JCVI Role Category_1 JCVI Role Category_2. histidinol phosphatase-related protein Unknown function NT01ST0303 AAL19211 STM0248

Additional Table 3. Detailed information on all 81 genes that showed evidence for positive selection from initial positive selection analysis, in Protein Name Gene name JCVI Role Category_1 JCVI Role Category_2 JCVI Locus (LT2) Genbank Locus (LT2) Primary Annotation No. (LT2) histidinol phosphatase-related protein Unknown function NT01ST0303 AAL19211 STM0248 conserved hypothetical protein Hypothetical proteins NT01ST1594 AAL20205 STM1280 multidrug resistance protein norm Cellular processes NT01ST1758 AAL20347 STM1425 acyl carrier protein acpd Fatty acid and phospholipid NT01ST2039 AAL20560 STM1642 phosphodiesterase metabolism outer membrane protein c precursor ompc Cell Envelope NT01ST2829 AAL21169 STM2267 CorE b2611 Viral functions NT01ST3328 AAL21567 STM2678 4Fe-4S binding domain protein Unknown function Cell Envelope NT01ST3543 AAL21728 STM2848 transcriptional regulator, DeoR family glpr Regulatory functions NT01ST4096 AAL22134 STM3262 conserved hypothetical protein Hypothetical proteins NT01ST4169 AAL22198 STM3329 TIGR01212 conserved hypothetical protein Hypothetical proteins NT01ST4329 AAL22325 STM3463 potential nitrite transporter Energy metabolism NT01ST4346 AAL22338 STM3476 acetyltransferase, GNAT family family Unknown function NT01ST4455 AAL22425 STM3565 PTS system, mannitol-specific IIC Transport and binding NT01ST4604 AAL22544 STM3685 component subfamily, putative proteins DNA polymerase III, beta subunit dnan DNA metabolism NT01ST4790 AAL22696 STM3837 vgrg protein, putative vgrg Unclassified NT01ST0349 AAL19246 STM0289 glycosyl hydrolase, family 13 malz Energy metabolism NT01ST0499 AAL19355 STM0401 catalase/peroxidase HPI katg Cellular processes NT01ST5107 AAL22946 STM4106 hypothetical protein Hypothetical proteins NT01ST5613 AAL23340 STM4522 2-oxoglutarate dehydrogenase, E1 suca Energy metabolism NT01ST0884 AAL19680 STM0736 component carbamoyl-phosphate synthase, small subunit cara Purines, pyrimidines, nucleosides, and nucleotides NT01ST0081 AAL19030 STM0066

conserved hypothetical protein Hypothetical proteins NT01ST0185 AAL19112 STM0148 conserved hypothetical protein Hypothetical proteins NT01ST0198 AAL19121 STM0157 salmonella atypical fimbria outer safc Cell Envelope NT01ST0369 AAL19258 STM0301 membrane usher prpe protein prpe Unknown function NT01ST0460 AAL19325 STM0371 phosphoribosylaminoimidazole pure Purines, pyrimidines, NT01ST0653 AAL19488 STM0534 carboxylase, catalytic subunit nucleosides, and nucleotides aminotransferase, class I arat Central intermediary NT01ST0731 AAL19554 STM0603 metabolism phosphoglucomutase, alpha-dglucose pgm Energy metabolism NT01ST0841 AAL19642 STM0698 phosphate-specific lipoprotein, putative Cell Envelope NT01ST0899 AAL19687 STM0743 conserved hypothetical protein Hypothetical proteins NT01ST1873 AAL20434 STM1515 TIGR00156 domain protein GDP-mannose mannosyl hydrolase Purines, pyrimidines, nucleosides, and nucleotides NT01ST2623 AAL21011 STM2107 cysteine synthase B cysm Amino acid biosynthesis NT01ST3032 AAL21334 STM2440 nrdi protein nrdi Purines, pyrimidines, nucleosides, and nucleotides NT01ST3491 AAL21691 STM2806 PTS system IIA component, putative Transport and binding proteins NT01ST4092 AAL22130 STM3258 oligopeptide ABC transporter, ATPbinding oppf Transport and binding NT01ST4531 AAL22487 STM3626 protein proteins aldehyde dehydrogenase B aldb Energy metabolism NT01ST4599 AAL22539 STM3680 xanthine/uracil permease family Transport and binding NT01ST4808 AAL22709 STM3851 protein proteins rard protein rard Unknown function NT01ST4920 AAL22799 STM3955 thih protein thih Biosynthesis of cofactors, NT01ST5159 AAL22987 STM4159 prosthetic groups, and carriers acetate operon repressor. iclr Energy metabolism NT01ST5191 AAL23011 STM4187 trehalose-6-phosphate hydrolase trec Energy metabolism NT01ST5527 AAL23273 STM4453 surface antigen b0177 Unknown function NT01ST0277 AAL19188 STM0224

tola protein tola Cellular processes NT01ST0904 AAL19691 STM0747 conserved hypothetical protein Hypothetical proteins NT01ST1047 AAL19797 STM0861 SseC ssec Unclassified NT01ST1735 AAL20324 STM1400 SseF ssef Unclassified NT01ST1739 AAL20328 STM1404 OmpS2 protein omps2 Cell Envelope NT01ST1814 AAL20393 STM1473 hypothetical protein Hypothetical proteins NT01ST1963 AAL20501 STM1583 outer membrane protein S1 (omps1) omps1 Cell Envelope NT01ST2489 AAL20905 STM1995 PTS system, IIC component, putative Transport and binding proteins Amino acid biosynthesis NT01ST2916 AAL21243 STM2342 sulfate ABC transporter, ATP-binding cysa Transport and binding NT01ST3033 AAL21335 STM2441 protein proteins glycine dehydrogenase gcvp Energy metabolism NT01ST3817 AAL21928 STM3053 ubih protein ubih Biosynthesis of cofactors, NT01ST3824 AAL21932 STM3057 prosthetic groups, and carriers 99 pct identical to TraF of plasmid Viral functions NT01ST5263 AAL23066 STM4242 R64 lipoate-protein ligase A lpla Protein fate Biosynthesis of cofactors, prosthetic groups, and carriers NT01ST5673 AAL23391 STM4576 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase folk-2 Biosynthesis of cofactors, prosthetic groups, and carriers NT01ST0225 AAL19147 STM0183 exonuclease SbcC, putative DNA metabolism NT01ST0490 AAL19349 STM0395 PipB pipb Unclassified NT01ST1346 AAL20020 STM1088 membrane protein, putative Cell Envelope NT01ST1778 AAL20363 STM1441 pyridoxal kinase Biosynthesis of cofactors, NT01ST1789 AAL20372 STM1450 prosthetic groups, and carriers Anaerobic dimethyl sulfoxide b1590 Energy metabolism NT01ST1847 AAL20415 STM1496 reductase chain C (DMSO reductase anchor subunit). hypothetical protein Hypothetical proteins NT01ST1895 AAL20451 STM1532 hypothetical protein Hypothetical proteins NT01ST2070 AAL20585 STM1668

oligopeptide ABC transporter, periplasmic oligopeptide-binding protein oppa Transport and binding proteins NT01ST2082 AAL20596 STM1679 conserved hypothetical protein Hypothetical proteins NT01ST2197 AAL20683 STM1768 conserved hypothetical protein Hypothetical proteins NT01ST2854 AAL21188 STM2287 thiosulfate-binding protein precursor Transport and binding NT01ST3036 AAL21338 STM2444 proteins glucarate dehydratase b2787 Energy metabolism NT01ST3694 AAL21840 STM2960 proton/peptide symporter family Unclassified NT01ST4488 AAL22452 STM3592 protein glycyl-trna synthetase, beta subunit glys Protein synthesis NT01ST4569 AAL22514 STM3655 glucosamine--fructose-6-phosphate glms Central intermediary NT01ST4821 AAL22719 STM3861 aminotransferase (isomerizing) metabolism hypothetical protein Hypothetical proteins NT01ST4989 AAL22854 STM4015 3-hydroxyisobutyrate dehydrogenase, Energy metabolism NT01ST4997 AAL22862 STM4023 putative conserved hypothetical protein Hypothetical proteins NT01ST2037 AAL20558 STM1640 malt regulatory protein. malt Energy metabolism NT01ST4393 AAL22377 STM3515 conserved hypothetical protein Hypothetical proteins NT01ST5283 AAL23082 STM4258 membrane protein, putative Cell Envelope NT01ST5539 AAL23283 STM4464 hypothetical protein Hypothetical proteins NT01ST2302 AAL20769 STM1854 similar to Cell Envelope NT01ST3484 AAL21686 STM2801 conserved hypothetical protein Hypothetical proteins NT01ST4820 AAL22718 STM3860 lipoprotein, putative Cell Envelope NT01ST5016 AAL22878 STM4039 cell division protein FtsK ftsk Cellular processes NT01ST1184 AAL19895 STM0960

a d N = number of non-synonymous changes per non-synonymous sites b d S = number of synonymous changes per synonymous sites c TO = overall test; Ch#= Choleraesuis branch specific test; Pty#= Paratyphi A branch specific test ; Ty# = Typhi branch specific test; Tym#= Typhimurium d Proportion of sites under positive selection e w =omega (i.e., d N /d S) f only sites with a probability >95% as being under positive seletion are shown; the first number indicates the aa sites identified by Bayes Empirical Baye indicates the posterior probability; ";" separates the aa sites; aa sites are based on site location in the alignment used for positive selection analyses (pro method is used to calculate posterior probabilities for site classes under alternative models (Model 2a and Model A if the LRT suggests presence of cod foreground branch) g Each distinct gene tree (n=18) was designated with a unique gene tree number h Gene trees used for positive seletion analyses are shown in Newick format; ATCC9150 = S. Paratyphi A, ch= S. Choleraesuis, CT18= S. Typhi CT18, T i Nc= effective number of codons used in a gene sequence was calculated using the program chips from EMBOSS package; Nc can take values from 20 codon is exclusively used for each amino acid) to 61 (which indicates that the use of alternative synonymous codons is equally likely (Wright. 1990. Gen

n which all genes, including genes with recombination, were used JCVI Locus (CT18) a d N b d S Alignment Length, bp Estimated diversity No. of informative sites p-value for TO c q-value for TO Prop. of sites under pos sel. (TO) d ω (TO) e NT03ST0283 573 0.0456 0.1285 0.0250 4 0.0013 0.1999 0.0942 8.2212 NT03ST1882 396 0.0114 0.0578 0.0130 5 0.0718 1.0000 0.0174 21.6655 NT03ST1745 1371 0.0042 0.0374 0.0060 2 0.0046 0.4836 0.0026 999.0000 NT03ST1456 603 0.0048 0.0680 0.0080 4 0.1058 1.0000 0.0056 26.8844 NT03ST2542 1134 0.0078 0.0683 0.0090 3 0.0354 1.0000 0.0057 52.9941 NT03ST2946 750 0.0058 0.0246 0.0050 4 0.0153 0.9920 0.0093 29.7078 NT03ST3061 540 0.0126 0.1738 0.0180 7 0.0008 0.1459 0.0056 86.8733 NT03ST3554 771 0.0019 0.0398 0.0060 3 0.1148 1.0000 0.0039 999.0000 NT03ST3620 927 0.0059 0.0431 0.0070 3 0.0196 1.0000 0.0037 71.4830 NT03ST4512 201 0.0136 0.0396 0.8000 0 0.0055 0.5080 0.0154 999.0000 NT03ST4495 807 0.0228 0.1692 0.0260 13 0.1767 1.0000 0.0092 15.6773 NT03ST4412 381 0.0201 0.1310 0.0200 2 0.0755 1.0000 0.0132 22.0877 NT03ST4272 1914 0.0022 0.1546 0.0190 41 2.2885E-06 0.0013 0.0016 999.0000 NT03ST4090 1098 0.0038 0.1122 0.0130 15 5.3452E-11 1.77E-07 0.0055 999.0000 NT03ST0329 1917 0.1320 0.4096 0.0620 94 9.3939E-06 0.0038 0.1806 2.5286 NT03ST0447 1815 0.0173 0.1270 0.0200 35 1.0000 1.0000 0.0782 1.0000 NT03ST3894 2178 0.0050 0.0657 0.0090 16 1.2396E-06 0.0008 0.0014 999.0000 NT03ST5092 699 0.0365 0.1292 0.0200 17 0.2396 1.0000 0.0132 26.2581 NT03ST0805 2799 0.0035 0.0784 0.0100 21 0.0726 1.0000 0.0024 21.0379 NT03ST0080 1140 0.0179 0.2323 0.0290 29 0.6665 1.0000 0.0513 1.5838

NT03ST0174 948 0.0211 0.0968 0.0180 14 0.2420 1.0000 0.0276 6.2034 NT03ST0186 1626 0.0246 0.1192 0.0230 45 0.0136 0.9021 0.0483 5.1844 NT03ST0340 2508 0.0254 0.0440 0.0120 29 1.0185E-05 0.0038 0.0688 9.1453 NT03ST0408 1884 0.0119 0.1026 0.0150 22 0.0004 0.0853 0.0063 23.2061 NT03ST0601 507 0.0169 0.1800 0.0320 25 0.0371 1.0000 0.0198 13.6957 NT03ST0667 1158 0.0025 0.0768 0.0120 16 0.1535 1.0000 0.0029 13.3770 NT03ST0765 1638 0.0069 0.0879 0.0140 24 0.5233 1.0000 0.0022 17.4805 NT03ST0813 273 0.0277 0.0521 0.0150 3 0.0437 1.0000 0.0545 14.3698 NT03ST1581 384 0.0436 0.1282 0.0330 17 0.0291 1.0000 0.0471 10.9797 NT03ST2358 435 0.0424 0.1124 0.0240 10 0.1428 1.0000 0.0153 60.8052 NT03ST2732 909 0.0136 0.2087 0.0250 11 0.2560 1.0000 0.0038 9.6748 NT03ST3017 408 0.0152 0.0985 0.0150 5 0.0984 1.0000 0.0076 246.4417 NT03ST3550 462 0.0622 0.1733 0.0510 39 0.0044 0.4825 0.1068 14.5336 NT03ST4332 1011 0.0069 0.1045 0.0160 19 0.0462 1.0000 0.0035 27.5550 NT03ST4277 1536 0.0073 0.1526 0.0200 36 0.0879 1.0000 0.0020 163.0558 NT03ST4080 1461 0.0020 0.0709 0.0100 13 1.0000 1.0000 0.0000 1.0000 NT03ST3727 879 0.0070 0.1075 0.0130 14 0.0050 0.4841 0.0041 62.9697 NT03ST3854 1131 0.0487 0.8182 0.0810 48 1.0000 1.0000 0.0049 1.0000 NT03ST4591 819 0.0053 0.0984 0.0140 7 0.4262 1.0000 0.0099 5.8102 NT03ST4996 1605 0.0134 0.0960 0.0150 17 0.0017 0.2420 0.0019 999.0000 NT03ST0255 2415 0.0130 0.0937 0.0150 36 6.5383E-05 0.0181 0.0146 10.6260

NT03ST0817 1257 0.0231 0.0987 0.0220 32 0.9976 1.0000 0.0117 3.0350 NT03ST0922 471 0.0102 0.0277 0.6000 0 0.0011 0.1797 0.0144 600.3252 NT03ST1765 1452 0.0393 0.0734 0.0230 28 0.0043 0.4825 0.0240 17.0764 NT03ST1761 780 0.0351 0.0853 0.0220 16 0.0781 1.0000 0.0082 26.7910 NT03ST1693 1149 0.0631 0.3224 0.0600 104 9.2328E-05 0.0236 0.0641 8.8788 NT03ST1514 630 0.0722 0.0789 0.0300 8 0.0009 0.1633 0.0054 276.7875 NT03ST2237 1203 0.0462 0.1211 0.0280 20 0.0102 0.7891 0.0602 6.6823 NT03ST2622 1389 0.0084 0.0746 0.0110 8 0.0423 1.0000 0.0188 14.2536 NT03ST2734 1095 0.0153 0.1534 0.0250 32 0.5458 1.0000 0.0268 3.6202 NT03ST3307 2787 0.0100 0.2243 0.0310 97 0.6524 1.0000 0.0369 1.6443 NT03ST3313 1176 0.0049 0.0798 0.0120 16 0.0237 1.0000 0.0026 182.7346 NT03ST4633 1284 0.0132 0.0224 0.0070 8 0.0743 1.0000 0.0023 508.4250 NT03ST5140 990 0.0364 0.1813 0.0330 24 0.0014 0.2047 0.0209 14.7725 NT03ST0217 477 0.0806 0.1474 0.0520 40 1.478E-07 0.0001 0.1175 90.2035 NT03ST0438 3096 0.0071 0.0648 0.0110 34 0.9752 1.0000 0.0060 5.5276 NT03ST1134 873 0.0241 0.0402 0.0130 13 0.0001 0.0268 0.0115 81.6436 NT03ST1726 1995 0.0066 0.0456 0.0080 14 0.0120 0.8710 0.0015 999.0000 NT03ST1716 666 0.0109 0.0415 0.0100 7 0.0979 1.0000 0.0047 85.5050 NT03ST1606 855 0.0242 0.1374 0.0320 42 0.0124 0.8710 0.0088 36.8354 NT03ST1566 678 0.0142 0.0657 0.0170 15 0.2732 1.0000 0.0373 8.2401 NT03ST1425 825 0.0601 0.1098 0.0360 37 0.0003 0.0677 0.0912 7.5396

NT03ST1411 1605 0.0108 0.0508 0.0090 9 0.1146 1.0000 0.0019 136.1688 NT03ST1308 1422 0.0162 0.0376 0.0090 12 5.1879E-08 8.6E-05 0.0021 999.0000 NT03ST2563 951 0.0719 0.1039 0.0320 35 2.382E-05 0.0072 0.1518 5.4785 NT03ST2737 1014 0.0204 0.1346 0.0220 13 0.3487 1.0000 0.0339 4.1073 NT03ST3194 1338 0.0219 0.1877 0.0260 26 0.4422 1.0000 0.0818 1.9686 NT03ST4374 1470 0.0061 0.0508 0.0090 10 1.3577E-05 0.0045 0.0021 999.0000 NT03ST4306 2067 0.0205 0.4399 0.0640 204 0.8642 1.0000 0.0599 1.2638 NT03ST4062 1827 0.0068 0.1456 0.0210 44 1.0000 1.0000 0.0210 1.0000 NT03ST4006 846 0.0196 0.0520 0.0160 19 0.0557 1.0000 0.0057 40.1930 NT03ST3998 840 0.0141 0.0318 0.0080 5 0.0572 1.0000 0.0424 17.2693 NT03ST1458 780 0.0207 0.1080 0.0190 8 0.0436 1.0000 0.0041 46.6526 NT03ST4451 2703 0.0053 0.0652 0.0100 26 0.4663 1.0000 0.0229 2.7717 NT03ST4649 1386 0.0160 0.0679 0.0130 20 0.1991 1.0000 0.0617 4.7258 NT03ST5008 1401 0.0111 0.1152 0.0160 15 0.0101 0.7891 0.0102 14.3013 NT03ST2029 162 0.0886 0.1922 4.0000 1 0.0062 0.5458 0.1384 114.4740 NT03ST3011 300 0.0095 0.0902 1.2000 0 0.0088 0.7307 0.0102 41.1050 NT03ST4068 1302 0.0834 0.2232 0.0430 9 8.9201E-08 9.86E-05 0.0883 11.0070 NT03ST3978 1029 0.0373 0.0844 0.0180 6 0.0007 0.1349 0.0637 10.1630 NT03ST0989 4116 0.0070 0.0782 0.0130 49 3.716E-06 0.0018 0.0014 231.5675

m branch specific test es (BEB), the number in bracket ovided as Additional file 5); BEB dons under positive selection on the Ty2= Typhi Ty2, LT2= Typhimurium LT2 0 (in case of extreme bias where one ne 87:23-29)

BEB (TO) f p-value for Ch# c q-value for Ch# Prop. of sites under pos sel. (Ch#) d ω(ch#) e BEB (Ch#) f p-value for Tym# c q-value for Tym# Prop. of sites under pos sel. (Tym#) d 175 (0.985); 184 (0.959) 3.36E-08 3.7125E-05 0.0653 999.0000 175 (0.999);184 (0.997); 1.0000 1.0000 0.0000 185 (0.992); 191 (0.982) 1.0000 1.0000 0.0000 1.0000 0.0000 0.0105 0.0169 1.0000 1.0000 0.0000 1.0000 0.0000 0.0087 0.0023 0.0007 0.1219 0.0053 765.2298 1.0000 1.0000 0.0000 0.0002 0.0388 0.0065 999.0000 274 (0.970) 1.0000 1.0000 0.0000 0.0003 0.0576 0.0088 115.3601 1.0000 1.0000 0.0000 60 (0.992) 1.0000 1.0000 0.0000 1.0000 1.0000 1.0000 0.0000 1.0000 1.0000 0.0000 1.0000 0.0007 0.1843 0.0041 0.0003 0.0659 0.0037 999.0000 1.0000 1.0000 0.0000 1.0000 1.0000 0.0033 1.0994 0.0001 0.0730 0.0154 1.0000 1.0000 0.0000 1.0000 0.0000 0.0334 0.0156 121 (0.964) 1.0000 1.0000 0.7660 1.0000 1.0000 1.0000 0.0000 1.0000 1.0000 0.0075 1.0000 1.0000 1.0000 0.0000 356 (1.000) 1.0000 1.0000 0.0000 1.0000 0.0012 0.2503 0.0072 14 (0.990); 45 (0.990); 129 (0.959); 597(0.957); 622 (0.959); 631 (0.973) 0.8277 1.0000 0.7461 71.5369 1.0000 1.0000 0.0000 1.0000 1.0000 0.0982 1.0000 0.0001 0.0696 0.0055 1.0000 1.0000 0.0000 1.0000 0.8723 1.0000 0.0458 0.4281 1.0000 0.6638 999.0000 0.0005 0.1649 0.0144 0.0002 0.0388 0.0011 999.0000 1.0000 1.0000 0.0274 1.0000 1.0000 0.0000 1.0000 0.0007 0.1843 0.0076

1.0000 1.0000 0.2006 1.0000 1.0000 1.0000 0.0000 405 (0.974) 1.0000 1.0000 0.0000 1.0000 1.0000 1.0000 0.0000 85 (0.951); 111 (0.955); 1.0000 1.0000 0.0000 1.0000 1.0000 1.0000 0.0000 405 (0.954); 692 (0.950) 95 (0.985) 1.0000 1.0000 0.0000 1.0000 1.0000 1.0000 0.0000 1.0000 1.0000 0.0000 1.0000 1.0000 1.0000 0.0000 1.0000 1.0000 0.0000 1.0000 1.0000 1.0000 0.0000 1.0000 1.0000 0.0822 1.0000 1.0000 1.0000 0.0000 0.0005 0.0886 0.0242 999.0000 1.0000 1.0000 0.0000 108 (0.976) 1.0000 1.0000 0.1978 1.0000 1.0000 1.0000 0.0000 1.0000 1.0000 0.0000 1.0000 0.0003 0.1081 0.0056 0.0011 0.1646 0.0040 202.9386 1.0000 1.0000 0.0000 1.0000 1.0000 0.0000 1.0000 1.0000 1.0000 0.0000 139 (0.984) 1.0000 1.0000 0.0015 1.0000 1.0000 1.0000 0.0000 1.0000 1.0000 0.0000 1.0000 1.0000 1.0000 0.0460 1.0000 1.0000 0.0429 1.0000 1.0000 1.0000 0.0214 0.0014 0.1956 0.0022 999.0000 1.0000 1.0000 0.0000 293 (0.969) 0.9989 1.0000 0.0000 1.0000 1.0000 1.0000 0.0000 0.0001 0.0269 0.0238 218.5096 1.0000 1.0000 0.0000 671 (0.985); 679 (0.989); 691 (0.986) 1.0000 1.0000 0.0000 1.0000 1.0000 1.0000 0.0000 0.0000 0.0024 0.0054 909.7454 535 (0.963) 1.0000 1.0000 0.0000 0.0000 0.0000 0.0079 313.8047 679 (0.998); 691(0.998) 1.0000 1.0000 0.4066

1.0000 1.0000 0.8694 1.0000 1.0000 1.0000 0.0000 1.0000 1.0000 0.1547 1.0499 0.0002 0.0910 0.0143 0.0006 0.1124 0.0057 98.8719 1.0000 1.0000 0.0203 238 (0.953) 0.0013 0.1920 0.0262 76.6192 1.0000 1.0000 0.0000 184 (0.954); 198 (0.970); 1.0000 1.0000 0.0000 1.0000 1.0000 1.0000 0.0000 252 (0.965); 282 (0.982) 189 (0.984) 0.0002 0.0414 0.0012 999.0000 1.0000 1.0000 0.3511 244 (0.977) 0.8312 1.0000 0.1013 1.9315 0.0000 0.0087 0.0123 2.42E-07 0.00020045 0.0120 999.0000 258 (0.970) 1.0000 1.0000 0.0000 1.0000 1.0000 0.0000 1.0000 0.0004 0.1449 0.0031 1.0000 1.0000 0.0000 1.0000 1.0000 1.0000 0.0000 171 (0.983) 1.0000 1.0000 0.0000 1.0000 0.0002 0.0910 0.0029 1.0000 1.0000 0.0000 1.0000 1.0000 1.0000 0.2490 318 (0.986); 324 (0.986) 3.52E-05 0.0117 0.0179 999.0000 0.0048 0.6982 0.0110 142 (0.997); 146 (0.996); 147 (0.962); 150 (0.986); 151 (0.965); 152 (0.994); 155 (0.998) 1.0000 1.0000 0.2453 1.0000 1.0000 1.0000 0.1484 1.0000 1.0000 0.0089 1.0000 1.0000 1.0000 0.0036 1.0000 1.0000 0.0000 173 (0.997) 0.0182 1.0000 0.0213 999.0000 173 (0.991); 178 (0.973); 261 (0.973) 2.85E-06 0.0019 0.0018 999.0000 1.0000 1.0000 0.0000 1.0000 1.0000 0.0000 1.0000 1.0000 1.0000 0.2121 1.0000 1.0000 0.3790 1.0000 1.0000 1.0000 0.4203 1.0000 1.0000 0.1694 1.0493 1.0000 1.0000 0.0923 263 (0.996); 264 (0.984) 1.0000 1.0000 0.6364 1.0000 1.0000 1.0000 0.2239

1.19E-05 0.0049 0.0051 933.5563 1.0000 1.0000 0.0000 45 (1.000) 0.0045 0.4671 0.0017 999.0000 1.0000 1.0000 0.0000 12 (0.994);189 (0.998) 1.0000 1.0000 0.0000 1.0000 1.0000 1.0000 0.0000 0.0000 0.0035 0.0160 999.0000 1.0000 1.0000 0.0000 1.0000 1.0000 0.0000 1.0000 1.0000 1.0000 0.0000 1.0000 1.0000 0.0000 1.0000 1.0000 1.0000 0.0000 1.0000 1.0000 0.1092 1.0000 1.0000 1.0000 0.0000 5.97E-05 0.0180 0.0037 762.9841 1.0000 1.0000 0.0000 1.0000 1.0000 0.0000 1.0000 0.4151 1.0000 0.7238 1.82E-05 0.0067 0.0048 999.0000 1.0000 1.0000 0.0051 1 1 0.2724 1.0000 1.0000 1.0000 0.2740 0.94770 1.00000 0.0200 1.0000 1.0000 1.0000 0.0000 1.00000 1.00000 0.0000 1.0000 1.0000 1.0000 0.2313 249 (0.955) 0.07446 1.00000 0.0048 26.2342 1.0000 1.0000 0.0000 45 (0.983) 1.00000 1.00000 0.0001 1.0000 1.0000 1.0000 0.0000 100 (0.955) 0.99887 1.00000 0.0000 1.0000 0.9989 1.0000 0.0000 6 (0.976); 7 (0.962); 13 (0.983);15 (0.988); 19 (0.973); 22 (0.973); 24 (0.979); 41 (0.979); 51 (0.976); 60 (0.971); 68 (0.975) 1.00000 1.00000 0.1506 1.0000 1.0000 1.0000 0.0000 279 (0.988) 1.54E-09 2.5569E-06 0.0197 999.0000 271 (0.966); 272 (0.975); 278 (0.975); 279 (0.997) 0.0284 1.0000 0.0027 0.0708 1.0000 0.0041 48.9541 1.0000 1.0000 0.0000

ω(tym#) e BEB (Tym#) f p-value q-value Ty# Prop. of sites Ty# c under pos sel. (Ty#) d ω (Ty#) e BEB (Ty#) f p-value for Pty# c q-value for Pty# Prop. of sites under pos sel. (Pty#) d 1.0000 ND ND ND ND ND 1.0000 1.0000 0.0000 999.0000 ND ND ND ND ND 1.0000 1.0000 0.1570 999.0000 ND ND ND ND ND 0.9952 1.0000 0.0000 1.0000 ND ND ND ND ND 1.0000 1.0000 0.0000 1.0000 ND ND ND ND ND 1.0000 1.0000 0.0000 1.0000 ND ND ND ND ND 0.9970 1.0000 0.9243 1.0000 ND ND ND ND ND 0.9206 1.0000 0.0812 999.0000 ND ND ND ND ND 1.0000 1.0000 0.0000 1.0000 ND ND ND ND ND 0.4423 1.0000 0.9482 999.0000 ND ND ND ND ND 1.0000 1.0000 0.0000 140.9876 ND ND ND ND ND 1.0000 1.0000 0.0513 1.0000 ND ND ND ND ND 0.0001 0.0189 0.0176 1.0000 ND ND ND ND ND 1.0000 1.0000 0.0000 321.1510 ND ND ND ND ND 1.0000 1.0000 0.0000 1.0000 ND ND ND ND ND 0.0000 0.0000 0.0512 766.8320 ND ND ND ND ND 1.0000 1.0000 0.0549 1.7945 ND ND ND ND ND 1.0000 1.0000 0.0000 391.8656 ND ND ND ND ND 0.2630 1.0000 0.6917 1.0000 ND ND ND ND ND 0.0001 0.0324 0.0016 998.9996 0.0009 0.0651 0.0041 999.0000 1.0000 1.0000 0.0000

1.0000 1.0000 1.0000 0.1035 1.0000 0.0000 0.0000 0.0114 1.0000 0.0000 0.0000 0.0143 999.0000 394 (0.984); 396 (0.986); 1.0000 1.0000 0.0000 400 (0.983); 401 (0.989); 405 (0.997) 1.0000 0.0114 0.4623 0.0015 252.8766 1.0000 1.0000 0.0000 1.0000 0.2267 1.0000 0.0084 62.5562 1.0000 1.0000 0.0000 1.0000 0.0001 0.0154 0.0207 769.2387 1.0000 1.0000 0.0000 1.0000 0.0029 0.1713 0.0029 176.6151 1.0000 1.0000 0.0000 1.0000 0.0001 0.0102 0.0035 999.0000 1.0000 1.0000 0.0253 1.0000 0.2776 1.0000 0.8552 999.0000 10 (0.956); 31(0.955) 1.0000 1.0000 0.0000 1.0000 0.0001 0.0119 0.0449 998.9997 1.0000 1.0000 0.0000 999.0000 1.0000 1.0000 0.2336 1.0000 1.0000 1.0000 0.1929 1.0000 1.0000 1.0000 0.2461 1.0000 1.0000 1.0000 0.1197 1.0000 0.0006 0.0588 0.0093 999.0000 1.0000 1.0000 0.2174 1.0000 0.0001 0.0102 0.1064 50.4382 124 (0.967); 139 (0.996); 1.0000 1.0000 0.0000 143 (0.984); 144 (0.970); 147 (0.977) 1.0000 0.0001 0.0102 0.0047 334.8240 1.0000 1.0000 0.0000 1.0000 0.9989 1.0000 0.0117 1.0000 0.0000 0.0049 0.0021 1.0000 1.0000 1.0000 0.0723 1.0000 1.0000 1.0000 0.0000 1.0000 0.0001 0.0154 0.0076 999.0000 1.0000 1.0000 0.0122 1.0000 0.6653 1.0000 0.0409 2.2379 1.0000 1.0000 0.0000 1.0000 0.0008 0.0592 0.0040 625.2594 1.0000 1.0000 0.0077 1.0000 1.0000 1.0000 0.6004 1.0000 1.0000 1.0000 0.0000 1.0000 ND ND ND ND ND 1.0000 1.0000 0.0000

1.0000 ND ND ND ND ND 0.0001 0.0429 0.0092 600.5735 ND ND ND ND ND 1.0000 1.0000 0.1392 1.0000 ND ND ND ND ND 0.9952 1.0000 0.0000 1.0000 ND ND ND ND ND 1.0000 1.0000 0.0000 1.0000 ND ND ND ND ND 1.0000 1.0000 0.0000 1.0000 ND ND ND ND ND 0.9959 1.0000 0.3282 245.8796 ND ND ND ND ND 0.1903 1.0000 0.7351 1.0000 ND ND ND ND ND 1.0000 1.0000 0.0001 999.0000 ND ND ND ND ND 1.0000 1.0000 0.2755 1.0000 ND ND ND ND ND 0.0000 0.0062 0.0038 999.0000 ND ND ND ND ND 0.8948 1.0000 0.0018 1.0501 ND ND ND ND ND 0.0000 0.0134 0.0030 102.0131 ND ND ND ND ND 0.4418 1.0000 0.8280 1.0608 1.8689E-14 2.3567E-11 0.1021 999.0000 145 (0.977); 146 (0.999); 147 (0.988); 149 (0.975); 150 (0.991); 151 (0.986); 152 (0.997); 155 (0.999) 1.0000 1.0000 0.0000 1.0000 0.0013 0.0873 0.0021 999.0000 1.0000 1.0000 0.0000 1.0000 1.0000 1.0000 0.0000 1.0000 1.0000 1.0000 0.0000 1.0000 1.0000 1.0000 0.0451 1.0000 0.9977 1.0000 0.0000 1.0743 0.0000 0.0042 0.0068 999.0000 0.9977 1.0000 0.0194 1.0000 0.0000 0.0000 0.0297 999.0000 29 (0.982); 41 (0.993) 1.0000 1.0000 0.0000 1.0547 0.0022 0.1378 0.0050 999.0000 1.0000 1.0000 0.1436 1.0000 0.1548 1.0000 0.0265 11.6874 0.1903 1.0000 0.0115

1.0000 1.0000 1.0000 0.1483 1.0000 1.0000 1.0000 0.2629 1.0000 0.0007 0.0588 0.0017 999.0000 1.0000 1.0000 0.0000 1.0000 1.0000 1.0000 0.0000 1.0000 1.0000 1.0000 0.0000 1.0000 0.9422 1.0000 0.0164 1.7511 1.0000 1.0000 0.0000 1.0000 1.0000 1.0000 0.0000 1.0000 0.0004 0.1051 0.0449 1.0000 0.3894 1.0000 0.9175 307.3132 0.5810 1.0000 0.0439 1.0000 0.0003 0.0335 0.0126 619.1814 313 (0.966) 1.0000 1.0000 0.1156 1.0000 1.0000 1.0000 0.0421 1.0000 1.0000 1.0000 0.0000 228.8519 0.0007 0.0592 0.0047 365.6776 1.0000 1.0000 0.1401 1.0000 1.0000 1.0000 0.3294 1.0000 1.0000 1.0000 0.0000 1.0000 1.0000 1.0000 0.0000 1.0000 0.0004 0.1051 0.0058 1.0000 0.0001 0.0164 0.0050 118.3799 801 (0.979) 1.0000 1.0000 0.0000 1.0000 0.0010 0.0727 0.0078 99.4822 1.0000 1.0000 0.1545 1.0000 1.0000 1.0000 0.0627 1.0000 0.0000 0.0000 0.0065 1.0000 ND ND ND ND ND 0.0003 0.0895 0.1489 1.0000 ND ND ND ND ND 0.0000 0.0062 0.0104 1.0000 ND ND ND ND ND 0.0000 0.0000 0.1019 148.9525 ND ND ND ND ND 1.0000 1.0000 0.0000 1.0000 ND ND ND ND ND 1 1 0.0000

ω (Pty#) e BEB (Pty#) f Tree group no g Gene Tree h p value for NSS q-value for NSS p-value Max Chi q-value for Max Chi Permutationbased p-value for PHI 1.0000 1 (((ATCC9150,ch),CT18),LT2,Ty2); 1 1 0.172 0.665654 0.506 1.0479 1 (((ATCC9150,ch),CT18),LT2,Ty2); 1 1 0.418 0.942154 1 18.5210 1 (((ATCC9150,ch),CT18),LT2,Ty2); 1 1 0.817 1 1 1.0000 1 (((ATCC9150,ch),CT18),LT2,Ty2); 0.52 1 0.462 0.974387 0.51 1.0000 1 (((ATCC9150,ch),CT18),LT2,Ty2); 0.326 1 0.451 0.969004 0.323 1.0833 1 (((ATCC9150,ch),CT18),LT2,Ty2); 1 1 0.348 0.870458 1 1.5811 1 (((ATCC9150,ch),CT18),LT2,Ty2); 0.684 1 0.024 0.247739 0.844 1.0000 1 (((ATCC9150,ch),CT18),LT2,Ty2); 1 1 0.567 1 1 574.0819 1 (((ATCC9150,ch),CT18),LT2,Ty2); 1 1 0.858 1 1 1.0000 1 (((ATCC9150,ch),CT18),LT2,Ty2); ND ND ND ND ND 1.0000 1 (((ATCC9150,ch),CT18),LT2,Ty2); 0.005 0.153172 0 0 0.215 999.0000 1 (((ATCC9150,ch),CT18),LT2,Ty2); 1 1 0.054 0.39651 1 1.0000 1 (((ATCC9150,ch),CT18),LT2,Ty2); 0.221 1 0.315 0.830958 0.053 1.0000 1 (((ATCC9150,ch),CT18),LT2,Ty2); 1 1 0.037 0.329416 1 997.8771 28 (0.977); 45 (0.958); 2 (((ATCC9150,ch),LT2),CT18,Ty2); 0.027 0.384615 0 0 0 46 (0.959); 83 (0.989); 84 (0.978); 85 (0.985); 97 (0.961); 114 (0.984); 124 (0.982); 129 (0.988) 1.0000 2 (((ATCC9150,ch),LT2),CT18,Ty2); 0.211 1 0.637 1 0.186 1.0000 2 (((ATCC9150,ch),LT2),CT18,Ty2); 0.074 0.658831 0.394 0.923873 0.053 999.0000 2 (((ATCC9150,ch),LT2),CT18,Ty2); 1 1 0.384 0.91244 1 999.0000 3 (((ATCC9150,CT18),ch),LT2,Ty2); 1 1 0 0 1 1.0000 5 ((ATCC9150,ch),(CT18,Ty2),LT2); 0 0 0.001 0.028778 0.539

999.0000 233 (0.958); 235(0.992) 5 ((ATCC9150,ch),(CT18,Ty2),LT2); 0.537 1 0.007 0.115278 0.416 1.0000 5 ((ATCC9150,ch),(CT18,Ty2),LT2); 0 0 0 0 0.084 1.0000 5 ((ATCC9150,ch),(CT18,Ty2),LT2); 0.086 0.724894 0.036 0.32457 0.364 1.0000 5 ((ATCC9150,ch),(CT18,Ty2),LT2); 0 0 0.022 0.236521 0.669 1.0000 5 ((ATCC9150,ch),(CT18,Ty2),LT2); 1 1 0.993 1 1 1.0000 5 ((ATCC9150,ch),(CT18,Ty2),LT2); 0.657 1 0.278 0.788867 1 1.0000 5 ((ATCC9150,ch),(CT18,Ty2),LT2); 0.461 1 0.595 1 0.751 1.0000 5 ((ATCC9150,ch),(CT18,Ty2),LT2); 1 1 0.237 0.759308 1 1.0000 5 ((ATCC9150,ch),(CT18,Ty2),LT2); 1 1 0.096 0.522952 1 1.0000 5 ((ATCC9150,ch),(CT18,Ty2),LT2); 1 1 0.321 0.836715 1 1.0000 5 ((ATCC9150,ch),(CT18,Ty2),LT2); 0.825 1 0.061 0.41676 0.158 1.0000 5 ((ATCC9150,ch),(CT18,Ty2),LT2); 1 1 0.761 1 1 1.0000 5 ((ATCC9150,ch),(CT18,Ty2),LT2); 1 1 0.531 1 1 1.0000 5 ((ATCC9150,ch),(CT18,Ty2),LT2); 1 1 0.162 0.65189 1 999.0000 5 ((ATCC9150,ch),(CT18,Ty2),LT2); 0.367 1 0.068 0.435353 0.1 1.0000 5 ((ATCC9150,ch),(CT18,Ty2),LT2); 0.021 0.338017 0.488 0.979783 0.169 1.0705 5 ((ATCC9150,ch),(CT18,Ty2),LT2); 1 1 0.427 0.947453 1 1.0000 5 ((ATCC9150,ch),(CT18,Ty2),LT2); 0 0 0 0 0.328 1.0000 5 ((ATCC9150,ch),(CT18,Ty2),LT2); 0.525 1 0.101 0.532869 0.941 1.0000 5 ((ATCC9150,ch),(CT18,Ty2),LT2); 0.001 0.045952 0.007 0.115278 0.419 1.0000 6 ((ATCC9150,(ch,LT2)),CT18,Ty2); 0 0 0 0 0

999.0000 6 ((ATCC9150,(ch,LT2)),CT18,Ty2); 0.001 0.045952 0 0 0.013 1.0500 6 ((ATCC9150,(ch,LT2)),CT18,Ty2); ND ND ND ND ND 1.0000 6 ((ATCC9150,(ch,LT2)),CT18,Ty2); 1 1 0.004 0.08258 1 1.0000 6 ((ATCC9150,(ch,LT2)),CT18,Ty2); 0.014 0.293279 0.015 0.18826 0.078 1.0000 6 ((ATCC9150,(ch,LT2)),CT18,Ty2); 0.015 0.303085 0.029 0.281983 0.005 5.8462 6 ((ATCC9150,(ch,LT2)),CT18,Ty2); 1 1 0 0 1 999.0000 6 ((ATCC9150,(ch,LT2)),CT18,Ty2); 1 1 0 0 1 1.0000 6 ((ATCC9150,(ch,LT2)),CT18,Ty2); 0.163 0.975603 0.001 0.028778 0.293 1.0000 6 ((ATCC9150,(ch,LT2)),CT18,Ty2); 0.181 1 0 0 0.291 999.0000 6 ((ATCC9150,(ch,LT2)),CT18,Ty2); 0.001 0.045952 0 0 0.11 13.2216 6 ((ATCC9150,(ch,LT2)),CT18,Ty2); 0.478 1 0.115 0.56131 0.551 999.0000 6 ((ATCC9150,(ch,LT2)),CT18,Ty2); 1 1 0.267 0.777 1 999.0000 6 ((ATCC9150,(ch,LT2)),CT18,Ty2); 1 1 0 0 1 1.0000 7 ((ATCC9150,(CT18,Ty2)),ch,LT2); 1 1 0.007 0.115278 1 1.0000 7 ((ATCC9150,(CT18,Ty2)),ch,LT2); 0.067 0.635187 0.72 1 0.454 1.0000 7 ((ATCC9150,(CT18,Ty2)),ch,LT2); 0.022 0.346287 0.262 0.77271 0.129 1.0000 7 ((ATCC9150,(CT18,Ty2)),ch,LT2); 0.444 1 0.23 0.74888 0.243 1.0981 7 ((ATCC9150,(CT18,Ty2)),ch,LT2); 1 1 0.12 0.564158 1 1.0000 7 ((ATCC9150,(CT18,Ty2)),ch,LT2); 1 1 0 0 1 1.0000 7 ((ATCC9150,(CT18,Ty2)),ch,LT2); 1 1 0.106 0.545116 1 24.7836 7 ((ATCC9150,(CT18,Ty2)),ch,LT2); 1 1 0.001 0.028778 1

1.0000 7 ((ATCC9150,(CT18,Ty2)),ch,LT2); 0.695 1 0.325 0.840986 0.972 1.0000 7 ((ATCC9150,(CT18,Ty2)),ch,LT2); 0.001 0.045952 0.119 0.56131 0.012 1.0000 7 ((ATCC9150,(CT18,Ty2)),ch,LT2); 0 0 0 0 0 1.0000 7 ((ATCC9150,(CT18,Ty2)),ch,LT2); 1 1 0.003 0.066773 1 12.0041 33 (0.973) 7 ((ATCC9150,(CT18,Ty2)),ch,LT2); 0.616 1 0 0 0.625 11.2062 7 ((ATCC9150,(CT18,Ty2)),ch,LT2); 0.123 0.873883 0.752 1 0.352 1.0000 508 (0.568) 7 ((ATCC9150,(CT18,Ty2)),ch,LT2); 0.019 0.322208 0.008 0.122538 0.23 1.0000 7 ((ATCC9150,(CT18,Ty2)),ch,LT2); 0.109 0.825907 0 0 0.043 1.0512 7 ((ATCC9150,(CT18,Ty2)),ch,LT2); 1 1 0.697 1 1 1.0000 7 ((ATCC9150,(CT18,Ty2)),ch,LT2); 0.675 1 0.075 0.455597 0.597 999.0000 8 (ATCC9150,(ch,(CT18,Ty2)),LT2); 0.734 1 0.588 1 0.537 1.0000 8 (ATCC9150,(ch,(CT18,Ty2)),LT2); 0.169 0.992744 0.011 0.154379 0.15 1.0000 8 (ATCC9150,(ch,(CT18,Ty2)),LT2); 1 1 0.339 0.860028 0.979 999.0000 8 (ATCC9150,(ch,(CT18,Ty2)),LT2); 0.036 0.447878 0.002 0.049121 0.851 999.0000 32 (0.992); 40 (0.992); 9 (((ATCC9150,LT2),ch),CT18,Ty2); ND ND ND ND ND 44 (0.958); 45 (0.977) 999.0000 9 (((ATCC9150,LT2),ch),CT18,Ty2); ND ND ND ND ND 999.0000 13 (0.999); 15 (0.999); 9 (((ATCC9150,LT2),ch),CT18,Ty2); 1 1 0 0 1 19 (0.998); 21 (0.990); 22 (0.997); 24 (0.999); 25 (0.989); 39 (0.995); 41 (0.998); 44 (0.991); 45 (0.988); 48 (0.964); 51 (0.998); 60 (0.998); 66 (0.992); 67 (0.993); 68 (0.999); 71 (0.991) 1.0000 9 (((ATCC9150,LT2),ch),CT18,Ty2); 0.35 1 0 0 0.603 1.0000 10 ((ATCC9150,CT18),(ch,LT2),Ty2); 0.094 0.767352 0.032 0.300885 0.598

q-value for PHI GENE- CONV inner p-value q-value for GENE-CONV Nc value for Paratyphi A i Nc value for Choleraesuis i Nc value for Typhi CT18 i Nc value for Typhimurium LT2 i Nc value for Typhi Ty2 i Average Nc i 1 0.0245 0.2080 50.312 51.848 51.519 53.53 51.519 51.7456 1 0.0332 0.2517 41.177 40.893 40.344 40.618 40.479 40.7022 1 0.0978 0.4140 47.39 46.942 47.467 47.71 47.467 47.3952 1 0.071 0.3617 44.286 45.597 44.204 44.087 44.204 44.4756 1 0.0786 0.3756 33.909 35.144 33.788 33.919 33.788 34.1096 1 0.114 0.4324 48.505 51.358 48.505 49.535 48.505 49.2816 1 0.0254 0.2121 37.811 37.235 38.406 39.019 38.406 38.1754 1 0.5098 0.8073 43.53 44.558 44.026 43.81 44.026 43.99 1 0.5067 0.8040 43.944 43.897 44.527 44.906 44.527 44.3602 ND 0.5016 0.8008 43.767 44.618 44.618 47.566 44.618 45.0374 1 0.0001 0.0057 42.43 42.23 40.852 44.341 40.852 42.141 1 0.0362 0.2619 46.598 48.219 49.176 48.706 49.176 48.375 1 0.026 0.2148 36.194 36.796 36.352 36.307 36.352 36.4002 1 0.0043 0.0798 39.187 39.535 40.727 38.888 40.727 39.8128 0 0 0.0000 45.505 44.503 43.706 43.787 43.706 44.2414 1 0.0142 0.1585 43.691 43.648 43.201 43.268 43.021 43.3658 1 0.2059 0.5552 40.58 40.883 41.284 41.381 41.284 41.0824 1 0.3691 0.7139 54.16 53.147 60.558 55.959 60.558 56.8764 1 0 0.0000 39.707 40.135 40.263 40.241 40.263 40.1218 1 0.0035 0.0700 43.604 41.558 41.655 43.745 41.652 42.4428

1 0.0006 0.0210 46.927 45.865 45.204 45.534 45.204 45.7468 1 0.0004 0.0164 49.196 50.233 50.725 49.442 50.725 50.0642 1 0.0842 0.3837 53.916 53.524 53.49 53.752 53.49 53.6344 1 0.0007 0.0230 40.013 40.395 40.219 40.448 40.219 40.2588 1 0.1444 0.4809 41.525 39.518 39.712 39.518 39.712 39.997 1 0.626 0.8808 48.212 48.133 47.428 47.848 47.428 47.8098 1 0.3602 0.7053 40.168 41.207 41.816 40.998 41.512 41.1402 1 0.172 0.5207 57.767 54.646 50.286 52.073 50.286 53.0116 1 0.1754 0.5236 44.925 46.98 50.605 47.235 50.605 48.07 1 0.6705 0.8934 43.449 43.668 43.994 44.313 43.994 43.8836 1 0.0531 0.3147 41.587 46.981 42.348 43.275 42.348 43.3078 1 0.2911 0.6693 49.358 45.791 45.092 46.195 45.092 46.3056 1 0.5319 0.8173 41.777 42.195 48.207 42.403 48.207 44.5578 1 0.0732 0.3644 42.234 42.963 43.374 43.356 43.374 43.0602 1 0.042 0.2802 44.866 45.584 45.627 44.902 45.627 45.3212 1 0.5461 0.8258 43.195 44.535 43.036 44.118 43.036 43.584 1 0.0955 0.4087 45.46 46.522 44.789 46.037 44.789 45.5194 1 0 0.0000 50.074 48.924 48.564 50.172 48.564 49.2596 1 0.0135 0.1558 45.438 44.335 44.775 44.084 44.775 44.6814 1 0.0042 0.0794 41.934 42.474 41.619 41.916 41.619 41.9124 0 0 0.0000 41.182 41.352 40.89 40.586 40.752 40.9524

0.64977 0.0001 0.0057 45.529 45.411 44.34 45.239 44.34 44.9718 ND 1 1.0000 48.47 46.368 47.732 48.394 47.732 47.7392 1 0.0005 0.0195 54.834 54.306 54.898 55.503 54.898 54.8878 1 0.0141 0.1585 55.701 59.047 55.351 55.256 55.351 56.1412 0.33917 0.0001 0.0057 37.82 39.46 37.964 39.734 37.964 38.5884 1 0.0048 0.0855 59.158 58.859 59.513 58.642 59.513 59.137 1 0 0.0000 34.072 38.375 34.294 36.064 34.294 35.4198 1 0.0037 0.0726 45.281 46.383 45.449 45.261 45.449 45.5646 1 0.0003 0.0136 42.098 41.155 42.469 41.391 42.469 41.9164 1 0 0.0000 39.033 41.456 40.348 40.383 40.348 40.3136 1 0.2734 0.6504 47.143 49.431 48.377 49.106 48.377 48.4868 1 1.0000 47.047 47.566 48.114 47.761 48.114 47.7204 1 0.0003 0.0136 40.228 41.605 40.314 40.725 40.314 40.6372 1 0.0001 0.0057 45.413 44.252 46.052 45.292 46.052 45.4122 1 0.5296 0.8173 47.339 47.216 47.922 47.831 47.87 47.6356 1 0.0535 0.3147 47.563 47.914 47.221 47.827 47.221 47.5492 1 0.147 0.4823 46.408 46.268 46.375 46.178 46.375 46.3208 1 0.0268 0.2203 50.37 50.305 49.368 49.611 49.264 49.7836 1 0 0.0000 40.581 40.978 40.594 40.24 40.594 40.5974 1 0.3993 0.7305 53.178 51.095 59.702 53.111 59.702 55.3576 1 0 0.0000 53.113 50.962 52.665 53.967 52.665 52.6744

1 0.5762 0.8477 48.278 50.433 48.262 48.083 48.262 48.6636 0.64506 0.0817 0.3815 46.262 47.542 47.919 45.844 47.919 47.0972 0 0.0004 0.0164 52.034 53.287 51.52 51.085 51.527 51.8906 1 0.0006 0.0210 41.644 40.87 42.355 42.076 42.355 41.86 1 0 0.0000 42.775 42.222 41.744 39.994 41.744 41.6958 1 0.4576 0.7687 42.87 42.607 42.961 42.549 42.961 42.7896 1 0.1544 0.4936 39.453 37.439 39.877 37.641 39.877 38.8574 1 0.0014 0.0363 38.619 37.523 38.693 38.163 38.693 38.3382 1 0.6291 0.8808 50.473 49.958 51.793 50.313 51.793 50.866 1 0.1759 0.5236 44.928 49.526 45.981 44.686 45.981 46.2204 1 0.8455 0.9771 49.46 50.556 52.159 51.884 52.159 51.2436 1 0.3114 0.6776 42.459 42.774 42.417 42.894 42.385 42.5858 1 0.1989 0.5525 53.012 53.71 52.094 52.232 52.094 52.6284 1 0.0057 0.0934 45.222 44.379 44.181 45.625 44.181 44.7176 ND 0.09 0.3968 55.514 52.746 52.746 50.674 52.746 52.8852 ND 0.5617 0.8368 55.467 51.544 51.419 53.85 51.419 52.7398 1 0 0.0000 53.546 50.7 49.95 50.368 49.95 50.9028 1 0.0046 0.0829 52.52 51.496 52.847 52.503 52.847 52.4426 1 0.0047 0.0842 46.013 45.738 46.336 45.788 46.336 46.0422