Vol.59 No , 2008

Transcript

1 Vol.59 No , 2008 Atsushi CHINO Nouysu SEKIYA Kenji OHNO Yoshiro HIRASAKI Ktsumi HAYASHI Yuji KASAHARA Toshiki KITA c Yukitk HIYAMA Tko NAMIKI Ikuo SAIKI d Ktsutoshi TERASAWA Deprtment of Frontier Jpnese Orientl (Kmpo) Medicine, Grdute School of Medicine, Chi University, Inohn, Chuo-ku, Chi , Jpn Deprtment of Jpnese Orientl (Kmpo) Medicine, Grdute School of Medicine, Chi University, Inohn, Chuoku, Chi , Jpn c Center for Environment, Helth nd Field Science, Chi University, Kshiwnoh, Kshiw, Chi , Jpn d Deprtment of Pthogenic Biochemistry, Institute of Nturl Medicine, University of Toym, 2630 Sugitni, Toym , Jpn We report three cses of skin disese successfully treted with juzentihoto. Juzentihoto hs een used trditionlly for deficiency of oth Ki nd Ketsu, nd, t present, cliniclly for the tretment of vrious skin diseses. Toll-like receptors (TLRs) hve recently een chrcterized s the receptors of innte immunity, which re minly expressed on ntigen-presenting cells. We previously reported tht juzentihoto enhnced interleukin-12 (IL-12) nd interferon-γ (IFN-γ) production through modultion of TLR 4 signling pthwys in murine peritonel exudtive mcrophges. Since Lngerhns cells, kind of the ntigen-presenting cell, re known to exist in epidermis, we speculte tht juzentihoto improves T helper 1 nd 2 (Th 1/2) lnce through modultion of TLR signling pthwys in Lngerhns cells. Our cses suggest tht influence to cquired immunity through the innte immune signling is ssumed to e one of the mechnisms of juzentihoto for controlling morid sttes of the skin. juzentihoto, skin disese, innte immunity, toll-like receptors, Lngerhns cells, cquired immunity γ γ

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7 Vol.59 No.1, 2008 nturl killer T NKTTh Th Toll-like receptors TLRs TLRs TLRs lipopolyscchride LPS Toll-like receptortlr nucler fctor-κb NF-κB mitogen-ctivted protein kinse MAPK

8 Vol.59 No.1, 2008 TLR NF-κB p c-jun N-terminl kinse JNK extrcellulr signl-regulted kinse ERK Th interleukin- IL- interferon-γ IFN -γ LPS TLR Th Th Th Lngerhns Lngerhns LPS Lngerhns IL- IFN-γ Th Th IL- IFN-γ IgE Th Lngerhns TLR TLR g g g!g gg gg gg g Kiyohr H, Mtsumoto T, Ymd H. Comintion effects of hers in multi-herl formul : expression of Juzentihoto s immuno-modultory ctivity on the intestinl immune system. Evid Bsed Complement Alternt Med 1 Mtsumoto T, Skuri MH, Kiyohr H, Ymd H. :

9 Vol.59 No.1, 2008 Orlly dministered decoction of Kmpo (Jpnese herl) medicine, Juzentihoto modultes cytokine secretion nd induces NKT cells in mouse liver. Immunophrmcology 46 Iijim K, Sun S, Cyong JC, Jyonouchi H. : Juzentihoto, Jpnese herl medicine, modultes type nd type T cell responses in old BALB/c mice. Am J Chin Med 27 Ae S, Tnsho S, Ishishi H, Ingki N, Komtsu Y, Ymguchi H. : Protective effect of orl dministrtion of trditionl medicine, Juzentihoto, nd its components on lethl Cndid licns infection in immunosuppressed mice. Immunophrmcol Immunotoxicol 20 Ymd H. nd Siki I. : Trditionl Herl Medicines for Modern Times Volume, Juzen-tiho-to (Shi- Qun-D-Bu-Tng) Scientific Evlution nd Clinicl Applictions, CRC Press Tylor & Frncis Group, BocRton, FL 46 Kisho T, Akir S. Toll-like receptors s djuvnt receptors. Biochim Biophys Act 1589 Akir S, Tked K, Kisho T. : Toll-like receptors : criticl proteins linking innte nd cquired immunity. Nt Immunol 2 Chino A., Skuri H, Choo MK, Koizumi K, Shimd Y, Tersw K, Siki I. : Juzentihoto, Kmpo medicine, enhnces IL- production y modulting Tolllike receptor signling pthwys in murine peritonel exudte mcrophges. Int Immunophrmcol 5 115