2011 11 Nov. 2011 CHEMICAL INDUSTRY AND ENGINEERING 28 6 Vol. 28 No. 6 1004-9533 2011 06-0068 - 06 1 2* 1 1. 300072 2. 300193 TQ46 A Advances in Recent Research on Protection Against Diabetes Mellitus of Iridoids YANG Chun-hui 1 MA Li 2* WEI Zhen-ping 1 1. School of Chemical Engineering Tianjin University Tianjin 300072 China 2. Tianjin Institute of Pharmaceutical Research Tianjin 300193 China Abstract The treatment of diabetes mellitus was mainly by the oral administration of western medicine in present it has rapid curative effect but there are still many adverse reactions reported in clinic for it is easy to produce resistance to drugs. Extration the compounds from chinese herbal crude drugs as the primary composition was researched by many scholar in these days to develop the new drug for controlling diabetes mellitus. Therefore a large number of research reports occur in this area. Above all iridoids such as catalpol iridoside in Corni Officinalis ICO and aucubin have obvious glucose-lowering effect and they have definite treatment action on complications of diabetes mellitus. This paper reviewed the dominant mechanism and the treatment effect of iridoids for curing diabetes mellitus. Our review to a certain extent provide necessary theoretical foundation for the further research and development of medicines containing iridoids to cure diabetes mellitus. Key words diabetes mellitus iridoids catalpol aucubin iridoside in Corni Officinalis. 2. 5 3 2010-06 - 22 2007BAI41B06 1986-022 23006851 E-mail zhihua504@ 163. com
28 6 69 1 Ⅰ Ⅱ Ⅰ Ⅱ 95% Ⅱ β β β 1 Catalpol C 15 H 22 O 10 2 7 α- 1971 8 9 200 mg / kg 500 mg / kg β- 10 3-4 mrna 4 11-12 5-6 13
70 2011 11 19 Cheng 14 TGF-B1 TGF-β1 mrna 20 mrna Ⅱ 80% 22-23 15 Young 16 2 2 24 Morroniside Loganin AGE 21 Ⅱ Xu 25 Sweroside iridoside in Corni Officinalis 4 Ⅱ Yokozawa 26 17 4 mrna 4 Chen 18 3 β- Aucubin C 15 H 22 O 9
28 6 71 β UCP2 β UCP2 Genipin - geniposide β UCP2 β 3 β β 27 UCP2 31 Bcl-2 Bax Bcl-2 Bax 28 GSH-PX SOD CAT NOS MDA Bcl-2 Bax GSH-PX SOD CAT Bcl-2 NOS THP-1 MDA Bax E- -1 -κb NOS Bcl-2 Bax 29 4 Scrophularia deserti Ⅱ β 2 UCP2 UCP2 0b /0b 5 scropolioside-d 30 C-3 C-4 C-6' C-8
72 2011 11 11 10 1 142-1 145 13. J. 2009 20 1 171-172 14 CHENG F WANG D LI H et al. Oral supplementation of catalpol ameliorates diabetic encephalopathy in rats J. Brain Research 2010 1 307 158-165 15. J. 2005 27 10 19-20 16 YOUNG J. Method of treating non-insulin dependent diabetes mellitus and related complications US 9. D. 22. 2003 J. 10 SHIEH J P CHENG K C CHUNG H H et al. Plasma 2003 19 6 713-715 glucozotocinose lowering mechanisms of catalpol An 23. 2 active principle from roots of Rehmannia glutinosa in strept-induced diabetic rats J. J Aqric Food Chem J. 2007 23 3 36-39 2011 59 8 3 747 11. 3t3-L1 J. 2007 38 10 1 523-1 526 20100292178 P. 2010-11-18 17. NIDDM GLU T4 1. M. J. 2001 26 12 859-862 1989 18 CHEN C HSU C Y CHEN C et al. Fructus Corni 2. Ⅱ J. suppresses hepatic gluconeogenesis related gene 2009 22 870-871 transcription enhances glucose responsiveness of 3. pancreatic beta-ceils and prevents toxin induced betacell J. 2010 6 11 531-533 death J. J Ethnophatmacol 2008 117 3 483-490 4. 19 YAMABE N KANG K S MATSUO Y et al. J. 2010 12 11 396-398 Identification of antidiabetic effect of iridoid glycosides and low molecular weight polyphenol fractions of Corni 5. Fructus a constituent of Hachimi-jio-gan in J. 2006 4 28 609-611 strepmzotocin induced diabetic rats J. Biol Pharm 6. Bull 2007 30 7 1 289-1 296 J. 2010 9 37 1 848-20 XU H HAO H. Effects of iridoid total glycoside from 1 851 Cornus officinalis on prevention of glomerular 7. J. 1971 271 721-722 overexpression of transforming growth factor beta 1 and matrixes in an experimental diabetes model J. Biol 8. Pharm Bull 2004 27 7 1 014-1 018 OL. http / / www. 21. paper. edu. cn / index. php / default / releasepaper / SOD J. content /200904-365 2003 14 1 23-24 24. C / / 12. 2002 3T3-L1 Glut-4 IRS-1 IRS-1 25 XU H SHEN J LIU H et al. Morroniside and loganin Ser307 J. 2008 extracted from Cornus officinalis have protective effects
28 6 73 on rat mesangial cell proliferation exposed to advanced glycation end products by preventing oxidative stress J. Can J Physiol Pharmacol 2006 84 12 1 267-1 273 26 YOKOZAWA T YAMABE N KIM H Y et al. Protective effects of morroniside isolated from Corni Fructus against renal dammage in streptozotocin-induced diabetic rats J. Biol Pharm Bull 2008 31 7 1 422-1 428 China C Life Sci 2008 7 38 599-605 29. D. 2008 30 AHMED B ALREHAILY A J ALHOWIRINY T A et al. Scropolioside-D2 and harpagoside-b Two new iridoid glycosides from Scrophularia deserti and their antidiabetic and antiinflammatory activity J. Biol Pharm Bull 2003 26 4 462-469 31 ZHANG C LAURA E CHIAN P Y et al. Genipin 27. inhibits UCP2-mediated proton leak and acutely reverses D. 2007 obesity- and high glucose-induced β cell dysfunction in 28 XUE H JIN L JIN L et al. Neufoprotection of isolated pancreatic islets J. Cell Metabolism 2006 6 aucubin in primary diabetic encephalopathy J. Sci 3 417-427 67 20 KIM J SOHN M KIM D et al. Production of granular activated carbon from waste walnut shell and its adsorption characteristics for Cu 2 + ion J. Journal of Hazardous Materials 2001 85 3 301-316 21. walnut shells via vacuum chemical activation and their J. 2010 4 10 2 273-2 277 22. 27. J. J. 2009 22 6 32-34 2009 28 8 1 693-1 700 23. Sorption properties of active carbons obtained from J. 2008 25 8 13-15 2009 167 1 /3 230-236 25 ZABIHI M HAGHIGHI ASL A AHMADPOUR A. Studies on adsorption of mercury from aqueous solution on activated carbons prepared from walnut shell J. Journal of Hazardous Materials 2010 174 1 /3 251-256 26 YANG J QIU K. Preparation of activated carbons from application for methylene blue removal J. Chemical Engineering Journal 2010 165 1 209-217 28 NOWICKI P PIETRZAK R WACHOWSKA H. walnut shells by chemical and physical activation J. Catalysis Today 2010 150 1 /2 107-114 24 ZABIHI M AHMADPOUR A ASI A. Removal of mercury from water by carbonaceous sorbents derived 29 GONZALEZ-GARCIA C GONZALEZ J ROMAN S. from walnut shell J. Journal of Hazardous Materials Removal efficiency of radioactive methyl iodide on TEDA-impregnated activated carbons J. Fuel Processing Technology 2011 92 2 247-252