12 4 1999 11 Journal of Iso topes V o l. 12 N o. 4 N ov. 1999 (EGF) (, 610041), 90%, 54%,, (EGF) (EGFR ) R 817 O 575 + 111,, CT M R I,,,,, (EGFR ) [ 1 3 ] EGFR [ 3, ], (EGF ) EGFR 1 EGF EGF, B runner [ 4 53 ], 1959 W alerfield (N GF),, [ 5, ] EGF (m EGF) 6 045 D, 416, 1125 s, 3, 1975, m EGF, (hegf), m EGF,, hegf m EGF 53 37, 3 EGF 6310 310 Λg 5210 315 Λg, ; EGF 6 17 80 29 272 2 4 ΛggL [ 6 ] 2 EGFR [ 7 EGFR 1 186 ], :, 33,, : 1999206222 : 1999210210
4 : (EGF) 223, EGF EGFR EGF EGFR, K d 0116 0177 nm o lgl [ 6, 8, 9 ] EGF, (T K) A T P, EGF,,, Ca 2+, C,, 3 EGFR, 90% EGFR, 54% [ 10 EGFR ], ( ) EGFR [ 1 3, 8, 9, 11 21 ] EGFR T K, (R T K), T K,, EGFR 992 1 068 1 173 C2Χ, EGFR 1 068 GRB 2, ras,, EGFR C2Χ GRB 2, EGF, EGFR, (T GF2Α), EGF, EGFR, 4 EGFR [ 8, 9 EGFR ] CT M R 1, Yo sh ida [ 3 ] EGFR EGF 21 (RCC) EGFR 16 EGFR, 11 EGFR, (P < 0. 000 1) RCC EGFR, 4 EGFR, EGFR, H arney [ 1 ] EGFR 425 EGFR 425 14 10, 1, 3 6, 4, 1, 425, 5 7 5, EGFR, EGFR 1997 Capala [ 15 ] 99 T c m EGF, EGFR 131 I 99 T c m EGF, C6EGFR, 131 I 131 I2EGF 30 m in,, 99 T c m 99 T c m 2EGF 6 h EGF, C6EGFR F ischer ; 4, 99 T c m 2 131 I2EGF Χ 131 I 99 T c m, 12 h 50% ;, 6 h, 20% 99 T c m EGF,, EGF EGFR EGFR
224 12 [ 8, 12, 22 ], EGFR : EGFR ( ) ; EGFR, ;,, 5 EGFR T K, T K,, R T K, R T K, R T K : EGFR, EGF R T K, EGFR,, Schm idt [ 23 ] EGFR EGFR EFGR 1992 B rady [ 18 ] 125 I EGFR 425, 1993 T akahash i [ 24 ] 131 I 425 F (ab ) 2 EGFR 555 M Bq 131 I 425 F (ab ) 2 U 287M G 131 I,, HAM A, ;,,, EGF EGFR, EGFR 6 1997 P irinen [ 22 ] 198 EGF, S EGF (P = 0. 007) (P = 0. 003) (P = 0. 003), EGF EGF, EGF EGFR, EGF, 131 I, :, Β, ; 99 T c m SPECT, 186 R e 90 Y, 99 T c m 186 R e 90 Y EGFR EGF, EGF EGF SH EGF 3,, EGFR ;,, D T PA EGF D T PA 2EGF, D T PA 99 T c m 186 R e 90 Y,, EGFR 99 T c m 2D T PA 2EGF 186 R e2 90 Y2D T PA 2EGF, EGFR 1 H arney JV, L iebert M,W edem eyer G, et al. T he Exp ression of Ep iderm al Grow th Facto r R ecep to r on H um an B ladder Cancer: Po tential U se in R adio imm uno scintigraphy. J U ro l, 1991, 146 (1): 227. 2 Kobaysh il T, Honke K, Gasa S, et al. R egulation of A ctivity L evels of Glyo lip id Sulfo transferases by
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226 12 EP ID ERM AL GROW TH FACTOR AND IM AGINE D IAGNOSIS AND THERAPY OF TUMOUR W ITH RAD IONUCL ID ES L i Yunchun T an T ianzh i (D ep artm ent of N uclear M ed icine, T he F irst U niversity H osp ital of W est Ch ina U niversity of M ed ical S ciences, Cheng d u 610041) Abstract It has a direct p ropo rtin co rrelation betw een the ep iderm al grow th facto r re2 cep to r levels of tum ou r and tum ou r differen tiation degree, tum ou r sizes, stage, m o to tic in2 dex o r cancer recu rrence. Ep iderm a l g row th facto r recep to r is detected in 90% of the tu2 m ou rs, in w h ich, 54% of ep iderm al grow th facto r recep to r of m alignan t tum ou rs can link w ith ex ternal genou s ligand. T herefo re, radionuclinde labelled ep iderm al grow th facto r w ill b ring abou t the im aging diagno sis and therapy of m alignan t tum ou rṡ T he research p resen t situation and clin ical sign ificance of radionuclinde labelled ep iderm al grow th facto r fo r recep2 to r im aging diagno sis and therapy of tum ou r are em phatically elabo rated in the papeṙ Key words Ep iderm al grow th facto r (EGF) tum ou r ep iderm al grow th facto r recep2 to r (EGFR ) im aging diagno sis therapy ( ), ( ) 20,,,