Research of postpartum depression and progesterone estradiol change before and after childbirth

E 2 P 2012 3-2012 9 395 EPDS ELISA 2 P 5 - HT 1 48 12. 15% 2 P < 0. 05 3 EPDS 5 - HT r = - 0. 881 ~ 0. 920 P < 0. 01 E 2 P 5-5 - HT R749. 4 A doi 10. 3969 /j. issn. 1007-3256. 2014. 05. 001 Research of postpartum depression and progesterone estradiol change before and after childbirth CHEN Jing 1 XIA Guang - yuan 1 TANG Wen - quan 2 WEI Hua 3 ZOU Tao 1 1 Psychological Department of Affiliated Hospital of Guiyang Medical College Guiyang 550004 China 2 Neurology Department of central Hospital of Yunyang County Chongqing 404500 China 3 Henan Nursing Vocational College Anyang 455000 China Abstract Objective To explore the impact of serum estradiol E 2 progesterone P on the postpartum depression about a week before and after childbirth. Methods Selection 395 cases of maternal who saw a doctor in guiyang medical college affiliated hospital as the research object in March 2012 - September 2012 using the Edinburgh postnatal depression scale EPDS to assess the postpartum depression and uses the biotin method of double antibody sandwich enzyme - linked immunosorbent ELISA determination of maternal serum estradiol E 2 progesterone P serotonin 5 - HT level. Results 1Depression detected the number of 48 cases detection rate of 12. 15% a week after childbirth. 2Female serum progesterone level difference after childbirth between depression with and without depression group was statistically significant P < 0. 05. 3The correlation analysis showed that the postpartum EPDS scores and prenatal serum estradiol level prenatal postpartum serum progesterone level and postnatal progesterone estradiol declines were positively correlated and negatively correlated with postpartum 5 - HT estradiol levels r = - 0. 881 ~ 0. 881 P < 0. 01. 3 1 5 20 10 8 385

http / /www. psychjm. net. cn 2014 27 5 Conclusion Maternal serum progesterone estradiol level declined obviously after delivery female progesterone and estradiol dramatic drops were important biological factors on postpartum depression. Key words Estradiol E 2 Progesterone P Serotonin 5 - HT Postpartum depression PPD EPDS l3 EPDS < 13 α 0. 76 1. 3 4ml - 80 1 ELISA 2 E 2 P 5 - HT 1. 4 SPSS18. 0 3 5 - hydroxytryptamine Excel2003 4-5 - HT 5 t Pearson 5 - HT 6-7 α = 0. 05 5 - HT 2 2. 1 3 395 E 2 P 5 - HT 48 12. 15% 2. 2 E 2 2. 2. 1 E 2 1 E 2 30162. 23 ± 2515. 51 pg /m1 29027. 57 ± 1724. 81 pg 1. 1 2012 3-2012 /ml P 9 < 0. 05 E 395 2 844. 35 ± 992. 26 pg /ml 990. 63 ± 1038. 16 pg /ml 1 2 P > 0. 05 3 E 3 2 29317. 88 ± 2942. 96 pg /ml 28036. 94 ± 1927. 52 pg /ml Edinburgh Postnatal Depression Scale EPDS P < 0. 05 1 1 13 1 1 E 2 3 2 x ± s pg /ml EPSD < 13 48 E 2 E 2 E 2 30162. 23 ± 2515. 51 844. 35 ± 992. 26 29317. 88 ± 2942. 96 347 45 29027. 57 ± 1724. 81 990. 63 ± 1038. 16 28036. 94 ± 1927. 52 1 1 t 2. 50-0. 68 2. 44 P 0. 014 0. 496 0. 017 1. 2 EPDS Cox 2 l0 4 0 ~ 3 0 ~ 30 2009 2323 550004 E - mail zoutaozou@ tom. com 1 E 2 386

48h 72h k E 2 E 2 8 2. 2 P F a - F b P 303. 45 ± 40. 39 nmol /L 261. 88 ± k E 2 = a - b 57. 01 nmol /L P < 0. 05 3 844. 35-30162. 23 = - 244. 32 P 48. 99 ± 19. 25 nmol /L - 48-72 48h 72h 3 P 254. 45 ± = 990. 63-29027. 57-233. 64-48 - 72 k E 2 < k E 2 < 0 E 2 35. 78 ± 18. 99 nmol /L P < 0. 05 k E 2 26. 86 nmol /L 226. 12 ± 40. 67nmol /L f a - f b k E 2 = P < 0. 05 2 2 a - b 2 2 P P x ± s nmol /L P P 303. 45 ± 40. 39 48. 99 ± 19. 25 254. 45 ± 26. 86 261. 88 ± 57. 01 35. 78 ± 18. 99 226. 12 ± 40. 67 t 3. 99 3. 28 3. 90 P 0. 000 0. 001 0. 000 P x ± s nmol /L 72h 48h k P 2. 3 EPDS k P = F a - F b 303. 45-48. 99 = - 2. 12 a - b - 48-72 5 - HT r = - 48h 72h 3 k P f a - f b 261. 88-35. 78 = - 1. 88 a - b - 48-72 k P = k P < k P < 0 P P 2. 2. 3 5 - HT 5 - HT 12. 47 ± 7. 03 ng /ml 17. 02 ± 7. 77 ng /ml t = - 2. 92 P = 0. 004 0. 881 ~ 0. 920 P < 0. 01 3 EPDS 5 - HT r 5 - HT E 2 E 2 E 2 P 5 - HT - 0. 560 a - - - - - - E 2 0. 406 a - 0. 621 a - - - - - E 2-0. 188 0. 356 a - 0. 130 - - - - E 2 0. 427 a - 0. 680 a 0. 920 a - 0. 509 a - - - P 0. 601 a - 0. 881 a 0. 636 a - 0. 193 0. 629 a - - P 0. 546 a - 0. 822 a 0. 728 a - 0. 159 0. 695 a 0. 873 a - P 0. 568 a - 0. 822 a 0. 520 a - 0. 191 0. 527 a 0. 964 a 0. 713 a a P < 0. 01 P 2. 4 31. 4% 78. 8% 5 387

http / /www. psychjm. net. cn 2014 27 5 5 E 2 P 5 - HT R 2 F P B Beta t p 0. 314 40. 290 0. 000 0. 015 0. 041-6. 347 0. 000 0. 010-0. 029-0. 300 0. 765 0. 060 0. 262 1. 707 0. 091 5-0. 788 51. 500 0. 000 0. 002 0. 000 4. 100 0. 000-0. 184 0. 033-5. 643 0. 000 15 3 EPDS 395 48 5 - HT 347 12. 15% 5 - HT 11. 0% ~ 35. 0% 5-5 - HIAA 3. 5% ~ 33% 9-10 16-5 - HT 17 5-5 - HT 18 5-5 - HT 17-5 - HT 18 5 - HT 5 - HT mrna 11-13 5 - HT 19 5 - HT P < 0. 05 16 13 EPDS 5 - HT 5 - HT 12-13 E 2 5 - HT 1 5 - HT 2 GABA - 5 - HT 16 5 - HT 14 GABA γ - - HPG - 20 P < 0. 05 21 EPDS - - HP- 388

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