Analysis Summary: Any Allergy

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1 Analysis Summary: Any Allergy Phenotype Description The any_allergy phenotype includes cases identified from the union of the following sources: Allergies and Asthma survey: An allergic reaction (with either a positive allergy test, or with specific allergy symptoms) to any of the following: Foods: chicken, eggs, milk, shellfish, fish, oats, peanut, soy, tree nuts, wheat, other Plants: trees, weeds, grasses, other Animals: cat, dog, other Drugs, penicillin, sulfa drug, mycin drug, aspirin Other: dust mites, mold, latex Your Medical History survey: Have you ever been diagnosed by a doctor with any of the following types of allergies? (Seasonal allergy: Yes, No, I don t know) Either Allergies and Asthma or Asthma survey: Allergic asthma cases (an asthma diagnosis with allergic trigger) We identified controls that reported having no allergies of any kind, based on information from many sources. A control had to provide at least one negative response and no positive responses to any of these questions: Your Health Profile survey Have you ever been diagnosed by a doctor with any of the following types of allergies? (Yes, No, I m not sure) Seasonal allergies Asthma Environmental (but not seasonal) allergy Food allergy Drug allergy Asthma Symptoms survey Have you ever been diagnosed by a doctor with asthma or bronchial asthma? (Yes, No, I m not sure) Do you currently have allergies? (Yes, No, I m not sure) Have you ever had any of the following? Please check all that apply. Positive allergen skin prick test or positive allergen blood test Atopic dermatitis/eczema (chronic itchy and scaly skin rashes caused by allergies) Allergic rhinitis (stuffed or dripping nose caused by allergies) Allergic conjunctivitis (red, itchy, or painful eyes caused by allergies) Allergies and Asthma survey Questions about a total of 38 allergens, including foods, plants, animals, molds, latex, medicines, vaccines, and other Have you ever had an asthma attack? (Yes, No, I m not sure) Phenotype Statistics The following table shows demographics of unrelated, European individuals included in the GWAS. Phenotype Group Total M F (0,30] (30,45] (45,60] (60,Inf] any_allergy case control The following table shows the phenotypic distribution across 23andMe genotyping platforms for individuals included in the GWAS. Phenotype Group Total v1/v2 v3 v4 any_allergy case control Null Model with Covariates The following table shows results of fitting a model for the trait based on just the covariates. Principal coordinates have been standardized, so these effect sizes are in units of standard deviations. Estimate Std. Error z value Pr(> z ) LRT Pr(>Chi) age sexf pc pc pc pc pc SNP level QC information The following table shows results for QC filters on the genotyped data:

2 failed passed no filters not V1/V2 only, chrm, chry parent offspring test MAF > 0% HWE > 1e gt.rate > 90% batch effects The following table shows results for QC filters on the imputed dosage data: failed passed no filters MAF > 0% imputation quality batch effects The following table shows results for QC filters on the merged association test results: passed total imputed only both passed genotyped only no test result failed to converge Genetic Association Tests We performed logistic regression assuming an additive model for allelic effects, using the model: any_allergy ~ age + sex + pc.0 + pc.1 + pc.2 + pc.3 + pc.4 + genotype This genome wide association analysis includes data from cases and controls of European ancestry, filtered to remove close relatives. The results in this report have been adjusted for a genomic control inflation factor λ= The equivalent inflation factor for 1000 cases and 1000 controls λ 1000 = 1.002, and for 10000, λ = Manhattan Plot Q Q Plot of GWAS Results

3 Index SNPs for Strongest Associations cytoband assay.name scaffold position alleles src pvalue OR 95% CI gene.context 2q12.1 rs chr G/T I [0.871,0.909] [IL1RL1] 6p21.32 rs chr A/G I [0.884,0.920] HLA DQA1 []HLA DQB1 5q22.1 rs chr C/T I [0.923,0.951] WDR36 [] CAMK4 16p13.13 rs chr C/T I [0.920,0.950] CLEC16A [] SOCS1 4p14 rs chr A/T I [1.062,1.104] TLR1 [] TLR6 17q12 rs chr C/T I [0.927,0.955] [GSDMB] 11q13.5 rs chr A/G I [0.929,0.957] LRRC32 2q37.3 rs chr C/T I [1.073,1.129] [D2HGDH] 1p36.23 rs chr C/T I [1.044,1.079] [RERE] 12q24.31 rs chr A/G I [1.047,1.087] CDK2AP1 [] SBNO1 2p25.1 rs chr A/G I [0.929,0.960] [] ID2 4q27 rs chr A/G I [1.039,1.073] IL2 [] IL21 10p14 rs chr A/G I [1.047,1.088] GATA3 [] 9p24.1 rs chr A/G I [1.060,1.115] RANBP6 [] IL33 11q23.3 rs chr C/T I [0.921,0.957] DDX6 [] CXCR5 10q24.32 rs chr D/I I [1.042,1.081] [SUFU] 2q33.1 rs chr A/T I [1.035,1.067] [PLCL1] 14q21.1 rs chr A/G I [1.041,1.080] FOXA1 [] TTC6 5q31.1 rs chr C/T I [1.041,1.080] [IL13] 1q23.3 rs chr C/T I [1.037,1.073] [FCER1G] 8q21.13 rs chr A/C I [0.938,0.967] TPD52 [] ZBTB10 3q28 rs chr A/G I [1.028,1.059] [LPP] 15q22.33 rs chr A/G I [1.034,1.073] [SMAD3] 9q34.2 rs chr C/T I [1.035,1.075] [ABO] 17q21.32 rs chr C/T I [1.029,1.062] [FLJ40194] Quality Statistics for Index SNPs assay.name is.v2 is.v3 is.v4 gt.rate hw.p.value p.date freq.b avg.rsqr min.rsqr p.batch dose.b qc.mask rs v2v3v4 rs v2v3v4 rs v2v3v4 rs v2v3v4 rs v2v3v4 rs v2v3v4 rs v2v3v4 rs v3 rs v2v3v4 rs v2v3v4 rs v2v3v4 rs v2v3v4 rs v2v3v4 rs v2v3v4 rs v2v3v4 rs v2v3v4 rs v2v3v4 rs v2v3v4 rs v2v3v4 rs v2v3v4 rs v2v3v4 rs v2v3v4 rs v2v3v4 rs v2v3v4 rs v2v3v4 SNP Statistics in the GWAS Sample

4 assay.name AA.0 AB.0 BB.0 im.num.0 dose.b.0 AA.1 AB.1 BB.1 im.num.1 dose.b.1 rs rs rs rs rs rs rs rs rs rs rs rs rs rs rs rs rs rs rs rs rs rs rs rs rs Annotations from NHGRI GWAS Catalog The following table shows, for each index SNP, all entries in the NHGRI GWAS Catalog that are within 500kb and in at least moderate linkage disequilibrium (r 2 > 0.5). region position our.name our.pval dist rsqr assay.name pvalue pubmed.id trait genes 2q rs rs Self reported allergy IL1RL2, IL1RL1 2q rs rs Asthma IL1RL1 2q rs rs Asthma IL1RL1, IL18R1 2q rs rs Allergic sensitization IL1RL1, IL18R1, IL18RAP 2q rs rs Asthma and hay fever IL1RL1 5q rs rs Eosinophilic esophagitis (pediatric) WDR36 5q rs rs Allergic rhinitis TSLP 5q rs rs Asthma and hay fever WDR36 5q rs rs Self reported allergy WDR36, CAMK4, TSLP 16p rs rs Atopic dermatitis CLEC16A 16p rs rs Asthma and hay fever CLEC16A 16p rs rs Self reported allergy CLEC16A 4p rs rs Helicobacter pylori serologic status TLR10,TLR1,FAM114A1,TLR6,KLF3 4p rs rs Alcohol consumption Intergenic 4p rs rs Asthma and hay fever TLR1 4p rs rs Self reported allergy TLR1,TLR6,TLR10 4p rs rs Allergic sensitization TLR1,TLR6, TLR10, 17q rs rs Inflammatory bowel disease IKZF3,ZPBP2,GSDMB,ORMDL3,GSDMA 17q rs rs Primary biliary cirrhosis IKZF3 Systemic lupus erythematosus and Systemic 17q rs rs sclerosis IKZF3 17q rs rs Primary biliary cirrhosis IKZF3, ZPBP2, 17q rs rs Primary biliary cirrhosis IKZF3,ZPBP2,GSDMB,ORMDL3 17q rs rs Type 1 diabetes autoantibodies ORMDL3 17q rs rs Ulcerative colitis IKZF3, ORMDL3, 17q rs rs Crohn s disease GSMDL,ZPBP2,ORMDL3,IKZF3 17q rs rs Rheumatoid arthritis IKZF3 17q rs rs Crohn s disease ORMDL3 17q rs rs Cervical cancer GSDMB 17q rs rs Fractional exhaled nitric oxide (childhood) ZPBP2, GSDMB 17q rs rs Asthma (childhood, severe) GSDMB 17q rs rs Asthma GSDMB 17q rs rs Ulcerative colitis ORMDL3,ZPBP2M,GSDML 17q rs rs Asthma GSDMB 17q rs rs Type 1 diabetes ORMDL3 17q rs rs Asthma ORMDL3 17q rs rs Self reported allergy GSDMB, IKZF3 17q rs rs Asthma ORMDL3 11q rs rs Atopic dermatitis C11orf30,LRRC32 11q rs rs Asthma LRRC32 11q rs rs Allergic sensitization C11orf30, LRRC32 11q rs rs Self reported allergy C11orf30, LRRC32 11q rs rs Inflammatory bowel disease Intergenic 11q rs rs IgE grass sensitization C11orf30, LRRC32 11q rs rs Allergic rhinitis C11orf30, LRRC32 11q rs rs Ulcerative colitis Intergenic 11q rs rs Atopic dermatitis C11orf30 11q rs rs Crohn s disease C11orf30 11q rs rs Crohn s disease C11orf30 1p rs rs Autism spectrum disorder, attention deficithyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) SLC45A1, RERE, ENO1 1p rs rs Schizophrenia 1p rs rs Bone mineral density RERE 12q rs rs Platelet counts ABCB9 12q rs rs Type 2 diabetes MPHOSPH9 12q rs rs Multiple sclerosis MPHOSPH9

5 12q rs rs Schizophrenia C12orf65, ABCB9, 12q rs rs Head circumference (infant) SBNO1 12q rs rs Height SBNO1 2p rs rs Self reported allergy ID2 4q rs rs Type 1 diabetes IL2 4q rs rs Type 1 diabetes 4q rs rs Self reported allergy ADAD1 4q rs rs Type 1 diabetes autoantibodies ADAD1 4q rs rs Ulcerative colitis IL21, IL2, ADAD1 4q rs rs Allergic sensitization IL2, ADAD1, 4q rs rs IgE grass sensitization IL2 11q rs rs Celiac disease and Rheumatoid arthritis DDX6 11q rs rs Primary biliary cirrhosis CXCR5 2q rs rs Dermatomyositis PLCL1 2q rs rs Crohn s disease PLCL1 2q rs rs Alcohol consumption PLCL1 2q rs rs Self reported allergy PLCL1 14q rs rs Self reported allergy FOXA1, TTC6 5q rs rs Asthma (childhood, severe) IL13 5q rs rs Atopic dermatitis IL13, RAD50 5q rs rs Atopic dermatitis KIF3A, IL13 5q rs rs Asthma IL13 5q rs rs Self reported allergy Intergenic 5q rs rs Hodgkin s lymphoma IL13 5q rs rs IgE levels IL13 5q rs rs Psoriasis IL13 8q rs rs Self reported allergy TPD52, ZBTB10 8q rs rs Asthma and hay fever ZBTB10 8q rs rs Atopic dermatitis ZBTB10 3q rs rs Allergic sensitization LPP, BCL6 3q rs rs Vitiligo LPP 3q rs rs Vitiligo LPP 3q rs rs Celiac disease LPP 3q rs rs Celiac disease LPP 3q rs rs Self reported allergy LPP, BCL6 15q rs rs Inflammatory bowel disease SMAD3 15q rs rs Crohn s disease SMAD3 15q rs rs Self reported allergy SMAD3 15q rs rs Asthma and hay fever SMAD3 9q rs rs Lipid traits ABO 9q rs rs Soluble ICAM 1 ABO 9q rs rs Soluble ICAM 1 ABO 9q rs rs Blood metabolite levels ABO 9q rs rs Serum alkaline phosphatase levels SURF6, ABO 9q rs rs End stage coagulation ABO 9q rs rs Metabolite levels ABO 9q rs rs E selectin levels ABO 9q rs rs Urinary metabolites (H NMR features) ABO 9q rs rs Coronary artery disease or large artery stroke ABO 9q rs rs Coronary artery disease or ischemic stroke ABO 9q rs rs Coronary artery disease ABO 9q rs rs Red blood cell traits ABO 9q rs rs Liver enzyme levels (alkaline phosphatase) ABO 9q rs rs Coronary heart disease ABO 9q rs rs Soluble levels of adhesion molecules ABO 9q rs rs Soluble E selectin levels ABO 9q rs rs Blood metabolite ratios ABO 9q rs rs Venous thromboembolism ABO 9q rs rs Red blood cell count ABO 9q rs rs Hematological and biochemical traits ABO 9q rs rs Angiotensin converting enzyme activity ABO 9q rs rs LDL cholesterol ABO 9q rs rs Cholesterol, total ABO 17q rs rs Blood pressure ZNF652 17q rs rs Diastolic blood pressure ZNF652, PHB Replication of GWAS Catalog Results

6 The following table shows, for each GWAS Catalog result for similar traits, our association test result for our best available proxy (distance < 100kb, r 2 > 0.8). region position our.name our.pval dist rsqr assay.name pvalue pubmed.id trait genes 2q rs rs Allergic sensitization IL1RL1, IL18R1, IL18RAP 2q rs rs Allergic sensitization ANAPC1 3q rs rs Allergic sensitization LPP, BCL6 4p rs rs Allergic sensitization TLR1,TLR6, TLR10, MIR574, FAM114A1 4q rs rs Allergic sensitization IL2, ADAD1, KIAA1109, IL21 5q rs rs Allergic sensitization SLC25A46, TSLP, WDR36, CAMK4 6p rs rs Allergic sensitization HLA B, MICA, HLA C, MICB 6p rs rs Allergic sensitization HLA DQB1, HLA DQA1, 6p rs rs Allergic sensitization COL21A1 8q rs rs Allergic sensitization MYC, PVT1 11q rs rs Allergic sensitization C11orf30, LRRC32 12q rs rs Allergic sensitization STAT6 5q rs rs Allergic rhinitis TMEM232, SLCA25A46 5q rs rs Allergic rhinitis TSLP 5q rs rs Allergic rhinitis SEMA6A 7p rs rs Allergic rhinitis GLI3 11q rs rs Allergic rhinitis C11orf30, LRRC32 14q rs rs Allergic rhinitis PPM1A, DHRS7 16p rs rs Allergic rhinitis CLEC16A 20p rs rs Allergic rhinitis ENTPD6 Nearby Nonsynonymous SNPs region position our.name our.pval dist rsqr assay.name gene aa.chg 2q rs rs IL1RL1 A78E 6p rs rs HLA DQA1 F41S 6p rs rs HLA DQB1 Y62? 4p rs rs TLR10 I775V 4p rs rs TLR1 N248S 17q rs rs ZPBP2 S173I 17q rs rs GSDMB P311S 17q rs rs GSDMB G304R 2q rs rs D2HGDH V338I 12q rs rs SBNO1 S729N 2q rs rs PLCL1 V667I 5q rs rs20541 IL13 Q144R Nearby Expression QTLs region position our.name our.pval dist rsqr assay.name eqtl.dist eqtl.gene eqtl.pval eqtl.rsqr tissue pubmed.id 6p rs rs HLA DQB T cell p rs rs HLA DQA Lymphoblastoid p rs rs HLA DQA Lymphoblastoid p rs rs HLA DQB Lymphoblastoid q rs rs TSLP Lymphoblastoid q rs rs TSLP Esophagus_Mucosa q rs rs TSLP Skin_Sun_Exposed_Lower_leg q rs rs TSLP Adipose_Subcutaneous q rs rs TSLP Artery_Tibial q rs rs TSLP Thyroid p rs rs TLR Liver p rs rs TLR Lymphoblastoid

7 4p rs rs TLR Lymphoblastoid p rs rs TLR Lymphoblastoid p rs rs TLR Monocyte p rs rs TLR Lymphoblastoid p rs rs TLR Lymphoblastoid p rs rs TLR Lymphoblastoid p rs rs TLR Lymphoblastoid p rs rs FAM114A Lymphoblastoid q rs rs GSDMB Lymphoblastoid q rs rs ORMDL Lymphoblastoid q rs rs GSDMB Whole_Blood q rs rs PGAP Thyroid q rs rs ZPBP Lymphoblastoid q rs rs GSDML Lymphoblastoid q rs rs ORMDL Lymphoblastoid q rs rs ORMDL Whole_Blood q rs rs IKZF Monocyte q rs rs PGAP Esophagus_Muscularis q rs rs ABCB Heart_Left_Ventricle q rs rs SNRNP B Cell q rs rs MPHOSPH Esophagus_Muscularis q rs rs MPHOSPH Monocyte q rs rs CDK2AP B Cell q rs rs ABCB Skin_Sun_Exposed_Lower_leg q rs rs CDK2AP Esophagus_Mucosa q rs rs CDK2AP Monocyte q rs rs RP11 282O Esophagus_Mucosa q rs rs CDK2AP Skin_Sun_Exposed_Lower_leg q rs rs CDK2AP Adipose_Subcutaneous q rs rs RP11 282O Adipose_Subcutaneous q rs rs CDK2AP Lymphoblastoid p rs rs ID Monocyte q rs rs DDX Liver q rs rs CCDC Liver q rs rs FXYD T cell q rs rs TREH Esophagus_Mucosa q rs rs TREH Stomach q rs rs PLCL Monocyte q rs rs PLCL Whole_Blood q rs rs SLC22A B Cell q rs rs FCER1G Monocyte q rs rs USF Monocyte q rs rs FCER1G Monocyte q rs rs BCL Monocyte q rs rs GNGT Monocyte q rs rs ITGA B Cell Nearby Clinical Variants source region our.name our.pval dist rsqr assay.name gene phenotype accession clinvar 4p14 rs rs TLR1 Leprosy 5 NCBI curation omim 4p14 rs rs TLR1 clinvar 5q31.1 rs rs20541 IL13 Asthma, susceptibility to NCBI curation clinvar 5q31.1 rs rs20541 IL13 Allergic rhinitis SNOMED CT Shared Associations with Other 23andMe Phenotypes region position our.name our.pval dist rsqr assay.name phenotype pvalue gene.context match 1p rs rs PD_all_pop_con [RERE] 1p rs rs any_animal_allergy [RERE] 1p rs rs any_plant_allergy [RERE] 1p rs rs dust_mites_allergy [RERE] 1p rs rs mold_allergy [RERE] 1p rs rs seasonal_allergies_broad [RERE] 1p rs rs tonsillectomy RERE [] ENO1 1p rs rs iqb.nail_biting_frequency ZMYM6NB DLGAP3 [] 1p rs rs any_immune [NEGR1] 1p rs rs hayfever_all [NEGR1] 1p rs rs seasonal_allergies_broad [NEGR1] 1p rs rs personality_ideas [NEGR1] 1p rs rs any_asthma [NEGR1] 1p rs rs astigmatism NEGR1[] 1p rs rs iqb.lost_20lbs NEGR1[] 1p rs rs juvenile_obesity NEGR1[] 1p rs rs any_psychiatric NEGR1[] 1p rs rs depression NEGR1[] 1p rs rs heart_metabolic_disease_burden NEGR1 [] 1p rs rs obesity NEGR1 [] 1p rs rs bmi NEGR1 [] 1p rs rs weight NEGR1 [] 1p rs rs heart_metabolic_disease NEGR1 [] 1p rs rs high_cholesterol_broad NEGR1 []

8 1p rs rs iqb.took_meds_depression_or_anxiety NEGR1 [] 1p rs rs any_plant_allergy NEGR1 [] 1q rs rs eczema [IL6R] 1q rs rs iqb.took_meds_anti_tnf_alpha [IL6R] 1q rs rs mosquito_severe [IL6R] 1q rs rs mosquito_combined [IL6R] 1q rs rs allergic_asthma []ADAMTS4 B4GALT3 1q rs rs any_asthma []ADAMTS4 B4GALT3 1q rs rs any_plant_allergy []ADAMTS4 B4GALT3 1q rs rs seasonal_allergies_broad []ADAMTS4 B4GALT3 1q rs rs any_animal_allergy [FCER1G] 1q rs rs hayfever_all [FCER1G] 1q rs rs iqb.took_meds_asthma_or_lung [FCER1G] 1q rs rs dust_mites_allergy [CD247] 1q rs rs any_asthma [CD247] 1q rs rs any_animal_allergy [CD247] 1q rs rs depression_anxiety_meds [] FAM5C 1q rs rs any_psychiatric [] FAM5C 1q rs rs heart_metabolic_disease_burden [FAM5C] 1q rs rs heart_metabolic_disease [FAM5C] 1q rs rs bmi [FAM5C] 1q rs rs weight [FAM5C] 2p rs rs mosquito_combined [] ID2 2p rs rs other_animal_allergy [] ID2 2p rs rs any_animal_allergy [] ID2 2p rs rs any_food_allergy [] ID2 2p rs rs any_plant_allergy [] ID2 2p rs rs dust_mites_allergy [] ID2 2p rs rs hayfever_all [] ID2 2p rs rs mold_allergy [] ID2 2p rs rs mosquito_severe [] ID2 2p rs rs seasonal_allergies_broad [] ID2 2p rs rs any_asthma [] ID2 2p rs rs insect_allergy [] ID2 2p rs rs rosacea_all BRE [] FOSL2 2p rs rs rosacea_dx [FOSL2] 2p rs rs iqb.gray_amount FOSL2 [] PLB1 2q rs rs iqb.recharge_by_socializing IL1R2 [] IL1R1 2q rs rs any_asthma IL1RL1 IL1RL2 [] 2q rs rs any_immune IL1RL1 IL1RL2 [] 2q rs rs juvenile_allergic_asthma [IL1RL1] 2q rs rs any_animal_allergy [IL1RL1] 2q rs rs any_food_allergy [IL1RL1] 2q rs rs any_plant_allergy [IL1RL1] 2q rs rs dust_mites_allergy [IL1RL1] 2q rs rs hayfever_all [IL1RL1] 2q rs rs mold_allergy [IL1RL1] 2q rs rs seasonal_allergies_broad [IL1RL1] 2q rs rs insect_allergy [IL1RL1] 2q rs rs milk_allergy [IL1RL1] 2q rs rs allergic_asthma [IL1RL1] 2q rs rs juvenile_asthma [IL1RL1] 2q rs rs other_animal_allergy [IL1RL1] 2q rs rs other_plant_allergy [IL1RL1] 2q rs rs iqb.took_meds_asthma_or_lung [IL18R1] 2q rs rs tree_nuts_allergy [IL18RAP] 2q rs rs any_drug_allergy [IL18RAP] 2q rs rs any_drug_allergy CALCRL ZSWIM2 [] 2q rs rs anxiety [COQ10B] 2q rs rs depression_anxiety_meds [RFTN2] 2q rs rs any_skin_cancer RFTN2 [] MARS2 2q rs rs morning_person [PLCL1] 2q rs rs any_animal_allergy [PLCL1] 2q rs rs any_plant_allergy [PLCL1] 2q rs rs seasonal_allergies_broad [PLCL1] 2q rs rs dust_mites_allergy [PLCL1] 2q rs rs age_first_menses SATB2 PLCL1 [] 2q rs rs any_immune KLF7 [] CREB1 2q rs rs any_asthma [DAW1] 2q rs rs any_animal_allergy [DAW1] 2q rs rs bmi [SPHKAP] 2q rs rs any_immune [D2HGDH] 2q rs rs other_animal_allergy [D2HGDH] 2q rs rs other_plant_allergy [D2HGDH] 2q rs rs allergic_asthma [D2HGDH] 2q rs rs any_animal_allergy [D2HGDH] 2q rs rs any_asthma [D2HGDH] 2q rs rs hayfever_all [D2HGDH] 2q rs rs juvenile_allergic_asthma [D2HGDH] 2q rs rs iqb.took_meds_asthma_or_lung GAL3ST2 D2HGDH [] 2q rs rs any_plant_allergy [GAL3ST2]

9 2q rs rs dust_mites_allergy [GAL3ST2] 2q rs rs mold_allergy [GAL3ST2] 2q rs rs seasonal_allergies_broad [GAL3ST2] 2q rs rs any_food_allergy [GAL3ST2] 3p : :C_CCA : :C_CCA any_drug_allergy []CADM2 3p : :C_CCA : :C_CCA penicillin_allergy []CADM2 3p rs rs personality_conscientiousness [CADM2] 3p rs rs personality_neuroticism [CADM2] 3p rs rs iqb.adventurous [CADM2] 3p rs rs any_plant_allergy [CADM2] 3p rs rs adhd_add_meds [CADM2] 3q rs rs any_immune [ILDR1] 3q rs rs nearsightedness [ZBTB38] 3q rs rs myopia_v_hyperopia [ZBTB38] 3q rs rs haircolor [ZBTB38] 3q rs rs any_animal_allergy [ZBTB38] 3q rs rs farsightedness [ZBTB38] 3q rs rs iqb.farsighted [ZBTB38] 3q rs rs height [ZBTB38] 3q rs rs weight [ZBTB38] 3q rs rs shoe_size_normalized [ZBTB38] 3q rs rs male_pattern_meta [ZBTB38] 3q rs rs iqb.stretch_marks [ZBTB38] 3q rs rs stretch_marks_any [ZBTB38] 3q rs rs other_animal_allergy BCL6 [] LPP 3q rs rs squamous_cell_carcinoma [LPP] 3q rs rs any_skin_cancer [LPP] 3q rs rs basal_cell_carcinoma [LPP] 3q rs rs any_non_melanoma_skin_cancer [LPP] 3q rs rs dust_mites_allergy [LPP] 3q rs rs any_plant_allergy [LPP] 3q rs rs seasonal_allergies_broad [LPP] 3q rs rs mosquito_combined [LPP] 3q rs rs any_animal_allergy [LPP] 3q rs rs hypothyroidism [LPP] 3q rs rs any_immune [LPP] 3q rs rs any_asthma [LPP] 3q rs rs psoriasis [CEP19] 4p rs rs mold_allergy [] 4p rs rs other_animal_allergy TLR10 [] TLR1 4p rs rs allergic_asthma [TLR1] 4p rs rs any_animal_allergy [TLR1] 4p rs rs any_asthma [TLR1] 4p rs rs any_plant_allergy [TLR1] 4p rs rs dust_mites_allergy [TLR1] 4p rs rs hayfever_all [TLR1] 4p rs rs iqb.took_meds_asthma_or_lung [TLR1] 4p rs rs juvenile_allergic_asthma [TLR1] 4p rs rs mold_allergy [TLR1] 4p rs rs seasonal_allergies_broad [TLR1] 4p rs rs rosacea_all [TLR6] 4p rs rs any_food_allergy FAM114A1 TLR6 [] 4q rs rs iqb.rotator_cuff_tear SLC39A8 BANK1 [] 4q rs rs iqb.excess_hair [SLC39A8] 4q rs rs any_animal_allergy [SLC39A8] 4q rs rs bmi [SLC39A8] 4q rs rs high_plasma_glucose [SLC39A8] 4q rs rs iqb.low_hdl [SLC39A8] 4q rs rs obesity [SLC39A8] 4q rs rs weight [SLC39A8] 4q rs rs height [SLC39A8] 4q rs rs iqb.arthritis_any [SLC39A8] 4q rs rs osteoarthritis_broad [SLC39A8] 4q rs rs iqb.stretch_marks [SLC39A8] 4q rs rs stretch_marks_any [SLC39A8] 4q rs rs allergic_asthma [KIAA1109] 4q rs rs any_asthma [KIAA1109] 4q rs rs any_immune IL2 [] IL21 4q rs rs any_plant_allergy IL2 [] IL21 4q rs rs seasonal_allergies_broad IL2 [] IL21 4q rs rs dust_mites_allergy IL2 [] IL21 4q rs rs iqb.took_meds_asthma_or_lung IL2 [] IL21 4q rs rs any_animal_allergy IL2 [] IL21 4q rs rs mold_allergy IL2 [] IL21 5p rs rs any_drug_allergy [MYO10] 5p rs rs any_plant_allergy [MYO10] 5p rs rs dust_mites_allergy [MYO10] 5p rs rs seasonal_allergies_broad [MYO10] 5p rs rs any_autoimmune [SPEF2] 5p rs rs eczema SPEF2 [] IL7R 5p rs rs mold_allergy [IL7R] 5p rs rs any_animal_allergy [IL7R] 5p rs rs any_immune [IL7R] 5p rs rs any_plant_allergy [IL7R] 5p rs rs seasonal_allergies_broad [IL7R]

10 5p rs rs hayfever_all [] PTGER4 5p rs rs any_animal_allergy [] PTGER4 5p rs rs any_plant_allergy [] PTGER4 5p rs rs seasonal_allergies_broad [] PTGER4 5q rs rs iqb.cry_easily MEF2C TMEM161B [] 5q rs rs gerd_broad TSLP SLC25A46 [] 5q rs rs any_asthma TSLP SLC25A46 [] 5q rs rs hayfever_all TSLP SLC25A46 [] 5q rs rs iqb.took_meds_asthma_or_lung TSLP SLC25A46 [] 5q rs rs juvenile_allergic_asthma TSLP SLC25A46 [] 5q rs rs juvenile_asthma TSLP SLC25A46 [] 5q rs rs mold_allergy TSLP SLC25A46 [] 5q rs rs allergic_asthma [WDR36] 5q rs rs any_animal_allergy CAMK4 WDR36 [] 5q rs rs any_food_allergy CAMK4 WDR36 [] 5q rs rs any_plant_allergy CAMK4 WDR36 [] 5q rs rs dust_mites_allergy CAMK4 WDR36 [] 5q rs rs other_animal_allergy CAMK4 WDR36 [] 5q rs rs seasonal_allergies_broad CAMK4 WDR36 [] 5q rs rs mosquito_severe PDLIM4 P4HA2 [] 5q rs rs high_cholesterol_broad C5orf56 [] IRF1 5q rs rs any_asthma [RAD50] 5q rs rs mold_allergy RAD50 [] IL13 5q rs rs seasonal_allergies_broad [IL13] 5q rs rs20541 psoriasis [IL13] 5q rs rs20541 other_animal_allergy [IL13] 5q rs rs20541 iqb.shampoo_type [IL13] 5q rs rs20541 rosacea_all [IL13] 5q rs rs20541 rosacea_dx [IL13] 5q rs rs iqb.alcohol_flush [IL13] 5q rs rs848 any_animal_allergy [IL13] 5q rs rs848 any_food_allergy [IL13] 5q rs rs848 any_plant_allergy [IL13] 5q rs rs848 dust_mites_allergy [IL13] 5q rs rs848 eczema [IL13] 5q rs rs848 insect_allergy [IL13] 5q rs rs848 iqb.took_meds_asthma_or_lung [IL13] 5q rs rs other_food_allergy IL13 [] IL4 5q rs rs peanut_allergy IL13 [] IL4 5q rs rs dust_mites_allergy AX ZMAT2 [] 5q rs rs any_autoimmune NDFIP1 GNPDA1 [] 5q rs rs any_animal_allergy [NDFIP1] 5q rs rs any_immune [NDFIP1] 5q rs rs any_asthma [NDFIP1] 6p rs rs vitiligo [ZSCAN26] 6p rs rs nearsightedness ZSCAN31 PGBD1[] 6p rs rs adhd_add_meds [ZSCAN31] 6p rs rs dental_superstar ZKSCAN3 ZSCAN31 [] 6p rs rs nose_concavity ZKSCAN3 ZSCAN31 [] 6p rs rs mold_allergy TRIM27 SCAND3 [] 6p rs rs dust_mites_allergy [HLA A] 6p rs rs mold_allergy [HLA A] 6p rs rs chicken_pox [RNF39] 6p rs rs blood_sugar_meds C6orf15 MUC22 [] 6p rs rs any_autoimmune HCG27 [] HLA C 6p rs rs depression_anxiety_meds HLA C [] MICA 6p rs rs iqb.iodine_treatment_ever HLA C [] MICA 6p rs rs allergic_asthma HLA C [] MICA 6p rs rs juvenile_allergic_asthma HLA C [] MICA 6p rs rs any_skin_cancer HLA C [] MICA 6p rs rs acid_reflux HLA C [] MICA 6p rs rs iqb.dandruff_frequency HLA C [] MICA 6p rs rs cavities_many HLA C [] MICA 6p rs rs number_of_cavities HLA C [] MICA 6p rs rs other_animal_allergy HLA C [] MICA 6p rs rs iqb.mononucleosis MICA [] MICB 6p rs rs iqb.ever_diagnosed_autoimmune MICA [] MICB 6p rs rs gender_difference_male [CSNK2B] 6p rs rs juvenile_asthma C6orf48 [] NEU1 6p rs rs iqb.low_hdl [SKIV2L] 6p rs rs tongue_flip C4B_2 []CYP21A2 6p rs rs any_cvd FKBPL [] PRRT1 6p rs rs blood_pressure_meds FKBPL [] PRRT1

11 6p rs rs high_blood_pressure FKBPL [] PRRT1 6p rs rs bmi [RNF5,AGER] 6p rs rs multiple_sclerosis HLA DRB5 HLA DRA [] 6p rs rs eczema HLA DQA1 HLA DRB5 [] 6p rs rs hyperthyroidism HLA DQA1 HLA DRB5 [] 6p rs rs rheumatoid_arthritis HLA DQA1 HLA DRB5 [] 6p rs rs actinic_keratosis HLA DQA1 HLA DRB5 [] 6p rs rs juvenile_asthma HLA DQA1 HLA DRB5 [] 6p rs rs iqb.bronchitis_frequency HLA DQA1 HLA DRB5 [] 6p rs rs any_skin_cancer HLA DQA1 HLA DRB5 [] 6p rs rs milk_allergy HLA DQA1 HLA DRB5 [] 6p rs rs iqb.plantar_warts HLA DQA1 HLA DRB5 [] 6p rs rs any_immune HLA DQA1 HLA DRB5 [] 6p rs rs hayfever_all HLA DQA1 HLA DRB5 [] 6p rs rs allergic_asthma HLA DQA1 HLA DRB5 [] 6p rs rs any_asthma HLA DQA1 HLA DRB5 [] 6p rs rs iqb.took_meds_asthma_or_lung HLA DQA1 HLA DRB5 [] 6p rs rs any_animal_allergy []HLA DQB1 HLA DQA1 6p rs rs any_food_allergy []HLA DQB1 HLA DQA1 6p rs rs any_plant_allergy []HLA DQB1 HLA DQA1 6p rs rs other_animal_allergy []HLA DQB1 HLA DQA1 6p rs rs seasonal_allergies_broad []HLA DQB1 HLA DQA1 6p rs rs iqb.celiac_w_biopsy []HLA DQB1 HLA DQA1 6p rs rs hypothyroidism []HLA DQB1 HLA DQA1 6p rs rs dust_mites_allergy []HLA DQB1 HLA DQA1 6p rs rs mold_allergy []HLA DQB1 HLA DQA1 6p rs rs scarlet_fever [HLA DQB1] 6p rs rs juvenile_allergic_asthma [HLA DQB1] 6p rs rs any_drug_allergy [HLA DQB1] 6p rs rs iqb.gluten_intolerance HLA DQA2 HLA DQB1 [] 6p rs rs acid_reflux_meds HLA DQA2 HLA DQB1 [] 6p rs rs lightheaded HLA DQA2 HLA DQB1 [] 6p rs rs juvenile_t1d HLA DQA2 HLA DQB1 [] 6p rs rs iqb.oral_corticosteroid_ever HLA DQA2 HLA DQB1 [] 6p rs rs iqb.pneumonia_frequency HLA DQA2 HLA DQB1 [] 6p rs rs iqb.iodine_treatment_ever [TAP2] 6p rs rs sunburns [BAK1] 6p rs rs mold_allergy [ITPR3] 6q rs rs seasonal_allergies_broad MAN1A1 [] 6q rs rs penicillin_allergy MAN1A1 [] 6q rs rs any_plant_allergy QKI [] 6q rs rs any_animal_allergy [FGFR1OP] 6q rs rs juvenile_asthma CCR6 FGFR1OP [] 7p rs rs height [ITGB8] 7p rs rs other_animal_allergy [ITGB8] 7p rs rs any_animal_allergy ABCB5 ITGB8 [] 7p rs rs any_animal_allergy [JAZF1] 7p rs rs tonsillectomy IKZF1 C7orf72 [] 7p rs rs mosquito_combined IKZF1 C7orf72 [] 7q rs rs any_plant_allergy [GSAP] 7q rs rs any_animal_allergy [GSAP] 8p rs rs insomnia [] UNC5D 8q rs rs any_immune ZBTB10 TPD52 [] 8q rs rs any_plant_allergy ZBTB10 TPD52 [] 8q rs rs eggs_allergy ZBTB10 TPD52 [] 8q rs rs dust_mites_allergy ZBTB10 TPD52 [] 8q rs rs hayfever_all ZBTB10 TPD52 [] 8q rs rs any_asthma ZBTB10 TPD52 [] 8q rs rs mold_allergy ZBTB10 TPD52 [] 8q rs rs seasonal_allergies_broad ZBTB10 TPD52 [] 8q rs rs any_animal_allergy ZBTB10 TPD52 []

12 8q rs rs eczema TPD52 [] ZBTB10 8q rs rs iqb.took_meds_asthma_or_lung ZBTB10 TPD52 [] 9p rs rs crohns_or_ulcerative_colitis RCL1 []JAK2 9p rs rs blood_disorder [JAK2] 9p rs rs mpn_narrow [JAK2] 9p rs rs mpn_or_v617f [JAK2] 9p rs rs jak2_v617f_cc [JAK2] 9p rs rs iqb.took_meds_asthma_or_lung [JAK2] 9p rs rs seasonal_allergies_broad [JAK2] 9p rs rs heartburn [INSL6] 9p rs rs any_food_allergy RANBP6 [] IL33 9p rs rs juvenile_asthma IL33 RANBP6 [] 9p rs rs any_animal_allergy IL33 RANBP6 [] 9p rs rs any_plant_allergy IL33 RANBP6 [] 9p rs rs dust_mites_allergy IL33 RANBP6 [] 9p rs rs iqb.took_meds_asthma_or_lung IL33 RANBP6 [] 9p rs rs mold_allergy IL33 RANBP6 [] 9p rs rs seasonal_allergies_broad IL33 RANBP6 [] 9p rs rs iqb.chronic_sinus_infections IL33 RANBP6 [] 9p rs rs allergic_asthma IL33 RANBP6 [] 9p rs rs juvenile_allergic_asthma IL33 RANBP6 [] 9p rs rs any_asthma RANBP6 [] IL33 9p rs rs hayfever_all RANBP6 [] IL33 9p rs rs any_drug_allergy TPD52L3 IL33 [] 9p rs rs iqb.travel_preferences TPD52L3 IL33 [] 9q rs rs iqb.took_meds_asthma_or_lung [COL15A1] 9q rs rs back_hair TRAF1 [] C5 9q rs rs iqb.lipoma [ABO] 9q : :GCGCC : :GCGCC gallstones_or_gall_bladder_removal [ABO] 9q rs rs healthy_old [ABO] 9q rs rs iqb.low_hdl [ABO] 9q rs rs any_animal_allergy [ABO] 9q rs rs dust_mites_allergy [ABO] 9q rs rs mold_allergy [ABO] 9q rs rs high_cholesterol_broad [ABO] 9q rs rs any_plant_allergy [ABO] 9q rs rs seasonal_allergies_broad [ABO] 9q rs rs iqb.need_braces [ABO] 9q : :TAAGA : :TAAGA hemorrhoids [ABO] 9q rs rs iqb.blood_donation_frequency [ABO] 9q : :CA_C : :CA_C iqb.childhood_ear_infections [ABO] 9q rs rs iqb.took_meds_blood_thinners [ABO] 9q rs rs iqb.varicose_veins_legs [ABO] 9q rs rs blood_clots [ABO] 9q : :AC_A : :AC_A heart_metabolic_disease [ABO] 9q : :AC_A : :AC_A heart_metabolic_disease_burden [ABO] 9q rs rs iqb.warfarin_ever ABO [] SURF6 9q rs rs tonsillectomy ABO [] SURF6 10p rs rs seasonal_allergies_broad [IL2RA] 10p rs rs dust_mites_allergy [IL2RA] 10p rs rs dust_mites_allergy GATA3 [] 10p rs rs iqb.took_meds_asthma_or_lung GATA3 [] 10p rs rs seasonal_allergies_broad GATA3 [] 10p rs rs scarlet_fever GATA3 [] 10p rs rs any_asthma GATA3 [] 10p rs rs any_plant_allergy GATA3 [] 10p rs rs any_animal_allergy GATA3 [] 10p rs rs any_food_allergy GATA3 [] 10p rs rs iqb.snore GATA3 [] 10q rs rs mold_allergy [TMEM180] 10q rs rs seasonal_allergies_broad [TMEM180] 10q rs rs height ACTR1A TMEM180[] 10q rs rs any_animal_allergy [ACTR1A] 10q rs rs any_food_allergy [ACTR1A] 10q rs rs insect_allergy [SUFU] 10q rs rs any_plant_allergy [SUFU] 10q rs rs dust_mites_allergy [SUFU] 10q rs rs other_animal_allergy [SUFU] 10q rs rs ever_tobacco_user [AS3MT] 11q rs rs blood_pressure_meds LRRC10B PPP1R32 [] 11q rs rs high_blood_pressure LRRC10B PPP1R32 [] 11q rs rs mosquito_combined [C11orf30] 11q rs rs other_animal_allergy LRRC32 11q rs rs other_food_allergy LRRC32

13 11q rs rs allergic_asthma LRRC32 11q rs rs any_immune LRRC32 11q rs rs any_animal_allergy LRRC32 11q rs rs any_asthma LRRC32 11q rs rs any_plant_allergy LRRC32 11q rs rs dust_mites_allergy LRRC32 11q rs rs eczema LRRC32 11q rs rs hayfever_all LRRC32 11q rs rs insect_allergy LRRC32 11q rs rs iqb.took_meds_asthma_or_lung LRRC32 11q rs rs juvenile_allergic_asthma LRRC32 11q rs rs juvenile_asthma LRRC32 11q rs rs mold_allergy LRRC32 11q rs rs seasonal_allergies_broad LRRC32 11q rs rs any_food_allergy LRRC32 11q rs rs tree_nuts_allergy LRRC32 11q rs rs food_allergy LRRC32 11q rs rs high_blood_pressure [LAYN] 11q rs rs any_plant_allergy LAYN [] SIK2 11q rs rs dust_mites_allergy LAYN [] SIK2 11q rs rs seasonal_allergies_broad LAYN [] SIK2 11q rs rs iqb.gap_between_teeth [SIK2] 11q rs rs any_animal_allergy [SIK2] 11q rs rs any_plant_allergy [SIK3] 11q rs rs seasonal_allergies_broad [SIK3] 11q rs rs any_animal_allergy [PCSK7] 11q : :A_ATT : :A_ATT any_plant_allergy TREH [] DDX6 11q rs rs any_animal_allergy TREH [] DDX6 11q rs rs dust_mites_allergy TREH [] DDX6 11q rs rs iqb.took_meds_asthma_or_lung TREH [] DDX6 11q rs rs mold_allergy DDX6 [] CXCR5 11q rs rs any_asthma DDX6 [] CXCR5 11q rs rs any_immune DDX6 [] CXCR5 11q rs rs seasonal_allergies_broad DDX6 [] CXCR5 11q rs rs hayfever_all DDX6 [] CXCR5 11q rs rs any_neurological IGSF9B SPATA19 [] 12q rs rs iqb.sweat_during_workout FAIM2 [] AQP2 12q rs rs any_animal_allergy [AQP2] 12q rs rs seasonal_allergies_broad [AQP2] 12q rs rs any_cvd [LIMA1] 12q rs rs any_autoimmune SUOX [] IKZF4 12q rs rs any_immune [IKZF4] 12q rs rs vitiligo RPS26 [] ERBB3 12q rs rs hypothyroidism RPS26 [] ERBB3 12q rs rs pcos RPS26 [] ERBB3 12q rs rs any_animal_allergy [STAT6] 12q rs rs mosquito_combined [STAT6] 12q rs rs mosquito_severe [STAT6] 12q rs rs juvenile_allergic_asthma [STAT6] 12q rs rs any_asthma STAT6 [] LRP1 12q rs rs iqb.red_wine_headache [LRP1] 12q rs rs migraine_diagnosis [LRP1] 12q rs rs seasonal_allergies_broad ATP2B1 [] 12q rs rs any_plant_allergy ATP2B1 [] 12q rs rs other_plant_allergy ATP2B1 [] 12q rs rs eyecolor_herc2_blue [LOC256021] 12q rs rs eyecolor_simple CLLU1OS BTG1 [] 12q rs rs height C12orf23 RIC8B [] 12q rs rs iqb.took_meds_blood_thinners SH2B3 FAM109A [] 12q rs rs any_cvd SH2B3 FAM109A [] 12q rs rs high_blood_pressure [SH2B3] 12q rs rs iqb.ever_diagnosed_autoimmune [SH2B3] 12q rs rs jak2_v617f_cc [SH2B3] 12q rs rs mpn_narrow [SH2B3] 12q rs rs mpn_or_v617f [SH2B3] 12q rs rs tonsillectomy [SH2B3] 12q rs rs bmi [SH2B3] 12q rs rs any_animal_allergy [ATXN2] 12q rs rs blood_pressure_meds [ATXN2] 12q rs rs hypothyroidism [ATXN2] 12q rs rs rosacea_all [ATXN2] 12q rs rs any_autoimmune [ATXN2] 12q rs rs iqb.curlier_in_humidity POP5 [] CABP1

14 12q rs rs any_plant_allergy SPPL3 [] HNF1A 12q rs rs any_animal_allergy CDK2AP1 C12orf65[] 12q rs rs any_plant_allergy CDK2AP1 C12orf65[] 12q rs rs seasonal_allergies_broad CDK2AP1 C12orf65[] 12q rs rs6576 any_food_allergy [SETD8] 12q rs rs6576 dust_mites_allergy [SETD8] 12q rs rs6576 mold_allergy [SETD8] 12q rs rs6576 height [SETD8] 13q rs rs rosacea_dx ELF1 SLC25A15 [] 13q rs rs iqb.dot_bone_loss TNFSF11 AKAP11 [] 13q rs rs osteoporosis TNFSF11 AKAP11 [] 13q rs rs osteoporosis_broad TNFSF11 AKAP11 [] 13q rs rs any_animal_allergy TNFSF11 AKAP11 [] 13q rs rs dust_mites_allergy TNFSF11 AKAP11 [] 13q rs rs seasonal_allergies_broad TNFSF11 AKAP11 [] 13q rs rs any_plant_allergy TNFSF11 AKAP11 [] 13q rs rs tonsillectomy TNFSF11 AKAP11 [] 13q rs rs other_allergy_general OLFM4 [] 13q rs rs any_immune OLFM4 [] 13q rs rs any_plant_allergy [PCDH9] 13q rs rs seasonal_allergies_broad [PCDH9] 13q rs rs dust_mites_allergy [KLF5] 13q rs rs dust_mites_allergy TM9SF2 UBAC2 [] 14q rs rs tonsillectomy FOXA1 MIPOL1 [] 14q rs rs any_animal_allergy FOXA1 [] TTC6 14q rs rs any_plant_allergy FOXA1 [] TTC6 14q rs rs seasonal_allergies_broad FOXA1 [] TTC6 14q rs rs dust_mites_allergy FOXA1 [] TTC6 14q rs rs any_plant_allergy [] C14orf177 14q rs rs dust_mites_allergy [] C14orf177 15q rs rs height INO80 [] EXD1 15q rs rs poison_oak [CHP1] 15q rs rs any_animal_allergy [RTF1] 15q rs rs dust_mites_allergy RTF1 [] ITPKA 15q rs rs insect_allergy RTF1 [] ITPKA 15q rs rs any_asthma RORA [] 15q rs rs iqb.took_meds_asthma_or_lung RORA [] 15q rs rs any_animal_allergy RORA [] 15q rs rs dust_mites_allergy RORA [] 15q rs rs seasonal_allergies_broad [SMAD3] 15q rs rs juvenile_asthma [SMAD3] 15q rs rs allergic_asthma [SMAD3] 15q rs rs hayfever_all [SMAD3] 15q rs rs iqb.took_meds_asthma_or_lung [SMAD3] 15q rs rs juvenile_allergic_asthma [SMAD3] 15q rs rs any_asthma [SMAD3] 15q rs rs thyroid_cancer [SMAD3] 15q rs rs any_food_allergy [SMAD3] 15q rs rs any_animal_allergy [SMAD3] 15q rs rs any_plant_allergy [SMAD3] 15q rs rs dust_mites_allergy [SMAD3] 15q rs rs mold_allergy [SMAD3] 16p rs rs iqb.shampoo_type [CLEC16A] 16p rs rs mold_allergy [CLEC16A] 16p rs rs severe_acne [CLEC16A] 16p rs rs iqb.acne_as_teenager [CLEC16A] 16p rs rs sulfa_drug_allergy [CLEC16A] 16p rs rs any_drug_allergy [CLEC16A] 16p rs rs other_animal_allergy [CLEC16A] 16p rs rs eczema [CLEC16A] 16p rs rs any_asthma [CLEC16A] 16p rs rs iqb.took_meds_asthma_or_lung [CLEC16A] 16p rs rs allergic_asthma [CLEC16A] 16p rs rs any_animal_allergy SOCS1 CLEC16A [] 16p rs rs any_food_allergy SOCS1 CLEC16A [] 16p rs rs any_immune SOCS1 CLEC16A [] 16p rs rs any_plant_allergy SOCS1 CLEC16A [] 16p rs rs dust_mites_allergy SOCS1 CLEC16A [] 16p rs rs hayfever_all SOCS1 CLEC16A [] 16p rs rs seasonal_allergies_broad SOCS1 CLEC16A [] 16p rs rs juvenile_allergic_asthma CLEC16A [] SOCS1 16p rs rs37940 other_plant_allergy SOCS1 CLEC16A []

15 16p rs rs any_animal_allergy IL4R [] IL21R 16p rs rs obesity SBK1 [] NPIPL1 16p rs rs any_food_allergy [NPIPL1] 16p rs rs heart_metabolic_disease [NPIPL1] 16p rs rs iqb.stretch_marks [NPIPL1] 16p rs rs stretch_marks_any [NPIPL1] 16p rs rs mosquito_severe [NPIPL1] 16p rs rs any_plant_allergy [NPIPL1,SULT1A2] 16p rs rs stretch_marks_qtl [NPIPL1,SULT1A1] 16p rs rs seasonal_allergies_broad [NPIPL1,SULT1A1] 16p rs rs bmi [NPIPL1] 16p rs rs weight [NPIPL1] 16p rs rs iqb.ingrown_hair_bumps [NPIPL1,ATP2A1] 16p rs rs shoe_size_normalized [NPIPL1,RABEP2] 16q rs rs iqb.acne_as_teenager NUDT7 ADAMTS18 [] 17p rs rs seasonal_allergies_broad [PAFAH1B1] 17p rs rs any_animal_allergy [ALOX15] 17p rs rs seasonal_allergies_broad [ALOX15] 17p rs rs height CHRNB1[] ZBTB4 17p rs rs myopia_v_hyperopia [ZBTB4] 17p rs rs glasses_any [ZBTB4] 17p rs rs nearsightedness TNFSF12 TNFSF13 POLR2A [] 17p rs rs any_plant_allergy [SHISA6] 17p rs rs seasonal_allergies_broad [SHISA6] 17p rs rs depression_anxiety_meds [SHISA6] 17q rs rs chronic_bronchitis [ERBB2] 17q rs rs crohns_or_ulcerative_colitis MIEN1 [] GRB7 17q rs rs any_asthma [ZPBP2] 17q rs rs any_plant_allergy [ZPBP2] 17q rs rs hayfever_all [ZPBP2] 17q rs rs any_food_allergy [GSDMB] 17q rs rs mold_allergy [GSDMB] 17q rs rs seasonal_allergies_broad [GSDMB] 17q : :CA_C : :CA_C iqb.took_meds_asthma_or_lung [GSDMB] 17q : :CA_C : :CA_C juvenile_allergic_asthma [GSDMB] 17q : :CA_C : :CA_C tree_nuts_allergy [GSDMB] 17q rs rs juvenile_asthma [GSDMB] 17q rs rs allergic_asthma [GSDMB] 17q rs rs any_animal_allergy [GSDMB] 17q rs rs dust_mites_allergy [GSDMB] 17q rs rs nonallergic_asthma [GSDMA] 17q rs rs nearsightedness GNGT2 B4GALNT2 [] 17q rs rs glasses_any FLJ40194 PHOSPHO1 [] 17q rs rs dust_mites_allergy [FLJ40194] 17q rs rs seasonal_allergies_broad [FLJ40194] 17q rs rs any_animal_allergy [ZNF652] 17q rs rs any_asthma [ZNF652] 17q rs rs iqb.excess_hair [ZNF652] 17q rs rs any_cvd [ZNF652] 17q : :A_AGC : :A_AGC blood_pressure_meds ZNF652 [] PHB 17q : :A_AGC : :A_AGC high_blood_pressure ZNF652 [] PHB 17q rs rs penicillin_allergy CSH1 [] CSHL1 17q rs rs weight [BPTF] 19p rs rs height [SBNO2] 19p rs rs any_plant_allergy [SBNO2] 19p rs rs hayfever_all [SBNO2] 19p rs rs insect_allergy SBNO2 [] STK11 19p rs rs any_animal_allergy [STK11] 19p rs rs iqb.sweat_during_workout IL12RB1 ARRDC2[] 19q rs rs any_animal_allergy CEBPA SLC7A10 [] 19q rs rs any_food_allergy CEBPA SLC7A10 [] 19q rs rs dust_mites_allergy CEBPA SLC7A10 [] 19q rs rs other_food_allergy CEBPA SLC7A10 [] 20q rs rs dust_mites_allergy ZNF217 TSHZ2 [] 20q rs rs myopia_v_hyperopia [STMN3] 20q rs rs nearsightedness [STMN3] 20q rs rs seasonal_allergies_broad [RTEL1] 20q rs rs eczema [TNFRSF6B] 20q rs rs prostate_cancer [ZGPAT] 20q rs rs height [ZGPAT] 21q rs rs age_first_menses PSMG1[] BRWD1 21q : :A_AG : :A_AG any_plant_allergy [BRWD1] 21q rs rs ever_tobacco_user [BRWD1] 21q rs rs iqb.age_started_reading HMGN1 BRWD1 IT2 [] 21q rs rs any_plant_allergy [SIK1] 21q rs rs seasonal_allergies_broad [SIK1] 22q rs rs dust_mites_allergy [EP300] 22q rs rs any_animal_allergy SERHL2 RRP7A [] 22q rs rs any_plant_allergy SERHL2 RRP7A []

16 SERHL2 22q rs rs seasonal_allergies_broad RRP7A [] 22q rs rs leg_jiggle SERHL2 RRP7A [] Xq rs rs any_animal_allergy VAMP7 [] IL9R Xq rs rs mold_allergy VAMP7 [] IL9R Xq rs rs seasonal_allergies_broad VAMP7 [] IL9R Regional Association Plots

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