344 210002 353 n = 173 n = 180 9 9 P < 0. 05 P < 0. 001 P > 0. 05 134 52. 86% 14. 18% 5. 22% 6. 72% P > 0. 05 R 756 R 758. 2 A 1673-3827201106-0344-06 Superficial fungal infection and allergic dermatitis LIU Fang SANG Hong HU Wen-xing KONG Qing-tao WANG Xue-lian WANG Gao-feng ZHANG Min DENG De-quan XIE Qi-mei Department of Dermatology Nanjing General Hospital of Nanjing Military Command Medical School of Nanjing University Nanjing 210002 China Abstract Objective To investigate superficial fungal infection in the etiology of allergic dermatitis by comparing the sensitivities of fungal allergens and unfungal allergens among allergic dermatitis patients with or without tineaand the identification of pathogens. Methods Totally 353 patients with chronic urticariaeczema or atopic dermatitis were divided into two groups classified by direct microscopic examinationthe group with superficial fungal infection n = 173and the contral group without superficial fungal infection n = 180. Skin prick tests were performed in all subjectsbut fungal culture were administered only in the patients with superficial fungal infection. Results Positive rates to Trichophyton Specific Penicillium Curvularia lunata and Aspergillus fumigatus in experiment group were higher than those in control group P < 0. 05. Positive rate to Trichophyton in experiment group was higher than that in control group P < 0. 001. There were no statistically significant differences among other fungal allergens and unfungal allergens P > 0. 05. T. rubrum 52. 86% T. mentagrophytes 14. 18% Epidermophyton floccosum 5. 22% and Candida 6. 72% were cultured in 134 cases of skin allergic diseases with superficial fungal infection. The positive rates were not statistically significant between Trichophyton and dermatophytes P > 0. 05. Conclusions Patients with chronic urticaria or eczema who present immediate hypersensitivity to Trichophyton always have dermatophyte infection. Superficial fungal infections seem to be an important factort in the subjects with chronic urticaria or eczema. Key words fungusinfectionallergic diseasesskin Chin J Mycol 2011 66 344-349. E-mailliufangndyx@ hotmail. com E-mailsanghong@ nju. edu. cn
345 Allergic diseases 0. 1% 1936 Wise Sulzberger 1 skin prick test SPT 1 2 cm 15 ~ 20 min 173 180 SPT > 1 /4 + 1 /2 + + 1 1. 1 2010 11 ~ 2011 4-2007 26 2 3 SPSS 13. 0 Williams 4 ± 12 23 d x 珋 ± s M 3 25% ~ 75% 4 χ 2 5 χ 2 P < 0. 05 P < 0. 01 2 2. 1 1. 2 173 114 59 44. 9 ± 17. 8 10% KOH 112 61 0 16 180 107 18 130 44 6 9 9 36 3 a II + + + > 2 + + + + 4 a 1 1 ~ 5 a 73 29. 6 ± 15. 6 2 1 ~ 5a 173 89% 33% Serpula lacrymans 5% < 5 a 29.
346 6% 5 a 70. 4% 21 11. 7% 1 2. 2 128 74. 0% 76 43. 9% 59 34. P < 0. 05 1% P > 0. 05 80. 4% 83. 0% P < 0. 53. 3% 05 42. 8% 16. 7% P > 0. 05 2 1 353 SPT + Tab. 1 Prevalence of inhalant allergens among 353 cases n = 173 n = 112 n = 61 n = 180 n = 130 n = 44 n = 6 128 74. 0% 80 48 21 11. 7% 17 4 0 27 15. 6% 19 8 6 3. 3% 2 4 0 18 10. 4% 12 6 3 1. 7% 3 0 0 II 17 9. 8% 11 6 10 5. 6% 8 2 0 13 7. 5% 10 3 5 2. 8% 3 2 0 15 8. 7% 11 4 12 6. 7% 8 4 0 2 1. 2% 2 0 5 2. 8% 4 1 0 1 0. 6% 1 0 4 2. 2% 2 2 0 4 2. 3% 3 1 6 3. 3% 6 0 0 76 43. 9% 53 23 96 53. 3% 71 20 5 59 34. 1% 41 15 77 42. 8% 55 16 6 41 23. 7% 23 18 30 16. 7% 21 9 0 7 4. 0% 4 3 16 8. 9% 11 2 3 5 2. 9% 3 2 8 4. 4% 6 2 0 3 1. 7% 2 1 7 3. 9% 5 2 0 5 2. 9% 3 2 6 3. 3% 5 1 0 3 1. 7% 3 0 7 3. 9% 3 4 0 4 2. 3% 2 2 2 1. 1% 1 1 0 2. 3 P = 0. 753 134 3 91. 80% 72. 39% 71 52. 99% Dermatophytes 19 14. 18% 7 5. 22% 9 6. 72% 17 12. 3 69% χ 2 = 0. 099
347 Tab. 2 2 SPT Percentage of positive skin tests in groups of chronic urticaria and eczema n = 112 n = 130 χ 2 P n = 61 n = 44 χ 2 P 80 71. 4% 17 13. 1% 85. 299 0. 000 48 78. 7% 4 9. 1% 49. 531 0. 000 19 17. 0% 2 1. 5% 18. 066 0. 000 8 13. 1 4 9. 1% 0. 409 0. 523 12 10. 7% 3 2. 3% 7. 313 0. 007 6 9. 8% 0 0-0. 039 II 11 9. 8% 8 6. 2% 1. 119 0. 290 6 9. 8% 2 4. 5% 0. 404 0. 525 10 8. 9% 3 2. 3% 5. 188 0. 023 3 4. 9% 2 4. 5% 0. 000 1. 000 11 9. 8% 8 6. 2% 1. 119 0. 290 4 6. 6% 4 9. 1% 0. 012 0. 912 2 1. 8% 4 3. 1% 0. 053 0. 818 0 0 1 1. 6% - 0. 419 1 0. 9% 2 1. 5% 0. 00 1. 000 0 0 2 4. 5% - 0. 173 3 2. 7% 6 4. 6% 0. 205 0. 650 1 1. 6% 0 0-1. 000 53 47. 3% 71 54. 6% 1. 281 0. 258 23 37. 7% 20 45. 5% 0. 635 0. 426 41 36. 6% 55 42. 3% 0. 817 0. 366 15 24. 6% 16 36. 4% 1. 703 0. 192 23 20. 5% 21 16. 2% 0. 777 0. 378 18 29. 5% 9 20. 5% 1. 097 0. 295 4 3. 6% 11 8. 5% 2. 475 0. 116 3 4. 9% 2 4. 5% 0. 000 1. 000 3 2. 7% 6 4. 6% 0. 205 0. 650 2 3. 3% 2 4. 5% 0. 000 1. 000 2 1. 8% 5 3. 8% 0. 324 0. 569 1 1. 6% 2 4. 5% 0. 083 0. 773 3 2. 7% 5 3. 8% 0. 021 0. 884 2 3. 3% 1 2. 3% 0. 000 1. 000 3 2. 7% 3 2. 3% 0. 000 1. 000 0 0 4 9. 1% - 0. 028 2 1. 8% 1 0. 8% 0. 017 0. 897 2 3. 3% 1 2. 3% 0. 000 1. 000 3 5 IH IgE Wilson 6 1 8 Ward 9 immediate hypersensitivi- ty IH IgE 100 mg /d 11 Hürlimann 7 2 1 10 11 1 / IH 2 IgE
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