* 541004 R285. 5 A 1005-9903 2011 01-0198-05 Progress on Chemical Constituents Pharmacological Effects and Clinical Applications from Broussonetia papyrifera ZHU Kai-mei LIU Jian-nan GU Sheng-jiu * ZHAO Lei College of Pharmacy Guilin Medical Univercity Guilin 541004 China Abstract Broussonetia papyrifera distributes many place in china the resource are very rich. With the development of science scholars more concerned about the development and use of the broussonetia. Found not just good pulp materials keeping materials also has very important clinical value of medicinal. To object described chemical constituents the clinical application of pharmacology research are for broussonetia of Chinese herbal medicines as a valuable reference for research and development. Key words Broussonetia papyritera chemical constituents pharmacological clinical Broussonetia papyrifera L1 vent Moreceae 1 Broussonetia 2 20 m 5 3 3-4 20100919 001 1 09321056 0815005-1-17 20090106-6 20080103-5 E-mail 5 glzkm@ 163. com Sephadex LH-20 * E- mail gushengjiu@ 163. com 8 apigenin 1 198
cosmosiin 2 vitexin 3 PTB-1B luteolin 4-7-O-β-D- luteolin-7-o-β-dglucopyranoside 5 7-7-methoxycoumarin 6 scopoletin 7 1-hentriacontanol 8 Lee 6 40 3 uralenol 4 oussochalcone A 5 7 ODS Sephadex LH-20 2. 2 5 1 quercetin 2 13 dihydroquercetin 3 butei-4-methyl ester 4 14 liquiritigenin 5 peroxide 2 D- D-galacitol 3 sulfuretin 4 liriodendrin 5 graveolone 6 8 9 2. 3 15 95% 10 Sephadex LH-20 kazinol B 7 16 4 -dihydroxy-3 -prenyflavan 3-3-methylbut-2-enyl -3 4 - trihydroxyflavane 4 6 6 ESI- MS NMR 2 S -7 3-8 d dihydroxy-4 -methoxyflavan 1 ergosterol 10 2. 68 ~ 6. 67 10-2 g ml - 1 75% 2 8-1 1-dimethylallyl -5-3-methylbut-2-3 4 5 7-pentahy droxyflavone oussochalcone A 5 3 uralenol 4 8-1 1- dimethylallyl -5-3-methylbut-2-enyl -3 4 5 7- tetrahydroxyflanvonol 1 3 3 4 5 7-pentahydroxyflavone 11 kazinol B 7 4 -dihydroxy-3 -prenyflavan 3-3- - methylbut-2-enyl -3 4 -trihydroxyflavane 43 37 25. 67% 14. 55% 11. 31% 6 10- -2-10. 96% 2 2. 1 PTB-1B PTB-1B 2006 Neel PTB-1B OH PTB-1B DPPH Fe 3 + PEPCK 6 22 75% G-6-P PTB-1B FBH FBH H 2 O 2 PTB-1B AMPK 12 enyl -3 4 5 7-tetrahy droxyflanvonol 1 3-3-methylbut-2- enyl -3 4 7- trihy droxyflavane 2 3 3 PTP-1B 10 5 17-19 9 2. 4 20 21 80% Fe 3 + 23 199
TFBP UVA TFBP 96 UVA MDA 3 SOD GSH-Px 24 1 kg 273 mg 25 D- 2. 8 31 BPAE BPF BPAE SOD GSH-Px BPF BPF NO MDA BPAE CaCl 2 2 3 BPAE BPF 2. 5 BPF 2 26 Lin Chun-nan 27 2. 9 32 6 0. 5 h 3 1 g ml - 1 brousochalcone A broussoaruone A kazinol A broussflavonol F 3 brousochalconea 2. 6 28 5 3 3. 1 33 MTT 2 2 10 μg L - 1 80% 76. 67% 50 μg L - 1 MTT 20% 30% 100 μg L - 1 2 50% 60% 5 3. 2 34 136 LPO SOD TC TG HDL 3 1 g ml - 1 60 d Dongho lee LPO SOD broussonina 5 7 2 4 - tetrahydroxy-3- TC TG geranylflavone isogemichacone 3 - γ- hydroxymethyl - E -γmethylally -2 4 2 4 -tet rahydroxychalcone -11 -O-coumarate HDL HDL SOD 2S -2 4 -dihydroxy-2-1-hydroxy-1-methyllethyl dihydrofuro CaCl 2 CaCl 2 LPO TC TG 2 3-H flavanone demethyl moracin 6 3. 3 35 e HBV-DNA NF-κB 29 2. 7 30-3. 4 36-38 200
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