1998; 16 (2) 133-137 Ch inese Journal of Parasito logy and Parasitic D iseases 133 200433,, : (A PC) (M HC) g, CD 4 + T, ;, M HC g, CD 8 + T (CTL ) T,,,,,,,,, CTL, DNA DNA, RNA RNA [ 1 ],, 1 1990 W o lff [ 2 ],, (CA T ) (L uciferase) Β- DNA RNA,,,,, 2,, 1992 T ang [ 3 ] DNA Α12 DNA, 1993 U lm er [ 4 ], 1994 5 W HO, [ 5 ] 2,,, DNA, 2. 1,, R SV CM V SV 40 SV 40,,
134 CM V R SV, R SV SV 40, PyCSP 1 000 [ 6 ], DNA BALB gc, CM V R SV DNA 4, 2. 2,,, PyCSP DNA PyH EP DNA 2. 3, 5 3,,, DNA,, DNA, H 22 (gene gun), 014, PyCSP Λg DNA [ 7 ], DNA, PyCSP,,,, PyCSP W eb ster [ 8 ] PyCS PDNA T DNA, PyCSP DNA,,, 3, 3. 1 Hoffm an [ 9, 10 ] CM V, (PyCSP), BALB gc, 100 Λg, 3 w k, 2-3, CD 8 +, (CTL ), CTL M HC,,, PyCSP DNA CTL 83% 3, 20-3. 2Xu L iew [ 11 ] CM V 40 Λg PyCSP DNA gp 63 200Λg, DNA BALB gc,, 100 Λg,, 17 kd a (PyH EP) cdna 40 d,, PCR, 5 4 W estern b lo t gp 63, CD 21,
gp 63, 40 d,,, IL 22 IL 24 IFN 2Χ, IL 22 IFN 2Χ, IL 24,, T h1 40 d, DNA 3. 3 W aine [ 1 ] (ADCC), T h,, Yang [ 12 ] (param yo sin, S j 97 kd a),. 4 1993,,, 1993 U lm er [ 4 ], (N P) cdna SV 40 CM V, N P, N P, DNA CTL, 50%, N P DNA. DNA [ 13 ] W halen [ 14 ] HB sa g CM V DNA,, HBV HB sa g L agging [ 15 ] (HCV ), HCV 21, DNA BALB gc,,, CTL Yokoyam a [ 16 ] CM V,,, CTL, M HC X iang [ 17 ] G SV 40 CM V,, DNA, O sterrieder [ 18 ] DNA gp 14 pcdna DNA, DNA, 3 pr SV CA T DNA,, DNA, g (gg ) DNA,, DNA [ 19 ] 135 L ow rie [ 20 ] CM V (h sp 65) DNA,
136 DNA BALB gc CTL, 5 RNA W o lff [ 2 ] RNA, U lm er [ 4 ] m RNA, CTL, RNA RNA,,,, RNA DNA,, 6 DNA,, [ 4, 13 ], M HCg,, CD 8 + T, T, M HC g, CD 4 + T, B, Ju stew icz [ 21 ] DNA CD 4 + T,,, 7 [22 ],,. ;, ;, DNA ; DNA W o lff [ 23 ] 1 880, DNA, DNA, DNA,, RNA, RNA DNA,,, 8 :, ;, ;, g g M HC,, CD 4 + CTL ; ; DNA, DNA,, ;,, ; ; DNA,, DNA ;
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