Human adiponectin and vascular function regulating

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1 Chinese Bulletin of Life Sciences Vol. 18, No. 5 Oct., (2006) , (NO) Q51; R A Human adiponectin and vascular function regulating FENG Shu-Ying, ZOU Zhu-Rong* (School of Life Sciences, East China Normal University, Shanghai , China) Abstract: Nowadays, increasing studies have been focused on the direct vascular effects of some plasma proteins, termed adipokines that are secreted from adipose tissues. Therein, adiponectin predominantly exhibits significant anti-inflammatory and anti-atherosclerotic effects. This brief review will summarize the recent work on the role of adiponectin in modulating the vascular functions, including the influences on the vascular structure, inflammatory responses of endothelium cells, nitric oxide (NO) generation and angiogenesis. Key words: adiponectin; endothelial cells; vascular function 2 [1] -α (TNF-α) (adiponectin) 2 [2] ( ) ( ) (1982 ) *

2 kDa 2~10 µ g/ml 1995 Scherer 3T3 C1q 30 Hu Maeda Nakano APM1 ADIPOQ GBP28 ( ) [3] amp1 3 q27 16 kb N C 22 Gly-X-Pro/X C1q C1q [3] (fad) C (gad) AdipoR1 AdipoR2 7 G AdipoR1 (gad) (fad) AdipoR2 [4] AdipoR1 gad [5~6] 2 AMP (AMPK) [7] ; AMPK ( ) (TZD) [8] AMPK AMPK [9] AMPK ATP [10] AMPK (enos) NO AMPK [11] AMPK ( 1) (AdipoR1 AdipoR2) (gad) AdipoR1 AMPK AMPK enos AMPK enos / (Akt) Akt -3 (PI-3K) [9] enos Akt NAD(P)H (oxldl) [13] (ROS) enos NO oxldl MAPK NO (proliferation) [14~15] (caspase) [16] TNF-α TNF-α oxldl MAPK NO

3 [12] AMP enos NO NAD(P)H ROS ROS enos NO : [17~18] (fad) [19] /apoe apoe [20] (VCAM-1) A TNF-α [21] [22] Kato [23] 3.2 TNF-α oxldl ROS ROS [24] TNF-α TNF-α (HAEC) TNF-α ( VCAM-1, E-selectin) (camp)- A (PKA) TNF-α -κb (NF-κB) (IκB-a) NF-κB TNF-α P38 Akt Jun-N [25] TNF-α HAEC IL-8 mrna [26] TNF-α (gad) oxldl (p42/p44 MAPK) [5] (LDL) enos ROS [27] ROS [15] 3.3 NO NO NO NO NO NO enos oxldl enos NO [5] ROS NO enos NO

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