ΚΛΙΝΙΚΕΣ ΜΕΛΕΤEΣ 2008 CLINICAL RESEARCH 2008

doctors reviews_σχέδιο 1 07/05/2010 11:32 Page 1 ΚΛΙΝΙΚΕΣ ΜΕΛΕΤEΣ 2008 CLINICAL RESEARCH 2008

Αθήνα, Απρίλιος 2009 Αγαπητοί συνάδελφοι, είμαστε στην ευχάριστη θέση με την παρούσα έκδοση να σας παρουσιάσουμε το ερευνητικό και συγγραφικό έργο που έλαβε χώρα στο Διαγνωστικό & Θεραπευτικό Κέντρο Αθηνών ΥΓΕΙΑ κατά το 2008, το οποίο απαρτίζεται τόσο από την εκπόνηση Ερευνητικών Πρωτοκόλλων όσο και από Επιστημονικές Δημοσιεύσεις (peer reviews) σε έγκριτα επιστημονικά περιοδικά. Το ερευνητικό αυτό έργο, αποτέλεσμα μακρόχρονης και εντατικής εργασίας αρκετών χρόνων, αποτελεί αναπόσπαστο τμήμα της καθημερινής μας επιστημονικής δραστηριότητας, η οποία δεν στοχεύει μόνο στην υψηλού επιπέδου ιατρική περίθαλψη αλλά συμβάλλει και στην προώθηση της ιατρικής έρευνας. Συγχαίρουμε τους συνεργάτες μας για την ανταπόκριση και την επιστημονική τους δραστηριότητα και ελπίζουμε η μελλοντική μας έκδοση να είναι ακόμη καλύτερη. Ο Πρόεδρος του Επιστημονικού Συμβουλίου Π. Κοσμίδης

ΚΛΙΝΙΚΕΣ ΜΕΛΕΤΕΣ C L I N I C A L R E S E A R C H ΑΛΙΒΙΖΑΤΟΣ Γ. Greenlight laser in benign prostatic hyperplasia: turning green into gold Curr Opin Urol. 2008 Jan;18(1):46-9, Alivizatos G, Skolarikos A Prognostic and predictive factors in patients with androgen-independent prostate cancer treated with docetaxel and estramustine: a single institution experience Eur Urol. 2008 Feb;53(2):323-31, Bamias A, Bozas G, Antoniou N, Poulias I, Katsifotis H, Skolarikos A, Mitropoulos D, Alamanis C, Alivizatos G, Deliveliotis H, Dimopoulos MA Should holmium laser enucleation be the new gold standard for bladder outlet obstruction caused by BΡH? Eur Urol. 2008 Jul;5(7):358-9, Alivizatos G, Skolarikos A Transurethral Photoselective Vaporization versus Transvesical Open Enucleation for Prostatic Adenomas>80ml: 12-mo Results of a Randomized Prospective Study Eur Urol. 2008 Aug;54(2):427-37, Alivizatos G, Skolarikos A, Chalikopoulos D, Papachristou C, Sopilidis O, Dellis A, Kastriotis I, Deliveliotis C Photoselective vaporization of the prostate to manage benign prostatic hyperplasia J Endourol. 2008 Sep;22(9):2117-9, Alivizatos G, Skolarikos A Eighteen-month results of a randomized prospective study comparing transurethral photoselective vaporization with transvesical open enucleation for prostatic adenomas greater than 80 cc. J Endourol. 2008 Oct;22(10):2333-40, Skolarikos A, Papachristou C, Athanasiadis G, Chalikopoulos D, Deliveliotis C, Alivizatos G Postradical cystectomy bowel perforation by a drainage tube: a case report Cases J. 2008 Nov 25;1(1):350, Chatzidarellis EP, Skolarikos A, Mazaris E, Mitsogiannis I, Alivizatos G ΑΝΔΡΕΟΥ I. Cardiac magnetic resonance detection and typical appearance of microvascular obstruction following myocardial infarction, Hellenic J Cardiol. 2008 (in press), Karatzis EN, Pipilis AG, Malios K, Andreou J, Roussakis A, Tsertos F, Danias PG Results and complications in 409 patients, Journal of Medical Imaging and Radiation Oncology 2008;52:458-462, Laspas F, Roussakis A, Efthimiadou R, Papaioannou D, Papadopoulos S, Andreou J 4 ΒΑΛΗΣ Δ. p53 Arg 72 Homozygosity and its Increased Incidence in Left-sided Sporadic Colorectal Adenocarcinomas, in a Greek-Caucasian population Anticancer Research 2008 (28), Dakouras A, Nikiteas N, Papadakis E, Perakis E, Valis D, Rallis G, Tzanakis N, Peros G, Tsigkris C, Kittas C, Karakitsos P

doctors reviews_σχέδιο 1 07/05/2010 11:32 Page 5 ΓΚΑΡΟΥΤΣΟΥ Π. Evaluation of continuous use of Real Time Glucose Monitoring (PRT), alone and combined with Insulin Pump Therapy, as a mean to normalize Glycaemic Control in IDDM Diabetes June 2008;57(1), Zoupas CS, Kepaptsoglou O, Taraoune I, = Giannakopoulos F, Garoutsou P, Barreto C, Vasilopoulos H, Kefaloyannis N, Kyrlaki E, Pappas A One year continuous use of Real Time Glucose Monitoring combined with Insulin Pump, as a mean to normalize Glucose Variability and HbA1c in IDDM Diabetologia Sept. 2008;51(1), Zoupas CS, Kepaptsoglou O, Kefaloyannis N, Taraoune I, = Giannakopoulos F, Sfakianaki M, Garoutsou P, Vasilopoulos H, Kyrlaki E, Pappas A = ΓΙΑΝΝΑΚΟΠΟΥΛΟΣ Φ. Evaluation of continuous use of Real Time Glucose Monitoring (PRT), alone and combined with Insulin Pump Therapy, as a mean to normalize Glycaemic Control in IDDM Diabetes June 2008;57(1), Zoupas CS, Kepaptsoglou O, Taraoune I, = Giannakopoulos F, Garoutsou P, Barreto C, Vasilopoulos H, Kefaloyannis N, Kyrlaki E, Pappas A One year continuous use of Real Time Glucose Monitoring combined with Insulin Pump, as a mean to normalize Glucose Variability and HbA1c in IDDM Diabetologia Sept. 2008;51(1), Zoupas CS, Kepaptsoglou O, Kefaloyannis N, Taraoune I, = Giannakopoulos F, Sfakianaki M, Garoutsou P, Vasilopoulos H, Kyrlaki E, Pappas A ΔΑΝΙΑΣ Π. Growth hormone therapy in congestive heart failure due to left ventricular systolic dysfunction: a meta-analysis Endocr Pract. 2008 Jan-Feb;14(1):40-9, Tritos NA, Danias PG Exposure to ionizing radiation from cardiovascular imaging and therapeutic procedures may be a considerable unrecognized risk for subsequent cancer development J Am Coll Radiol. 2008 Jun;5(6):694-5, Karatzis EN, Danias PG Endocardial metastases as the only site of relapse in a patient with bladder carcinoma: A case report and review of the literature Int J Cardiol. 2008 Nov 29, Mountzios G, Bamias A, Dalianis A, Danias P, Pantelidaki E, Nanas J, Dimopoulos MA Cardiac magnetic resonance detection and typical appearance of microvascular obstruction following myocardial infarction Hellenic J Cardiol. 2008 (in press), Karatzis EN, Pipilis AG, Malios K, Andreou J, Roussakis A, Tsertos F, Danias PG Cardiovascular MRI. 150 Muliple Choice Questions and Answers Humana Press, Totowa, NJ, USA ISBN:978-1-934115-59-6, Danias PG ΕΥΘΥΜΙΑΔΟΥ Ρ. Results and complications in 409 patients Journal of Medical Imaging and Radiation Oncology 2008;52:458-462, Laspas F, Roussakis A, Efthimiadou R, Papaioannou D, Papadopoulos S, Andreou J 5

ΖΟΥΠΑΣ X. Evaluation of continuous use of Real Time Glucose Monitoring (PRT), alone and combined with Insulin Pump Therapy, as a mean to normalize Glycaemic Control in IDDM Diabetes June 2008;57(1), Zoupas CS, Kepaptsoglou O, Taraoune I, = Giannakopoulos F, Garoutsou P, Barreto C, Vasilopoulos H, Kefaloyannis N, Kyrlaki E, Pappas A One year continuous use of Real Time Glucose Monitoring combined with Insulin Pump, as a mean to normalize Glucose Variability and HbA1c in IDDM Diabetologia Sept. 2008;51(1), Zoupas CS, Kepaptsoglou O, Kefaloyannis N, Taraoune I, = Giannakopoulos F, Sfakianaki M, Garoutsou P, Vasilopoulos H, Kyrlaki E, Pappas A ΚΕΠΑΠΤΣΟΓΛΟΥ Ο. Evaluation of continuous use of Real Time Glucose Monitoring (PRT), alone and combined with Insulin Pump Therapy, as a mean to normalize Glycaemic Control in IDDM Diabetes June 2008;57(1), Zoupas CS, Kepaptsoglou O, Taraoune I, = Giannakopoulos F, Garoutsou P, Barreto C, Vasilopoulos H, Kefaloyannis N, Kyrlaki E, Pappas A One year continuous use of Real Time Glucose Monitoring combined with Insulin Pump, as a mean to normalize Glucose Variability and HbA1c in IDDM Diabetologia Sept. 2008;51(1), Zoupas CS, Kepaptsoglou O, Kefaloyannis N, Taraoune I, = Giannakopoulos F, Sfakianaki M, Garoutsou P, Vasilopoulos H, Kyrlaki E, Pappas A 6 ΚΟΣΜΙΔΗΣ Π. Predicting Metastatic Behaviour in Lung Adenocarcinoma European Oncology 2008, Boukovinas I, Kosmidis P Paclitaxel and gemcitabine versus carboplatin and gemcitabine in patients with advanced non-small-cell lung cancer. A phase III study of the Hellenic Cooperative Oncology Group Ann Oncol. 2008 Jan;19;(1):115-22, Kosmidis P, Kalofonos HP, Christodoulou C, Syrigos K, Makatsoris T, Skarlos D, Bakogiannis C, Nikolaides C, Bafaloukos D, Bamias A, Samantas E, Xiros N, Boukovinas I, Fountzilas G, Dimopoulos M Paclitaxel, epirubicin, and carboplatin in advanced or recurrent endometrial carcinoma: A Hellenic Co-operative Oncology Group (HeCOG) study Gynecol Oncol. 2008 Jul; 110(1):87-92, Papadimitriou C, Bafaloukos D, Bozas G, Kalofonos H, Kosmidis P, Aravantinos G, Fountzilas G, Dimopoulos M; Hellenic Cooperative Oncology Group Potential value of PTEN in predicting cetuximab response in colorectal cancer. An exploratory study BMC Cancer 2008 Aug 13; 8:234, Razis E, Briasoulis E, Vrettou E, Skarlos DV, Papamichael D, Kostopoulos I, Samantas E, Xanthakis I, Bobos M, Galanidi E, Bai M, Gikonti I, Koukouma A, Kafiri G, Papakostas P, Kalogeras KT, Kosmidis P, Fountzilas G Somatic Mutations of the Tyrosine Kinase Domain of Epidermal Growth Factor Receptor and Tyrosine Kinase Inhibitor Response to TKIs in Non-small Cell Lung Cancer: An analytical Database J Thorac Oncol. 2008 Aug.; 3(8):832-9, Murray S, Dahabreh IJ, Linardou H, Manoloukos M, Bafaloukos D, Kosmidis P

doctors reviews_σχέδιο 1 07/05/2010 11:32 Page 7 ΚΟΣΜΙΔΗΣ Π. Myelotoxicity as a prognostic factor in patients with advanced breast cancer treated with chemotherapy: a pooled analysis of two randomized trials conducted by the Hellenic Cooperative Oncology Group Anticancer Res. 2008 Sep-Oct;28(5B):2913-20, Koutras A, Fountzilas G, Dafni U, Dimopoulos M, Pectasides D, Klouvas G, Papakostas P, Kosmidis P, Samantas E, Gogas H, Briasoulis E, Vourli G, Petsas T, Xiros N, Kalofonos HP; Hellenic Cooperative Oncology Group Carboplatin and paclitaxel versus cisplatin, paclitaxel and doxorubicin for first-line chemotherapy of advanced ovarian cancer: a Hellenic Cooperative Oncology Group (HeCOG) study Eur J Cancer. 2008 Oct;44(15):2169-77, Aravantinos G, Fountzilas G, Bamias A, Grimani I, Rizos S, Kalofonos HP, Skarlos D, Economopoulos T, Kosmidis P, Stathopoulos G, Briasoulis E, Pectasides D, Samantas E, Timotheadou E, Papadimitriou C, Papanikolaou A, Onyenadum A, Papakostas P, Bafaloukos D, Dimopoulos M; Hellenic Cooperative Oncology Group study Gemcitabine combined with gefitinib in patients with inoperable or metastatic pancreatic cancer: a phase II Study of the Hellenic Cooperative Oncology Group with biomarker evaluation Cancer Invest. 2008 Oct;26(8):784-93, Fountzilas G, Bobos M, Kalogera-Fountzila A, Xiros N, Murray S, Linardou H, Karayannopoulou G, Koutras A, Bafaloukos D, Samantas E, Christodoulou C, Econopoulos T, Kalogeras K, Kosmidis P Assessment of somatic k-ras mutations as a mechanism associated with resistance to EGFR-targeted agents: a systematic review and meta-analysis of studies in advanced non-small-cell lung cancer and metastatic colorectal cancer Lancet Oncol 2008 Oct;9(10):962-972, Linardou H, Dahabreh I, Kanaloupiti D, Siannis F, Bafaloukos D, Kosmidis P, Papadimitriou C, Murray S ΛΑΜΠΡΟΠΟΥΛΟΣ Σ. Quantitative Measurement of Imatinib (Gleevec) in Human Glioblastoma Biopsies Using Liquid Chromatography - Tandem Mass Spectrometry J of Chromatography B. Submitted, Norris J, Kalebic T, Razis E, Selviaridis P, Karanastasi S, Labropoulos S, Fountzilas G ΛΑΣΠΑΣ Φ. Results and complications in 409 patients Journal of Medical Imaging and Radiation Oncology 2008;52:458-462, Laspas F, Roussakis A, Efthimiadou R, Papaioannou D, Papadopoulos S, Andreou J ΜΑΛΛΙΟΣ Κ. Cardiac magnetic resonance detection and typical appearance of microvascular obstruction following myocardial infarction Hellenic J Cardiol. 2008 (in press), Karatzis EN, Pipilis AG, Malios K, Andreou J, Roussakis A, Tsertos F, Danias PG 7

ΜΠΑΚΟΓΙΑΝΝΗΣ Χ. Paclitaxel and gemcitabine versus carboplatin and gemcitabine in patients with advanced non-small-cell lung cancer. A phase III study of the Hellenic Cooperative Oncology Group Ann Oncol. 2008 Jan;19;(1):115-22, Kosmidis P, Kalofonos HP, Christodoulou C, Syrigos K, Makatsoris T, Skarlos D, Bakogiannis C, Nikolaides C, Bafaloukos D, Bamias A, Samantas E, Xiros N, Boukovinas I, Fountzilas G, Dimopoulos M HLA Class II alleles and the presence of circulating Epstein-Barr virus DNA Greek patients with nasopharyngeal carcinoma Strahlether Oncol. 2008 Jun;184(6):325-31, Karanikiotis C, Daniilidis M, Karyotis N, Bakogiannis C, Econopoulos T, Murray S, Papamichael D, Samantas E, Nikolaou A, Skoura L, Tselis N, Zamboglou N, Fountzilas G ΠΑΝΟΣ A. Reply to the Editor Ann Thorac Surg. 2008;86:1399-1400, Panos A Pseudoaneurysm of the anterior tibial artery following an ankle sprain: a case report of an uncommon ankle trauma with review of the literature Foot Ankle Surg. 2008;14(1):40-2, Christofilopoulos P, Panos A, Masterson K, Abrassart S, Assal M Novel technique for aortic arch surgery under mild hypothermia Ann Thorac Surg. 2008 Jan;85(1):347-8, Panos A, Myers PO, Kalangos A Primary repair of infracardiac total anomalous pulmonary venous connection using a modified sutureless technique Ann Thorac Surg. 2008 Jul;86(1):320-2, Buitrago E, Panos A, Ricci M Modified Cabrol shunt after complex aortic surgery Ann Thorac Surg. 2008 Aug;86(2):669-70, Salerno TA, Carvalho EM, Panos A, Ricci M ΠΑΠΑΔΑΚΗΣ Ε. p53 Arg 72 Homozygosity and its Increased Incidence in Left-sided Sporadic Colorectal Adenocarcinomas, in a Greek-Caucasian population Anticancer Research 2008 (28), Dakouras A, Nikiteas N, Papadakis E, Perakis E, Valis D, Rallis G, Tzanakis N, Peros G, Tsigkris C, Kittas C, Karakitsos P ΠΑΠΑΔΟΠΟΥΛΟΣ Σ. Results and complications in 409 patients Journal of Medical Imaging and Radiation Oncology 2008;52:458-462, Laspas F, Roussakis A, Efthimiadou R, Papaioannou D, Papadopoulos S, Andreou J ΠΑΠΑΙΩΑΝΝΟΥ Ι. Results and complications in 409 patients Journal of Medical Imaging and Radiation Oncology 2008;52:458-462, Laspas F, Roussakis A, Efthimiadou R, Papaioannou D, Papadopoulos S, Andreou J 8

doctors reviews_σχέδιο 1 07/05/2010 11:32 Page 9 ΠΕΡΔΙΚΗ Μ. Mutinous Changes in melanocytic nevi and review of the literature Am J Dermathopathol 2008 Jun; 30(3):236-40, Perdiki M, Bhawan J ΠΙΠΙΛΗΣ Α. Cardiac magnetic resonance detection and typical appearance of microvascular obstruction following myocardial infarction Hellenic J Cardiol. 2008 (in press), Karatzis EN, Pipilis AG, Malios K, Andreou J, Roussakis A, Tsertos F, Danias PG ΡΑΖΗ Ε. Potential value of PTEN in predicting cetuximab response in colorectal cancer. An exploratory study BMC Cancer 2008 Aug 13; 8:234, Razis E, Briasoulis E, Vrettou E, Skarlos DV, Papamichael D, Kostopoulos I, Samantas E, Xanthakis I, Bobos M, Galanidi E, Bai M, Gikonti I, Koukouma A, Kafiri G, Papakostas P, Kalogeras KT, Kosmidis P, Fountzilas G Greek BRCA1 and BRCA2 mutation spectrum: Two BRCA1 mutations account for half the carriers found among high-risk breast/ovarian cancer patients Breast Cancer Res Treat 107:431-441, 2008, Konstantopoulou I, Rampias T, Ladopoulou A, Koutsodontis G, Armaou S, Anagnostopoulos T, Nikolopoulos G, Kamakari S, Nounesis G, Stylianakis A, Karanikiotis C, Razis E, Gogas H, Keramopoulos A, Gaki V, Markopoulos C, Skarlos D, Pandis N, Bei T, Arzimanoglou I, Fountzilas G, Yannoukakos D Quantitative Measurement of Imatinib (Gleevec) in Human Glioblastoma Biopsies Using Liquid Chromatography-Tandem Mass Spectrometry J of Chromatography B. Submitted, Norris J, Kalebic T, Razis Ε, Selviaridis P, Karanastasi S, Labropoulos S, Fountzilas G Differential EGFR and VEGFR mrna expression in two subtypes of basal-like breast cancer identified by molecular Classification J. Clin. Oncol. 2008, Papadimitriou C, Wirtz R, Economopoulos T, Samantas E, Papakostas P, Gogas H, Razis E, Lianos E, Aravantinos G, Fountzilas G; (HECOG) Evaluation of the Prognostic and Predictive Value of HER Family mrna Expression in High-Risk Early Breast Cancer British Journal of Cancer, Koutras A, Kalogeras K, Dimopoulos M-A, Wirtz R, Dafni U, Briasoulis E, Pectasides D, Gogas H, Christodoulou C, Aravantinos G, Zografos G, Timotheadou E, Papakostas P, Linardou H, Razis E, Economopoulos T, Kalofonos H, Fountzilas G Trastuzumab Combined with Pegylated Liposomal Doxorubicin in Patients with Metastatic Breast Cancer. A Phase II Study of the Hellenic Cooperativ Oncology Group (HeCOG) with Biomarker Evaluation Submitted, Christodoulou C, Kostopoulos I, Kalofonos H, Lianos E, Bobos M, Briasoulis E, Gogas H, Razis E, Skarlos D, Fountzilas G ΡΟΥΣΑΚΗΣ Α. Results and complications in 409 patients Journal of Medical Imaging and Radiation Oncology 2008;52:458-462, Laspas F, Roussakis A, Efthimiadou R, Papaioannou D, Papadopoulos S, Andreou J 9

ΣΚΟΛΑΡΙΚΟΣ Α. Greenlight laser in benign prostatic hyperplasia: turning green into gold Curr Opin Urol. 2008 Jan;18(1):46-9, Alivizatos G, Skolarikos A Prognostic and predictive factors in patients with androgen-independent prostate cancer treated with docetaxel and estramustine: a single institution experience Eur Urol. 2008 Feb;53(2):323-31, Bamias A, Bozas G, Antoniou N, Poulias I, Katsifotis H, Skolarikos A, Mitropoulos D, Alamanis C, Alivizatos G, Deliveliotis H, Dimopoulos MA Should holmium laser enucleation be the new gold standard for bladder outlet obstruction caused by BPΗ? Eur Urol. 2008 Jul;5(7):358-9, Alivizatos G, Skolarikos A Transurethral Photoselective Vaporization versus Transvesical Open Enucleation for Prostatic Adenomas>80ml: 12-mo Results of a Randomized Prospective Study Eur Urol. 2008 Aug;54(2):427-37, Alivizatos G, Skolarikos A, Chalikopoulos D, Papachristou C, Sopilidis O, Dellis A, Kastriotis I, Deliveliotis C Photoselective vaporization of the prostate to manage benign prostatic hyperplasia J Endourol. 2008 Sep;22(9):2117-9, Alivizatos G, Skolarikos A Eighteen-month results of a randomized prospective study comparing transurethral photoselective vaporization with transvesical open enucleation for prostatic adenomas greater than 80 cc. J Endourol. 2008 Oct;22(10):2333-40, Skolarikos A, Papachristou C, Athanasiadis G, Chalikopoulos D, Deliveliotis C, Alivizatos G Postradical cystectomy bowel perforation by a drainage tube: a case report Cases J. 2008 Nov 25;1(1):350, Chatzidarellis EP, Skolarikos A, Mazaris E, Mitsogiannis I, Alivizatos G ΣΟΠΙΛΙΔΗΣ Ο. Transurethral Photoselective Vaporization versus Transvesical Open Enucleation for Prostatic Adenomas>80ml: 12-mo Results of a Randomized Prospective Study Eur Urol. 2008 Aug;54(2):427-37, Alivizatos G, Skolarikos A, Chalikopoulos D, Papachristou C, Sopilidis O, Dellis A, Kastriotis I, Deliveliotis C ΤΑΡΑΟΥΝΕ Ι. Evaluation of continuous use of Real Time Glucose Monitoring (PRT), alone and combined with Insulin Pump Therapy, as a mean to normalize Glycaemic Control in IDDM Diabetes June 2008;57(1), Zoupas CS, Kepaptsoglou O, Taraoune I, = Giannakopoulos F, Garoutsou P, Barreto C, Vasilopoulos H, Kefaloyannis N, Kyrlaki E, Pappas A 10 One year continuous use of Real Time Glucose Monitoring combined with Insulin Pump, as a mean to normalize Glucose Variability and HbA1c in IDDM Diabetologia Sept. 2008;51(1), Zoupas CS, Kepaptsoglou O, Kefaloyannis N, Taraoune I, = Giannakopoulos F, Sfakianaki M, Garoutsou P, Vasilopoulos H, Kyrlaki E, Pappas A

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