Prior Authorization October 2018

Prior Authorization October 2018 Not all benefit plans include the Prior Authorization program. Check your plan materials to see if this information applies to you. What Is Prior Authorization? It s a quality and safety program that promotes the proper use of certain medications. If your doctor prescribes a medication that is included in our Prior Authorization program, you must get prior approval before your plan will cover your medication. We base the Prior Authorization program on U.S. Food and Drug Administration and manufacturer guidelines, medical literature, safety, accepted medical practice, appropriate use and benefit design. Which Medications Are Included? This list includes both specialty and non-specialty drugs that require prior authorization under your pharmacy benefit. You will also find information on where your doctor should send requests for prior authorization. Some drugs require Medical Necessity Prior Authorization (MNPA). Before your plan will cover these drugs, you must try one or more covered alternatives first. If your health plan requires prior authorization for specialty drugs under the medical benefit, you can find more information on the Medical Prior Authorization drug list online at your health plan s website. What Are the Possible Outcomes of a Prior Authorization Request? If you meet the requirements, your drug will be approved, and we will cover it. Your drug may be approved for up to one year or more. You will be sent a letter letting you know that your drug has been approved. If you do not meet the requirements, your prior authorization will be denied. Also, if your doctor does not send in the requested information within a certain period of time, your prior authorization will be denied. If your request is denied, both you and your doctor will be sent a letter explaining the denial. The letter will include information about how you can appeal the decision. What Happens at the Pharmacy? The pharmacist enters your prescription information into the computer system. If your medication needs prior authorization and you already have it, the pharmacist will fill your prescription. If you do not have prior authorization, you have three choices: You or your pharmacist can call your doctor and get a prescription for a different medication that does not need prior authorization. You can pay full price for your medication. You or your pharmacist can ask your doctor to get prior authorization for you. If you do not meet the requirements for prior authorization, you can still choose another option. You and your doctor make the final decision about the medication that is right for you. If you submit your prescription to your plan s mail-order pharmacy and do not get the required prior authorization, the pharmacy will not fill your prescription. You will receive notification by mail. What Happens at a Specialty Pharmacy? Usually, your doctor will call or fax a prescription directly to the specialty pharmacy. If your prescription requires prior authorization, the specialty pharmacy will tell your doctor how to request this. Your benefit document defines actual benefits available and may exclude coverage for certain drugs listed here. Check your benefit information to verify coverage or view your personal benefit information on our website. This list may contain trademarks or registered trademarks of pharmaceutical manufacturers that are not affiliated with your health plan. This list may change or expand from time to time without prior notice. When we list brand-name drugs, programs may also apply to any available generic equivalents. Prior Authorization Drug List Effective 10/1/18 1

Prior Authorization List Specialty Drugs This list applies to specialty drug coverage under the pharmacy benefit only. To request prior authorization for these drugs, please have your doctor call CVS Specialty at 800-237-2767. Your doctor can also fax requests to 866-249-6155. CVS Specialty is a division of CVS Health, an independent company that provides pharmacy services on behalf of your health plan. To request prior authorization for drugs listed with a (^), please have your doctor call the precertification number on the back of your member identification card. Preferred drugs under the pharmacy benefit are listed with a (#). Drugs listed with a (+) require medical necessity prior authorization see Table A for more information. A Abraxane Actemra (+) Actimmune Adagen Adcetris Adcirca (brand & generic) (+) Adempas (#) Advate Adynovate Afinitor Aldurazyme Alecensa Alimta Aliqopa Alphanate Alphanine SD Alprolix Alunbrig Ampyra (#) Apokyn Aralast NP Aranesp Arcalyst Arzerra Astagraph XL Aubagio (#) Avastin Avonex (+) Azacitidine (#) B Bavencio Bebulin VH Beleodaq Bendeka Benefix Benlysta Berinert Besponsa Betaseron (#) Bethkis Bexarotene (#) Bivigam Blincyto Botox Bravelle (+) Buphenyl C Cabometyx Calquence Capecitabine (#) Caprelsa Carbaglu Carimune NF Cayston Cerdelga Cerezyme Cetrotide Cholbam Cimzia (+) Cinryze Coagadex Cometriq Copaxone Copegus Cosentyx (#) Cotellic Cyramza Cystadane Cystagon Cystaran D Dacogen Darzalex Decitabine (#) Deferoxamine (#) Desferal Docefrez Docetaxel (#) Dofetilide (#) Duopa Dupixent Dysport E Egrifta Elaprase Elelyso Eligard Eloctate Empliciti Enbrel (#) Entecavir (#) Entyvio (+) Epclusa (#) Epogen Epoprostenol sodium (#) Erbitux Erivedge Erleada Erwinaze Esbriet Euflexxa (+) Exjade Extavia (+) Eylea F Fabrazyme Farydak Feiba NF Ferriprox Firazyr Firmagon Flebogamma Flolan Follistim AQ (+) Folotyn Forteo (#) Fusilev G Gamastan S/D Gammagard Gammaked Gammaplex Gamunex C Ganciclovir (#) Ganirelix Gattex Gazyva Gel-One (#) Gemcitabine Gemzar Genotropin (+) Gilenya (#) Gilotrif Glassia Glatopa (#) Gleevec (+) Gonal-F (#) Granix Grastek H Haegarda Halaven Harvoni (#) Helixate FS (+) Hemofil-M Herceptin Hetlioz Hizentra HP Acthar Humate-P Humatrope (#) Humira (#) Hyalgan (#) Hycamtin Hydroxyprogesterone (#) HyQvia I Ibrance Iclusig Ilaris Illuvien Imatinib (#) Imbruvica Imfinzi Increlex Inflectra (+) Inlyta Intron-A Iressa Istodax Ixempra Ixinity J Jadenu Jakafi Jetrea Jevtana Juxtapid (+) K Kadcyla Kalbitor Kalydeco Kanuma Keytruda Kineret (+) Kisqali Kisqali/Femara Pack Kitabis Pak Koate-DVI Kogenate FS (#) Korlym (^) Krystexxa Kuvan Kynamro (+) Kyprolis L Lartruvo Lemtrada Lenvima Letairis (#) Leukine Leuprolide (#) Lonsurf Lucentis Lumizyme Lupaneta Lupron Depot/PED Lynparza M Macugen Matulane (#) Mavyret (#) Mekinist Menopur Mitoxantrone HCI inj Prior Authorization Drug List Effective 10/1/18 2

Moderiba (+) Monoclate-P Mononine Monovisc (+) Mozobil Myfortic Myobloc N Naglazyme Natpara Nerlynx Neulasta Neumega Neupogen (+) Nexavar Ninlaro Norditropin (#) Northera Novoeight Novoseven Nplate Nutropin/AQ (+) O Obizur Ocrevus (+) Octagam Octreotide Acetate Odomzo Ofev Omnitrope (+) Oncaspar Onivyde Opdivo Opsumit (+) Oralair Orencia IV/SC (+) Orenitram Orfadin Orkambi Orthovisc (+) Otezla (#) Otrexup Ovidrel Ozurdex P Pamidronate Disodium (#) Pegasys (#) PEG-Intron (+) Perjeta Plegridy (+) Pomalyst Prialt Privigen Procrit (#) Procysbi Profilnine SD Proleukin Prolia Promacta Provenge Pulmozyme Purixan Q Qutenza R Radicava Ragwitek Rasuvo Ravicti Rebetol (+) Rebif/Rebidose (#) Reclast Recombinate Regranex Remicade (+) Remodulin Repatha (#) Retisert Revatio (brand & generic) (+) Prior Authorization List Specialty Drugs Revlimid Ribapak (+) Ribasphere Ribatab Ribavirin (#) Riluzole (#) Rituxan (+) Rixubis Rubraca Ruconest Rydapt S Sabril Saizen (+) Samsca Sandimmune Sandostatin/LAR Sensipar (#) Serostim Signifor LAR Sildenafil (#) Simponi/Aria (+) Sirolimus (#) Soliris Somatuline Depot Somavert Spinraza Sprycel Stelara (#) Stimate Stivarga Strensiq Supartz FX (#) Supprelin LA Sutent Sylatron Sylvant Synagis Synribo Synvisc/One (+) T Tafinlar Tagrisso Tarceva Targretin Tasigna Taxotere Tecentriq Tecfidera (#) Temodar (+) Temozolomide (#) Tetrabenazine (#) Thalomid TOBI Podhaler (+) Tobramycin (#) Topotecan Torisel Tracleer (#) Treanda Trelstar Tykerb Tysabri (+) Tyvaso U V Valchlor Valstar Vandetanib Vantas Vectibix Velcade Veletri Venclexta Ventavis Verzenio Vidaza Vigabatrin (#) Vimizim Visudyne Voriconazole (#) Vosevi (#) Votrient VPRIV W Wilate Winrho SDF X Xalkori Xeljanz/XR (+) Xeloda (+) Xeomin Xermelo Xgeva Xiaflex Xolair Xtandi Xyntha Xyrem (^) Y Yervoy Z Zarxio Zavesca Zejula Zelboraf Zemaira Zoladex Zoledronic acid (#) Zolinza Zomacton (+) Zometa Zorbtive Zydelig Zykadia Zytiga Prior Authorization Drug List Effective 10/1/18 3

Table A: Specialty Drugs Requiring Medical Necessity Prior Authorization Condition/Drug Class Before you have coverage for one of these drugs you must have tried one (or more) of these alternative drugs first. Brain Cancer Temodar temozolomide Colon Cancer Xeloda capecitabine Cystic Fibrosis TOBI Podhaler Tobramycin inhalation Decrease in White Blood Cells Growth Deficiency Neupogen Genotropin, Nutropin/AQ, Omnitrope, Saizen, Zomacton Zarxio Humatrope, Norditropin Flexpro Hemophilia Helixate FS Kogenate High Cholesterol Juxtapid, Kynamro Repatha Infertility Bravelle, Follistim AQ Gonal-F (all) Inflammatory Conditions (Crohn s Disease, Psoriasis, Rheumatoid Arthritis) Actemra, Cimzia, Entyvio, Inflectra, Kineret, Orencia, Remicade, Rituxan, Simponi/Aria, Xeljanz/XR Cosentyx, Enbrel, Humira, Otezla, Stelara Leukemia/Multiple Cancers Gleevec imatinib Multiple Sclerosis Avonex, Extavia, Ocrevus, Plegridy, Tysabri Aubagio, Betaseron, Copaxone, Gilenya, glatopa, Rebif, Tecfidera Osteoarthritis of the Knee Euflexxa, Monovisc, Orthovisc, Synvisc/One Gel-One, Hyalgan, Supartz Pulmonary Arterial Hypertension (A) Pulmonary Arterial Hypertension (B) Adcirca, Revatio Opsumit tadalafil, sildenafil Letairis, Tracleer Prior Authorization Drug List Effective 10/1/18 4

Prior Authorization Non-specialty Drugs To request prior authorization for these drugs, please have your doctor call the CVS Caremark Prior Authorization department at 800-294-5979. Your doctor can also fax requests to 888-836-0730. CVS Caremark is a division of CVS Health, an independent company that provides pharmacy services on behalf of your health plan. Drugs listed with a (+) require medical necessity prior authorization see Table B for more information. A Abstral Actiq Altoprev (+) Ambien/CR (+) Amitiza (+) Anadrol-50 Apidra (+) Avalide (+) Avapro (+) B Basaglar (+) Beconase AQ (+) Belsomra (+) Buprenorphine Byetta (+) C Celebrex Compound Drugs (costing $300 or more) Cozaar (+) Crestor (+) D Detrol/LA (+) Diabetic Test Strips (+) Diovan/HCT (+) Ditropan XL (+) Dulera (+) Dymista (+) E Edarbi (+) Edarbyclor (+) Edluar (+) Epanova F Fentora Flector patch (+) Flonase (+) Freestyle Libre (receiver only) G H Humalog (+) Humulin (except U- 500) (+) Hyzaar (+) I Incruse Ellipta (+) Intermezzo (+) Invokamet/XR (+) Invokana (+) J Jentadueto/XR (+) K Kazano (+) L Lazanda Lescol/XL (+) Levemir (+) Lidocaine (generic) Lipitor (+) Livalo (+) Lovaza Lumigan (+) M Mevacor (+) Micardis/HCT (+) Modafinil (generic Provigil) Myrbetriq (+) N Naprelan (+) Nasacort AQ (+) Nesina (+) O Oleptro (+) Olux-E (+) Omega 3 Ethyl Esters Omnaris (+) Omtryg Onsolis Oseni (+) Oxytrol (+) P Pradaxa (+) Pravachol (+) Prevacid Solutab Proscar Q Qnasl (+) R Rhinocort AQ (+) Riomet (+) S Sanctura (+) Savaysa (+) Seebri Neohaler (+) Sonata (+) Soriatane Sporanox Oral Capsules & Oral Solution Subsys Sustol T Tanzeum (+) Tekturna/HCT (+) Teveten/HCT (+) Tobacco Cessation Toviaz (+) Tradjenta (+) Tresiba (+) Trulicity (+) Tudorza Pressair (+) U V Vascepa Viberzi (+) W X Xifaxan 550 mg (+) Y Z Zetonna (+) Zocor (+) Zohydro Zolpimist (+) Prior Authorization Drug List Effective 10/1/18 5

Table B: Non-specialty Drugs Requiring Medical Necessity Prior Authorization Condition/Drug Class Before you have coverage for one of these drugs you must have tried one (or more) of these alternative drugs first. Arthritis/Pain Flector patch, Naprelan generic NSAIDs Asthma/COPD (A) Dulera Advair, Symbicort Asthma/COPD (B) Incruse Ellipta, Seebri Neohaler, Tudorza Pressair Spiriva, Spiriva Respimat Blood Clots Savaysa, Pradaxa Xarelto, Eliquis Cholesterol Lowering (high potency) Cholesterol Lowering Crestor Lescol/XL, Lipitor, Livalo, Mevacor, Pravachol, Zocor atorvastatin, ezetimibe/simvastatin (generic for Vytorin), rosuvastatin atorvastatin, fluvastatin, fluvastatin ext-rel, lovastatin, pravastatin, rosuvastatin, simvastatin Depression Oleptro trazodone Dermatologic Olux-E Clobetasol propionate foam 0.05% Diabetes (Insulin) All Apidra, Humalog, Humulin (except U-500) Novolog, Novolin Diabetes (long-acting insulin) Basaglar, Levemir, Tresiba Lantus, Toujeo Diabetes (Biguanides) Riomet metformin/xr (generics for Glucophage/XR) Diabetes (DPP-4) Kazano, Nesina, Oseni, Tradjenta, Jentadueto/XR Januvia, Janumet/XR, Onglyza, Kombiglyze/XR Diabetes (SGLT2) Invokana, Invokamet/XR Farxiga, Jardiance, Synjardy/XR, Xigduo XR Diabetes (GLP-1) Diabetes Supplies Byetta, Tanzeum, Trulicity All test strips other than OneTouch Members on insulin pumps that require specific test strips other than OneTouch may be granted a lifetime approval to continue to fill their current test strips. Bydureon/BCISE, Victoza These drugs require use of metformin and authorization through the CVS Caremark Prior Authorization department. OneTouch Glaucoma Lumigan lantanoprost, Travatan Z, Zioptan Hypertension Irritable Bowel Syndrome (constipation predominant) Irritable Bowel Syndrome (diarrhea predominant) (A) Irritable Bowel Syndrome (diarrhea predominant) (B) Nasal Steroids Overactive Bladder Sleep Medications Avapro, Avalide, Cozaar, Hyzaar, Diovan/HCT, Edarbi, Edarbyclor, Micardis/HCT, Tekturna/HCT, Teveten/HCT Amitiza Viberzi Xifaxan 550 mg Beconase AQ, Dymista, Flonase, Nasacort AQ, Omnaris, Qnasl, Rhinocort AQ, Zetonna Detrol/LA, Ditropan XL, Myrbetriq, Oxytrol, Toviaz Ambien/CR, Belsomra, Edluar, Intermezzo, Sonata, Zolpimist generic ARBs generic lomotil, immodium, Linzess generic lomotil, immodium loperamide, diphenoxylate/atropine budesonide nasal spray, flunisolide, fluticasone nasal, mometasone furoate nasal spray, triamcinolone oxybutynin ext-rel, tolterodine, tolterodine ext-rel, trospium, trospium ext-rel, Gelnique, Vesicare eszopiclone, zolpidem, zolpidem ext-rel, zaleplon Prior Authorization Drug List Effective 10/1/18 6