Genetic regula tion of apoptos is of sperma togen ic cells

(A cta A cadem iae M edicinae CPA PF ) V o l19 N o11 67 100825041 (2000) 0120067204 Genetic regula tion of apoptos is of sperma togen ic cells ( 300162) ; ; R 329128; R 32111 A (A pop to sis),,, 1, R egaud, 25% 75%, A 50%, [1, 2 ], (N ecro sis),, (P rogramm ed cell death),,,,,,,,,, DNA, 180 200bp DNA,,,, A T P,, : ; ; [3, 4 ] [5, 7 ] DNA g g g g, g g 20 30 ( ) 2 3 ( DNA ) [7 10 ], [5 9, 11 ],,, 2, (Casade) (Caeno rhabditis elegens, CE), W o lgem uth [12 ] 1,,,, 211 bcl22 bcl22 1998

68 (A cta A cadem iae M edicinae CPA PF ) V o l19 N o11 A C2elk, C2k it, C2ref, C2trkB B C2flk, C2src C H 2ras, K2ras, N 2ras D GT P H 2ras, K2ras, N ras E C2abla, C2fo s, C2jun, C2m yc, C2erba, C2ets21, C2eta22 F P53, RB G int21, C2rel T sujimo to [13 ] t (18) B 18q21, 3 2, 26Ku,,, Bcl22, Bcl22 Bcl22 Bcl22 Bcl2x Bax Bak M cl21 Bcl22 Bcl2x, (Bcl2xl) Bcl22 M cl2 ; (Bcl2xs) Bax Bak,, Bcl22,, Bcl2x, Bcl22 Bcl2xl [14 ] [15 ], 2 4, Bax, Bax Bax Bcl22,, Bcl22, [16 ] Bcl22 [17 ] BaxgBcl22 Bcl22, [18, 19 ], Bcl22 Bcl22 [20 ] : Bcl22 Bcl2xl Bax ; Bcl2xs Bad Bcl22 Bcl2xl Bax 212 P53 P53 P53,, P53 P53 DNA, DNA DNA, P53, DNA, GogG1, S, DNA, M ;,, P53,, P53 P53 P53,, [21 ] P53, P53,,, P53,, P53,, P53,, P53, [22 ],, P53,, P53, g (DN ase g ), DN ase g DNA,, P53 25 P53 P53 [23 ] m dm 22 mrna, P53, m dm 22 mrna P53, Bax Bcl22,

(A cta A cadem iae M edicinae CPA PF ) V o l19 N o11 69,,,,, P53 Bax Bcl22 P53 Bcl22 Bax, Bax 4 P53 213 C2m yc C2m yc,,, C2m yc,, C2m yc, C2m yc C2m yc,, C2m yc,, : C2m yc,, 3 ; 1) C2m yc, ; 2) C2m yc,, ; 3) C2m yc,, H irabayash i (1996) [24 ] C2m yc, C2m yc,,, DNA C2m yc, C2m yc [25 ] [26 ],,, C2m yc,, C2m yc,,, C2m yc 214 Fas Fas cdna T KT 23 cdna 253bp, 325, 45Ku Fas N, 3 ; C, 80, C 15,,, Fas B cdna T OX40, Fas (FasL ), FasL 40Ku,, FasL 810Kb, 1 q23, 4 Fas FasL, Fas, Fas N o rthen, Fas Fas (Serto li cell) (M EH P 2, 52HD ),,, Fas FasL, Fas, FasL Fas FasmRNA, Fas, FasL [27 ], Fas2FasL [28 ], ( ) Bcl2 2, Fas, DNA Fas, Bcl22 Fas 1p r Fas, [20 ] Fas, 215 CR EM CAM P (Cyclic AM P2responsive elem ent modulater, CR EM ),, CR EM, [30 ] CR EM, Α Β, ;, CR EM, Α Β CR EM Α CR EM Β CR EM,, FSH, [31 ] CR EM, 216

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