13 4 2000 11 Journal of Iso topes V o l. 13N o. 4 N ov. 2000 (, 100034) :,,, : ; ; ; : R 817 : A : 100027512 (2000) 0420227208 X2CT [ 1 M R I ],, PET SPECT,,, ( ) ( ), ; ; 1 100 L angley,,, 52 [ 2 (BZ) ] (1) : 1979 Eckelm an [ 3 ], Com ar [ 4 ] 11 C ( 11 C2F lun itrazepam ), (2) : 1982, : 2000207210; : 2000209227 : (1956), ( ),,,
228 13 1983 W agner [ 5 ] 11 C2N 2m ethyl2sp iperone ( 11 C 2N 2 2, 11 C2NM SP) D 2 PET, (PD ) (EP) [ 69 ] [ 10 (3) : 1996 ] 99 T c m (DA T ) 99 T c m 2TRODA T 21, (DA ), 1996, (RRA ) (RA ) 20, (ECT ) PET, M R I X2CT PET,,,,,, ; PET ; PET,,, SPECT ; PET, [ 11 ], 1 1 123 I2IL IS, 123 I2IBZM, 123 I2Β2C IT, 99 T c m 2TRODA T 21 18 F2dopa, 11 C2NM SP, 11 C2raclop ride, 11 C2d 2th reo2m P, 11 C2Β2C IT 123 I2IQNB 11 C2nico tine, 11 C2QNB 123 I2iom azenil 11 C2flum azenil 52 123 I222ketanserin, 123 I2Β2C IT 76 B r222ketanserin, 11 C2Β2C IT 123 I2mo rph ine, 123 I2o2IA 2D PN, 131 I2D PN 11 C2D PN, 11 C2CFN 2 ( 500 ) (SPECT, SPECT gpet, PET ), 1998 100
4 : 229 5 %, 21 20 %, 21, FDA 18 F2dopa, 11 C2NM SP 11 C2raclop ride ( ),, 19891992 018 ( 2Α2 ), Χ2 gbz, 3 H 2018 BZ, BZ 131 [ 12, 13 I2018 ] [ 14, 15 ] D 1 125 I2IBZP, 131 I2IBZP SPECT D 1, 60 m in 120 m in 4. 23 3. 45 % ID g - 1 [ 16 ] 131 I2IBZM M PT P (PD ) SPECT PD D 2, PD D 2, PD PD PD [ 17 ] 42 2N 2(12 2 22 ) 252222 ( 125 I2A IBZM ), 125 I2A IBZM, 125 I2A IBZM D 2 [ 18, ] 125 I2IBZM Scatchard K d= 0. 53 0. 06 nm o lgl, B m ax= 466. 4545. 88 fm o lgl IBZM D 2 (7Α2o2IA 2D PN ), (K i= 410-4 Λm o lg L ) M u sach io L ever T afan i [ 1922 SPECT ] 123 I2 [ 23 ] [ 24 C IT DA T, PD ] 123 I2iom azen il [ 25, M R I ] PD D 2, PD [ 26 DA, PD D 2 ] 99 T c m 2 TRODA T 21, 120 m in 4. 45 2. 57 3. 40 % ID g - 1 1982 8 1999 4, PET, 10, 70, 4, SC I 3, 51, 13, 15 10 3 2
230 13 2 52 D 1, D 2 DA T ( ) M ( ) N ( ) GABA PBZ NM DA 52H T 1 A, B, C, 52H T 2, 3 52H T T (52 ) Λ,, ϑ PD, HD ( ) PD, PD, EP ( ) EP, g PD EP,,, 311, D 2 PD PD HD PD,,,,,, (PD ) PD, ( ) PD, X2CT M R I, D 2 18 F 11 C2NM SP 11 C2 raclop ride D 2 PD ( )D 2,, HD ( ) D 2, L 2, PD g PET 11 C2 NM SP D 2, IBZM SPECT D 2, PD D 2, PD, PD, [ 9, 27 D 2 ] D 2 PD ( IBZM ) PD ( ),, [ 28 PD PD ] 123 I2 IBZM SPECT,,,, [ 29 ] D 2, D 2, D 2, D 2
4 : 231 DA T, 99 T c m 2TRODA T 21 Β2C IT DA T DA T, PDL aih inen 9 PD 3 11 C2Β2C IT, PD 11 C2Β2C IT, 11 C2Β2C IT Seibyl 15 PD 12 123 I2Β2C IT SPECT DA T, PD 55 %, 15 PD 14 PD,, 15 PD 1 NDR ( ), 123 I2Β2C IT SPECT DA T PD PD, [ 30, 31 ] DA T,, 99 T c m 2TRODA T 2 1 11 C2d 2th reo2m ethylphen idate ( 11 C2d 2 2, 11 C2d 2th reo2m P) 11 C2 123 I2Β2C IT DA T (K i= 0. 39 nm o lgl ) DA T [ 3234 PD ],,, [ 33 DA T m RNA ], DA T PD 312 11 C 123 I2QNB 11 C2n ico tin (AD ), M 2, 11 C2 n ico tin,, AD [ 3537 ] 313 EP, [ 24, M R I ] 123 I2iom azen ily, [ 38 EP ] 3145-52 g, 123 I222ketan serin 123 I2Β2C IT SPECT 52, C italop ram [ 39 52 ] 315 [ 40,, ] PET g 11 C2D PN 11 C2carfen tan il SEPCT g 123 I2D PN 123 I2o2IA 2D PN [ 41, 42, EP ] [ 43 ] PET 11 C2carfen tan il M ethadon (, 1018 nggd) M ethadon, M ethadon
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