Chin J Pharm Anal 2013 336 907 * 201203 ICP - AES R917 A 0254-1793201306 - 0907-08 Current situation of the application of ICP - AES for the pharmaceutical analysis in China CHEN Yang JIN Wei YANG Yong - jian * Shanghai Institute for Food and Drug Control Shanghai 201203 China AbstractInductively coupled plasma - atomic emission spectrometryicp - AESis a common method for element analysis with many advantages such as low detection limit high accuracy wide dynamic linear range and simultaneous determination of multiple elements etc which has great application potential in pharmaceutical analysis fields. This paper reviews the application situation of ICP - AES in the domestic pharmaceutical analysis mainly including heavy metals in Chinese herbal medicine and Chinese patent medicine elemental impurities in chemical medicine assay of major elements determination of non - metal elements biochemical samples drug metabolism and pharmacokinetics etc and describes the prospect of the development of this technique. Key wordsicp - AESpharmaceutical analysisapplication situationoverviewheavy metal determinationbiochemical samples analysismetal foreign matternonmetals elementpharmacokinetics ICP - AES 2 20 70 ICP - AES ICP - MS 1-4 ICP - AES ICP ICP - AES 1ICP 70 2 3 4 4 ~ 5 5 CCD CID 1 * Tel 02138839900E - mailyongjianyang@ 163. com
908 Chin J Pharm Anal 2013 336 2 ICP - AES As Cd Cu Fe 8 12 ICP - AES 20 Fe Mn Cu Zn 2000 Ni As Cd Pb ICP - AES Fe Pb Cd As 1 Pb As Cd 4 Hg 5 5 Cd 14 6 2001 15 Cd 5 Pb 2 0. 3 mg kg - 1 20 mg kg - 1 2. 0 mg kg - 1 5. 0 mg kg - 1 2005 Pb Cd 0. 1% 2 Cd 6 ICP - MS ICP - AES 7 ICP - AES 18 ICP - AES 5 Cd Hg Pb 3 Zn 8 Cu Cd Pb As 9 Pb Ca Fe Zn Se 13 11 13 ICP - AES Cu Pb 16 17 Cd Pb Cd Cu Mn Ni Pb 10 ICP - AES Pb Cd
Chin J Pharm Anal 2013 336 909 19 As Ba Cd Cr Cu Pb 6 - Cu Pb As Cd Hg 5 30 ICP - AES 85% 20 K Ca Cu Na Mg Mn Fe Zn Pb Cd 10 2 21 ICP - AES 25 Pb Cu Cd Cr ICP - AES 2 2008 ICP - AES 22 ICP - AES 31 < 232 > 4 ICP - AES Pb Cd Cu 32 Q3D 33 ICP - AES ICP - AES 23 34 Al Mn Ni 3 ICP - AES 15 35 ICP - AES 24-25 HNO 3 - HClO 4-13 Ca Cu Zn Fe Mg Mn Pb 15 ICP - AES Cu Pb Zn As Sb Cd 26-27 Hg Au Cu Pb 4 28 2 Pb Cr Cd As 4-1 5 1 1 Ag Pd Cd HCl - HNO 3 29 36-37 Cu Al Pb 3 38 ICP - AES
910 Chin J Pharm Anal 2013 336 39 - / ICP - AES 19 2 ICP - AES ICP - MS ICP - AES ICP - AES 40 ICP - AES 47 Pb As ICP - AES Hg 41 14 3 ICP - AES ICP - AES H C N O F Cl 42 ICP - AES ICP - AES Mg Ca Cu Fe Mn K Zn Cr P Mo 10 44 ICP - AES 51 - Si 100. 2% 52 ICP - AES I 45 Ag ICP - AES 328. 068 nm I - I 2 46 ICP - MS ICP - AES 4 48 ICP - AES 2 2 ICP - AES 43 ICP - AES 49 ICP - AES B Mg Al 500 700 B ICP - AES 0. 0032 mg L - 1 B 50 B I 2 0. 4 μg g - 1
Chin J Pharm Anal 2013 336 911 5 2 ICP - AES 53-100. 9 ± 16. 2% D ICP - AES 59 ICP - AES 54 Pb Cr Cd As Hg 5 - - - - 3 98. 0% ~ 103. 0% RSD 0. 5% ~ 1. 6% 6 - Zn - FDP Zn - 55 Zn - FDP - Zn - G 4 ICP - AES Zn Zn - FDP Hg Zn - G Zn - G Hg 194. 16 nm Zn - FDP 6 t 60 ICP - AES 1 G 61 ICP - AES Al ICP - AES 56 - / 396. 153 nm Al 96. 0% ~ 99. 5% 8 6 h ICP - AES Al PKS Al 2 Al 7 P < 0. 05 62 Gd - DTPA 57 Gd - DTPA - / - Gd - DTPA 58 ICP - AES 18 3 3 Gd 3 3 2 600 mg D 8 ICP - AES 0 ~ 24 ICP - AES h
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