528 2012 6 21 6 Chin J Gastroenterol Hepatol Jun 2012 Vol. 21 No. 6 doi 10. 3969 /j. issn. 1006-5709. 2012. 06. 011 Meta 430060 Cochrane Library Pubmed 2 Revman 5. 0 6 484 Meta Meta R573. 2 A 1006-5709 2012 06-0528 - 05 E-mail zhangchali1987@ 163. com E-mail yuhonggang @ yahoo. com 2012-02-13 Octretide joint proton pump inhibitors in treating non-variceal gastrointestinal bleeding a Metaanalysis ZHANG Chali YU Honggang Department of Gastroenterology Renmin Hospital of Wuhan University Wuhan 430060 China Abstract Objective To evaluate the efficacy of octretide joint proton pump inhibitors in treating non-variceal gastrointestinal bleeding. Methods All the randomized controlled trials RCTs about treating non-variceal gastrointestinal bleeding with octretide joint proton pump inhibitors were collected by searching Cochrane Library Pubmed Wangfang. The assessment of methodological quality and data extraction of the included studies were performed independently by two reviewers and Meta-analysis was conducted with Revman 5. 0 software. Results A total of 6 studies involving 484 patients met inclusion criteria. The results of Meta-analysis showed that octretide joint proton pump inhibitors was effective in treating non-variceal gastrointestinal bleeding. Conclusion Octretide joint proton pump inhibitors is effective in treating non-variceal gastrointestinal bleeding. Because of the lower methodological quality and publication bias of the included trials it is necessary to perform more high-quality and large scale randomized controlled trials to make the conclusion more reliable. Key words Octretide Proton pump inhibitors Upper gastrointestinal bleeding Non-variceal Meta-analysis H + - K + -ATP 8% ~ H + K + 13. 7% ph 1 1 2 3 4 ph > 6. 0 ph < 5. 0 LH GnRH 30% ~ 40% 5-HT
2012 6 21 6 Chin J Gastroenterol Hepatol Jun 2012 Vol. 21 No. 6 529 Oct- 1 25% ~ 40% reotide Upper gastrointestinal hemorrhage UGIB Omeprazole Pantoprazole Upper gastrointestinal bleeding ph ph > 6. 0 1. 3 Cochrane Reviewer s Handbook 2 / 4 A B Meta C 1. 1. 5 1 37 6 2 3 2. 2 6 4 484 246 238 1. 2 Cochrane Lirary Pubmed 1. 4 2 1 1. 1 1. 1. 1 3-4 1. 5 Revman 5. 0 1 1. 1. 2 P > 0. 1 I 2 50% Meta 1 2 3 2 48 h Z μ 1. 1. 3 P < 0. 05 OR 1 95% 1 3 1. 1. 4 = + / 2 2. 1 325 282 12 h 24 h 48 h
530 2012 6 21 6 Chin J Gastroenterol Hepatol Jun 2012 Vol. 21 No. 6 1 Tab 1 The basic situation of the study 40 20 ml 25 15 25 μg /h 7 d 3 d 40 mg + 100 ml q 12 h 2009 5 82 2 42 28 14 100 μg 5% P < 0. 05 41 32 78 2 42 25 17 35 0. 1 mg 3 4 38 6 25 ~ 50 μg /h 36 27 9 2009 40 mg + 3 d 29 20 100 ml q 12 h 4 3 P < 0. 05 24 15 9 0. 1 mg 17 3 0. 3 mg + 20 ml 4 22 25 ~ 26 17 9 50 μg /h 40 2 d 16 4 14 mg + 100 ml 6 q 12 h P < 0. 05 2008 7 50 2 36 25 ~ 50 μg /h 40 3 d mg + 100 ml q 12 h 2011 8 72 2 36 0. 1 mg P > 0. 05 4 1 0. 1 mg + 20 ml 1 25 ~ 30 22 3 d 50 μg /h 1 4 40 mg q 12 h 1 1 1 P > 0. 05 2009 9 60 2 43 17 30 22 2 33 26 29 25
2012 6 21 6 Chin J Gastroenterol Hepatol Jun 2012 Vol. 21 No. 6 531 142 2 0. 1 mg 70 72 25 ~ 50 μg /h 3 d 40 mg + 150 ml q 12 h P > 0. 05 2011 10 68 43 2. 3 6 7 B P = 0. 94 I 2 = 0% Meta Z = 6. 79 P < 0. 00001 OR = 7. 89 95% CI 4. 35 14. 33 2. 4 Meta 2. 4. 1 6 1 1 Fig 1 The total effective rate of Octretide peptide proton pump inhibitors combined treatment of varicose veins upper gastrointestinal bleeding 2. 4. 2 11 3 Meta OR = 7. 89 > 1 OR 24 h 2 1 6 5 2 6 OR 2 Fig 2 The OR funnel figure of the treatment of non-variceal gastrointestinal bleeding
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