285 P450 1 1 1 1 515041 2 2 100191 arachidonic acid AA AA P450 - EETs 20-20-HETE EETs 20-HETE P450 P450-20- R587. 1 AA P450 1993 Nelson CYP450 CYP450 CYP450 40% CYP arachidonic acid AA CYP2 55% A2 phospholipase A2 PLA2 CYP2C P450 cyclooxyge- CYP2C8 nases COXs lipoxygenases LOXs P450 cytochrome P450 CYP AA CYP CYP - epoxyeicosatrienoicacid EETs 5 6-8 9-11 12-14 15-EET CYP ω- - hydroxyeicosatetraenoic acid HETEs CYP CYP2J CYP2C AA EETs CYP 2C8 2C9 2J2
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287 12-15-HETE CYP 5- enos 8-9- 11-12- 15-HETE CYP ω- PI3K p-akt MAPK AMP 16-17- 18-19- 20-HETE HETEs AMPK CYP2J3 CYP2J3 /EETs 20-HETE enos IR /IRS-1 PI3K /AKT ATP 20-HETE glucose transporter GLUTs COX 20- E2 20- EETs -1 heme oxygenase-1 I2 Miyata. 2005 COX GLUT-4 COX COX-1 COX-2 AKT AMPK COX-1 7 COX-2 seh EETs NIT-1 seh 8 seh 4 COX-1 seh NF-κB COX-2 EETs seh EETs CYP2J STZ α EETs 5 EETs 5 6-EET Mustafa. 2009 EETs 25mM Ephx2 - / - Ca 2 + Ephx2 + / + t-aucb EETs - Ephx2 + / + 25mM EETs Ephx2 - / - Ca 2 + Ephx2 - / - EETs 2 Ephx2 + / + insulin seh receptor IR -1 in- STZ sulin receptor substrate-1 IRS-1 PI3K-Akt seh 6 IRS- seh 1 EETs Xu 6 CYP2J3 /EETs CYP2J3 CYP2J3 db /db HO-1 / Olearczyk. 2009 Luo 8 seh streptozocin STZ seh t-aucb Ephx2 Ephx2 + / + seh Ohtoshi 2005 86 2 seh db /db 2 860A 860A db /db seh G860A IRS-1 seh G860A 2
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