CHINESE JOURNAL OF ALLERGY & CLINICAL IMMUNOLOGY # 400038 R751 A 1673-8705 2013 01-0079-05 Cutaneous Diseases with Eosinophilia DENG Xiao-rong ZHONG Hua SONG Zhi-qiang HAO Fei # Department of Dermatology Southwest Hospital Third Military Medical University Chongqing400038 China Eosinophil is one kind of multifunctional leukocyte that play vital role in infection non-specific tissue injury allergic disease and malignancy. It can be involved in the initiation and progress of diverse inflammatory responses. The clinical manifestation pathogenesis etiology and therapy of cutaneous diseases with eosinophilia was summarized in this review. Key words eosinophils atopic dermatitis drug rush bullous pemphigoid Chin J Allergy Clin Immunol 2013 7 1 79-83 eosinophils DNA 1% ~ 3% 0. 35 10 9 L interleukin IL -4 IL-5 IL-10 IL-12 0. 35 ~ 1. 5 10 9 L 1. 5 ~ 5. 0 10 9 L transforming growth factor TGF -α TGF-β > 5. 0 10 9 L 1 3 A B 2 Th # 023-68765416 haofei62@ medmail. com 79
DRESS Wells atopic dermatitis AD AD hypereosinophilic dermatitis HED T IL-3 IL-5 major basic protein MBP granulocyte-macrophage colony-stimulating factor GM- eosinophilic cationic protein CSF ECP AD IL-5 11 MBP ECP 4 5 AD IL-5 AD IL-5 AD 1 MBP 6 AD IL-5 7 IL-3 GM-CSF 12 AD 8 IL-5 AD 10 AD bullous pemphigoid BP 9 drug reaction with eosinophilia and systemic symptoms DRESS BP180 BP230 B T IL-5 IL-5 BP 14 DRESS ECP MBP 10% DRESS 13 BP dermatitis herpetiformis DH 80 March 2013
22 eosinophilic pustular folliculitis EPF IgA TG2 TG3 15 TG2 DH gluten-free diet GFD EPF 23 Wells human immunodeficiency virus HIV Wells 24-26 EPF 27 Wells HES AD herpes simplex virus HSV -2 10 HED AD Wells Wells TNF-α Wells hypereosinophilic syndrome EPF HES 37% HES 16 IL-5 HES IL-5 T IL-5 HES 17 T T Treg 28 18 HED HES 19-21 HES 81
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