ISSN 1007-7626 CN 11-3870 / Q http / /cjbmb bjmu edu cn Chinese Journal of Biochemistry and Molecular Biology 2015 2 31 2 135 ~ 139 DOI 10 13865 /j cnki cjbmb 2015 02 04 T * 410000 T regulatory T cell CD 4 + T CD 8 + T NK B T R73 Regulatory T Cells and Immunotherapy for Gliomas FENG Jian-Bo WU Ming-Hua * LI Gui-Yuan Cancer Research Institute of Central South University Changsha 410000 China Abstract Regulatory T cell is a cell type that negatively regulates other immune cells suppresses the activation and proliferation of CD 4 + and CD 8 + lymphocytes NK cells B lymphocytes and dendritic cells to keep the stability of immune system and to avoid the occurrence of autoimmune diseases In recent research cells was known to a play critical role in tumors as tumor cells can suppress immune response by propagating or recruiting cells This suggested that the role of may be significant in tumorigenesis and progression Therefore reducing the number or activation of cells could be an effective way to improve the immunotherapy of tumors including glioma Key words regulatory T cell immune escape glioma immunotherapy T CD 4 + CD 25 + FoxP3 + 3 20 70 T 1995 Sakaguchi 1 CD 4 + CD 25 + T CD 4 CD 25 CD 4 + CD 25 + T 1 1 2014-08-15 2014-09-05 No 81272297 2 1 * Tel 0731-82355401 E-mail wuminghua554@ aliyun com Received August 15 2014 Accepted September 5 2014 Supported by National Natural Science Foundation of China No 81272297 * Corresponding author Tel 0731-82355401 E-mail wuminghua554@ aliyun com
136 31 CD4 + CD8 + NK CD4 + CD25 + 1 1 1 CD4 + CD 4 + thymus-derived regulatory T cell t CD 122 + CD 8 + peripherally derived regulatory T cell pcd 8 + CD 8 + CD 28- CD8 + in vitro-induced regulatory T cell i 4 T CD4 + CD8 + CD 4 + Foxp3 T Foxp3 5 MS CD 4 + CD 25 + CD 4 + CD 25 + CD 4 + CD 25 + CD4 + T 5% ~ 10% T T CD 8 + IL-2 /IFNγ 6 CD 4 + CD 25 + CD4 2 α CD25 CD8 + CD8 + T 4 cytotoxic T lymphocyteassociated antigen-4 CTLA-4 T 5% ~ 10% glucocorticoid-induced tumor necrosis factor receptor GITR CD 4 + CD 25 + 11 NK 2 Foxp3 T CD56 bright CD16 - NK CD56 dim CD16 + NK CD56 dim CD16 + NK 90% Foxp3 T 10% CD56 bright CD16 - CD127 Foxp3 + CD127 NK CD 4 + CD 25 + CD127 Tian CD 4 + CD 25 + CD127 12 NK CD 4 + CD 25 + Verneris 13 NK Foxp3 7 CD 4 + CD 25 + NK T 2 IL-2 NK T T cell antigen receptor TCR NK B 8 9 1 1 2 CD8 + CD 8 + CD 8 + CD 8 + CD 8 + CD 8 + CD 25 + CD 8 + Foxp3 + Kouchaki 10 CD8 + CD8 + IL-6 IL-10 CD8 + 1 1 3 NK NK T CD3 - CD56 + CD3 - CD56 + allo-hct CD 4 + CD 8 + T NK 1 2 CD4 + CD8 + T B APC antigen presenting cell CD 4 + CD 25 + CD8 + T
2 T 137 1 2 14 2 1 2 1 3 - major CTLA-4 histocompatibility complex MHC IL-2 T CTLA-4 CTLA-4 2 2 15 1 2 2 TGF-β IL-10 1 MHC TGF-β B7H1 TGF-β B7-H1 i 1 programmed death-1 TGF-β PD-1 T 17 2 NK Ig IFN-γ IL-2 B IL-10 3 16 IL-10 cyclooxygenase COX A E2 prostaglandin E2 PGE2 1 3 PGE2 inductible nitric oxide synthase inos vascular endothelial growth factor VEGF T 18 DC IL-2 IFN-α PGE2 COX-2-1 inhibitor of differentiation-1 ID1 19 4 T T 3 CD 4 + CD 25 + Foxp3 T 2 Ⅱ- 2 1 FasL TGF-β PGE Ⅲ-Ⅳ 20 Wainwright 21
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