(dendrimers), Tomalia D A. , dendrimers. ( branch units) (dendron),, dendron. dendrimers. Dendrimers, Dendrimers.

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1 22 4 JOURNAL OF CHINESE BIOTECHNOLOGY , ( ) ( ),,, (dendrimers), Tomalia D A 80 [1 ] 20,dendrimers,,,,,,, [2 ] dendrimers 1 Dendrimers [ 2,3] Dendrimers,,, (core), : ( 1 ) (divergent growth method ) ; (2) ( covergent growth method) (initiator),, (layer generation, G), G 0, G 1, G 2 G 10 dendrimers 3 ( ) ( :00ZB14053) 3 3 :,e2mail :LU HUAZHONG@SOHU. COM, dendrimers, 10, ;,,,, dendrimers,, ( branch units) (dendron),, dendron Dendrimers, G 0 G ! ( G 0 G 4 ) dendrimers, ( G 5 G 10 ),dendrimers,, (hydrophobic void spaces), Dendrimers,,,,

2 4 : 7 DNA, Dendrimers (unimolecular micelles),, ( self2assembling,liu M dendrimeric drug delivery system) Dendrimers [7 ] 2,, ( ) (PEG) PEG 2 Dendrimers Dendrimers (indomethacin) 11wt %, ; (1) dendrimers ; (2) 2. 2 Dendrimers2 dendrimers, ( multivalent recognition) dendrimer ( physical entrapment) Dendrimers, 2 (cavity),,,, Dendrimers,, (host2guest) Meijer,, 2 (dendritic box),, t2boc (tert2butoxycarbonyl ) 5,,dendrimers 64,,, Rose Bengal,,, Boc, [4 ] Roy [8,9 ] 1993, [8 ], ; [5 ],,, dendritic box, dendrimers,, 12,, (lectin limax flavus ),, 8. 22nmolΠLΠIC50 Newkome Moorefield, [6 ],, [9 ],

3 8 22 Stoddart, A [10] A, A 40ku, 50ku 6 EPR dendrimers2 Stoddart PAMAM 9 18, A, 0. 65nmolΠLΠIC50,, dendrimers, dendrimers2, dendrimers, dendrimers dendrimers Duncan PAMAM dendrimer2, 60 70ku,, 25 45ku, EPR, dendrimers ; dendrimers EPR, 50ku ( ), dendrimers, dendrimers, EPR,, [11 ], Zhuo (cyclic core) PAMAM dendrimers dendrimers, 52 G 4 G 5 Meijer dendrimers,, 52 [12 ] dendrimers, dendrimers,,, [13 ] 2. 3 dendrimers Dendrimers, ( ) Maeda ( enhanced, [16 ] Zimmerman dendrimers,, [17 ] 4 34ku,, 90!, 6ku,, dendrimers permeability and retention, EPR) [14 ] 3 Dendrimers :,, Duncan Maeda HPMA EPR,, [15 ] ku,,

4 4 : 9 10, Dendrimers Dendrimers 90,Szoka,, (luciferase) 2 ( 2galactosidase), [18 ], dendrimers, dendrimers, dendrimers DNA,,,dendrimers DNA, dendrimers [19 ], 2 ( poly amidoamine,pamam ) dendrimers dendrimers,,, PAMAM dendrimers, ( 30! ) C ( 40! ) ( 55! ) G 3 G 4 PAMAM dendrimers G 5 G 6 PAMAM dendrimers DNA, DNA G 7 G 10 PAMAM dendrimers2 DNA, ( G 1 G 5 ), [2,19 ], PAMAM DNA DNA ( ) Dendrimers Dendrimers2DNA DNA dendrimers G 5, (endocytosis) Attia PAMAM dendrimers, M., PAMAM dendrimers,, dendrimers, PAMAM, [20 ] Bielinska DNA2 PAMAM [21 ] ( SDS),,,dendrimers,,PAMAM dendrimers MRNA, DNA dendrimers2 DNA dendrimers dendrimers, DNA dendrimers, [22 ],,, dendrimers dendrimers, Arima PAMAM dendrimers (cyclodextrins, CyDs) ( CDE ), 2 2 2CyDs dendrimers 1 1, CDE DNA (pdna) pdna Dnase I, dendrimers 2CyD ( 2CDE ),

5 10 22 dendrimers dendrimers 2CyD 100, 2CDE [23 ], dendrimers2dna, pdna (trafficking) dendrimers dendrimers,,,dendrimers : ( 1) dendrimers,,, ; (2),dendrimers, ; (3),dendrimers ; (4) dendrimers DNA, ; (5) dendrimers,,, ; (6) dendrimers, HIV [24 ] 4 Dendrimers 4 2 PAMAM dendrimers, 109 % [25 ] 5,dendrimers,, (polydispersity),, dendrimers, ; DNA ;, (nanomedicine),, dendrimers [7,26 ] dendrimers,dendrimers, dendrimers,,dendrimers ( ), dendrimers,, Dendrimers (MRI),, ( multivalent effect),,, Dendrimers MRI Wiener DTPA G 2 G 6 PAMAM dendrimers PAMAM2 DTPA, G ( Gd 3 + ), dendrimers PAMAM dendrimers, [ 1 ] Tomalia D A. Polymer Journal,1985,12 (1) : [ 2 ] Esfand R,Tomalia D A. Drug Discovery Today,2001,6 : [ 3 ] Shultz L G,Zimmerman S C. Pharmanews,1999,6 (3) : [ 4 ] Jansen J F,et al. Science,1994,266 : [ 5 ] Jansen J F,et al.j Am Chem Soc,1995,117 : [ 6 ] Newkome G R,et al. Chem Commun,1996, [ 7 ] Liu M,Frechet J M J. Pharm Sci Tech Today,1999,2 : [ 8 ] Roy R,et al. Chem Commun,1993,24 : [ 9 ] Zanini D,Roy R.J Am Chem Soc,1997,119 : [10 ] Ashton R,et al.j Org Chem,1998,63 : [ 11 ] Malik N, Evagorou E G, Duncan R. Proc Int Symp Control Release Bioact Mater,1997,24 : [12 ] Zhuo R X,Du B,Lu Z R. J Control Release,1999,57 : [13 ] Vogtle F,Fischer M. Angew Chem Int Ed,1999,38 : [ 14 ] Maeda H,Matsumura Y. Critical Reviews in Therapeutic Drug

6 4 : 11 Carrier Systems,1989,6 : [15 ] Noguci Y,et al.japan J Cancer Res,1998,89 : [16 ] Van J C,et al. Science,1995,268 : [17 ] Zimmerman S C,et al. Science,1996,271 : [18 ] Haensler J,Szoka F C. Bioconjug Chem,1993,5 (4) : [19 ] Eichman J D,et al. Pharm Sci Tech Today,2000,3 : [20 ] Attia S A,et al. Antisense and Nucleic Acid Drug Development, 1998,8 : [ 21 ] Bielinska A U, et al. Biochimica et Biophysica Acta, 1997, 1353 : [22 ] Qin L,et al. Hum Gene Ther,1998,9 (4) : [23 ] Arima H,et al. Bioconjug Chem,2001,12 (4) : [24 ] Witvrouw M,et al. Mol Pharmacol,2000,58 (5) : [25 ] Wiener E C,et al. Inverstigative Radiology,1997,32 : [26 ] Malik N,et al.j Control Release,2000,68 (2) : Progress of Dendrimers in Biomedicinal Applications Xiao Juan 1,2 Lu Huazhong 1 Zou Ping 2 (1 Laboratory for Blood Engineering Institution of Transfusion Shanghai Blood Center,Shanghai ) (2Institute of Hematology Xiehe Hospital Tongji Medical College Huazhong University of Science & Technology Wuhan ) Abstract Dentritic polymers ( dendrimers) are belonging to a special class of synthetic nanostructures, which have attracted considerable attention in pharmaceutical and biomedicinal chemestry particularly. Their accurately controlled structures and unique physical and chemical properties have demonstrated great versatilities in many life science application. This review briefly discusses dendrimers used as a novel macromolecular vector for safety,high bioavailability and low mammalian toxicity,and their potential applications in drug delivery system and as gene delivery agents and magnetic resonance imaging agents. Key words Dendrimers Drug delivery Gene transfer Medicinal imaging (Medicine in the 21st Century, the Second Sino2US Symposium, Shanghai) , 1998 Ferid Murad 50 :,,,,,,,,, :11 ;21,200 ;31 ; word 163. com, word :, : (200025) :http :ΠΠwww. simc2002. net

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