TXNIP Gene in Tumorigenesis and Metastasis

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1 ISSN CN / Q http / / cjbmb bjmu edu cn Chinese Journal of Biochemistry and Molecular Biology ~ 226 TXNIP 1 * thioredoxin-interacting proteintxnip TXNIP thioredoxintrx Trx Trx DNA TXNIP TXNIP TXNIP TXNIP TXNIP NK natural killer cellnk cell TXNIP Trx R73 TXNIP Gene in Tumorigenesis and Metastasis LI Li-Fu 1 * LIANG Li 2 1 First Clinical Medical College of Southern Medical UniversityGuangzhou 2 Department of Pathology of Southern Medical UniversityGuangzhou China China Abstract Thioredoxin-interacting protein TXNIP is a multifunctional protein that is involved in cell proliferationapoptosisand differentiation TXNIP is also related to cancers and other stress-related diseases As a major redox regulatortxnip interacts with thioredoxin Trx and negatively regulates Trx expression and its antioxidant function which is critical in DNA damage and apoptosis This review will overview the TXNIP gene functions for its strongly association with tumorigenesismetastasis and its commonly reduced expression in tumor tissuessuch as breastlungand liver cancers TXNIP deficiency increases cell proliferation and protects the cells from apoptosis We discuss various molecular mechanisms with the reports of TXNIP signaling and biological functionsincluding cell cycle arrest hypoxia and NK developmentwhich explain the tumor suppressive role of TXNIP Key words thioredoxin-interacting protein TXNIP thioredoxin Trx tumor metastasis thioredoxin-interacting D-3 HL-60 protein TXNIP D3 1 3 TXNIP vitamin D3 up-regulating protein 1 VDUP1 α- thioredoxin TXNIP Trx No Trx * Tel @ qq com Received September Accepted December Supported by National Natural Science Foundation of China No TXNIP TXNIP 1q bp TXNIP 1 25 NK * Corresponding author Tel @ qq com

2 3 TXNIP 223 TXNIP 1 HTLV-1 T TXNIP 1 TXNIP TXNIP TXNIP Trx NK 4 TXNIP Trx TXNIP TXNIP Trx TXNIP apoptosis signal- regulating kinase 1 ASKⅠ mitogen-activated protein kinase MAPK 4 6 TXNIP TXNIP 3 calcitonin receptor-stimulating peptide 3 TXNIP CRSP3 15 Kiss1 HGMW-approved symbol 2 TXNIP TXNIP TXNIP TXNIP Kiss1 KISS1 CRSP3 Kiss1 TXNIP Song 7 TXNIP TXNIP CRSP3 Kiss1 cdna FasL CD44 TXNIP TXNIP - β Turturro 16 d- 9 TXNIP 6 h TXNIP 10 d- Trx TXNIP TXNIP d- TXNIP G 1 TXNIP 1 chromosome RT-PCR region maintenance 1 protein CRM1 TXNIP 12 TXNIP 1α hypoxia-inducible factor 1α HIF1α 18 HIF1α 1 TXNIP VHL Von Hippel-Lindau TXNIP protein pvhl TXNIP 13 TXNIP pvhl β pvhl HIF1α TXNIP HIF1α TXNIP T pvhl / HIF1α HIF1α 1 human T lymphotropic virus type- T ATL 14 TXNIP TXNIP

3 TXNIP Fig 1 TXNIP Trx NK 1 TXNIP 3 Fig 1 TXNIP signaling pathways and tumor suppressive functions TXNIP is involved in a variety of cellular function including NK developmentgrowth inhibition apoptosis in Trx-mediated antioxidant function and modulating other molecules such as CRSP3 Kiss1 and CRM1 signs indicate activation and signs indicate inhibition 4 1 TXNIP TXNIP Northern G 0 /G 1 TXNIP TXNIP TXNIP TXNIP 19 TXNIP A cyclin A p16 p27kip TXNIP cyclin A 20 TXNIP pvhl HIF1α TXNIP p16 T p27 1 p27 kinase inhibition protein 1 p27kip1 1 G 1 / S TXNIP carbohydrate response Jun 1 Jun activation domain-binding elementchores protein1 jab1 p27kip1 24 MLX ChoREs jab1 p27kip1 Le Jan HIF1α pvhl MAX X MAX-like protein X MLX G 1 / S 22 TXNIP 25 TXNIP TXNIP 1 TXNIP 4 2 TXNIP 4 3 TXNIP NK TXNIP NK

4 3 TXNIP 225 NK J TXNIP NK 26 NK TXNIP NK cancer cells J TXNIP NK T CTL CD TXNIP 5 TXNIP OH 2 D 3 HL- 60 Trx TXNIP TXNIP TXNIP 1 TXNIP 3 TXNIP CRSP3 Kiss1 TXNIP TXNIP HIF1α TXNIP TXNIP TXNIP NK and its relation to stage of diseasej Trx 6C TXNIP overexpressed in a subset of aml patients J References 1 Zhou JYu QChng W J Txnip vdup-1tbp-2 A major redox regulator commonly suppressed in cancer by epigenetic mechanisms J Int J Biochem Cell Biol Le Bras MClement M VPervaiz Set al Reactive oxygen species and the mitochondrial signaling pathway of cell death J Histol Histopathol Chen K SDeluca H F Isolation and characterization of a novel cdna from hl-60 cells treated with 1 25-dihydroxyvitamin d-3 Biochim Biophys Acta Kim S YSuh H WChung J Wet al Diverse functions of vdup1 in cell proliferationdifferentiationand diseases J Cell Mol Immunol Lee J HJeong E GChoi M Cet al Inhibition of histone deacetylase 10 induces thioredoxin- interacting protein and causes accumulation of reactive oxygen species in snu-620 human gastric Mol Cells Stoltzman C AKaadige M RPeterson C Wet al Mondoa senses non-glucose sugars Regulation of txnip and the hexose transport curb J J Biol Chem Song HCho DJeon J Het al Vitamin d 3 up-regulating protein 1 vdup1 antisense DNA regulates tumorigenicity and melanogenesis of murine melanoma cells via regulating the expression of fas ligand and reactive oxygen species J Immunol Lett Vaira SFriday EScott Ket al Wnt / beta-catenin signalling pathway and thioredoxin- interacting protein txnip mediate the glucose sensor mechanism in metastatic breast cancer derived cells mda-mb-231 J J Cell Physiol Yamaguchi FTakata MKamitori Ket al Rare sugar d-allose induces specific up-regulation of txnip and subsequent g1 cell cycle arrest in hepatocellular carcinoma cells by stabilization of p27kip1 J Int J Oncol Sheth S SBodnar J SGhazalpour Aet al Hepatocellular carcinoma in txnip-deficient mice J Oncogene Hoshikawa HMori TMori N In vitro and in vivo effects of d- allose Up-regulation of thioredoxin-interacting protein in head and neck cancer cells J Ann Otol Rhinol Laryngol Ikarashi MTakahashi YIshii Yet al Vitamin d3 upregulated protein 1 vdup1 expression in gastrointestinal cancer Anticancer Res Erkeland S JPalande K KValkhof Met al The gene encoding thioredoxin-interacting protein txnip is a frequent virus integration site in virus-induced mouse leukemia and is Leuk Res Chen ZLopez-Ramos D AYoshihara Eet al Thioredoxinbinding protein-2 tbp-2 / vdup1 / txnip regulates t-cell sensitivity to glucocorticoid during htlv-i-induced transformation J Leukemia Goldberg S FMiele M EHatta Net al Melanoma metastasis suppression by chromosome 6 Evidence for a pathway regulated by crsp3 and txnip J Cancer Res Turturro FFriday EWelbourne T Hyperglycemia regulates thioredoxin-ros activity through induction of thioredoxininteracting protein txnip in metastatic breast cancer- derived cells mda-mb-231 J BMC Cancer

5 Muoio D M Txnip links redox circuitry to glucose control J Cell Metab Shin DJeon J HJeong Met al Vdup1 mediates nuclear export of hif1alpha via crm1- dependent pathway J Biochim Biophys Acta Han S HJeon J HJu H Ret al Vdup1 upregulated by tgfbeta1 and 1 25-dihydorxy vitamin d3 inhibits tumor cell growth by blocking cell-cycle progression J Oncogene Yam C HFung T KPoon R Y Cyclin a in cell cycle control and cancer J Cell Mol Life Sci Nishinaka YNishiyama AMasutani Het al Loss of thioredoxin-binding protein-2 / vitamin d3 up-regulated protein 1 in human t-cell leukemia virus type i-dependent t-cell transformation Implications for adult t-cell leukemia leukemogenesis J Cancer Res Jeon J HLee K NHwang C Yet al Tumor suppressor vdup1 increases p27 kip1 stability by inhibiting jab1 J Cancer Res Le Jan SLe Meur NCazes Aet al Characterization of the expression of the hypoxia- induced genes neuritintxnip and igfbp3 in cancerj FEBS Lett Chai T FLeck Y CHe Het al Hypoxia-inducible factor independent down-regulation of thioredoxin-interacting protein in hypoxia J FEBS Lett Yu F XChai T FHe Het al Thioredoxin-interacting protein txnip gene expression Sensing oxidative phosphorylation status and glycolytic rate J J Biol Chem Lee K NKang H SJeon J Het al Vdup1 is required for the development of natural killer cells J Immunity Barber M AZhang TGagne B Aet al Nk cells negatively regulate antigen presentation and tumor-specific ctls in a syngeneic lymphoma model J J Immunol Cell UMMS Job Dekker Frederick Alt UMMS Rachel Patton McCord 3D McCord Dekker 2009 Hi-C B Alt HTGTS 3D Dekker Dekker UMMS 3D EurekAlertFeb