian Peng,* b Dong Wang, a and Zhigang Shuai* a a Key Loratory of Organic
Statistics 104: Quantitative Methods for Economics Formula and Theorem Review
Harvard College Statistics 104: Quantitative Methods for Economics Formula and Theorem Review Tommy MacWilliam, 13 tmacwilliam@college.harvard.edu March 10, 2011 Contents 1 Introduction to Data 5 1.1 Sample
UDZ Swirl diffuser. Product facts. Quick-selection. Swirl diffuser UDZ. Product code example:
UDZ Swirl diffuser Swirl diffuser UDZ, which is intended for installation in a ventilation duct, can be used in premises with a large volume, for example factory premises, storage areas, superstores, halls,
Aluminum Electrolytic Capacitors
Aluminum Electrolytic Capacitors Snap-In, Mini., 105 C, High Ripple APS TS-NH ECE-S (G) Series: TS-NH Features Long life: 105 C 2,000 hours; high ripple current handling ability Wide CV value range (47
Supplemental Table 1. ICD-9-CM codes and ATC codes used in this study
Supplemental Table 1. ICD-9-CM codes and ATC codes used in this study Comorbidities ICD-9-CM codes Medication ATC codes Diabetes 250 Angiotensin-converting enzyme inhibitors C09AA Ischemic heart disease
Zebra reaction or the recipe for heterodimeric zinc complexes synthesis
Electronic Supplementary Material (ESI) for Dalton Transactions. This journal is The Royal Society of Chemistry 05 Supporting Information Zebra reaction or the recipe for heterodimeric zinc complexes synthesis
Supplementary Figure 1
NSC N2d N5d TNFRSFa TNFRSFb RIPK RelA Madd I-TRAF/TANK GAPDH γ-actin Supplementary Figure A 2 hrs Day : Cell seeding Day 9: +ng/ml TNF-α Day 9: Fixation B Merge Nestin PH-3 Hoechst Acute TNF-α Control
ΜΕΛΕΤΗ ΤΗΣ ΠΛΑΣΤΙΚΟΤΗΤΑΣ ΑΡΓΙΛΟΥΧΩΝ ΜΙΓΜΑΤΩΝ ΜΕ ΠΡΟΣΘΗΚΗ ΣΙΔΗΡΑΛΟΥΜΙΝΑΣ ΑΠΟ ΤΗ ΔΙΕΡΓΑΣΙΑ BAYER
Πρακτικά 1ου Πανελληνίου Συνεδρίου για την Αξιοποίηση των Βιομηχανικών Παραπροϊόντων στη Δόμηση, ΕΒΙΠΑΡ, Θεσσαλονίκη, 24-26 Νοεμβρίου 2005 ΜΕΛΕΤΗ ΤΗΣ ΠΛΑΣΤΙΚΟΤΗΤΑΣ ΑΡΓΙΛΟΥΧΩΝ ΜΙΓΜΑΤΩΝ ΜΕ ΠΡΟΣΘΗΚΗ ΣΙΔΗΡΑΛΟΥΜΙΝΑΣ
ΕΦΑΡΜΟΓΗ ΕΥΤΕΡΟΒΑΘΜΙΑ ΕΠΕΞΕΡΓΑΣΜΕΝΩΝ ΥΓΡΩΝ ΑΠΟΒΛΗΤΩΝ ΣΕ ΦΥΣΙΚΑ ΣΥΣΤΗΜΑΤΑ ΚΛΙΝΗΣ ΚΑΛΑΜΙΩΝ
ΤΕΧΝΟΛΟΓΙΚΟ ΕΚΠΑΙ ΕΥΤΙΚΟ Ι ΡΥΜΑ ΚΡΗΤΗΣ ΤΜΗΜΑ ΦΥΣΙΚΩΝ ΠΟΡΩΝ ΚΑΙ ΠΕΡΙΒΑΛΛΟΝΤΟΣ ΕΦΑΡΜΟΓΗ ΕΥΤΕΡΟΒΑΘΜΙΑ ΕΠΕΞΕΡΓΑΣΜΕΝΩΝ ΥΓΡΩΝ ΑΠΟΒΛΗΤΩΝ ΣΕ ΦΥΣΙΚΑ ΣΥΣΤΗΜΑΤΑ ΚΛΙΝΗΣ ΚΑΛΑΜΙΩΝ ΕΠΙΜΕΛΕΙΑ: ΑΡΜΕΝΑΚΑΣ ΜΑΡΙΝΟΣ ΧΑΝΙΑ
Table of Contents 1 Supplementary Data MCD
Electronic Supplementary Material (ESI) for Dalton Transactions. This journal is The Royal Society of Chemistry 2017 Supporting Information for Magnetic circular dichroism and density functional theory
Reminders: linear functions
Reminders: linear functions Let U and V be vector spaces over the same field F. Definition A function f : U V is linear if for every u 1, u 2 U, f (u 1 + u 2 ) = f (u 1 ) + f (u 2 ), and for every u U
LP N to BD* C-C = BD C-C to BD* O-H = LP* C to LP* B =5.
Electronic Supplementary Material (ESI) for Physical Chemistry Chemical Physics. This journal is the Owner Societies 2016 MS No.: CP-ART-03-2016-002134.R1 Optical Response and Gas Sequestration Properties
Correction Table for an Alcoholometer Calibrated at 20 o C
An alcoholometer is a device that measures the concentration of ethanol in a water-ethanol mixture (often in units of %abv percent alcohol by volume). The depth to which an alcoholometer sinks in a water-ethanol