21 36 20171228 Chinese Journal of Tissue Engineering Research December 28, 2017 Vol.21, No.36 CT ( 646000 646000). CT [J].201721(36):5775-5780. DOI:10.3969/j.issn.2095-4344.2017.36.007 ORCID: 0000-0003-3392-435X() CT CT CT 1990 CT CBCT CT X CT CT CT CT CT mg/cm CT 646000 :R318 :A :2095-4344 (2017)36-05775-06 2017-09-16 CT CT CT CT 90 CT ()(mg/cm ) (P < 0.001) (P < 0.05)> >>(P < 0.05) CT CT CT (2017JY0111)(16PJ174) Bone mineral density of cancellous bone in edentulous areas: quantitative CT measurement Huang Ying, Zhang Hui, Cai Yue, Zeng Fan-gang, Guo Ling ( Department of Prosthodontics, Department of Radiology, Hospital of Stomatology Affiliated to Southwest Medical University, Luzhou 646000, Sichuan Province, China) Abstract BACKGROUND: The bone mineral density (BMD) in unit volume can be accurately measured with the theory of quantitative CT. After tooth loss, bone resorption certainly exists in the alveolar bone healing. Therefore, it is important to accurately evaluate the BMD of cancellous bone in the plantation area before implantation. OBJECTIVE: To evaluate the changes in BMD of alveolar cancellous bone after the loss of tooth, and explore whether the BMD shows the differences in different genders, ages and dental sites. Huang Ying, Studying for master s degree, Physician, Department of Prosthodontics, Hospital of Stomatology Affiliated to Southwest Medical University, Luzhou 646000, Sichuan Province, China Corresponding author: Guo Ling, M.D., Associate professor, Department of Prosthodontics, Hospital of Stomatology Affiliated to Southwest Medical University, Luzhou 646000, Sichuan Province, China ISSN 2095-4344 CN 21-1581/R CODEN: ZLKHAH 5775
. CT METHODS: Corrected voxel values were obtained from the cone-beam CT with the theory of quantitative CT. Ninety patients underwent cone-beam CT, and their BMD (mg/cm ) in dentulous areas and control areas (homonymous region of the same jaw) was obtained. RESULTS AND CONCLUSION: The BMD of alveolar cancellous bone reduced after the loss of tooth (P < 0.001). The BMD reduction of the edentulous cancellous bone, normal cancellous bone and the cancellous bone after tooth loss had no correlation with gender. The BMD reduction of the edentulous cancellous bone and the cance llous bone after tooth loss was not associated with age (P > 0.05), while the BMD of the control area decreased with increasing age (P < 0.05). The order of the BMD of cancellous bone was as follows: mandibular posterior region > mandibular anterior region > maxillary anterior region > maxillary posterior region. To conclude, quantitative CT is a available method for detecting the changes in the BMD of alveolar cancellous bone after tooth loss. Subject headings: Tissue Engineering; Bone Density; Mandible; Maxilla Funding: a grant from the Science and Technology Department of Sichuan Province, No. 2017JY0111; the Project of Sichuan Provincial Health and Family Planning Commission, No. 16PJ174 Cite this article: Huang Y, Zhang H, Cai Y, Zeng FG, Guo L. Bone mineral density of cancellous bone in edentulous areas: quantitative CT measurement. Zhongguo Zuzhi Gongcheng Yanjiu. 2017;21(36):5775-5780. 0 Introduction CT(cone-beam computed tomography CBCT) CT [1] CT CT [2-3] CT [3] CT(quantitative computed tomographyqct) XCT CT (region of interestroi) CT [4] CT(bone mineral densitybmd) X(dual-energy X-ray absorptiometry DXA) [5] CTCT 1Subjects and methods 1.1 1.2 20144201610 1.3 20144201610 CT 9041491977 5776 (45±13) 18/ 3 6 () 1.4 (K 2 HP 4 ) ()Naitoh [5] 050150250350450550650 750850 mg/cm 3 K 2 HP 4 15 ml 1.5 1.5.1 CT K 2 HP 4 CT(pax-uni3D CT89 kvp 8.0 ma360 8.0 cm 8.0 cm) DicomEz3D plus 1 mm2 mm 10 CT(1)10CT CT 1.5.2 CT DicomEz3D plus 4 1 CT(2) P.O. Box 10002, Shenyang 110180
. CT CT (3) CT CTCT1 2 CT 1.6 CT CT 1.7 SPSS 17.0 K 2 HP 4 CT CT (mg/cm 3 )x±s t () t () t () α=0.05 2Results 2.1 90 2.2 1 2.3 CTr =0.947 P < 0.05CT R =0.897 F =69.708P < 0.05 CTt t=1.953p < 0.05CT y=91.233+1.953x(4) CT(HU) (mg/cm 3 ) t r =0.889 P < 0.001 t P < 0.001 2.4 t ()(P > 0.05) ()(2) 2.5 () 3 () () (P > 0.05)3 () (P < 0.053) t (P < 0.05) 404160> 60 2.6 () 4 ()(P > 0.05) (P < 0.0014) t (P < 0.05) >>> 3Discussion [7] CT CT CT [8] CTX [9-10] CT [11-12] CT CT CT [13-14] CT X CTCTX [314] ISSN 2095-4344 CN 21-1581/R CODEN: ZLKHAH 5777
. CT A B 1 K HP CT Figure 1 The cone-beam CT values of the K HP body models CT 2 CT Figure 2 Cone-beam CT values of the proximal cancellous bone in the edentulous area A B CT A B 2 000 CBCT (HU) 1 500 1 000 500 3 CT Figure 3 Cone-beam CT values of the proximal cancellous bone in the control area A B CT 0 500 0 200 400 600 800 1 000 (mg/cm³) 4 CT(CBCT) Figure 4 Linear regression fitting of the liquid concentration and cone-beam CT values 1 Table 1 Basic information of the participants n 49 41 90 (x±s) 42±14 49±12 45±13 (x±smg/cm ) (x±smg/cm ) 352.89±86.11 296.26±92.75 320.64±80.62 385.49±77.24 363.81±76.56 379.52±73.27 2 ( ) (x ±smg/cm ) Table 2 Comparison of cancellous bone mineral density between the edentulous area and control area and their difference value of different sexes n () 49 352.89±86.11 385.49±77.24 73.61±15.43 41 296.26±92.75 363.81±76.56 46.34±16.75 (P > 0.05) 3 ( ) (x±smg/cm ) Table 3 Comparison of cancellous bone mineral density between the edentulous area and control area and their difference value at different ages () n () 40 29 307.60±75.86 406.77±64.98 69.87±19.48 4160 47 343.25±84.01 383.20±58.52 56.77±24.98 > 60 14 309.73±46.52 354.96±80.32 63.20±28.52 (P < 0.05) 4 ( ) (x±smg/cm ) Table 4 Comparison of cancellus bone mineral density between the edentulous area and control area and their difference value at different dental sites n () 15 295.24±50.04 348.58±77.45 73.61±35.43 28 280.55±63.15 328.17±72.68 46.34±29.75 13 250.97±74.11 366.87±97.00 55.87±32.23 34 379.56±73.73 450.83±89.83 71.26±52.68 (P < 0.05) 5778 P.O. Box 10002, Shenyang 110180
. CT X X [15-16] CT CTX CTCTCT(HU) (mg/cm 3 )CT CT [17-18] CT (Ca 5 OH(PO 4 )) (K 2 HP 4 ) [19] CT CT 3 70%80% [20-21] 1.2 mm4.4 mm [22] [23] [24-25] [26] 40 4060>60 3040 65 [27-28] 30%50% 2%3%30% 6580 50% () 60 CT >>> [29-30] Norton [31] 32139 Fanuscu [32] CT51529 HU 186389 HU CTCT Turkyilmaz [33] ( ) CT CNKI 3 ISSN 2095-4344 CN 21-1581/R CODEN: ZLKHAH 5779
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