Μεταπτυχιακό
Η επιστήμη στην ιατρική εξαρτάται από την επικοινωνία Να αναμεταδώσουμε Παρατηρήσεις μας Τα συμπεράσματα Την εξήγηση Και την πιθανή εξήγηση μας
Υποθέσεις Μέθοδος Υλικό Στατιστική Συμπεράσματα
Μέθοδος Προοπτική Ανασκόπηση Περιπτώσεις
Στατιστική Αριθμός περιστατικών Τι στατιστική μέθοδο θα χρησιμοποιήσουμε Τι θα συγκρίνουμε με τι Μεταβλητές Σύμβουλο βιοστατιστικης H συχνότητα της νόσου
Υλικό Τεχνολογία Ασθενείς Τεχνική
Title How would you look for the paper in index medicus Describe your study Identify the subject matter
Introduction Reasons for the study Hypothesis Why the question is important Type of the study Brief prior publications
Materials and method How the research will contact The materials Population Demographics Procedures Selection criteria Exclusion Inclusion
Results Logical sequence Observations Implications Emphasize what you did not find
Discussion Implications Relate to the previous report Related to the introduction What actually you found No speculation Clinical implications Caution of recommendations of clinical practice Weaknesses
Important conclusions Negative Positive
Research Reproducible Evidence I.II,III
Level I( At least one randomized study) Level II( Well control trials without randomization) Level II-2( Cohort, case control analysis) Level-II-3(Multiple time series with or without intervention or dramatic results) Level III ( Opinions of authorities base of descriptive studies,reports, or expert comities)
Standards for different type of articles CONSORT( Standards for reporting randomized trials PRISMA (For meta-analyses and systematic reviews of randomized trials MOOSE (Meta-analyses and systematic review of observational studies) STARD ( Reporting studies of diagnostic accuracy) STRODE Reporting observational studies)
Standard of Care Is different between the clinical application and base evidence medicine Some times the base evidence medicine cannot apply in specific cases
Research Deteriorating fetal environment and NICU Infection and premature labor Prenatal care and prenatal mortality Obstetrical intervention and prenatal mortality Refinement of technique of fetal surveillance and developed better indices for better function Genetics
Genomic Identify genes and pathways with a role in health and diseases How they interact with environmental factors APLY GENOMS BASED DIAGNOSTIC METHODS Prediction of the diseases Prediction of drug response Accurate molecular classification Translate genomic information to therapeutic advance Bioethics
Proteonomics proteins
Most obstetrical out comes are complex disorders
Epimiological criteria for gene association studies Tabor,Rich Nat Rev Genet 2002 Nature review Genetics
Integratation of biomarkers in clinical trials Large clinical trials provide an excellent opportunity to acquire biological materials Fundamental information and predictors for disorder being studied also aid the understanding the results Will guide future studies
Animal Model in pregnancy Toxicology Fetal/maternal physiology Fetal programming Diabetes Obesity Hypertation Autoimmune Obstetrical complications
Preeclapsia IUGR Perinatal asphyxia Preterm Labor Immune inflammation Hormones Genetics
ΠΡΟΣΟΧΗ Να περάσει από επιτροπή έρευνας και δεοντολογίας Να τηρούνται τα αρχεία τα πρωτότυπα για 5 χρόνια Να μην υπάρχει αντιγραφή από άλλη εργασία πάνω από 200 λέξεις Να μπορεί να επαληθευθεί η έρευνα Να μην γίνει αλλοίωση των αποτελεσμάτωνν Όλοι οι συγγραφείς είναι υπεύθυνοι για
The revitalize Gynecology Data Definition initiative www.acog.org/revitalize Σκοπό έχει να μιλάμε όλοι την ίδια γλώσσα
Challenge EVERYBODY NO BODY IS A GOD EVERY BODY DOES A MISTAKE THE SCIENCES PROGRESS BY QUESTION