Wednesday to Saturday November 10 13, 2010

Transcript

1 Wednesday to Saturday November 10 13, 2010 San Diego Society for Neuroscience Final program California Scientific Sessions Listings Sessions 1 109

2 Information at a Glance Important Phone Numbers Annual Meeting Headquarters Office Logistics and Programming Logistics San Diego Convention Center: Sails Pavilion, (619) * Programming San Diego Convention Center: Sails Pavilion, (619) ** Society Executive Meeting Room San Diego Convention Center: Room 13, (619) *** General Information Booths San Diego Convention Center Lobby A, (619) Lobby D, (619) Sails Pavilion, (619) Press Offices Press Room San Diego Convention Center: Room 15B, (619) Exhibit Management San Diego Convention Center: Lobby D, (619) First Aid and Hospital Numbers First Aid Room San Diego Convention Center: Lobby C, (619) Scripps Mercy Hospital th Avenue San Diego, CA (619) * Annual meeting logistics, audiovisual, and advance registration inquiries. ** Sessioning information for symposia, minisymposia, nanosymposia, poster sessions, special lectures, and socials for the 2010 and 2011 annual meetings. *** Matters of Council, Committees, and Past Presidents. Key to Poster Floor by Themes The poster floor will begin with Theme A and end with Theme H. Refer to the poster floor map at the end of this booklet. Theme A Development B Neural Excitability, Synapses, and Glia: Cellular Mechanisms C Disorders of the Nervous System D Sensory and Motor Systems E Homeostatic and Neuroendocrine Systems F Cognition and Behavior G Novel Methods and Technology Development H History, Teaching, Public Awareness, and Societal Impacts in Neuroscience NOTE: Theme H Posters will be located in Halls B-H beginning at 1 p.m. on Saturday, Nov. 13, and will remain posted until 5 p.m., Sunday, Nov. 14.

3 Saturday Highlights Preregistration Required $ Course Fee Professional Development ` Networking Public Outreach Professional Skills Workshop* (Part II) $ 8:30 a.m. 1 p.m. Manchester Grand Hyatt: Emma CB NIH Funding for Your Research, Training, and Career Development* 8:30 10 a.m. Manchester Grand Hyatt: Randle CDE Support contributed by: NINDS, NIMH, and NICHD, in collaboration with other institutes of NIH Meet-the-Expert Series 9 10:30 a.m. Manchester Grand Hyatt: Seaport Tower Dialogues Between Neuroscience and Society Bringing Change to Mind on Mental Illness Glenn Close Support contributed by: Elsevier 11 a.m. 1 p.m. San Diego Convention Center: Ballroom 20 Public Symposium Autism: Progress and Prospects CME Chair: Gerald D. Fischbach, MD Support contributed by: The Autism Science Foundation and Pfizer, Inc. 1:30 4 p.m. San Diego Convention Center: Room 6A Symposium CNS Pericytes in Health and Diseases CME Chair: David I. Attwell, PhD Co-chair: Turgay Dalkara, MD, PhD 1:30 4 p.m. San Diego Convention Center: Room 6B Symposium Emerging Biology of Orexin/Hypocretin and Related Peptides CME Chair: Anantha Shekhar, MD, PhD Co-chair: Gary S. Aston-Jones, PhD 1:30 4 p.m. San Diego Convention Center: Room 6F Minisymposium Neural Mechanisms Underlying Vocalization in Multiple Species: A Special Focus on Parkinson s Disease CME Chair: Julie E. Miller, PhD 1:30 4 p.m. San Diego Convention Center: Room 30E Minisymposium Reelin: From Neurodevelopment to Adult Synaptic Plasticity and Age-Related Neurodegeneration CME Chair: Irene Knuesel, PhD Co-chair: Michael Frotscher, MD 1:30 4 p.m. San Diego Convention Center: Room 29D Minisymposium Super-Resolved Neurobiology: Gaining Insights to Synaptic Function and Plasticity at the Nanoscale CME Chair: Valentin Nägerl, PhD Co-chair: Thomas A. Blanpied, PhD 1:30 4 p.m. San Diego Convention Center: Room 6E Special Lecture Architecture, Symmetry, and Mechanism of Ionotropic Glutamate Receptors CME Eric Gouaux, PhD Oregon Health & Science University, Vollum Institute/ Howard Hughes Medical Institute 2 3:10 p.m. San Diego Convention Center: Ballroom 20 Navigating the SfN Meeting 2 3:30 p.m. San Diego Convention Center: Room 3 Organizers: Jennifer Yates, PhD; David Riddle, PhD Careers Beyond Academia 2 5 p.m. San Diego Convention Center: Room 4 Annual Brain Awareness Campaign Event Your Neuroscience Legacy Is Our Future 3 4:30 p.m. San Diego Convention Center: Room 28 Presidential Special Lecture Adventures in Nontranslational Research: Neuronal Differentiation and Mechanosensory Transduction in C. elegans CME Martin Chalfie, PhD Columbia University 5:15 6:25 p.m. San Diego Convention Center: Ballroom 20 Poster Sessions ` Diversity Fellows 6:30 8:30 p.m. Hilton San Diego Bayfront: Sapphire A International Fellows 6:30 8:30 p.m. Hilton San Diego Bayfront: Sapphire I Travel Award Recipients 6:30 8:30 p.m. Hilton San Diego Bayfront: Sapphire L Career Development Topics: A Mentoring and Networking Event ` 7:30 9:30 p.m. Hilton San Diego Bayfront: Sapphire H *Presented by an SfN partner organization Plan to Attend Sunday, Nov. 14 Special Lecture Neurogenetics of Circadian Clocks in Mammals CME Joseph S. Takahashi, PhD University of Texas Southwestern Medical Center/Howard Hughes Medical Institute 8:30 9:40 a.m. San Diego Convention Center: Ballroom 20 Fred Kavli Distinguished International Scientist Lecture Understanding Sound Processing in the Auditory System: Advances Rooted in the Genetic Approach CME Christine Petit, MD, PhD College de France & Pasteur Institute Support contributed by: The Kavli Foundation 10 11:10 a.m. San Diego Convention Center: Ballroom 20 Special Lecture Joining the Dots: Epigenetics, Plasticity, and the Circadian Clock CME Paolo Sassone-Corsi, PhD University of California, Irvine 11:30 a.m. 12:40 p.m. San Diego Convention Center: Ballroom 20 Special Lecture Connecting Motor Circuits CME Silvia Arber, PhD Biozentrum, University of Basel 1 2:10 p.m. San Diego Convention Center: Ballroom 20 Peter and Patricia Gruber Lecture Brain Circuits for Active Vision Robert H. Wurtz, PhD National Eye Institute/National Institutes of Health Support contributed by: Peter and Patricia Gruber Foundation 2:30 3:40 p.m. San Diego Convention Center: Ballroom 20 NSF Funding Opportunities for Research and Education in Neuroscience* 4 5:30 p.m. San Diego Convention Center: Room 10 Presidential Special Lecture Motivational Neuronal Circuits for Value, Salience, and Information CME Okihide Hikosaka, MD, PhD National Eye Institute/ National Institutes of Health Support contributed by: Johnson & Johnson 5:15 6:25 p.m. San Diego Convention Center: Ballroom 20 Careers Away From the Bench* 6:30 8 p.m. San Diego Convention Center: Room 4 I

4 Chronological List of Saturday Sessions Theme Descriptions A Development B Neural Excitability, Synapses, and Glia: Cellular Mechanisms C Disorders of the Nervous System D Sensory and Motor Systems E Homeostatic and Neuroendocrine Systems F Cognition and Behavior G Novel Methods and Technology Development H History, Teaching, Public Awareness, and Societal Impacts in Neuroscience All Posters will be presented in the San Diego Convention Center, Halls B-H. All lecture, symposia, minisymposia, and nanosymposia rooms are in the San Diego Convention Center. NOTE: Theme H Posters will be located in Halls B-H beginning at 1 p.m. on Saturday, Nov. 13, and will remain posted until 5 p.m., Sunday, Nov. 14. Session Number Theme Title Presentation Type Poster-Board Number Location Session Time CME Credit Featured Programs 1 Bringing Change to Mind on Mental Illness Dialogues Between Neuroscience and Society Ballroom a.m. 1 p.m. 2 C Public Symposium Autism: Progress and Prospects Symposium Room 6A 1:30 4 p.m C Emerging Biology of Orexin/Hypocretin and Related Peptides Symposium Room 6F 1:30 4 p.m C CNS Pericytes in Health and Disease Symposium Room 6B 1:30 4 p.m B 6 C 7 D Super-Resolved Neurobiology: Gaining Insights to Synaptic Function and Plasticity at the Nanoscale Reelin: From Neurodevelopment to Adult Synaptic Plasticity and Age-Related Neurodegeneration Neural Mechanisms Underlying Vocalization in Multiple Species: A Special Focus on Parkinson s Disease Minisymposium Room 6E 1:30 4 p.m. 2.5 Minisymposium Room 29D 1:30 4 p.m. 2.5 Minisymposium Room 30E 1:30 4 p.m B Architecture, Symmetry, and Mechanism of Ionotropic Glutamate Receptors Special Lecture Ballroom :10 p.m Adventures in Nontranslational Research: Neuronal Differentiation and Mechanosensory Transduction in C. elegans Nanosymposia (1 5 p.m.) Presidential Special Lecture Ballroom 20 5:15 6:25 p.m B Modulation of Synaptic Transmission Nanosymposium Room 25A 1 3:15 p.m. 11 C APP Metabolism and Processing Nanosymposium Room 31C 1 2:45 p.m. 12 C Animal Models of Alzheimer s and Neurodegeneration Nanosymposium Room 23A 1 3:30 p.m. 13 C Hereditary Ataxias Nanosymposium Room 7B 1 3:30 p.m. 14 C Ischemia: Therapeutic Approaches Nanosymposium Room 24A 1 3:30 p.m. 15 C Apoptosis and Caspases Nanosymposium Room 32B 1 2:45 p.m. 16 C Neurodevelopmental Disorders I Nanosymposium Room :45 p.m. 17 C Alcohol and Reward Nanosymposium Room 2 1 4:30 p.m. 18 D Neural Basis of Auditory Perception and Action Nanosymposium Room 33C 1 4:15 p.m. 19 D Extrastriate Cortex: Organization and Circuitry Nanosymposium Room 1B 1 3:30 p.m. 20 D Brain Machine Interface: Neuroprosthetics Nanosymposium Room 5B 1 4:30 p.m. Theme H Posters (1 5 p.m.) 21 H History of Neuroscience Poster MMM73- NNN22 Halls B-H 1 5 p.m. 22 H Brain Awareness Events and Outreach Activities Poster NNN23- NNN39 Halls B-H 1 5 p.m. 23 H K-12 Education, Brain Fairs, and Brain Bees Poster NNN40-OOO6 Halls B-H 1 5 p.m. 24 H Undergraduate Organizations, Journals, and Conferences Poster OOO7-OOO16 Halls B-H 1 5 p.m. 25 H Undergraduate Education: Experiments, Resources, and Simple Animal Models Poster OOO17- OOO43 Halls B-H 1 5 p.m. II Neuroscience 2010

5 Session Number Theme Title Presentation Type Poster-Board Number Location Session Time CME Credit Theme H Posters (1 5 p.m.) 26 H College, Graduate, and Professional Poster OOO44- OOO73 Halls B-H 1 5 p.m. 27 H Public Awareness and Outreach Poster OOO74- PPP20 Halls B-H 1 5 p.m. 28 H Ethical and Policy Issues Poster PPP21-PPP33 Halls B-H 1 5 p.m. Posters (1 5 p.m.) 29 A Proliferation I Poster A1-B20 Halls B-H 1 5 p.m. 30 A Fate Specification Poster B21-C17 Halls B-H 1 5 p.m. 31 A Postnatal Neurogenesis I Poster C18-D6 Halls B-H 1 5 p.m. 32 A Motor System Development Poster D7-D33 Halls B-H 1 5 p.m. 33 A Somatosensory Development Poster D34-E4 Halls B-H 1 5 p.m. 34 A Transplantation Poster E5-E20 Halls B-H 1 5 p.m. 35 B Amino Acids: Intracellular Signalling Poster E21-E39 Halls B-H 1 5 p.m. 36 B Nitric Oxide and Other Gases Poster E40-F1 Halls B-H 1 5 p.m. 37 B Nicotinic Acetylcholine Receptors: Physiology and Function Poster F2-F14 Halls B-H 1 5 p.m. 38 B Nicotinic Acetylcholine Receptors: Regulation and Signaling Poster F15-F37 Halls B-H 1 5 p.m. 39 B Nicotinic Acetylcholine Receptors: Pharmacology and Structure-Function Poster F38-G9 Halls B-H 1 5 p.m. 40 B Nonselective Cation Channels Poster G10-G39 Halls B-H 1 5 p.m. 41 B HCN and Nonselctive Ion Channels Poster G40-G54 Halls B-H 1 5 p.m. 42 B Gap Junctions Poster G55-H10 Halls B-H 1 5 p.m. 43 B Transcription and Translation in Plasticity I Poster H11-H28 Halls B-H 1 5 p.m. 44 B Oscillations and Synchronization: Unit Studies Poster H29-H40 Halls B-H 1 5 p.m. 45 B Network Interactions Poster H41-H50 Halls B-H 1 5 p.m. 46 B Neuronal Firing: Ion Channels Poster H51-H69 Halls B-H 1 5 p.m. 47 B Plasticity of Intrinsic Membrane Properties Poster H70-I9 Halls B-H 1 5 p.m. 48 C Alzheimer s Disease: Abeta, Mechanisms of Cell Death, and Injury Poster I10-I29 Halls B-H 1 5 p.m. 49 C Tau: Molecular and Cellular Mechanisms of Tauopathy and FTD Poster I30-J5 Halls B-H 1 5 p.m. 50 C Alzheimer s Disease: APP/Tau Animal Models Poster J6-J19 Halls B-H 1 5 p.m. 51 C Parkinson s Disease: Human Studies Poster J20-L9 Halls B-H 1 5 p.m. 52 C Rodent Models of Parkinsonism Poster L10-M16 Halls B-H 1 5 p.m. 53 C Metabolism and Toxicity of Alpha-Synuclein I Poster M17-O6 Halls B-H 1 5 p.m. 54 C Motor Neuron Dysfunction Poster O7-Q1 Halls B-H 1 5 p.m. 55 C Epilepsy: Status Epilepticus Poster Q2-R5 Halls B-H 1 5 p.m. 56 C Ischemia: Cellular and Molecular Mechanisms I Poster R6-S7 Halls B-H 1 5 p.m. 57 C Ischemia: Cell-Based Therapies Poster S8-T15 Halls B-H 1 5 p.m. 58 C Trauma: Peripheral Nerve Poster T16-V1 Halls B-H 1 5 p.m. 59 C Cell Death Mechanisms: Mitochondria Poster V2-W5 Halls B-H 1 5 p.m. 60 C Sensory Disorders: Somatosensation and Pain: Human Subjects Poster W6-X3 Halls B-H 1 5 p.m. 61 C Psychotic Disorders: Animal Models Poster X4-Y3 Halls B-H 1 5 p.m. 62 C Generating Animal Models of Psychotic Diagnoses Poster Y4-AA2 Halls B-H 1 5 p.m. 63 C Molecular and Treatment Factors in Mood Disorders Poster AA3-AA15 Halls B-H 1 5 p.m. 64 C Anxiety Disorders: Animal Models and Neuropeptide/Gaba/Glutamate Systems Poster AA16-BB18 Halls B-H 1 5 p.m. 65 C Anxiety Disorders: Animal Models and Monoamine Systems Poster BB19-DD13 Halls B-H 1 5 p.m. III

6 Session Number Theme Title Presentation Type Poster-Board Number Location Session Time CME Credit Posters (1 5 p.m.) 66 C Alcohol Intake and Preference Poster DD14-FF7 Halls B-H 1 5 p.m. 67 C Addiction: Behavioral Pharmacology Poster FF8-HH1 Halls B-H 1 5 p.m. 68 C Cocaine and Related Drugs of Abuse Poster HH2-HH19 Halls B-H 1 5 p.m. 69 C Amphetamines: Signaling, Gene Expression, and Imaging Poster HH20-JJ3 Halls B-H 1 5 p.m. 70 C Regulation of Neurotransmitter Expression and Action Poster JJ4-KK5 Halls B-H 1 5 p.m. 71 D Olfactory Receptor Neurons Poster KK6-LL7 Halls B-H 1 5 p.m. 72 D Subcortical Visual Pathways: Pulvinar and Superior Colliculus Poster LL8-MM12 Halls B-H 1 5 p.m. 73 D Striate Cortex: Neural Coding Poster MM13-OO7 Halls B-H 1 5 p.m. 74 D Visual Motion: Neural Mechanisms I Poster OO8-PP9 Halls B-H 1 5 p.m. 75 D Sensorimotor Integration and Parietal Cortex Poster PP10-QQ4 Halls B-H 1 5 p.m. 76 D Eye Position, Reference Frames, and Eye-Hand Coordination Poster QQ5-QQ15 Halls B-H 1 5 p.m. 77 D Saccades: Superior Colliculus, Brainstem, and Behavior Poster QQ16-RR14 Halls B-H 1 5 p.m. 78 D Nociceptors: Molecular and Pharmacological Studies Poster RR15-SS14 Halls B-H 1 5 p.m. 79 D Pain Psychophysics and Behavior Poster SS15-TT6 Halls B-H 1 5 p.m. 80 D Pain Models: Physiology Poster TT7-UU6 Halls B-H 1 5 p.m. 81 D Pain: Musculoskeletal, Inflammatory, and Central Sensitization Poster UU7-WW7 Halls B-H 1 5 p.m. 82 D Spinal Cord Injury: Plasticity I Poster WW8-XX7 Halls B-H 1 5 p.m. 83 D Cortical Control of Voluntary Movement: Neuroimaging Poster XX8-YY10 Halls B-H 1 5 p.m. 84 D Motor Cortex Plasticity Poster ZZ1-AAA8 Halls B-H 1 5 p.m. 85 D Recording Devices Poster AAA9-AAA22 Halls B-H 1 5 p.m. 86 D BMI: Tissue Response and Analytical Methods Poster BBB1-BBB12 Halls B-H 1 5 p.m. 87 E HPG Axis: GnRH Neurons, Control and Function Poster BBB13- CCC12 Halls B-H 1 5 p.m. 88 E Sexual Behavior: Neural Mechanisms Poster CCC13-DDD7 Halls B-H 1 5 p.m. 89 E Hormones and Cognition: Peptides, Stress, Sex Differences Poster DDD8-FFF6 Halls B-H 1 5 p.m. 90 E Stress-Modulated Pathways: BNST and Amygdala Poster FFF7-GGG5 Halls B-H 1 5 p.m. 91 E Food Intake and Energy Balance: Integration of Peripheral Signals I Poster GGG6-HHH9 Halls B-H 1 5 p.m. 92 E Blood-Brain Barrier Poster HHH10- HHH27 Halls B-H 1 5 p.m. 93 F Perception and Imagery: Auditory, Somatosensory, and Supramodal Processing Poster HHH28- HHH44 Halls B-H 1 5 p.m. 94 F Perceptual and Spatial Learning Poster HHH45-III8 Halls B-H 1 5 p.m. 95 F Human Memory in Diseases of the Brain and Their Treatments Poster III9-III23 Halls B-H 1 5 p.m. 96 F Decision Making: Prefrontal Cortex Poster III24-III38 Halls B-H 1 5 p.m. 97 F Social Cognition: Perception, Empathy, and Judgment Poster III39-JJJ5 Halls B-H 1 5 p.m. 98 F Timing and Temporal Processing Poster JJJ6-JJJ36 Halls B-H 1 5 p.m. 99 F Learning and Memory Systems: Hippocampus I Poster JJJ37-KKK16 Halls B-H 1 5 p.m. 100 F Learning and Memory: Cortical and Hippocampal Circuits I Poster KKK17- KKK40 Halls B-H 1 5 p.m. 101 F Learning and Memory: Cortical and Hippocampal Circuits II Poster KKK41- KKK65 Halls B-H 1 5 p.m. 102 F Motivation and Emotion: Neurocircuitry of Decision Making I Poster KKK66-LLL18 Halls B-H 1 5 p.m. 103 F Emotions: Neurocircuitry Poster LLL19-LLL39 Halls B-H 1 5 p.m. 104 F Neuroethology: Auditory, Chemical, and Other Sensory Systems Poster LLL40-LLL49 Halls B-H 1 5 p.m. IV Neuroscience 2010

7 Session Number Theme Title Presentation Type Poster-Board Number Location Session Time CME Credit Posters (1 5 p.m.) 105 G Techniques to Analyze Function or Structure of Living Tissue Poster LLL50-MMM7 Halls B-H 1 5 p.m. 106 G Optogenetics I Poster MMM8- MMM24 Halls B-H 1 5 p.m. 107 G Neuroinformatics Poster MMM25- MMM42 Halls B-H 1 5 p.m. 108 G Simulations of Systems with Well-Described Substructure Poster MMM43- MMM59 Halls B-H 1 5 p.m. 109 G Simulation of Behavior, Whole Brain, and Similar Large Structures Poster MMM60- MMM72 Halls B-H 1 5 p.m. Workshops, Meetings & Events (Friday, Nov. 12 Saturday, Nov. 13) W01 Society for Neuroscience Short Course #1: Genes, Photons, and Electrons: New Solutions for Problems in Systems Neuroscience Workshops/Meetings Room 6B Friday, Nov. 12 7:30 a.m. 5:30 p.m. W02 Neurobiology of Disease Workshop: The Neurobiology of Obesity Workshops/Meetings Room 6A Friday, Nov a.m. 5 p.m. W03 Society for Neuroscience Short Course #2: Posttranscriptional Regulation in Nervous System Development and Plasticity Workshops/Meetings Room 6F Friday, Nov a.m. 6 p.m. W04 Society for Neuroscience Short Course #3: Analysis and Function of Large-Scale Brain Networks Workshops/Meetings Room 6E Friday, Nov. 12 8:30 a.m. 6:30 p.m. W05 Professional Skills Workshop* (Part I) Workshops/Meetings W06 NIH Funding for Your Research, Training, and Career Development Workshops/Meetings W07 Professional Skills Workshop* (Part II) Workshops/Meetings W08 Meet-the-Expert Series Workshops/Meetings University of California, San Diego: Institute of the Americas The Weaver Center Manchester Grand Hyatt: Randle CDE Manchester Grand Hyatt: Emma CB Manchester Grand Hyatt: Seaport Tower Friday, Nov a.m. 7 p.m. Saturday, Nov. 13 8:30 10 a.m. Saturday, Nov. 13 8:30 a.m. 1 p.m. Saturday, Nov :30 a.m. W09 Careers Beyond Academia Workshops/Meetings Room 4 W10 Navigating the SfN Meeting Workshops/Meetings Room 3 W11 Annual Brain Awareness Campaign Event Workshops/Meetings Room 28 Saturday, Nov p.m. Saturday, Nov :30 p.m. Saturday, Nov :30 p.m. W12 Diversity Fellows Posters Session Workshops/Meetings W13 International Fellows Poster Session Workshops/Meetings W14 Travel Award Recipients Poster Session Workshops/Meetings W15 Career Development Topics: A Mentoring and Networking Event Workshops/Meetings Hilton San Diego Bayfront: Sapphire A Hilton San Diego Bayfront: Sapphire I Hilton San Diego Bayfront: Sapphire L Hilton San Diego Bayfront: Sapphire H Saturday, Nov. 13 6:30 8:30 p.m. Saturday, Nov. 13 6:30 8:30 p.m. Saturday, Nov. 13 6:30 8:30 p.m. Saturday, Nov. 13 7:30 9:30 p.m. V

8 Friday Saturday Workshops, Meetings & Events Preregistration Required $ Course Fee Professional Development ` Networking Public Outreach Friday, Nov. 12 SfN Short Course #1 $ Genes, Photons, and Electrons: New Solutions for Problems in Systems Neuroscience Friday, Nov. 12, 7:30 a.m. 5:30 p.m. San Diego Convention Center: Room 6B Organizer: Michael Hausser, DPhil Contact: Liz Larabell, llarabell@sfn.org The last decade has seen a dramatic resurgence of interest in systems neuroscience, together with new optimism that many of its longstanding problems can soon be solved. This has been driven in part by the growing realization that an understanding at the level of the neural circuit is essential if we are to link the cellular and molecular properties of neurons and synaptic connections to behavior; and by the development of a range of new technologies for manipulating neural circuits with unprecedented temporal and spatial precision. This course brings together tool developers at the forefront of these advances and those who are applying new tools to address longstanding challenges in systems neuroscience. Lecturers span the range of approaches and levels involved in the modern study of neural circuits, from new genetically encoded probes for circuit tracing and activity monitoring, to new imaging and electrophysiological approaches for dissecting activity patterns in defined neural populations during behavior, to new methods for manipulating activity in intact circuits to make causal links between Workshop Fees Short Course (includes lunch and syllabus book) Student Member... $95 Student Nonmember... $125 Postdoctoral Member... $165 Postdoctoral Nonmember... $205 Faculty Member... $210 Faculty Nonmember... $260 Neurobiology of Disease Workshop Fee... $36 (includes lunch) NOTE: Preregistration online is required for all Short Courses and the Neurobiology of Disease Workshop. circuit elements and behavior. Emphasis will be on defining the key open questions in systems neuroscience and how new tools can be used to solve them, and on comparing practical advantages and limitations of various methods, with a view toward future developments. This day-long course consists of a series of lectures, followed by informal breakout sessions. SfN Short Course #2 $ Posttranscriptional Regulation in Nervous System Development and Plasticity Friday, Nov. 12, 8 a.m. 6 p.m. San Diego Convention Center: Room 6F Organizers: Kenneth S. Kosik, MD; Sourav Banerjee, PhD Contact: Liz Larabell, llarabell@sfn.org The micrornas are a cytoplasmic layer of posttranscriptional control comparable in complexity to the transcriptional control system in the nucleus. As a system mirna target sets are capable of revealing functional networks of transcripts and their local roles in dendrites have revealed much about plasticity. mirna biology also has opened a broad window on developmental neurobiology. Using a diversity of model systems, the course highlights the growing realms of RNA-mediated regulation. This day-long course consists of a series of lectures, followed by informal breakout sessions. SfN Short Course #3 $ Analysis and Function of Large-Scale Brain Networks Friday, Nov. 12, 8:30 a.m. 6:30 p.m. San Diego Convention Center: Room 6E Organizer: Olaf Sporns, PhD Contact: Liz Larabell, llarabell@sfn.org Identification and quantitative analysis of brain networks offers new perspectives on the structure and function of the human brain. This course provides an introduction to graph-based and dynamic tools for network analysis, and surveys their application to resting and task-evoked brain activity, individual variations in cognition and behavior, neurocognitive development, and disease states of the brain. This day-long course consists of a series of lectures, followed by informal breakout sessions. Neurobiology of Disease Workshop $ The Neurobiology of Obesity Support contributed by Lundbeck Research USA and NINDS Friday, Nov. 12, 8 a.m. 5 p.m. San Diego Convention Center: Room 6A Organizers: Timothy Moran, PhD; Martin Myers, MD, PhD Contact: Liz Larabell, llarabell@sfn.org Obesity represents an escalating global health threat that predisposes millions of individuals to a plethora of comorbid illnesses and reduced life expectancy, and incurs $117 billion in annual health care costs in the United States alone. Pharmacologic therapies to decrease appetite and increase energy expenditure would be useful in preventing and treating obesity, but the limited understanding of the neural and molecular mechanisms that regulate these processes previously hindered the development of truly effective long-term therapies. Recent work has made important inroads into the neural mechanisms underlying the control of energy balance, and ongoing research promises to continue apace. This workshop focuses on the neurobiology of energy balance, with a major focus on the processes that control eating. Starting with the description of the obesity syndrome, patient experience, and the physiologic systems that modulate feeding and energy balance, the morning sessions will present the pertinent neural systems and their interaction with peripheral cues and current treatment options and their theoretical and practical limitations. In the afternoon, interactive workshop sessions delve into issues and methodology relating to the neural regulators of energy homeostasis (including hypothalamic, hindbrain, and reward centers), as well as important environmental, hormonal, and developmental regulators of these systems. Neuroimaging and genetic methods will be covered, along with pharmacologic approaches to intervention. Participants will leave with a broad exposure to the current state of our knowledge of the pathophysiology of this profound public health challenge. Target audience: graduate students, postdoctoral fellows, and assistant professors. Registration is limited and only available online. VI Neuroscience 2010

9 Professional Skills Workshop* (Part I) $ Friday, Nov. 12, 9 a.m. 7 p.m. University of California, San Diego: Institute of the Americas The Weaver Center Organizers: Beth Fischer, PhD; Michael Zigmond, PhD; Julio Ramirez, PhD Contact: Beth Fischer, survival@pitt.edu, (412) These workshops provide participants with training in a number of key professional skills needed for a successful career. Days 1 and 2 are designed to be independent of each other, so participants may choose to attend either or both days. The workshop is relevant to individuals ranging from undergraduates to faculty, and participants may tailor the event to their specific interests by selecting from a variety of sessions. DAY 1 focuses on issues relevant to job hunting and career advancement. Sessions include strategies for interviewing and negotiating effectively, using social networking as a career development tool, developing leadership skills, and becoming more creative in selecting and pursuing research questions. Trainees from abroad can gain advice on dealing with the challenges of adapting to the U.S. culture of training and research. A discussion with panelists representing a range of attractive careers for individuals with advanced research training will be followed by a networking reception. See Saturday listing for Day 2 details. COST: Day 1, $35 in advance, $40 at the door (includes lunch and networking reception). Day 2, no cost for sessions; however, advance registration is appreciated. The complete workshop schedule and registration forms are available online at Saturday, Nov. 13 Professional Skills Workshop* (Part II) $ Saturday, Nov. 13, 8:30 a.m. 1 p.m. Manchester Grand Hyatt: Emma CB Organizers: Beth Fischer, PhD; Michael Zigmond, PhD; Julio Ramirez, PhD Contact: Beth Fischer, survival@pitt.edu, (412) These workshops provide participants with training in a number of key professional skills needed for a successful career. Days 1 and 2 are designed to be independent of each other, so participants may choose to attend either or both days. The workshop is relevant to individuals ranging from undergraduates to faculty, and participants may tailor the event to their specific interests by selecting from a variety of sessions. DAY 2 is devoted to a discussion of grant writing and is being offered in conjunction with staff from NINDS. Participants will be able to learn what funding mechanisms are available and how grants are reviewed, and will gain advice on preparing a winning grant proposal. For more information on Day 2 activities, see the description for NIH Funding for Your Research, Training, and Career Development below. NIH Funding for Your Research, Training, and Career Development* Saturday, Nov. 13, 8:30 10 a.m. Manchester Grand Hyatt: Randle CDE Organizer/Moderator: Stephen Korn, PhD Contact: NINDSTrainingOffice@ninds.nih.gov, (301) Support contributed by NINDS, NIMH, and NICHD, in collaboration with other institutes of NIH This workshop is for graduate students, postdoctoral fellows, and junior faculty at all stages of training and career development. Program and review staff from NIH will discuss and answer questions on fellowships, career development grants, and junior investigator issues related to R-series grants. The workshop will discuss the Do s and Don ts of how to apply, good grantsmanship, picking the appropriate mentor/ sponsor, picking the appropriate grant mechanism, how the review process works, what to expect from review, and other issues. This is a good opportunity to get to know NIH staff, establish contacts, and get ahead. Those in attendance are welcome to stay from 10 a.m. to noon for the Professional Skills Workshop presentation on grant writing. Meet-the-Expert Series Saturday, Nov. 13, 9 10:30 a.m. Manchester Grand Hyatt: Seaport Tower Contact: Liz Larabell, llarabell@sfn.org Experts describe their research techniques and accomplishments in a personal context that offers participants a behind-the-scenes look at factors influencing the expert s work. Each session offers an opportunity for students and postdoctoral researchers to engage the expert in an informal dialogue over breakfast. No registration is required but seating is limited. Marius Wernig, MD, PhD, Stanford University Using Transcription Factors to Induce Cell Fate Changes Manchester Grand Hyatt: Oxford The ultimate promise of pluripotent stem cell research is the potential to create customized genetically matched cells that, when transplanted, will repair and replace damaged tissues. Researchers are exploring the therapeutic potential of pluripotent stem cells by differentiating into neural precursors and evaluate their migration, subtype specification and functional integration after transplantation. More recently, researchers asked whether factor-induced reprogramming can be applied to other systems and have identified three transcription factors that could convert fibroblasts into functional neurons. Yasmin Hurd, PhD, Mount Sinai School of Medicine Post-Mortem Studies of the Human Brain: Dissecting the Confounds to Illuminate Addiction Disorders Manchester Grand Hyatt: Del Mar Molecular studies of the human brain are fraught with pre- and post-mortem confounds related to technical issues and individual considerations that have important implications for experimental design and interpretation of results. Despite these challenges, researchers have demonstrated the feasibility of studying discrete gene and protein expression in the brains of drug abusers. This has helped to illuminate specific neurobiological features underlying addiction disorders. In this session, the expert discusses advantages and challenges of molecular analyses of the human brain in relation to addiction disorder. *Presented by an SfN partner organization Find faculty and speakers at VII

10 Preregistration Required $ Course Fee Professional Development ` Networking Public Outreach Marla Feller, PhD, University of California-Berkeley Using Synaptic Physiology, Imaging, and Transgenic Mice to Study the Development of Retinal Circuits Manchester Grand Hyatt: Mohsen The expert will highlight how the retinal circuitry changes during development such that it transitions from spontaneously generating retinal waves to an adult sensory epithelium that performs specific computations on the visual scene. Specifically, the expert describes recent results that address whether retinal waves play a role in establishment of circuits that mediate direction selective responses the retina. Dietmar Plenz, PhD, National Institutes of Health Neuronal Avalanches: Off the Beaten Path Manchester Grand Hyatt: Ford AB Complex systems, when poised at the transition between order and disorder, exhibit scale-free, power law dynamics. These critical systems are highly adaptive and flexibly process and store information, which for decades prompted the conjecture that the brain might operate at criticality. Discovery of neuronal avalanches in superficial layers of cortex in 2001 provides solid experimental evidence that indeed the brain might be critical. Results demonstrate that neuronal avalanches and coherence potentials are signatures of critical network dynamics at which the cortex gains universal properties found at criticality. George Paxinos, PhD, Prince of Wales Medical Research Institute and The University of New South Wales Brain, Behavior, and Evolution Manchester Grand Hyatt: Madeleine AB Support contributed by Yerkes National Primate Research Center, Emory University After collaborating with Luis Puelles to construct an atlas of the bird brain, Charles Watson and the expert became interested in what genetic markers can tell us about brain organization. Birds, incidentally, have a firstclass brain; they just have not had good public relations. Based on what was learned from work on the bird brain and subsequent validation on the mouse brain using transgenic mice, researchers constructed an ontology of the brain that can be found in BrainNavigator. The most controversial suggestion is that the pons do not exist as a subdivision of the brain in the same subordination as the rhombencephalon, mesencephalon, and diencephalon. Bruce Cumming, MD, PhD, National Institutes of Health Bridging the Gap Between Sensory Neurons and Sensation Manchester Grand Hyatt: Madeleine CD Two successes of systems neuroscience have been (1) quantitative models that give a good account of the mechanisms that produce signals in the visual cortex; and (2) techniques that identify contributions of these signals to perception in awake animals. However, many models deliver signals that are insufficient to support perception. These differences are well defined in binocular vision, providing an effective model system to improve our understanding of how early processing is specialized for perceptually relevant processing, and how this is related to perceptual judgments. Theresa Lee, PhD, University of Michigan How to Pick the Right Species for the Right Problem: Creating a Non-Standard Research Career Manchester Grand Hyatt: Annie AB The expert has chosen a variety of research problems that led to working with nonstandard lab animals. She will discuss how to think outside the box to come up with interesting research questions and select the best model systems for studying them. While using unusual models to study behavior, physiology, and neuroscience, the same principles can be applied to more molecular levels of analysis. The expert will provide examples of how different animal models can be developed, the benefits and drawbacks of not working with common lab animals, and how taking the uncommon path leads to an uncommon career. Jane Taylor, PhD, Yale University Why Sex Differences Should Matter to Neuroscientists Manchester Grand Hyatt: Maggie Sex differences are being revealed in brain function and behavior. Recent studies have focused on the underlying genetic and molecular mechanisms. It is becoming clear that sex differences are not simply reflective of differences in sex hormones, but also in chromosomal complement. How sex differences impact learning, memory, and adaptive behavior both in health and psychiatric disease has become an emerging focus of my research. What are the advantages and disadvantages to incorporating the study of sex differences into research, and do we have an obligation to do so? Allison Doupe, MD, PhD, University of California, San Francisco A Bird s Eye View of Song, Science, and Psychiatry Manchester Grand Hyatt: Ford C Songbirds provide a powerful animal model for the process of human speech learning. Because they have neural circuitry similar to all vertebrates but have a specialized subset of these for their vocal behavior, the study of brain-behavior relationships in the song pathways is simplified. Such study has recently begun to provide general insights into mechanisms of sensory and motor learning, with potential relevance to neuropsychiatric disease. The expert shares her enthusiasm for this system, as well as some science and thoughts on the plusses and minuses of working in a nonmammalian model and on being an MD/PhD. Cedric Williams, PhD, University of Virginia Interactions Between the Periphery and Brain: Clues to Understanding the Impact of Emotional Arousal on Memory Formation Manchester Grand Hyatt: Emma A Hormones secreted from the adrenals after exposure to emotional encounters facilitate memory by initiating norepinephrine output in limbic regions. Hormones such as epinephrine cannot enter the brain to produce direct effects on structures that actively process memory. As such, the session will present a summary of the behavioral, electrophysiological and neurochemical approaches used to identify how neural pathways in the periphery convey the actions of arousal-related hormones to brainstem noradrenergic neurons to produce optimal mnemonic performance. VIII Neuroscience 2010

11 Navigating the SfN Meeting Saturday, Nov. 13, 2 3:30 p.m. San Diego Convention Center: Room 3 Organizers: Jennifer Yates, PhD; David Riddle, PhD Contact: Liz Larabell, llarabell@sfn.org For first-timers, navigating the SfN annual meeting can be overwhelming and taking advantage of all the opportunities is challenging. Students and others new to the SfN meeting are invited to attend this session, where experienced participants will share tips on how to get the most from the conference. Whether you are looking for strategies on how to network, or simply ways to make your experience productive and enjoyable, this session will be beneficial. A diverse panel will answer questions and discuss ways to make the most of your SfN meeting experience. Careers Beyond Academia Saturday, Nov. 13, 2 5 p.m. San Diego Convention Center: Room 4 Organizer: Elisabeth Van Bockstaele, PhD Contact: Liz Larabell, llarabell@sfn.org More frequently than ever SfN members are expressing interest in pursuing or transitioning into non-academic careers. In this workshop, a panel of experts will provide graduates in neuroscience-related disciplines with an understanding of the multiple career choices that exist outside of academia (e.g., nonprofit organizations, pharmaceutical companies, government, and advocacy). Panel members will draw from and share personal experiences. Substantial time will be set aside for Q&A. At the conclusion of the workshop, attendees will be better informed about alternative career choices and how to go about transitioning into them. Poster Sessions ` Diversity Fellows Saturday, Nov. 13, 6:30 8:30 p.m. Hilton San Diego Bayfront: Sapphire A Contact: Anne Busse, abusse@sfn.org Join us for a special poster and networking event presented by participants in the Neuroscience Program Scholars diversity fellowship programs. International Fellows Saturday, Nov. 13, 6:30 8:30 p.m. Hilton San Diego Bayfront: Sapphire I Contact: Mark Storey, mstorey@sfn.org Come see posters presented by recipients of international travel awards and fellowships. Travel Award Recipients Saturday, Nov. 13, 6:30 8:30 p.m. Hilton San Diego Bayfront: Sapphire L Contact: Anne Busse, abusse@sfn.org Join us for posters presented by recipients of SfN s Graduate Student and Postdoctoral Fellow Travel Awards. Career Development Topics: A Mentoring and Networking Event ` Saturday, Nov. 13, 7:30 9:30 p.m. Hilton San Diego Bayfront: Sapphire H Contact: Anne Busse, abusse@sfn.org More than 50 experienced neuroscientists will be on hand to offer mentoring on a wide range of topics in an informal, roundtable format. Topics will include: work-life balance, teaching, securing grants, being a clinician-scientist, choosing graduate schools and postdoc positions, and many others. Participants from diverse backgrounds, fields, and work sectors are encouraged to attend. Annual Brain Awareness Campaign Event Your Neuroscience Legacy Is Our Future Saturday, Nov. 13, 3 4:30 p.m. San Diego Convention Center: Room 28 Contact: Corinne Dreskin, corinne@sfn.org Neuroscience can revolutionize science education! Scientists can create legacies that shape our future. SfN Councilor, 2010 Presidential Citizens Medal awardee, and former SfN Science Educator Award recipient Roberta Diaz Brinton from the University of Southern California will present strategies to innovate, implement, and disseminate advances to catapult science education into the 21st century. The formal presentation will be followed by a poster session/networking reception to celebrate Brain Awareness Week success stories. Find faculty and speakers at IX

12 Wednesday Saturday Satellite Events & Non-SfN Socials Full descriptions and the latest details on these satellite events and socials not sponsored by SfN are available online at These events also are available in the online Neuroscience Meeting Planner (NMP). Attendees can access the NMP on-site or at Title For More Information Time Location Room Wednesday, November 10 20th Neuropharmacology Conference: High Resolution Neurophamacology Structure Changes the Paradigm 11 a.m. 8:30 p.m. Westin San Diego Update on Alzheimer Research: Workshop for PhD Students 8:30 a.m. 5:30 p.m. Catamaran Resort Hotel, San Diego Bay Thursday, November 11 2nd International Workshop on Advances in Electrocorticography 20th Neuropharmacology Conference: High Resolution Neurophamacology Structure Changes the Paradigm A Brain Research Meeting: The Emerging Neuroscience of Autism Spectrum Disorders Etiologic Insights ents/2010brainmappingbrochure.pdf 8:30 a.m. 5 p.m. San Diego Marriott Hotel & Marina f.webb@elsevier.com 9 a.m. 8 p.m. Westin San Diego felicityox@yahoo.co.uk 8 a.m. 5 p.m. Westin San Diego Barrels XXIII joshua.brumberg@qc.cuny.edu 8 a.m. 10 p.m. Dynamical Neuroscience XVIII: The Resting Brain: Not at Rest University of California, San Diego nwilson@dixongroup.com 8 a.m. 7 p.m. Manchester Grand Hyatt J. B. Johnston Club powers.alice@gmail.com 8 a.m. 7 p.m. Horton Grand Hotel Molecular and Cellular Cognition Society Meeting cristina.alberini@mssm.edu 6 9 p.m. San Diego Marriott Hotel & Marina San Diego Ballroom A General Session: Elizabeth Ballroom FG Poster Session: Elizabeth Ballroom H Marina Ballroom Salons D & E Neuroethics Society Annual Meeting 5 7:30 p.m. Manchester Grand Hyatt George Bush Room Patient HM Second Annual Neurobiology of Language Conference Update on Alzheimer Research: Workshop for PhD Students Friday, November 12 2nd International Workshop on Advances in Electrocorticography 20th Neuropharmacology Conference: High Resolution Neurophamacology Structure Changes the Paradigm A Brain Research Meeting: The Emerging Neuroscience of Autism Spectrum Disorders Etiologic Insights A Fresh Look at Dopamine Release and Uptake (NIDA Mini-Convention) event/ :30 p.m. Lyceum Space Theatre, 79 Horton Plaza tremblay@neurolang.org 7 a.m. 8 p.m. Rancho Bernardo Inn info@neuronworkshops.nl ents/2010brainmappingbrochure.pdf 8:30 a.m. 5:30 p.m. 8:30 a.m. 5 p.m. Catamaran Resort Hotel, San Diego Bay San Diego Marriott Hotel & Marina f.webb@elsevier.com 9 a.m. 6:30 p.m. Westin San Diego felicityox@yahoo.co.uk 9 a.m. 5 p.m. Westin San Diego frontiers2010/ 2:40 4:40 p.m. San Diego Marriott Hotel & Marina Advances in Computational Motor Control IX todorov@cs.washington.edu 12:30 9 p.m. Convention Center 7AB Advances in Disease Modeling for ALS and FTD sutherlandm@ninds.nih.gov 9 a.m. 5 p.m. Manchester Grand Hyatt ASNR Satellite: The New Science of Brain Repair and Rehabilitation Barrels XXIII joshua.brumberg@qc.cuny.edu 8 a.m. 5 p.m. San Diego Ballroom A Marriott Hall Madeleine A-D and Del Mar AB 8:30 a.m. 1 p.m. Manchester Grand Hyatt Randle Ballroom DE University of California, San Diego X Neuroscience 2010

13 Title For More Information Time Location Room Connectivity of the Human Brain and its Disruption by Drugs of Abuse (NIDA Mini-Convention) Dynamical Neuroscience XVIII: The Resting Brain: Not at Rest Early Career Investigators Poster Session (NIDA Mini-Convention) Frontiers in Addiction Research (NIDA Mini-Convention) frontiers2010/ 4:50 6:35 p.m. San Diego Marriott Hotel & Marina 8 a.m. 5:30 p.m. Manchester Grand Hyatt frontiers2010/ frontiers2010/ 12:40 2:40 p.m. 8 a.m. 6:35 p.m. San Diego Marriott Hotel & Marina San Diego Marriott Hotel & Marina J. B. Johnston Club powers.alice@gmail.com 8 a.m. 9 p.m. Horton Grand Hotel Jacob P. Waletzky Memorial Lecture (NIDA Mini-Convention) Journal of Physiology Symposium: Microcircuit-Specific Processing in the Hippocampus frontiers2010/ g-maccaferri@northwestern.edu 10 10:35 a.m. 4 7 p.m. San Diego Marriott Hotel & Marina San Diego Marriott Hotel & Marina Marriott Hall General Session: Elizabeth Ballroom FG Poster Session: Elizabeth Ballroom H Marriott Hall Marriott Hall Marriott Hall Torrey 1-3 Molecular and Cellular Cognition Society Meeting cristina.alberini@mssm.edu 8 a.m. 6:30 p.m. Convention Center 29ABCD Neuroethics Society Annual Meeting 8 a.m. 6 p.m. Manchester Grand Hyatt Douglas Pavilion A Neuroimmune Mechanisms of Brain Function and Alcohol-Related Disorders Patient HM Role of Nicotinic Receptors in the Habenula in Mediating Addiction to Nicotine and other Drugs (NIDA Mini-Convention) NIAAASfNSatellite event/ frontiers2010/ 8:30 a.m. 5:30 p.m. 7 8:30 p.m. 8:15 10 a.m. San Diego Marriott Hotel & Marina Lyceum Space Theatre, 79 Horton Plaza San Diego Marriott Hotel & Marina Second Annual Neurobiology of Language Conference tremblay@neurolang.org 7 a.m. 8 p.m. Rancho Bernardo Inn Columbia 1-3 Marroitt Hall Society for Social Neuroscience Meeting Noon 5 p.m. Manchester Grand Hyatt Randle Ballroom ABC Society for Social Neuroscience Reception p.m. Manchester Grand Hyatt Tucker-Davis Symposium on Advances and Perspectives in Auditory Neurophysiology (APAN) Update on Alzheimer Research: Workshop for PhD Students Using Model Organisms to Discover Unanticipated Pathways to Addiction (NIDA Mini-Convention) ycohen@mail.med.upenn.edu info@neuronworkshops.nl frontiers2010/ 8:30 a.m. 6:30 p.m. 8:30 a.m. 5:30 p.m. 10:55 a.m. 12:40 p.m. San Diego Marriott Hotel & Marina Catamaran Resort Hotel, San Diego Bay San Diego Marriott Hotel & Marina Randle Foyer and Terrace Marina Ballroom Salons F & G Marriott Hall Saturday, November 13 Expansion and Characterization of Stem Cells gregg.hickey@rndsystems.com 6:30 8 p.m. Convention Center Room 4 g.tec s Brain-Computer Interface Workshop vogt@gtec.at 6:30 9:30 p.m. Convention Center Room 10 Patient HM event/ :30 p.m. Rehabilitaton and Neurology Social horakf@ohsu.edu 6:30 8:30 p.m. Lyceum Space Theatre, 79 Horton Plaza San Diego Marriott Hotel & Marina Torrance XI

14 Notes XII Neuroscience 2010

15 Complete Session Listing Saturday PM Sat. PM DIALOGUES BETWEEN NEUROSCIENCE AND SOCIETY San Diego Convention Center 1. Bringing Change to Mind on Mental Illness Sat. 11:00 AM - 1:00 PM Ballroom 20 Speaker: G. CLOSE Support contributed by Elsevier Join award-winning actress and advocate Glenn Close for a discussion of how science and society can work together to change minds on mental illness. The Web site which Close founded, aims to combat the stigma associated with mental illness.while the next decade will bring sustained progress in uncovering the biological bases of mental illness, much work must be done to help the American public understand that mental illness is brain disease. How do we reduce misconceptins, stigma, and bias that confront those with conditions like depression, bipolar disorder, and PTSD? With mental illness increasingly recognized as a global health challenge and science poised for continued discovery, how can we help the public discern fact from fiction to bring positive change for families struggling with mental illness? SYMPOSIUM San Diego Convention Center 2. Public Symposium - Autism: Progress and Prospects CME Sat. 1:30 PM - 4:00 PM Room 6A Chair: G. D. FISCHBACH Support contributed by the Autism Science Foundation and Pfizer, Inc. Remarkable progress has been made in brain research relevant to Autism in recent years. Progress has been driven by the urgency of the problem, by the influx of extraordinary scientists, and by extraordinary advances in genomics and neuroscience. This Symposium will provide an overview of genetic, cellular and behavioral analyses to illustrate the current state of the various approaches. It will also suggest ways that the various approaches might reinforce each other. 1: Introduction. 1: Autism: From genes to behavior. G. D. FISCHBACH. Simons Fndtn Autism Proj. 2: Towards fulfilling the promise of molecular medicine in autism. M. F. BEAR. Picower Ctr. for Learn & Mem. 2: Neural signatures of autism. K. PELPHREY. Yale Sch. of Med. 2: Neurobiology of Rett Syndrome and the relevance to autism. H. Y. ZOGHBI. Baylor Col. of Medicine/ Howard Hughes Med. Inst. 3: Insights into the Genetic basis of autism. E. EICHLER. Univ. of Washington. 3: Closing Remarks. SYMPOSIUM San Diego Convention Center 3. Emerging Biology of Orexin/Hypocretin and Related Peptides CME Sat. 1:30 PM - 4:00 PM Room 6F Chair: A. SHEKHAR Co-Chair: G. S. ASTON-JONES Orexin/hypocretin (ORX) producing neurons regulate feeding, wakefulness, vigilance, reward seeking and autonomic responses. Loss of ORX neurons has been linked to narcolepsy and new data that the opposite situation of over activity of the ORX neurons leads to panic attacks. This symposium will bring international experts on this topic to discuss the role of ORX in narcolepsy, obesity, addictions and panic disorder, using novel techniques such as gene regulation and optical stimulation. 1: Introduction. 1: Optogenetic control of hypocretin neurons. L. DE LECEA. Stanford Univ. 2: Metabolic regulation of orexin pathways. M. STOFFEL. Swiss Federal Inst. of Technol. 2: Role of orexin in panic and other anxiety disorders. A. SHEKHAR. Indiana Univ. Sch. Med. 3: Role of orexin/hypocretin in addictions. S. L. BORGLAND. Univ. of British Columbia. 3: Closing Remarks. SYMPOSIUM San Diego Convention Center 4. CNS Pericytes in Health and Disease CME Sat. 1:30 PM - 4:00 PM Room 6B Chair: D. I. ATTWELL Co-Chair: T. DALKARA Pericytes, cells on the outside of brain capillaries, have recently been shown to regulate cerebral blood flow and thus are likely to contribute to functional imaging signals. After stroke they produce a long-lasting decrease of blood flow that damages neurons. They also have roles in angiogenesis and blood brain barrier maintenance, and they may act as stem cells. This symposium will provide the latest information what we do and do not know about pericyte function. 1: Introduction. 1: The multiple functions of pericytes. P. A. DORE- DUFFY. Wayne State Univ. Sch. Med. 2: Signalling to pericytes underlying control of brain blood flow. D. I. ATTWELL. Univ. Col. London. 2: The membrane properties of retinal pericytes and their role in diabetic retinal damage. D. G. PURO. Univ. Michigan. 3: The surprising role of pericytes in acute brain ischemia. T. DALKARA. Hacettepe Univ. Fac Med. 3: Closing Remarks. Indicated a real or perceived conflict of interest, see page 79 for details. Indicates a high school or undergraduate student presenter. Neuroscience 2010 Saturday PM 1