72 Chin J Gastroenterol2015Vol. 20No. 2 * # 230000 20 UC UC UC 1 1 103 UC 103 UC NSAIDs P < 0. 05 Logistic NSAIDs UC P < 0. 05 UC P < 0. 05 UC NSAIDs UC Study on Hygiene Hypothesis and Other Related Factors of Ulcerative Colitis YUAN ShaWANG QiaominSONG JizhongWU ZhengxiangXIE LiL ChaolanWANG Chao. Department of GastroenterologyAnhui Provincial Hospital Affiliated to Anhui Medical UniversityHefei 230000 Correspondence to WANG QiaominEmail wqmin928@ 163. com Background The incidence of ulcerative colitis UC is increasing over the past two decades in China. Environmental factorssuch as childhood hygiene and dietary factors were found to be implicated in the etiology of UC in recent studies. Aims To investigate the possible pathogenic factors of UC. Methods A hospital-based case-control study matched 1 1 on gender and age was carried out in Anhui Provincial Hospital. A total of 103 UC cases and 103 control subjects were recruited to fulfill a questionnaire survey. Information on childhood hygienebreastfeedingpassive smoking daily diet prior to UCpast medical history and other related factors were collected. Univariate and multivariate analysis were performed to screen the factors related with UC. Results In univariate analysisnumber of siblings in the family childhood life including contacting animalsdrinking raw waterand consumption of unwashed fruits /vegetablesdaily dietary factors including consumption of whole grainssweets and fried foodeating habitsand use of non-steroidal antiinflammatory drugs NSAIDs and antibiotics were significantly different between UC group and control group P < 0. 05. Multivariate conditional Logistic regression analysis revealed that frequent consumption of fried food in daily life and frequent use of NSAIDs and antibiotics were risk factors for UC P < 0. 05 whereas frequent consumption of unwashed fruits / vegetables in childhood and frequent consumption of whole grains in daily life were protective factors for UC P < 0. 05. Conclusions Highly hygienic living conditions in childhood may increase the risk of UC. Fewer fried foodsuitable whole grains and fair use of NSAIDs and antibiotics might protect against the occurrence of UC. Key words ColitisUlcerative Risk Factors Hygiene Hypothesis Environmental Factors Case-Control Studies ulcerative colitisuc DOI 10. 3969 /j. issn. 1008-7125. 2015. 02. 002 * Email 506564135@ qq. com # Email wqmin928@ 163. com Crohn s diseasecd inflammatory bowel disease IBD UC 20
2015 20 2 73 UC / / / / UC /3 ~ 4 // 2 < 100 g /250 g / > 500 g 3 UC 2 /3 ~ 6 / 7 4 IBD / / 3 / 1 5 6 / UC 3 ~ 4 // 7 UC / 8 / / UC 1 1 103 // 瑏瑤 /< 2 // 2013 2 16 2014 5 30 2 // UC 4. 1 2012 1 2 IBD 1 103 UC 2 3 3 4 5 / / 6 9 10 UC 1. 1 2 3 2. 12 1 / 2 3 135 103 4 < 20 m 2 /20 ~ 40 m 2 / > 40 m 2 5 508 103 6 7 8 9 10 瑏瑡 / / 瑏瑢 SPSS 19. 0 瑏瑣 / / 瑏瑤 / χ 2 / 瑏瑥 3 / > 3 / 瑏瑦 9 / / 10 / / 3 / 1 瑏瑡 / / 瑏瑢 /< 10 // 10 // 瑏瑣 /< 2 // 2 7 8 UC 76. 3% 750 t Wilcoxon P < 0. 05 3. 1 / Logistic P < 0. 05
74 Chin J Gastroenterol2015Vol. 20No. 2 OR 95% CI Logistic = 2 Cox = 1 = 2 = 1 = 2 = 0 = 1 = 0 = 1 = 2 / = 3 / = 4 = 5 = 1 = 2 62 41 18 ~ 75 < 20 m 2 = 1 20 ~ 40 m 2 = 2> 40 m 2 = 3 / 1 = 1 2 = 2 3 = 3> 3 = 4 73. 14 1 1 = 0 = 1 = 2 3 = 1> 3 = 2 = 3 = 1 3 ~ 4 /= 2 = 3 < 100 g = 1 250 g = 2> 500 g = 3 2 = 1 3 ~ 6 = 2 7 = 3 = 0 3 ~ 4 /= 1 = 2 = 1 = 2 = 3 = 0 = 1 P < 0. 05 = 2 = 0 = 1 = 2 / / = 0 = 1 = 2 = 3 / = 0= 1 P < 0. 05 / / = 0 = 1 44. 17 ± 12. 49 1 ~ 30 53. 34 ± 44. 42 ± 12. 54 P = 0. 885 NSAIDs 1 1 UC n = 103 n = 103 P / 62 /41 62 /41 χ 2 = 0. 000 1. 000 x 珋 ± s 44. 17 ± 12. 49 44. 42 ± 12. 54 t = 0. 580 0. 564 / 7 /96 10 /93 χ 2 = 0. 577 0. 447 * 9 /10 /42 /21 /19 /2 2 /10 /44 /14 /30 /3 Z = - 1. 611 0. 107 / 81 /22 88 /15 χ 2 = 1. 614 0. 204 30 /28 /34 /7 /4 /0 25 /33 /27 /13 /4 /1 Z = - 0. 718 0. 473 49 /29 /23 /1 /1 /0 50 /27 /20 /4 /2 /0 Z = - 0. 091 0. 928 / 66 /37 68 /35 χ 2 = 0. 085 0. 770 < 20 m 2 /20 ~ 40 m 2 / > 40 m 2 38 /39 /26 57 /19 /27 Z = - 1. 759 0. 079 1 /2 /3 / > 3 5 /34 /18 /46 4 /13 /33 /53 Z = - 2. 053 0. 040 1 /2 /3 / > 3 29 /39 /18 /17 29 /32 /22 /20 Z = - 0. 613 0. 540 / 19 /84 23 /80 χ 2 = 0. 479 0. 489 / 14 /89 11 /92 χ 2 = 0. 410 0. 522 / 95 /8 91 /12 χ 2 = 0. 886 0. 347 / 29 /74 23 /80 χ 2 = 0. 926 0. 336 / 65 /38 45 /58 χ 2 = 7. 803 0. 005 / / 12 /57 /34 8 /44 /51 Z = - 2. 366 0. 018 / 53 /50 43 /60 χ 2 = 1. 951 0. 163 / / 5 /80 /18 19 /67 /17 Z = - 1. 896 0. 058 / / 27 /63 /13 18 /53 /32 Z = - 2. 944 0. 003 3 / > 3 / 8 /46 /49 15 /29 /59 Z = - 0. 745 0. 457 / 31 /72 29 /74 χ 2 = 0. 094 0. 759 /3 ~ 4 // 73 /19 /11 44 /35 /24 Z = - 4. 011 0. 000
2015 20 2 75 1 n = 103 n = 103 P < 100 g /250 g / > 500 g 38 /60 /5 31 /58 /14 Z = - 1. 689 0. 091 2 /3 ~ 6 / 7 77 /20 /6 72 /25 /6 Z = - 0. 725 0. 468 / / 1 /76 /26 6 /80 /17 Z = - 2. 041 0. 041 / 66 /37 69 /34 χ 2 = 0. 193 0. 660 /3 ~ 4 // 84 /10 /9 90 /10 /3 Z = - 1. 259 0. 208 / 11 /68 /24 3 /77 /23 Z = - 0. 790 0. 430 / / 8 /55 /40 9 /50 /44 Z = - 0. 414 0. 679 / / 5 /70 /28 15 /79 /9 Z = - 3. 893 0. 000 / / 9 /50 /44 7 /53 /43 Z = - 0. 031 0. 975 / / 14 /51 /38 13 /76 /14 Z = - 2. 800 0. 005 / / / 59 /15 /17 /12 61 /12 /25 /5 Z = - 0. 419 0. 675 / / / 42 /29 /29 /3 42 /33 /26 /2 Z = - 0. 328 0. 743 / / / 24 /40 /39 /0 17 /48 /38 /0 Z = - 0. 465 0. 642 / 55 /48 46 /57 χ 2 = 1. 573 0. 210 / 98 /5 92 /11 χ 2 = 2. 439 0. 118 / 97 /6 100 /3 χ 2 = 0. 465 0. 495 NSAIDs / 83 /20 93 /10 χ 2 = 3. 902 0. 048 / 101 /2 96 /7 χ 2 = 1. 859 0. 173 / 103 /0 101 /2 χ 2 = 0. 505 0. 477 / 75 /28 94 /9 χ 2 = 11. 893 0. 001 * / / / / / 10 Logistic NSAIDs UC 5 UC UC 2 NSAIDs 2 UC Logistic B S. E. Wald P OR 95% CI - 0. 723 0. 270 7. 146 0. 008 0. 485 0. 286 ~ 0. 825 - - - 0. 085 - - - - - 0. 128 - - - - - 0. 148 - - - 0. 609 0. 281 4. 697 0. 030 0. 544 0. 314 ~ 0. 943 1. 672 0. 467 12. 809 0. 000 5. 325 2. 131 ~ 13. 306 - - - 0. 217 - - - - - 0. 127 - - NSAIDs 1. 230 0. 524 5. 519 0. 019 3. 422 1. 226 ~ 9. 552 1. 512 0. 484 9. 761 0. 002 4. 537 1. 757 ~ 11. 714
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