Hypertension Transdermal Delivery Company Profile Eldrug S.A is a spin off Biotechnology Company established in January 2007, with expertise in Drug Multiple Sclerosis Immunotherapy Cancer LHRH Peptides Discovery and Development. It is located at the Patras Science Park nearby the University of Patras. The company was financed mainly by VIANEX S.A and by GSRT of Ministry of Development towards the development of active peptides and mimetics for Clinical investigation.

Myelin Research Networking Department of Chemistry, University of Patras, Greece Department of Medicine, University of Patras, Greece Pasteur Institute, Athens, Greece Department of Medicine, University of Thessaloniki, Greece Burnet-Austin Research Institute, Australia University of Florence, Italy University of Tubingen, Germany Temple University, Pennsylvania, USA University of Cardiff, UK

Angiotensin Research Networking Department of Chemistry, University of Patras, Greece Department of Medicine, University of Patras, Greece University of Cardiff, UK National Hellenic Research Foundation (NHRF) Athens, Greece University of Exeter, UK University of Calgary, Alberta, Canada Medical School, University of Crete, Greece Department of Chemistry, University of Athens, Greece Institute of Organic Chemistry And Biochemistry, Academy of Sciences of The Czech Republic Department of Internal Medicine, Attikon University Hospital, Athens, Greece

Equipment UPLC-MS/MS Alliance HPLC Preparative HPLC Liberty Peptide Synthesizer- CEM Freeze Dryer Water purification System Hydrogenolysis Apparatus Drying oven Centrifuge Eppendorf 5424 Analytical balances Rotavapors

Equipment UPLC/MS/MS: Acquity Waters UPLC system TQD MS/MS Waters Detector, Empower and Mass Lynx Software APPLICATIONS: Physical and Chemical Characterization of pharmaceutical products Analysis and identification of peptides and organic molecules Identification of impurities Development of analytical methods (drug analysis in biological samples) ESI and APCI probe for polar and less polar compounds respectively Quantitation analysis

Equipment Waters Preparative HPLC PDA Detector, Empower Software APPLICATIONS: Purification intermediate and final products (small and large scale) Isolation of impurities in pharmaceutical products

Equipment Waters Alliance HPLC PDA Detector, Empower Software APPLICATIONS: Chromatographic analysis of intermediate scaffolds and pharmaceutical products Development of analytical methods (drug analysis in biological samples) Quantitation analysis

Equipment Liberty Microwave Peptide Synthesizer Discover Pressurized Microwave System, CEM APPLICATION: Microwave Assisted Solid Phase Peptide Synthesis (MW-SPPS) of linear and cyclic peptides (small scale for research purposes).

Services Organic Synthesis Eldrug provides specific Medicinal Chemistry services for drug development process. Our Medicinal Chemists undertake synthesis of scaffolds and organic molecules (small scale, non GMP synthesis for research purposes). Peptide Technology Custom Peptides Synthesis Eldrug s Peptide chemists design and synthesize peptides in small and large scale. We synthesize high yield of linear and cyclic peptides by conventional or Microwave methods in solid phase.

Services Analytical services In our laboratory, we offer chromatographic analyses (HPLC, UPLC- MS/MS) and services specializing particularly in the analysis and identification of peptides and organic molecules Physical and Chemical Characterization Purification of Peptides and Organic Molecules Method Development and Validation Quality management Eldrug has been certified with ISO 9001:2008 quality management system from TUV. Our lab pays attention on every simple detail in it's production process, continually improving on the methodology so as to meet the needs of our collaborators and customers and produce the best quality of it's services and end products.

Funding ΠΡΑΞΕ Α: Ανταγωνιστικότητα Ministry of Development Title: Αξιοποίηση Kαινοτόµου Aντι-υπερτασικού προϊόντος Εlsartan και Τεχνολογίας Μιµητών Πεπτιδίων µέσω Σύστασης Εταιρείας Εlfar για την Ανάπτυξη των ΠΡΑΞΕ Β Ministry of Development Title: Υποστήριξη ερευνητικών Μονάδων για την προτυποποίηση και την εµπορική εκµετάλλευση ερευνητικών αποτελεσµάτων. Εντοπισµός και αξιοποίηση ερευνητικών αποτελεσµάτων µε δηµιουργία νέων επιχειρήσεων (Spin off). Φάση Β VIANEX SA Title: Development of Elmyelin and Elsartan Cooperation Ministry of Development Title: Pre-clinical and Toxicology Evaluation of Immunodominant Myelin Peptides/Mimetics Conjugated with Mannan towards Clinical Phase I-II Studies: A Potential Therapeutic Vaccine Drug in the Treatment of Multiple Sclerosis (MS). «Ανταγωνιστικότητα & Επιχειρηµατικότητα: Υποστήριξη Νέων Επιχειρήσεων για ραστηριότητες Έρευνας & Τεχνολογικής Ανάπτυξης» Ministry of Development Title: Σύνθεση και Προκλινική Αξιολόγηση της ραστικής Αντιϋπερτασικής Ένωσης BV6 για έγκριση Κλινικών οκιµών και Προώθηση του Προϊόντος στην Αγορά Total Funding: ~ 6.000.000 Other funding in support of Eldrug s R&D ΕΠΕΑΕΚ, ΕΠΑΝ ΥΒ 76, ΕΠΑΝ ΥΒ 84

Awards - Distinctions Η ΕΛΛΑ Α ΚΑΙΝΟΤΟΜΕΙ, ΣΕΒ Eurobank ύο προτάσεις της Eldrug µεταξύ των 10 τελικών προκριθέντων: Ανάπτυξη Θεραπευτικού Εµβολίου για την Σκλήρυνση κατά Πλάκας (Ελµυελίνη) Ανάπτυξη ιαδερµικού Αντιυπερτασικού Προϊόντος (Ελσαρτάνη) INNOVATION PROJECT, ΣΦΕΕ (Σύνδεσµος Φαρµακευτικών Εταιρειών Ελλάδος) Τρεις προτάσεις της Eldrug µεταξύ των 20 τελικών προκριθέντων: Εξατοµικευµένη Ανοσοθεραπεία της Σκλήρυνσης Κατά Πλάκας µε χορήγηση ex-vivo ενδριτικών Κυττάρων ασθενών, ενεργοποιηµένων από Αντιγονικά Πεπτίδια. Ανάπτυξη Ελµυελίνης, εν δυνάµει Θεραπευτικό Εµβόλιο, στην Ανοσοθεραπεία της Σκλήρυνσης Κατά Πλάκας. ιαδερµική Χορήγηση Σαρτανών, Λοσαρτάνης, Βαλσαρτάνης και Σαρτάνης V8COOH: Μια νέα Προσέγγιση στη Θεραπεία της Υπέρτασης.

ELDRUG- VIANEX Patents Patent Applications Pending and Granted Myelin Patents (Europe, USA, China, Australia) "Peptide analogues of Myelin Basic Protein epitopes in the treatment of Experimental Autoimmune Encephalomyelitis (EAE) and Multiple Sclerosis (MS)". "Immunotherapy of Multiple Sclerosis using MBP83-99 peptide analogues and mannan". "Immunotherapy of Multiple Sclerosis using mannosylated peptides as Therapeutic Vaccines". Angiotensin Patents (Europe, USA, China) Novel Sartans in the treatment of hypertension, transdermally.

Visitors in Eldrug S.A. Investors Vianex S.A. James Watson (Nobel in Medicine) Jean-Marie Lehn (Nobel in Chemistry) Andrew V. Schally (Nobel in Medicine)

Visitors in Eldrug S.A. Investors Vianex S.A. James Watson (Nobel in Medicine) Ada Yonath (Nobel in Chemistry) Kyriakos Nicolaou

Contact Details Tel.: +30-2610-911-546 Fax.: +30-2610-911-545 E-mail: eldrug@eldrug.gr