This Accepted Manuscript has not been copyedited and formatted. The final version may differ from this version. Research Article: New Research Cognition and Behavior Longitudinal Changes in Component Processes of Working Memory Longitudinal changes in working memory Anna Rieckmann 1,2, Sara Pudas 2,3 and Lars Nyberg 1,2,3 1 Department of Radiation Sciences, Umeå University, Umeå, Sweden 2 Center for Functional Brain Imaging, Umeå University, Umeå, Sweden 3 Department of Integrative Medical Biology, Umeå University, Umeå, Sweden DOI: 10.1523/ENEURO.0052-17.2017 Received: 15 February 2017 Accepted: 27 February 2017 Published: 6 March 2017 Author contributions: A.R. analyzed data; A.R., S.P., and L.N. wrote the paper; S.P. and L.N. designed research; S.P. and L.N. performed research. Funding: Knut och Alice Wallenbergs Stiftelse (Knut and Alice Wallenberg Foundation) 501100004063 Funding: Söderberg's Foundation Funding: European Commission (EC) 501100000780 Conflict of Interest: Authors report no conflict of interest. Correspondence should be addressed to Anna Rieckmann, Umeå Center for Functional Brain Imaging and Department of Radiation Sciences, Umeå University, 901 87 Umeå, Sweden. Phone: +46 733 809273. E-mail: anna.rieckmann@umu.se Cite as: eneuro 2017; 10.1523/ENEURO.0052-17.2017 Alerts: Sign up at eneuro.org/alerts to receive customized email alerts when the fully formatted version of this article is published. Accepted manuscripts are peer-reviewed but have not been through the copyediting, formatting, or proofreading process. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. Copyright 2017 the authors
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Abstract
Significance statement
s
Materials & Methods Participants
WM task and Performance subgroups
MRI acquisition FMRI analyses
Results Age-related increases in posterior parts of the maintenance network
Age-related decreases in the DLPFC during WM manipulation
Individual differences
Discussion
Age-related decreases in lateral prefrontal activity during WM manipulation accompany changes in performance
Drop-out is predicted by parietal brain activity
Study limitations
Conclusions increases decreases
References
Figure legends Figure 1. Condition-general longitudinal increase in parietal activity over 4 years. Figure 2. Condition-specific (Manipulation Maintenance) decrease in brain activity over 4 years. Figure 3. Drop out analysis.
Figure 4. Subgroup analyses.
Tables Table 1. Peak loci of activation changes (increases and decreases) Contrast T k threshold Condition-general (Manipulation & Maintenance) Condition-specific (Manipulation - Maintenance)
Table 2. Task performance (Hits False Alarms and SD) by condition
Table 3. Predictors of later drop-out Variable OR SE p
Statistical Table Data / Dependent variable ID Type of test Statistic Confidence Methods: Performance subgroups Results: FMRI 2nd level voxelwise analyses using SPM12
Results: Post-hoc/Individual difference analyses