458 2013 44 6 * GDNF 221002 glial cell line-derived neurotrophic factor GDNF β GDNF dopamine DA ventral tegmental area VTA DA GDNF VTA DA GDNF GDNF R964 GDNF GDNF 211 19 dopamine DA 68 ventral tegmental area VTA DA N nucleus accumbens NAc GDNF TGF-β 134 7 TGF-β NAc DA GDNF DA GDNF DA DA DA DA tyrosine hydroxy- lase TH GDNF VTA DA GDNF glial cell linederived neurotrophic factor GDNF 1993 Lin conditioned place preference CPP B49 1. 2000 Messer DA GDNF CPP GDNF GDNF CPP DA * 30900417 30901402 GDNF 08KJB180011 09KJD320008
2013 44 6 459 Messer GDNF VTA GDNF GDNF CPP GDNF 9 CPP GDNF GDNF CPP Niwa GDNF CPP GDNF CPP Leu-Ile GDNF CPP GDNF GDNF Leu-Ile Leu-Ile CPP GDNF 1 GDNF CPP 2007 Yan GDNF GDNF CPP GDNF 6 Carnicella CPP 2 GDNF GDNF CPP 10 CPP 3 GDNF CPP Lu Niwa 3mg /kg VTA GDNF CPP GDNF 3 10 GDNF 1 14 CPP 4 Airavaara VTA GDNF 5mg /kg 10mg /kg GDNF 11 31 CPP CPP 5 GDNF 11 CPP Niwa GDNF Airavaara VTA 2. Green-Sadan 2003 2005 GDNF Yan GDNF 6 GDNF Airavaara 12 VTA NAc GDNF Carnicella GDNF 10 3 GDNF GDNF VTA GDNF GDNF 7 VTA GDNF 8 DA DA GDNF VTA DA VTA TH-DA NMDAR1
460 2013 44 6 GDNF GDNF TH GDNF TH HSP90 TH-HSP90 TH GFRα1 Ret TH GDNF-GFRα1 13 TH Ret GDNF TH Ret GDNF Fyn GDNF 2008 GDNF integrinβ1 Shc GDNF integrinβ1 GDNF Yoshimura 602 GDNF GDNF DA N-cadherin β-catenin GDNF N-cadherin GDNF GDNF DA 14 GDNF GDNF GDNF GDNF GDNF TH 16 Messer 2000 GDNF GDNF GDNF VTA GDNF GDNF VTA GDNF GDNF TH NMDAR1 He GDNF GDNF TH DA SH-SY5Y TH mrna TH GDNF α1 GDNF family receptor camp /PKA TH α1 GFRα1 HSP90 TH Ret neural cell adhesion molecule NCAM GDNF GDNF Ret NCAM GDNF Heberlein GFRα1 RET GDNF NCAM integrinβ1 N-cadherin GDNF GDNF GDNF Carnicella GDNF 10 GFRa1 15 Heberlein CPP Messer GDNF 2000 GDNF VTA Ret VTA GDNF CPP VTA GDNF GDNF CPP
2013 44 6 461 GDNF Ret 1 GDNF CPP NCAM VTA DA Barke VTA PSA-NCAM DA Erk GDNF 17 Masami 2006 NCAM GDNF GDNF GDNF GDNF GDNF Ret micrornas MEK /Erk1 /2 PI3K /Akt PLCγ /PKC VTA GDNF 19 GDNF Erk micrornas VTA Erk MEK GDNF Erk GDNF PLCγ GDNF PLCγ GDNF GDNF Erk PI3K 7 24 VTA NAc DA NAc DA 1 GDNF DA 3 DA GDNF NAc VTA DA GDNF VTA miniature excitatory postsynaptic current VTA PI3K GDNF PI3K GD- NF VTA mepsc GDNF / miniature inhibitory postsynaptic current mipsc VTA DA GDNF NAc DA GDNF Erk 18 VTA GDNF GDNF CPP GDNF Erk GDNF NAc DA GD-
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