JOURNAL OF HYGIENE RESEARCH. ghrelin LDL-C. HDL-C ghrelin. ghrelin P < BMI % BF

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1 JOURNAL OF HYGIENE RESEARCH Vol. 42 No. 2 Mar ghrelin ghrelin ~ 10 BMI % BF TC TG LDL-C HDL-C ghrelin ghrelin BMI % BF P < HDL-C P < TC ghrelin BMI % BF TG HDL-C TC LDL-C ghrelin BMI % BF R R A Relationships between serum ghrelin and lipid profile and serum leptin adiponectin and insulin among children in Beijing China DU Songming HU Xiaoqi LIU Ailing ZHANG Qian PAN Hui MA Guansheng Institute of Nutrition and Food Safety Chinese Center for Diseases Control and Prevention Beijing China Abstract Objective To study the relationship between serum ghrelin and lipid profile and serum leptin adiponectin and insulin among children in Beijing. Methods A total of 879 pupils aged 8-10 years were randomly selected. Height body weight waist circumference body mass index BMI body fat percentage %BF blood lipid serum leptin insulin adiponectin and ghrelin were measured in all samples. Results Ghrelin associated negatively with body weight waist circumference BMI %BF serum leptin level and positively with HDL-C. Factor analysis has shown five factors which were sufficient to explain correlations between variables-body composition and leptin dyslipidemia glucose metabolism and adiponectin. Conclusion Serum ghrelin level correlated strongly with body weight waist circumference BMI %BF and leptin Our finding suggested significantly increased leptin levels following decreased ghrelin levels could mostly disordered adipose metabolism at early obesity in children. Key words children and adolescents obesity ghrelin leptin insulin dusm9709@ 126. com 1 mags@ chinacdc. cn

2 2. ghrelin 253 ghrelin - growth hormone secretagogue receptor GHSR percentage body fat %BF = - / growth hormone GH "100% fat free mass FFM = cm 2 / kg ghrelin ghrelin cm / = 1 = = ghrelin ghrelin ghrelin TC TG LDL-C 20 HDL-C FBG ~ ghrelin enzyme-linked immunoadsordent assay ELASA Seca WGOC model 890 Hamburg kg cm 1. 3 BMI = kg / m ± quartile QR 2 cm t 0. 1cm 2cm χ 2 ghrelin 4 < Q 1 Q 1 ~ Q 2 ~ Q 3 ~ 4 % BF h 3000r / min 1ml Automatic Analyzer HITACHI Phoenix Biotech EpiData ghrelin RJL2System 101 USA 50kHz 800μA 1 -

3 P < % 420 SAS % BMI % 1 % BF P < % 28. 3% 15. 0% 1 Table 1 The characteristics of subjects n % % cm kg cm BMI % BF ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± P < t P < ghrelin ghrelin P = TG TC HDL-C LDL-C P = P = Table 2 Plasma lipid and adipokines concentration in study group TG TC HDL-C LDL-C ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± 0. 6 μg / ml ghrelin P <

4 2. ghrelin ghrelin C 3 ghrelin 4 ghrelin BMI % BF P < HDL-C P < TC P = TG LDL- Table 3 3 ghrelin Body composition of the study group by ghrelin quartile ghrelin / % % cm kg cm BMI %BF < Q / ± ± ± ± ± 6. 3 Q 1 ~ / ± ± ± ± ± 7. 2 Q 2 ~ / ± ± ± ± ± 7. 1 Q3 ~ / ± ± ± ± ± 7. 1 P < ghrelin ghrelin Table4 ghrelin 4 ghrelin Plasma lipid and adipokines level of the study group by ghrelin quartile TG TC HDL-C < Q ± ± ± ± Q 1 ~ ± ± ± ± Q 2 ~ ± ± ± ± Q 3 ~ ± ± ± ± P < < ghrelin LDL-C μg / ml < Q ± Q 1 ~ ± Q 2 ~ ± Q 3 ~ ± P < ghrelin 2. 4 ghrelin ghrelin 5 BMI %BF TG ghrelin HDL-C3 TC LDL-C4 ghrelin 42. 2% 14. 0% 9. 6% % 6. 2% 80. 1% 3 ghrelin 9 CUMINGS 10 adipokines -6 resistin 6 8 ~ 10 ghrelin ghrelin 8 ghrelin ghrelin

5 Table 5 5 Factor-analysis of the study group according to body composition plasma lipid and adipokines BMI %BF TC TG HDL-C LDL-C % % ghrelin ghrelin 11 ghrelin 1 KOJIMA M HOSODA H DATE Y. Ghrelin is a growth-hormone releasing acylated peptide from stomach BMI % BF J. Nature ghrelin BMI 2. DVC ghrelin ghrelin NPY mrna AgRP mrna BMI ghrelin BMI TG LDL-C ghrelin ghrelin BMI %BF Diabetes Rev ghrelin 7 CUMMINGS D E. Ghrelin and the short- and long-term β regulation of appetite and body weight J. Physiol 14 ghrelin Behav HOSODA H KOJIMA M KANGAWA K. Biological physiological and pharmacological aspects of ghrelin J. J Pharmacol Sci ghrelin 9 NAKAZATO M MURAKAMI N DATA Y et al. A ghrelin role for ghrelin in the central regulation of feeding J. 16 Nature J ghrelin J ~ 18 ghrelin J ghrelin. J BULC O C FERREIRA S R GIUFFRIDA F M et al. The new adipose tissue and adipocytokines J. Curr 262

6 behaviour therapy intervention to promote emotional 1. resilience J. Arch J Dis Child FLORES E CICCHETTI D ROGOSCH F A. Predictors of 2. Resilience in Maltreated and Nonmaltreated Latino J Children M. Dev Psychol M J M SPSS11 M. D SPSS M. J LA GRECA A M DANDES S K WICK P et al. Development of the social anxiety scale for children reliability and concurrent validity J. J Clin Child J Psychol M J J J J J J J J GREG A SCOTT B MARK D. Guidebook to the California health kids survey part Ⅱ survey content resilience and youth development module EB / OL J J J J. 13 STALLARD P SIMPSON N ANDERSON S et al. An evaluation of the FRIENDS programme a cognitive CUMMINGS D E PURNELL J Q FRAYO R S et al. A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans J. Diabetes MURDOLO G LUCIDI P DI LORETO C et al. Insulin is required for prandial ghrelin suppression in humans J. Diabetes CUMMINGS D E WEIGLE D S FRAYO R S et al. Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery J. N Engl J Med PARK H S LEE K U KIM Y S et al. Relationships between fasting plasma ghrelin levels and metabolic parameters in children and adolescents J. Metabolism GAUNA C MEYLER F M JANSSEN J A et al. Administration of acylated ghrelin reduces insulin sensitivity whereas the combination of acylated plus unacylated ghrelin strongly improves insulin sensitivity J. J Clin Endocrinol Metab P YKK S M KELLOKOSKI E H RKK S et al. Low plasma ghrelin is associated with insulin resistance hypertension and the prevalence of type 2 diabetes J. Diabetes GALE S M CASTRCANE V D MANTZOROS C S. Energy homeostasis obesity and eating disorders recent advances in endocrinology J. J Nutr

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