1074 2011 8 31 8 CJITWM August 2011 Vol. 31 No. 8 1 2 2 3 3 3 4 5 1 1 1 chronic kidney disease CKD 2009 5 1 2006 2 3 2010 CKD Logistic 102 78 CKD 41 52. 6% 41 /78 58. 5% 24 /41 12. 2% 5 /41 34. 1% 14 /41 17. 1% 7 /41 4. 9% 2 /41 Logistic Enter P < 0. 05 A Survey and Analysis of Chinese Patent Medicine for Outpatients with Chronic Kidney Disease SU Guobin LIU Xu-sheng WENG Jun-xiong et al Department of Nephropathy Peking University Third Hospital Beijing 100191 ABSTRACT Objective To investigate the current state of oral administration of Chinese patent medicine in treatment of chronic kidney disease CKD in the Western medicine hospitals. Methods Outpatients of Department of Nephropathy Peking University Third Hospital with diagnosed CKD confirmed by CKD diagnosis standard were surveyed by questionnaire in May 2009. The following patients' information was collected using the Questionnaire of the Current State of Oral Administration of Chinese Patent Medicine at CKD Clinics. 1 The present symptoms tongue figure pulse figure were syndrome typed referring to The Diagnosis Syndrome Typing and Efficacy Assessment of Chronic Renal Failure 2006 by Chinese Society of Renal Diseases Chinese Society of Traditional Chinese Medicine. 2 Names of Chinese patent medicines and Western medicines patients use presently the dose and dosage names of hospitals responsible for prescriptions. 3 Patients' basic diseases including diabetes hypertension hyperuricemia and so on at present. Irrational applications of Chinese patent medicines were classified according to the drug instruction and Guiding Principle of Clinical Application of Chinese Patent Medicines issued by State Administration of Traditional Chinese Medicine. The irrationality was analyzed. Correlated factors such as age sex deficiency in origin syndrome sthenia in superficiality syndrome the nature and grade of hospitals responsible for prescriptions total numbers of Chinese patent medicines and primary dis- No. 985 1. 100191 2. 510000 3. 510000 4. 2008 100029 5. 100091 Tel 010-82266699 8850 E-mail wangt@ bjmu. edu. cn
2011 8 31 8 CJITWM August 2011 Vol. 31 No. 8 1075 eases etc. were analyzed using Logistic regression model. These factors might result in irrational application of Chinese patent medicines. Results 102 questionnaires were handed out with 78 effective ones. Of them 41 patients 41 /78 accounting for 52. 6% were taking Chinese patent medicines. Of the 41 patients irrational application happened to 24 patients 24 /41 accounting for 58. 5% absolute discrepancy of medicines and syndromes to 5 5 /41 accounting for 12. 2% repeated medication to 7 7 /41 accounting for 17. 1% and interaction to 2 2 /41 accounting for 4. 9%. Logistic regression model was analyzed. Variables were screened by Enter method. The number of Chinese patent medicines had statistic significance P <0. 05. Conclusions The occurrence rate of irrational application of Chinese patent medicines in CKD outpatients in Western medicine hospitals was higher. They were mainly manifested as absolute discrepancy of medicines and syndromes and repeated medication. Increased numbers of Chinese patent medicines in recipes would increase the occurrence rate of irrational application of Chinese patent medicines. KEYWORDS chronic kidney disease Chinese patent medicine survey of the current state chronic kidney disease CKD 4 4. 1 CKD CKD CKD 1 2 3 CKD 2 CKD 1 2010 5 7 30 CKD 1 2 2. 1 CKD 2 glomerular fil- 3 tration rate GFR < 60 ml / min 1. 73 m 2 3 1 4. 3 2010 2. 2 CKD CKD 2 3 3. 1 CKD 3. 2 1 2 4. 3. 2 3 4 5 1 4. 2 4 3 4. 3. 1
1076 2011 8 31 8 CJITWM August 2011 Vol. 31 No. 8 4. 3. 3 12. 2% 5 /41 4. 9% 2 /41 4. 3. 4 12. 2% 5 /41 2. 4% 1 /41 7. 3% 3 /41 5 CKD 5 4. 3. 5 53. 6% 22 /41 1 13 CKD 52. 5 ± 32. 4 % 2 53. 6% 22 /41 5 SPSS 17. 0 6 CKD x ± s 58. 5% 24 /41 t χ 2 2 /5 Logistic 1 /5 2 /5 α = 0. 05α < 0. 05 34. 1% 14 /41 102 2 /14 78 17. 1% 7 /41 CKD 41 1 /7 52. 6% 41 /78 41 1 /7 1 /7 1 28 ~ 83 67. 1 16 25 17 /41 61. 0% 25 4. 9% 2 /41 26. 8% 11 /41 CKD 1 CKD1 1 /2 7. 3% 3 /41 2 24. 4% 10 /41 3 43. 9% 18 /41 4 17. 1% 7 /41 5 7. 3% 3 / 41 3 12. 2% 5 /41 12. 2% 5 /41 26. 8% 11 /41 41. 5% 17 /41 7. 3% 3 /41 9. 8% 4 /41 19. 5% 8 / 41 9. 8% 4 /41 92. 7% 38 /41 78. 0% 32 /41 12. 2% 5 /41 11 /14 1 /14 1 /7 1 /7 2 CKD 1 /7 75. 6% 31 /41 41. 5% 1 /7 1 /2 7 P = 0. 001 P < 0. 05 P = 0. 002 P = 0. 046 CKD 4 82. 9% 34 /41 CKD
2011 8 31 8 CJITWM August 2011 Vol. 31 No. 8 1077 2. 1 Logistic Enter 5 1 6 P > 0. 05 B > 0 OR > 1 P = 0. 007 1 8. 59 6 7 1 Logistic B S. E Wals χ 2 P OR 2. 151 0. 797 7. 283 0. 007 8. 592-20. 898 17 021. 850 0. 000 0. 999 0. 000 0. 792 0. 958 0. 684 0. 408 2. 208-3. 270 1. 291 6. 416 0. 011 0. 038 CKD CKD 1 CKD 1. 1 CKD CKD 4 CKD CKD 10 1 1. 2 CKD 2 CKD CKD CKD CKD 2. 2 2 CKD
1078 2011 8 31 8 CJITWM August 2011 Vol. 31 No. 8 5 2. 3 1 /6 1 /3 ~ 1 /2 2 /3 3 9 CKD CKD 1 2 3 PAF 10 CKD 1 K /DOQI clinical practice guidelines for chronic kidney disease evaluation classification and stratification J. Am J Kidney Dis 2002 39 2 Suppl 1 S1-S266. 2. J. 2006 40 8 8-9. He LQ. The diagnosis differentiation and efficacy assess- 2005 ment of chronic renal failure trial J. Shanghai J Tradit Chin Med 2006 40 8 8-9. 3. M. 11 CKD 2010 30 2010 9-15. State Administration of Traditional Chinese Medicine of the People's Republic China. Guiding principle of clinical appli- 2. 4 CKD 12 4 1 ~ 5 8 CKD cation of Chinese patent medicines trial M. 2010 9-15.
2011 8 31 8 CJITWM August 2011 Vol. 31 No. 8 1079 4 Stevens LA Levey AS. Chronic kidney disease in the elderly how to assess risk. J. N Engl J Med 2005 352 20 2122-2124. J. 2009 6 10 48-51. Sun W Wei MG. How to rationally use traditional Chinese patent medicine for chronic kidney disease patients One J. China Licensed Pharm 2009 6 10 48-51. 6. 4 2002 4 6 378-382. D. 2008 69. Huang WZ. The interaction of Chinese herbs and chemical Zhang E. Correlation study on Chinese medicine syndromes medicine J. Adverse Drug React J 2002 4 6 378-382. and clinical factors of chronic kidney disease stage 4 D. 11. Beijing Univ Chin Med 2008 69. J. 2009 27 7. 3 4 50-51. D. 2009 9. Lei SH Liu K. Measurements to avoid adverse reaction caused Feng DH. Correlation study on Chinese medicine syn- by unreasonable use of traditional Chinese medicine patents dromes and clinical factors of chronic kidney disease stage 3 D. Heibei Univ Chin Med 2009 9. 8. J. 2002 28. 2009 7 7 181-182. Li Y Luo CL Jia Y. Analysis of current exploration of Chinese patent medicine for nephrology J. Chin Med Modern Distance Educ China 2009 7 7 181-182. 9. 2004 2007 J. 2009 12 4 301-304. 5. Zhang BH Gao SQ Fu DX. A review of adverse drug reaction of traditional Chinese patent medicines in Beijing Hospital from 2004 to 2007 J. Chin Gen Pract 2009 12 4 301-304. 10. J. J. J Sichuan Tradit Chin Med 2009 27 4 50-51. 12. M. Huang ZS editor. Chinese materia medica M. Beijing People's Medical Publishing House 2002 28. 2010-09 - 08 2011-04 - 18 2012 1981 2001 2002-2009 8 3 4 4 MEDLINE CA AJ JST Ulrich's PD IC CABI WHO WPRIM 16 144 20. 00 / 240. 00 ISSN 1003-5370 CN 11-2787 /R 2-52 M640 1 100091 010-62886827 62876547 62876548 010-62874291 E-mail cjim@ cjim. cn http / /www. cjim. cn