Supplementary Figure S1. Single X-ray structure 3a at probability ellipsoids of 20%.
|
|
|
- Αργυρός Μήτζου
- 5 χρόνια πριν
- Προβολές:
Transcript
1 Supplementary Figure S1. Single X-ray structure 3a at probability ellipsoids of 20%. S1
2 Supplementary Figure S2. Single X-ray structure 5a at probability ellipsoids of 20%. S2
3 H 15 Ph Ac Ac I AcH Ph Ac 12 Isolated Ph Ph H TMS 20 mol% CHCl 3, 1 h retro-michael (retro-friedel-crafts) bond energy C- > C-C > C-Br Ac H Ph Supplementary Figure S3. Preparation of the stable p-acetoxy quinol 12 and catalyst I catalyzed retro-michael addition reaction of 12. S3
4 Supplementary Figure S4. Monitoring quinol formation by 1 H MR. S4
5 Supplementary Table S1. Screening of Catalysts for the cascade reactions using enal 1a and 3- bromoindole 4a 2 H Br Catalyst 20 mol % TEA 1.2 equiv. CH 2 Cl 2, r.t. H 1a, 1.0 equiv. 2a, 2.0 equiv. 3a 2 H IX Entry Catatlyst t Yield E/Z (a) 1 I 6D 0% 2 II 6D 0% D (b) D 3 III 5D 27% 81:19 4 IV 5D 25% 98:2 5 V 6D 6% D 6 VI 3D 52% >99:1 7 VII 6D 9% D 8 VIII 5D 38% 98:2 9 IX 5D 21% 98:2 10 i-prh 8D <5% - Unless specified, the reaction was carried out with 0.1 mmol 1a and 0.2 mmol 2a in the presence of 20 mol % organocatalyst in 0.5 ml of DCM at r.t. (a) E/Z was determined by 1 H MR of crude reaction mixture. (b) ot determined. S5
6 Supplementary Table S2. Effect of additives and solvents on the synthesis of (E)-α-indolyl-βarylacrylaldehyde 5a Br Cat. VI 20 mol % 2 H 1a, 1.0 equiv. 2, 2.0 equiv. Additive, Solvent Temperature H 3a E/Z >99:1 2 Entry Solvent Additive T t Yield 1 CH 2 Cl 2 2,6-Lutidine, 1.2 eq. r.t. 5D 46% 2 CH 2 Cl 2 aac, 1.2 eq. r.t. 3D 62% 3 CH 2 Cl 2 aac, 4 eq. r.t. 3D 73% 4 CH 2 Cl 2 ahc 3, 4 eq. r.t. 3D 66% 5 CH 2 Cl 2 a 2 C 3, 4 eq. r.t. 3D 71% 6 CHCl 3 aac, 4 eq. r.t. 3D 81% 7 MeH aac, 4 eq. r.t. 3D 79% 8 MeC aac, 4 eq. r.t. 3D 52% 9 THF aac, 4 eq. r.t. 3D 73% 10 Toluene aac, 4 eq. r.t. 3D 78% 11 Et 2 aac, 4 eq. r.t. 3D 66% 12 DMF aac, 4 eq. r.t. 3D 59% 13 Acetone aac, 4 eq. r.t. 3D 77% 14 CHCl 3 aac, 4 eq. 60 C 7h 89% 15 CHCl 3 aac, 4 eq. 60 C 22h 90% Unless specified, the reaction was carried out with 0.1 mmol 1a and 0.2 mmol 2 in the presence of 20 mol % organocatalyst VI in 0.5 ml of solvent at the designated temperature. (a) E/Z was determined by proton MR of crude reaction mixture. S6
7 Supplementary Methods Me 3l H (E)-2-(4-Hydroxyphenyl)-3-(2-methoxyphenyl)acrylaldehyde (3l) (Table 2, entry 12). The title compound was prepared according to the typical procedure, as described above in 52% yield. M. P ºC; 1 H MR (acetone-d 6, 500 MHz): δ = 9.76 (s, 1H), 8.47 (br, 1H), 7.74 (s, 1H), 7.30 (t, J = 7.8 Hz, 1H), 7.06 (d, J = 8.0 Hz, 1H), 7.00 (d, J = 8.5 Hz, 2H), 6.97 (d, J = 7.5 Hz, 1H), 6.82 (d, J = 8.5 Hz, 2H), 6.68 (t, J = 7.5 Hz, 1H), 3.91 (s, 3H); 13 C MR (acetone-d 6, 125 MHz): δ = 194.3, 159.0, 158.0, 144.5, 142.1, 132.1, 131.6, 130.8, 125.4, 124.1, 120.6, 116.0, 111.9, 56.0; HRMS (ESI) calcd. for C 16 H 14 3 : m/z ([M + a] + ), found m H (E)-2-(4-Hydroxyphenyl)-3-o-tolylacrylaldehyde (3m) (Table 2, entry 13). The title compound was prepared according to the typical procedure, as described above in 50% yield. M. P ºC; 1 H MR (acetone-d 6, 500 MHz): δ = 9.83 (s, 1H), 8.45 (br, 1H), 7.69 (s, 1H), 7.19 (d, J = 5.0 Hz, 1H), 7.17 (m, 1H), 6.95 (m. 4H), 6.76 (d, J = 8.5 Hz, 2H), 2.40 (s, 3H); 13 C MR (acetone-d 6, 125 MHz): δ = 194.5, 158.0, 148.5, 143.1, 138.3, 134.9, 131.9, 131.0, 130.0, 129.8, 126.1, 124.8, 115.8, 19.9; HRMS (ESI) calcd. for C 16 H 14 2 : m/z ([M + a] + ), found H 3n (E)-3-(Furan-2-yl)-2-(4-hydroxyphenyl)acrylaldehyde (3n) (Table 2, entry 14). The title compound was prepared according to the typical procedure, as described above in 46% yield. 1 H MR (acetone-d 6, 500 MHz): δ = 9.68 (s, 1H), 8.55 (br, 1H), 7.68 (s, 1H), 7.36 (s, 1H), 7.06 (d, J = 8.0 Hz, 2H), 6.90 (d, J = 8.5 Hz, 2H), 6.50 (d, J = 2.0 Hz, 1H), 6.34 (d, J = 3.5 Hz, 1H); 13 C MR (acetone-d 6, 125 MHz): δ = 193.2, 158.2, 151.8, 146.3, 139.5, 135.9, 131.3, 130.8, 125.3, 116.6, 116.0, 113.4; HRMS (ESI) calcd. for C 13 H 10 3 : m/z ([M + a] + ), found S7
8 3o H (E)-2-(4-Hydroxyphenyl)-3-(naphthalen-2-yl)acrylaldehyde (30) (Table 2, entry 15). The title compound was prepared according to the typical procedure, as described above in 84% yield. M. P ºC; 1 H MR (acetone-d 6, 500 MHz): δ = 9.81 (s, 1H), 8.62 (br, 1H), 7.98 (s, 1H), 7.84 (d, J = 7.5 Hz, 1H), 7.80 (d, J = 8.0 Hz, 1H), 7.69 (m, 2H), 7.51 (m, 2H), 7.27 (d, J = 8.5 Hz, 1H), 7.06 (d, J = 8.5 Hz, 2H), 6.89 (d, J = 8.5 Hz, 2H); 13 C MR (acetone-d 6, 125 MHz): δ = 194.3, 158.2, 149.7, 142.7, 134.4, 133.8, 133.2, 132.3, 131.6, 129.2, 128.3, 128.2, 128.1, 127.2, 127.1, 125.1, 116.1; HRMS (ESI) calcd. for C 19 H 14 2 : m/z ([M + a] + ), found p H (E)-2-(4-Hydroxyphenyl)-3-(naphthalen-1-yl)acrylaldehyde (3p) (Table 2, entry 16). The title compound was prepared according to the typical procedure, as described above in 68% yield. 1 H MR (acetone-d 6, 500 MHz): δ = (s, 1H), 8.45 (br, 1H), 8.25 (d, J = 8.5 Hz, 1H), 8.20 (s, 1H), 7.95 (d, J = 7.5 Hz, 1H), 7.87 (d, J = 8.0 Hz, 1H), 7.58 (m, 2H), 7.30 (t, J = 7.8 Hz, 1H), 7.22 (d, J = 7.5 Hz, 1H), 6.97 (d, J = 8.5 Hz, 2H), 6.72 (d, J = 8.5 Hz, 2H); 13 C MR (acetone-d 6, 125 MHz): δ = 194.5, 157.9, 147.6,144.3, 134.4, 132.9, 132.4, 131.9, 130.9, 130.1, 129.4, 128.5, 127.5, 127.0, 125.8, 124.7, 115.8; HRMS (ESI) calcd. for C 19 H 14 2 : m/z ([M + a] + ), found Me 3r H (E)-2-(4-Hydroxy-3-methoxyphenyl)-3-phenylacrylaldehyde (3r) (Table 2, entry 18). The title compound was prepared according to the typical procedure, as described above in 99% yield. 1 H MR (acetone-d 6, 500 MHz): δ = 9.75 (s, 1H), 7.79 (br, 1H), 7.51 (s, 1H), 7.31 (m, 5H), 6.86 (d, J = 8.0 Hz, 1H), 6.75 (s, 1H), 6.63 (d, J = 8.0 Hz, 1H); 13 C MR (acetone-d 6, 125 MHz): δ = 194.3, 149.7, 148.3, 147.4, 142.7, 135.4, 131.2, 130.5, 129.1, 125.5, 123.1, 116.0, 113.6, 56.1; HRMS (ESI) calcd. for C 16 H 14 3 : m/z ([M + a] + ), found H 3s S8
9 (E)-2-(4-Hydroxy-3,5-dimethylphenyl)-3-phenylacrylaldehyde (3s) (Table 2, entry 19). The title compound was prepared according to the typical procedure, as described above in 86% yield. M. P ºC; 1 H MR (acetone-d 6, 500 MHz): δ = 9.74 (s, 1H), 7.47 (s, 2H), 7.30 (m, 5H), 6.75 (s, 2H), 2.20 (s, 6H); 13 C MR (acetone-d 6, 125 MHz): δ = 194.5, 153.9, 149.5, 142.9, 135.5, 131.2, 130.5, 129.9, 129.0, 125.3, 124.9, 16.4; HRMS (ESI) calcd. for C 17 H 16 2 : m/z ([M + a] + ), found H 3t (E)-2-(4-Hydroxy-2-methylphenyl)-3-phenylacrylaldehyde (3t) (Table 2, entry 20). The title compound was prepared according to the typical procedure, as described above in 91% yield. 1 H MR (acetone-d 6, 500 MHz): δ = 9.77 (s, 1H), 8.40 (br, 1H), 7.29 (m, 6H), 6.80 (d, 2H), 6.72 (m, 1H), 1.95 (s, 3H); 13 C MR (acetone-d 6, 125 MHz): δ = 194.4, 158.1, 150.6, 142.8, 138.2, 135.6, 131.0, 130.8, 129.3, 125.6, 117.7, 114.0, 19.6; HRMS (ESI) calcd. for C 16 H 14 2 : m/z ([M + a] + ), found F 3u H (E)-2-(3-Fluoro-4-hydroxyphenyl)-3-phenylacrylaldehyde (3u) (Table 2, entry 21). The title compound was prepared according to the typical procedure, as described above in 79% yield. 1 H MR (acetone-d 6, 500 MHz): δ = 9.74 (s, 1H), 8.88 (br, 1H), 7.57 (s, 1H), 7.31 (m, 5H), 7.02 (t, J = 8.8 Hz, 1H), 6.94 (d, J = 12 Hz, 1H), 6.81 (d, J = 8.0 Hz, 1H); 13 C MR (acetone-d 6, 125 MHz): δ = 193.9, 153.0, 151.1, 150.4, 145.5, 145.4, 141.4, 135.1, 131.1, 130.7, 129.1, 126.6, , 118.6, 118.0, 117.8; HRMS (ESI) calcd. for C 15 H 11 F 2 : m/z ([M + a] + ), found Cl 3v H (E)-2-(3-Chloro-4-hydroxyphenyl)-3-phenylacrylaldehyde (3v) (Table 2, entry 22). The title compound was prepared according to the typical procedure, as described above in 62% yield. 1 H MR (acetone-d 6, 500 MHz): δ = 9.75 (s, 1H), 9.05 (br, 1H), 7.58 (s, 1H), 7.32 (m, 6H), 7.18 (s, 1H), 7.04 (d, J = 8.5 Hz, 1H), 6.95 (d, J = 8.0 Hz, 1H); 13 C MR (acetone-d 6, 125 MHz): δ = 194.0, 153.6, 150.6, 141.2, 135.1, 131.6, 131.2, 130.8, 130.1, 129.2, 126.7, 121.0, 117.6; HRMS (ESI) calcd. for C 15 H 11 Cl 2 : m/z ([M + a] + ), found S9
10 Cl H 3w (E)-2-(2-Chloro-4-hydroxyphenyl)-3-phenylacrylaldehyde (3w) (Table 2, entry 23). The title compound was prepared according to the typical procedure, as described above in 62% yield. 1 H MR (acetone-d 6, 500 MHz): δ = 9.76 (s, 1H), 7.72 (s, 1H), 7.33 (m, 6H), 7.02 (d, J = 2.5 Hz, 1H), 6.98 (d, J = 8.0 Hz, 1H), 6.87 (dd, J = 8.0, 2.5 Hz, 1H); 13 C MR (acetone-d 6, 125 MHz): δ = 193.4, 159.1, 151.1, 140.6, 135.2, 134.2, 132.6, 131.0, 129.4, 125.0, 117.1, 115.6; HRMS (ESI) calcd. for C 15 H 11 Cl 2 : m/z ([M + a] + ), found H 2 3x (E)-2-(2-Hydroxynaphthalen-1-yl)-3-(4-nitrophenyl)acrylaldehyde (3x). A mixture of 1- bromo-2-naphthol (0.1 mmol), trans-4-nitrocinnamaldehdye (0.2 mmol), catalyst I (0.02 mmol), and aac (0.4 mmol) in 0.5 ml of CH 3 C was stirred at 60 C for 3 d. The solvent was evaporated and the residue was purified by column chromatography, eluting with a mixture of ethyl acetate and hexane. 1 H MR (acetone-d 6, 500 MHz): δ = 9.98 (s, 1H), 8.76 (s, 1H), 8.13 (s, 1H), 8.02 (d, J = 8.5 Hz, 2H), 7.87 (m, 2H), 7.52 (d, J = 8.5 Hz, 2H), 7.42 (d, J = 8.0, 1H), 7.30 (m, 3H); 13 C MR (DMS-d 6, 125 MHz): δ = 194.5, 152.6, 148.8, 147.6, 140.9, 139.9, 132.0, 130.5, 130.1, 128.3, 127.9, 126.8, 123.6, 123.0, 122.9, 118.3, 112.2; HRMS (ESI) calcd. for C 19 H 13 4 : m/z ([M + a] + ), found H 5o (E)-2-(1H-Indol-3-yl)-3-(naphthalen-1-yl)acrylaldehyde (5o) (Table 3, entry 15). The title compound was prepared according to the typical procedure, as described above in 96% yield. 1 H MR (CDCl 3, 500 MHz): δ = (s, 1H), 8.38 (br, 1H), 8.27 (d, J = 8.0 Hz, 1H), 8.11 (s, 1H), 7.89 (d, J = 8.0, 1H), 7.74 (d, J = 8.0, 1H), 7.64 (t, J = 7.5, 1H), 7.57 (t, J = 7.5, 1H), 7.47 (d, J = 2.5, 1H), (m, 2H), (m, 2H), (m, 2H); 13 C MR (CDCl 3, 125 MHz): δ = 194.9, 145.9, 136.3, 136.1, 133.8, 132.3, 131.9, 130.1, 129.2, 128.0, 127.2, 126.7, 126.4, 125.4, 123.9, 122.6, 122.3, 121.1, 120.1, 111.4, 108.0; HRMS (ESI) calcd. for C 21 H 15 : m/z ([M + a] + ), found S10
11 2 5p H (E)-2-(2-Methyl-1H-indol-3-yl)-3-(4-nitrophenyl)acrylaldehyde (5p) (Table 3, entry 16). The title compound was prepared according to the typical procedure, as described above in 100% yield. 1 H MR (CDCl 3, 500 MHz): δ = 9.90 (s, 1H), 8.33 (br, 1H), 8.02 (d, J = 8.5 Hz, 2H), 7.60 (s, 1H), 7.45 (d, J = 8.5 Hz, 2H), 7.30 (d, J = 8.0 Hz, 1H), 7.13 (t, J = 7.0 Hz, 1H), 6.99 (m, 2H), 2.11 (s, 3H); 13 C MR (CDCl 3, 125 MHz): δ = 194.4, 147.9, 145.9, 141.6, 138.2, 136.1, 134.5, , 126.9, , 122.2, 120.6, 119.4, 111.1, 104.9, 13.2; HRMS (ESI) calcd. for C 18 H : m/z ([M + a] + ), found q H (E)-3-(4-itrophenyl)-2-(2-phenyl-1H-indol-3-yl)acrylaldehyde (5q) (Table 3, entry 17). The title compound was prepared according to the typical procedure, as described above in 100% yield. 1 H MR (CDCl 3, 500 MHz): δ = 9.76 (s, 1H), 8.68 (br, 1H), 7.94 (d, J = 8.5, 2H), 7.66 (s, 1H), (m, 5H), (m, 3H), 7.20 (t, J = 7.5 Hz, 1H), (m, 2H); 13 C MR (CDCl 3, 125 MHz): δ = 194.0, 147.9, 145.0, 141.4, 138.1, 137.1, 136.7, 132.3, , , 128.6, , 127.3, , 123.5, 121.1, 120.0, 111.8, 105.4; HRMS (ESI) calcd. for C 23 H : m/z ([M + a] + ), found H 5r 2 (E)-2-(5-itro-1H-indol-3-yl)-3-(4-nitrophenyl)acrylaldehyde (5r) (Table 3, entry 18). The title compound was prepared according to the typical procedure, as described above in 65% yield. 1 H MR (CDCl 3, 500 MHz): δ = 9.93 (s, 1H), 9.09 (br, 1H), (m, 3H), 7.80 (d, J = 1.5 Hz, 1H), 7.61 (s, 1H), 7.59 (d, J = 2.5 Hz, 1H), 7.48 (d, J = 9.0 Hz, 2H), 7.45 (d, J = 9 Hz, 1H); 13 C MR (CDCl 3, 125 MHz): δ = 193.6, 148.2, 146.7, 142.5, 141.0, 139.3, 136.2, , 129.6, 124.6, , 118.6, 117.5, 112.1, 109.2; HRMS (ESI) calcd. for C 17 H : m/z ([M + a] + ), found Br H 5s 2 S11
12 (E)-2-(5-Bromo-1H-indol-3-yl)-3-(4-nitrophenyl)acrylaldehyde (5s) (Table 3, entry 19). The title compound was prepared according the typical procedure, as described above in 100% yield. 1 H MR (acetone-d 6, 500 MHz): δ = (br, 1H), 9.93 (s, 1H), 8.09 (d, J = 8.0 Hz, 2H), 7.75 (s, 1H), 7.64 (s, 1H), 7.63 (d, J = 8.0 Hz, 2H), 7.45 (d, J = 8.5 Hz, 1H), 7.19 (d, J = 8.5 Hz, 1H), 6.90 (s, 1H); 13 C MR (acetone-d 6, 125 MHz): δ = 194.5, 148.4, 145.4, 143.0, 137.8, 136.2, , 129.7, 127.6, 125.3, , 123.4, 114.5, 113.2, 106.7; HRMS (ESI) calcd. for C 17 H 11 Br 2 3 : m/z ([M + a] + ), found Me Br 5t H (E)-2-(2-Bromo-5-methoxy-1H-indol-3-yl)-3-(4-nitrophenyl)acrylaldehyde (5t) (Table 3, entry 20). The title compound was prepared according to the typical procedure, as described above in 87% yield. 1 H MR (CDCl 3, 500 MHz): δ = 9.89 (s, 1H), 8.65 (br, 1H), 8.05 (d, J = 8.5 Hz, 2H), 7.70 (s, 1H), 7.45 ((d, J = 8.5 Hz, 2H), 7.21 (d, J = 9.0 Hz, 1H), 6.83 (dd, J = 9.0, 2.0 Hz, 1H), 6.47 (d, J = 2.0 Hz, 1H), 3.66 (s, 3H); 13 C MR (CDCl 3, 125 MHz): δ = 193.1, 155.2, 148.2, 146.9, 141.1, 136.4, 131.8, , 127.3, 124.0X2, 113.6, 112.2, 110.2, 108.5, 101.2, 55.9; HRMS (ESI) calcd. for C 18 H 13 Br 2 4 : m/z ([M + a] + ), found Preparation of -Boc protected 5m. Compound 5m (1 mmol) was dissolved in 5 ml of dry THF. 1.1 equiv. (1.1 mmol) di-tert-butyl dicarbonate, and 0.1 equiv. (0.1 mmol) 4- dimethylaminopyridine were added to the reaction mixture. After the indole was totally consumed (determined by TLC analysis), the solvent was evaporated and the residue was purified by column chromatography, eluting with a mixture of ethyl acetate and hexane to desired product in 100% yield. H 15 3-(4-Hydroxyphenyl)-3-phenylpropanal (15). The title compound was synthesized according to a known procedure H MR (CDCl 3, 500 MHz): δ = 9.73 (s, 1H), (m, 5H), 7.09 (d, J = 9.0 Hz, 2H), 6.75 (d, J = 9.0 Hz, 2H), 4.62 (br, 1H), 4.56 (t, J = 8.0 Hz, 1H), 3.13 (dd, J 1 = 8.0, J 2 = 2.0 Hz, 2H). 12 S12
13 4-xo-1-(3-oxo-1-phenylpropyl)cyclohexa-2,5-dienyl acetate (12). The title compound was synthesized according to a known procedure. 57 (Diacetoxyiodo)benzene (0.5 mmol) was added to a solution of 3-(4-hydroxyphenyl)-3-phenylpropanal 15 (0.5 mmol) in glacial AcH (2.0 ml) at 0 C. After starting material was totally consumed, the reaction was concentrated and purified by flash chromatography. 1 H MR (CDCl 3, 500 MHz): δ = 9.60 (s, 1H), (m, 5H), 6.73 (m, 2H), 6.31 (d, J = 10.0 Hz, 1H), 6.24 (d, J = 10.0 Hz, 1H), 3.81 (m, 1H), 2.95 (m, 2H), 2.10 (s, 3H). Supplementary References 56. Caschi, S., La Torre, F., Palmieri. G. The palladium-catalyzed conjugate addition type reaction of aryl iodides with α, β-unsaturated aldehydes. J. rganometat. Chem. 268, c48-c51 (1984). 57. Vo,. T., Pace, R. D. M., Hara, F. & Gaunt, M. J. An enantioselective organocatalytic oxidative dearomatization strategy. J. Am. Chem. Soc. 130, (2008). S13
Supporting Information One-Pot Approach to Chiral Chromenes via Enantioselective Organocatalytic Domino Oxa-Michael-Aldol Reaction
Supporting Information ne-pot Approach to Chiral Chromenes via Enantioselective rganocatalytic Domino xa-michael-aldol Reaction Hao Li, Jian Wang, Timiyin E-Nunu, Liansuo Zu, Wei Jiang, Shaohua Wei, *
Supplementary Figure 1. (X-ray structures of 6p and 7f) O N. Br 6p
Supplementary Figure 1 (X-ray structures of 6p and 7f) Me Br 6p 6p Supplementary Figures 2-68 (MR Spectra) Supplementary Figure 2. 1 H MR of the 6a Supplementary Figure 3. 13 C MR of the 6a Supplementary
Enantioselective Organocatalytic Michael Addition of Isorhodanines. to α, β-unsaturated Aldehydes
Electronic Supplementary Material (ESI) for Organic & Biomolecular Chemistry. This journal is The Royal Society of Chemistry 2016 Enantioselective Organocatalytic Michael Addition of Isorhodanines to α,
Supporting Information
Supporting Information for AgOTf-catalyzed one-pot reactions of 2-alkynylbenzaldoximes with α,β-unsaturated carbonyl compounds Qiuping Ding 1, Dan Wang 1, Puying Luo* 2, Meiling Liu 1, Shouzhi Pu* 3 and
Copper-Catalyzed Oxidative Dehydrogenative N-N Bond. Formation for the Synthesis of N,N -Diarylindazol-3-ones
Electronic Supplementary Material (ESI) for Organic Chemistry Frontiers. This journal is the Partner Organisations 2016 Supporting information Copper-Catalyzed Oxidative Dehydrogenative - Bond Formation
Supporting Information
Electronic Supplementary Material (ESI) for ChemComm. This journal is The Royal Society of Chemistry 2015 Synthesis of 3-omosubstituted Pyrroles via Palladium- Catalyzed Intermolecular Oxidative Cyclization
Eco-friendly synthesis of diverse and valuable 2-pyridones by catalyst- and solvent-free thermal multicomponent domino reaction
Electronic Supplementary Material (ESI) for Green Chemistry. This journal is The Royal Society of Chemistry 2015 SUPPRTIG IFRMATI Eco-friendly synthesis of diverse and valuable 2-pyridones by catalyst-
Supporting Information
Electronic Supplementary Material (ESI) for ChemComm. This journal is The Royal Society of Chemistry 2017 Supporting Information 1. General experimental methods (S2). 2. Table 1: Initial studies (S2-S4).
A facile and general route to 3-((trifluoromethyl)thio)benzofurans and 3-((trifluoromethyl)thio)benzothiophenes
Electronic Supplementary Material (ESI) for ChemComm. This journal is The Royal Society of Chemistry 2014 A facile and general route to 3-((trifluoromethyl)thio)benzofurans and 3-((trifluoromethyl)thio)benzothiophenes
Zuxiao Zhang, Xiaojun Tang and William R. Dolbier, Jr.* Department of Chemistry, University of Florida, Gainesville, FL
Photoredox-Catalyzed Intramolecular Difluoromethylation of -Benzylacrylamides Coupled with a Dearomatizing Spirocyclization: Access to CF2H Containing 2- Azaspiro[4.5]deca-6,9-diene-3,8-diones. Zuxiao
Room Temperature Highly Diastereoselective Zn-Mediated. Allylation of Chiral N-tert-Butanesulfinyl Imines: Remarkable Reaction Condition Controlled
Supporting Information for: Room Temperature Highly Diastereoselective Zn-Mediated Allylation of Chiral N-tert-Butanesulfinyl Imines: Remarkable Reaction Condition Controlled Stereoselectivity Reversal
Supporting Information
Supporting Information Ceric Ammonium Nitrate (CAN) catalyzed efficient one-pot three component aza-diels-alder reactions for a facile synthesis of tetrahydropyranoquinoline derivatives Ravinder Goud Puligoundla
Chiral Phosphoric acid Catalyzed Enantioselective N- Alkylation of Indoles with in situ Generated Cyclic N-Acyl Ketimines
Electronic Supplementary Material (ESI) for ChemComm. This journal is The Royal Society of Chemistry 2018 Chiral osphoric acid Catalyzed Enantioselective - Alkylation of Indoles with in situ Generated
Novel and Selective Palladium-Catalyzed Annulation of 2-Alkynylphenols to Form 2-Substituted 3-Halobenzo[b]furans. Supporting Information
![Novel and Selective Palladium-Catalyzed Annulation of 2-Alkynylphenols to Form 2-Substituted 3-Halobenzo[b]furans. Supporting Information](/thumbs/64/50937700.jpg "Novel and Selective Palladium-Catalyzed Annulation of 2-Alkynylphenols to Form 2-Substituted 3-Halobenzo[b]furans. Supporting Information")
Novel and Selective Palladium-Catalyzed Annulation of 2-Alkynylphenols to Form 2-Substituted 3-Halobenzo[b]furans Liang Yun, Shi Tang, Xu-Dong Zhang, Li-Qiu Mao, Ye-Xiang Xie and Jin-Heng Li* Key Laboratory
and Selective Allylic Reduction of Allylic Alcohols and Their Derivatives with Benzyl Alcohol
FeCl 3 6H 2 O-Catalyzed Disproportionation of Allylic Alcohols and Selective Allylic Reduction of Allylic Alcohols and Their Derivatives with Benzyl Alcohol Jialiang Wang, Wen Huang, Zhengxing Zhang, Xu
Supplementary information
Electronic Supplementary Material (ESI) for MedChemComm. This journal is The Royal Society of Chemistry 2015 Supplementary information Synthesis of carboxyimidamide-substituted benzo[c][1,2,5]oxadiazoles
The N,S-Bidentate Ligand Assisted Pd-Catalyzed C(sp 2 )-H. Carbonylation using Langlois Reagent as CO Source. Supporting Information.
Electronic upplementary Material (EI) for rganic & Biomolecular Chemistry. This journal is The Royal ociety of Chemistry 2018 The,-Bidentate Ligand Assisted Pd-Catalyzed C(sp 2 )-H Carbonylation using
Supporting Information. Consecutive hydrazino-ugi-azide reactions: synthesis of acylhydrazines bearing 1,5- disubstituted tetrazoles
Supporting Information for Consecutive hydrazino-ugi-azide reactions: synthesis of acylhydrazines bearing 1,5- disubstituted tetrazoles Angélica de Fátima S. Barreto*, Veronica Alves dos Santos, and Carlos
Metal-free Oxidative Coupling of Amines with Sodium Sulfinates: A Mild Access to Sulfonamides
Electronic Supplementary Material (ESI) for RSC Advances. This journal is The Royal Society of Chemistry 2014 Supporting information for Metal-free Oxidative Coupling of Amines with Sodium Sulfinates:
Supporting Information
Electronic Supplementary Material (ESI) for Organic & Biomolecular Chemistry. This journal is The Royal Society of Chemistry 2018 Supporting Information Silver or Cerium-Promoted Free Radical Cascade Difunctionalization
Supporting Information for
Supporting Information for A ovel Synthesis of luorinated Pyrazoles via Gold(I)-Catalyzed Tandem Aminofluorination of Alkynes in the Presence of Selectfluor Jianqiang Qian, Yunkui Liu,* Jie Zhu, Bo Jiang,
Electronic Supplementary Information
Electronic Supplementary Information Unprecedented Carbon-Carbon Bond Cleavage in Nucleophilic Aziridine Ring Opening Reaction, Efficient Ring Transformation of Aziridines to Imidazolidin-4-ones Jin-Yuan
Copper-catalyzed formal O-H insertion reaction of α-diazo-1,3-dicarb- onyl compounds to carboxylic acids with the assistance of isocyanide
Electronic Supplementary Material (ESI) for ChemComm. This journal is The Royal Society of Chemistry 2014 Copper-catalyzed formal O-H insertion reaction of α-diazo-1,3-dicarb- onyl compounds to carboxylic
Direct Palladium-Catalyzed Arylations of Aryl Bromides. with 2/9-Substituted Pyrimido[5,4-b]indolizines
![Direct Palladium-Catalyzed Arylations of Aryl Bromides. with 2/9-Substituted Pyrimido[5,4-b]indolizines](/thumbs/87/95187440.jpg "Direct Palladium-Catalyzed Arylations of Aryl Bromides. with 2/9-Substituted Pyrimido[5,4-b]indolizines")
Direct Palladium-Catalyzed Arylations of Aryl Bromides with 2/9-Substituted Pyrimido[5,4-b]indolizines Min Jiang, Ting Li, Linghua Meng, Chunhao Yang,* Yuyuan Xie*, and Jian Ding State Key Laboratory of
Regioselectivity in the Stille coupling reactions of 3,5- dibromo-2-pyrone.
Regioselectivity in the Stille coupling reactions of 3,5- dibromo-2-pyrone. Won-Suk Kim, Hyung-Jin Kim and Cheon-Gyu Cho Department of Chemistry, Hanyang University, Seoul 133-791, Korea Experimental Section
Site-Selective Suzuki-Miyaura Cross-Coupling Reactions of 2,3,4,5-Tetrabromofuran
1 Site-Selective Suzuki-Miyaura Cross-Coupling Reactions of 2,3,4,5-Tetrabromofuran Munawar Hussain, a Rasheed Ahmad Khera, a Nguyen Thai Hung, a Peter Langer* a,b a Institut für Chemie, Universität Rostock,
Peptidomimetics as Protein Arginine Deiminase 4 (PAD4) Inhibitors
Peptidomimetics as Protein Arginine Deiminase 4 (PAD4) Inhibitors Andrea Trabocchi a, icolino Pala b, Ilga Krimmelbein c, Gloria Menchi a, Antonio Guarna a, Mario Sechi b, Tobias Dreker c, Andrea Scozzafava
Divergent synthesis of various iminocyclitols from D-ribose
Electronic Supplementary Material (ESI) for rganic & Biomolecular Chemistry. This journal is The Royal Society of Chemistry 205 Divergent synthesis of various iminocyclitols from D-ribose Ramu Petakamsetty,
Supporting Information. Asymmetric Binary-acid Catalysis with Chiral. Phosphoric Acid and MgF 2 : Catalytic
Supporting Information Asymmetric Binary-acid Catalysis with Chiral Phosphoric Acid and MgF 2 : Catalytic Enantioselective Friedel-Crafts Reactions of β,γ- Unsaturated-α-Ketoesters Jian Lv, Xin Li, Long
Supporting Information. Table of Contents. II. Experimental procedures. II. Copies of 1H and 13C NMR spectra for all compounds
Electronic upplementary Material (EI) for rganic & Biomolecular Chemistry. This journal is The Royal ociety of Chemistry 2017 Laboratoire de Méthodologie et ynthèse de Produit aturels. Université du Québec
Supporting Information
Supporting Information Montmorillonite KSF-Catalyzed One-pot, Three-component, Aza-Diels- Alder Reactions of Methylenecyclopropanes With Arylaldehydes and Aromatic Amines Li-Xiong Shao and Min Shi* General
Supporting Information. Copyright Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, 2006
Supporting Information Copyright Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, 2006 1 A Facile Way to Synthesize 2H-Chromenes: Reconsideration of the Reaction Mechanism between Salicylic Aldehyde and
9-amino-(9-deoxy)cinchona alkaloids-derived novel chiral phase-transfer catalysts
Electronic Supplementary Material (ESI) for Organic & Biomolecular Chemistry. This journal is The Royal Society of Chemistry 2014 9-amino-(9-deoxy)cinchona alkaloids-derived novel chiral phase-transfer
Rh(III)-Catalyzed C-H Amidation with N-hydroxycarbamates: A. new Entry to N-Carbamate Protected Arylamines
Rh(III)-Catalyzed C-H Amidation with N-hydroxycarbamates: A new Entry to N-Carbamate Protected Arylamines Bing Zhou,* Juanjuan Du, Yaxi Yang,* Huijin Feng, Yuanchao Li Shanghai Institute of Materia Medica,
Supporting Information Table of Contents 1. General remarks...s1 2. Synthesis of catalyst L S1
Diastereo- and Enantioselective Conjugate Addition of 3-Substituted xindoles to itroolefins Catalyzed by a Chiral i(ac) 2 -Diamine Complex under Mild Conditions Yan-Yan Han,, Zhi-Jun Wu, Wen-Bing Chen,,
Fluorinative Ring-opening of Cyclopropanes by Hypervalent Iodine Reagents. An Efficient Method for 1,3- Oxyfluorination and 1,3-Difluorination
Electronic Supplementary Material (ESI) for Chemical Science. This journal is The Royal Society of Chemistry 2016 Supporting Information Fluorinative Ring-opening of Cyclopropanes by Hypervalent Iodine
Construction of Cyclic Sulfamidates Bearing Two gem-diaryl Stereocenters through a Rhodium-Catalyzed Stepwise Asymmetric Arylation Protocol
Supporting Information for: Construction of Cyclic Sulfamidates Bearing Two gem-diaryl Stereocenters through a Rhodium-Catalyzed Stepwise Asymmetric Arylation Protocol Yu-Fang Zhang, Diao Chen, Wen-Wen
Supporting Information
Supporting Information for Lewis acid-catalyzed redox-neutral amination of 2-(3-pyrroline-1-yl)benzaldehydes via intramolecular [1,5]-hydride shift/isomerization reaction Chun-Huan Jiang, Xiantao Lei,
Supporting Information
Supporting Information Selective Synthesis of xygen-containing Heterocycles via Tandem Reactions of 1,2-Allenic Ketones with Ethyl 4-Chloroacetoacetate Qiang Wang, a, b Zhouqing Xu b and Xuesen Fan a *
Supporting Information for
Supporting Information for Palladium-Catalyzed C-H Bond Functionalization of C6-Arylpurines Hai-Ming Guo,* Wei-Hao Rao, Hong-Ying iu, Li-Li Jiang, Ge ng, Jia-Jia Jin, Xi-ing Yang, and Gui-Rong Qu* College
Ligand-free Cu(II)-mediated aerobic oxidations of aldehyde. hydrazones leading to N,N -diacylhydrazines and 1,3,4-oxadiazoles
Electronic Supplementary Material (ESI) for rganic & Biomolecular Chemistry. This journal is The Royal Society of Chemistry 2017 Ligand-free Cu(II)-mediated aerobic oxidations of aldehyde hydrazones leading
Supporting Information
Electronic Supplementary Material (ESI) for ChemComm. This journal is The Royal Society of Chemistry 15 Supporting Information For Visible-light-induced photocatalytic oxytrifluoromethylation of -allylamides
Cu-Catalyzed/Mediated Synthesis of N-Fluoroalkylanilines from Arylboronic Acids: Fluorine Effect on the Reactivity of Fluoroalkylamines
Electronic Supplementary Material (ESI) for Organic & Biomolecular Chemistry. This journal is The Royal Society of Chemistry 2018 S1 Cu-Catalyzed/Mediated Synthesis of N-Fluoroalkylanilines from Arylboronic
Supporting Information for
Supporting Information for An atom-economic route to densely functionalized thiophenes via base-catalyzed rearrangement of 5-propargyl-2H-thiopyran-4(3H)-ones Chunlin Tang a, Jian Qin b, Xingqi Li *a a
Supporting Information
Supporting Information An Approach to 3,6-Disubstituted 2,5-Dioxybenzoquinones via Two Sequential Suzuki Couplings. Three-step Synthesis of Leucomelone Xianwen Gan, Wei Jiang, Wei Wang,,,* Lihong Hu,,*
Vilsmeier Haack reagent-promoted formyloxylation of α-chloro-narylacetamides
Electronic Supplementary Material (ESI) for RSC Advances. This journal is The Royal Society of Chemistry 205 Vilsmeier aack reagent-promoted formyloxylation of α-chloro-arylacetamides by formamide Jiann-Jyh
Eur. J. Inorg. Chem WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim, 2007 ISSN SUPPORTING INFORMATION
Eur. J. Inorg. Chem. 2007 WILEY-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, 2007 ISSN 1434 1948 SUPPORTING INFORMATION Title: Synthesis of Cyclic Carbonates from Atmospheric Pressure Carbon Dioxide Using
Supporting Information
Supporting Information Lewis acid catalyzed ring-opening reactions of methylenecyclopropanes with diphenylphosphine oxide in the presence of sulfur or selenium Min Shi,* Min Jiang and Le-Ping Liu State
First DMAP-mediated direct conversion of Morita Baylis. Hillman alcohols into γ-ketoallylphosphonates: Synthesis of
Supporting Information File 1 for First DMAP-mediated direct conversion of Morita Baylis Hillman alcohols into γ-ketoallylphosphonates: Synthesis of γ-aminoallylphosphonates Marwa Ayadi 1,2, Haitham Elleuch
Supporting Information For
Electronic Supplementary Material (ESI) for rganic & Biomolecular Chemistry. This journal is The Royal Society of Chemistry 2017 Supporting Information For ne-pot synthesis of 2,3-difunctionalized indoles
Supporting Information for Fe-Catalyzed Reductive Coupling of Unactivated Alkenes with. β-nitroalkenes. Contents. 1. General Information S2
Supporting Information for Fe-Catalyzed Reductive Coupling of Unactivated Alkenes with β-nitroalkenes Jing Zheng, Dahai Wang, and Sunliang Cui* College of Pharmaceutical Sciences, Zhejiang University,
Diastereo- and Enantioselective Propargylation of Benzofuranones. Catalyzed by Pybox-Copper Complex
Diastereo- and Enantioselective Propargylation of Benzofuranones Catalyzed by Pybox-Copper Complex Long Zhao, Guanxin Huang, Beibei Guo, Lijun Xu, Jie Chen, Weiguo Cao, Gang Zhao, *, Xiaoyu Wu *, Department
Cu(I)-Catalyzed Asymmetric Multicomponent Cascade Inverse. Electron-Demand aza-diels-alder/nucleophilic Addition/Ring-Opening
Cu(I)-Catalyzed Asymmetric Multicomponent Cascade Inverse Electron-Demand aza-diels-alder/nucleophilic Addition/Ring-Opening Reaction Involving 2-Methoxyfurans as Efficient Dienophiles Rong Huang, Xin
Supporting Information. Synthesis and biological evaluation of 2,3-Bis(het)aryl-4-azaindoles Derivatives as protein kinases inhibitors
Supporting Information Synthesis and biological evaluation of 2,3-Bis(het)aryl-4-azaindoles Derivatives as protein kinases inhibitors Frédéric Pin, a Frédéric Buron, a Fabienne Saab, a Lionel Colliandre,
Supporting Information for. Rhodium-Catalyzed β-selective Oxidative Heck-Type
Supporting Information for Rhodium-Catalyzed β-selective Oxidative Heck-Type Coupling of Vinyl Acetate via C-H Activation Hui-Jun Zhang,* Weidong Lin, Feng Su, and Ting-Bin Wen* Department of Chemistry,
Supplementary Material (ESI) for Organic & Biomolecular Chemistry This journal is (c) The Royal Society of Chemistry 2008
Palladium(0)-catalyzed direct cross-coupling reaction of allylic alcohols with aryland alkenylboronic acids Hirokazu Tsukamoto, Tomomi Uchiyama, Takamichi Suzuki and Yoshinori Kondo Graduate School of
Efficient and Simple Zinc mediated Synthesis of 3 Amidoindoles
Electronic Supplementary Material (ESI) for rganic and Biomolecular Chemistry SUPPRTIG IFRMATI Efficient and Simple Zinc mediated Synthesis of 3 Amidoindoles Anahit Pews-Davtyan and Matthias Beller* Leibniz-Institut
Copper-Catalyzed Direct Acyloxylation of C(sp 2 ) H Bonds. in Aromatic Amides
Supporting Information for Copper-Catalyzed Direct Acyloxylation of C(sp 2 ) H Bonds in Aromatic Amides Feifan Wang, Qiyan Hu, Chao Shu, Zhiyang Lin, Dewen Min, Tianchao Shi and Wu Zhang* Key Laboratory
Supporting Information
Supporting Information Wiley-VCH 10 69451 Weinheim, Germany Selective and Bond Formations through Copper- Catalyzed Aerobic xidative Dehydrogenative Couplings of H-hosphonates Yongbo Zhou, Shuangfeng Yin,
Synthesis of spiropyrazoline oxindoles by a formal [4+1] annulation reaction between 3-bromooxindoles and in situ-derived 1,2-diaza-1,3- dienes
![Synthesis of spiropyrazoline oxindoles by a formal [4+1] annulation reaction between 3-bromooxindoles and in situ-derived 1,2-diaza-1,3- dienes](/thumbs/85/91355529.jpg "Synthesis of spiropyrazoline oxindoles by a formal [4+1] annulation reaction between 3-bromooxindoles and in situ-derived 1,2-diaza-1,3- dienes")
Electronic Supplementary Material (ESI) for rganic Chemistry Frontiers. This journal is the Partner rganisations 2017 Supporting Information for Synthesis of spiropyrazoline oxindoles by a formal [4+1]
Effect of uridine protecting groups on the diastereoselectivity
Supporting Information for Effect of uridine protecting groups on the diastereoselectivity of uridine-derived aldehyde 5 -alkynylation Raja Ben Othman, Mickaël J. Fer, Laurent Le Corre, Sandrine Calvet-Vitale*
Supporting Information
Supporting Information Copper/Silver Cocatalyzed Oxidative Coupling of Vinylarenes with ICH 2 CF 3 or ICH 2 CHF 2 Leading to β-cf 3 /CHF 2 -Substituted Ketones Niannian Yi, Hao Zhang, Chonghui Xu, Wei
Supplementary Material for Synthesis of Compact Multidentate Ligands to Prepare Stable Hydrophilic Quantum Dot Fluorophores
Supplementary Material for Synthesis of Compact Multidentate Ligands to Prepare Stable Hydrophilic Quantum Dot Fluorophores 5-[1,2]-Dithiolan-3-yl-pentanoic acid 2-[2-(2-{2-[2-(2-hydroxy-ethoxy)-ethoxy]-ethoxy}-
Supporting Information
Supporting Information Regioselective Reversal in the Cyclization of 2-Diazo-3,5-dioxo-6-ynoates (ynones, ynamide): Construction of -Pyrones and 3(2H)-Furanones Starting from Identical Materials Feng Wang,
Supporting Information
Supporting Information Wiley-VCH 2008 69451 Weinheim, Germany Ligand-Free Pd-Catalyzed Highly Selective Arylation of Allylic Esters with Retention of the Traditional Leaving Group (Supporting Information)
Hiyama Cross-Coupling of Chloro-, Fluoroand Methoxy- pyridyl trimethylsilanes : Room-temperature Novel Access to Functional Bi(het)aryl
Hiyama Cross-Coupling of Chloro-, Fluoroand Methoxy- pyridyl trimethylsilanes : Room-temperature Novel Access to Functional Bi(het)aryl Philippe Pierrat, Philippe Gros* and Yves Fort Synthèse Organométallique
Supporting Information
1 upporting Information Rhodium(III)-Catalyzed rtho Halogenations of N-Acylsulfoximines and ynthetic Applications toward Functionalized ulfoximine Derivatives Ying Cheng, Wanrong Dong, Kanniyappan Parthasarathy,
Synthesis and evaluation of novel aza-caged Garcinia xanthones
Electronic Supplementary Material (ESI) for rganic & Biomolecular Chemistry Synthesis and evaluation of novel aza-caged Garcinia xanthones Xiaojin Zhang, a,1 Xiang Li, a,1 Haopeng Sun, * b Zhengyu Jiang,
Supporting Information. Copyright Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, 2006
Copyright Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, 2006 Silver-Catalyzed Asymmetric Synthesis of 2,3-Dihydrobenzofurans: A New Chiral Synthesis of Pterocarpans Leticia Jiménez-González, Sergio
gem-dichloroalkenes for the Construction of 3-Arylchromones
Electronic Supplementary Material (ESI) for ChemComm. This journal is The Royal Society of Chemistry 2015 Pd(OAc)2/S=PPh3 Accelerated Activation of gem-dichloroalkenes for the Construction of 3-Arylchromones
Phosphorus Oxychloride as an Efficient Coupling Reagent for the Synthesis of Ester, Amide and Peptide under Mild Conditions
Supplementary Information for Phosphorus xychloride as an Efficient Coupling Reagent for the Synthesis of Ester, Amide and Peptide under Mild Conditions u Chen,* a,b Xunfu Xu, a Liu Liu, a Guo Tang,* a
Supporting Information. Copyright Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, 2007
Supporting Information Copyright Wiley-VCH Verlag GmbH & Co. KGaA, 6945 Weinheim, 2007 A New Method for Constructing Quaternary Carbon Centres: Tandem Rhodium-Catalysed,4-Addition/Intramolecular Cyclization.
Supporting Information. Microwave-assisted construction of triazole-linked amino acid - glucoside conjugates as novel PTP1B inhibitors
Supporting Information Microwave-assisted construction of triazole-linked amino acid - glucoside conjugates as novel PTP1B inhibitors Xiao-Peng He, abd Cui Li, d Xiao-Ping Jin, b Zhuo Song, b Hai-Lin Zhang,
Protease-catalysed Direct Asymmetric Mannich Reaction in Organic Solvent
Supplementary information for the paper Protease-catalysed Direct Asymmetric Mannich Reaction in Organic Solvent Yang Xue, Ling-Po Li, Yan-Hong He * & Zhi Guan * School of Chemistry and Chemical Engineering,
Supplementary Data. Engineering, Nanjing University, Nanjing , P. R. China;
Supplementary Data Synthesis, Chemo-selective Properties of Substituted 9-Aryl-9H-fluorenes from Triarylcarbinols and Enantiomerical Kinetics of Chiral 9-Methoxy-11-(naphthalen-1-yl)-11H-benzo[a]fluorene
Supporting Information
Supporting Information Lewis Acid Mediated [2,3]-Sigmatropic Rearrangement of Allylic α-amino Amides. Jan Blid, Peter Brandt, Peter Somfai*, Department of Chemistry, rganic Chemistry, Royal Institute of
Asymmetric Synthesis of New Chiral β-amino Acid Derivatives by Mannich-type Reactions of Chiral N- Sulfinyl Imidates with N-Tosyl Aldimines
Asymmetric Synthesis of New Chiral β-amino Acid Derivatives by Mannich-type Reactions of Chiral N- Sulfinyl Imidates with N-yl Aldimines Filip Colpaert, Sven Mangelinckx, and Norbert De Kimpe Department
Supporting Information. Design and Synthesis of 2-Arylbenzimidazoles and. Evaluation of Their Inhibitory Effect against. Chlamydia pneumoniae
Supporting Information Design and Synthesis of 2-Arylbenzimidazoles and Evaluation of Their Inhibitory Effect against Chlamydia pneumoniae Leena Keurulainen,, Olli Salin,, Antti Siiskonen,, Jan Marco Kern,
Supporting Information
Electronic Supplementary Material (ESI) for rganic Chemistry Frontiers. This journal is the Partner rganisations 2018 Palladium-catalyzed direct approach to α-cf 3 aryl ketones from arylboronic acids Bo
Highly enantioselective cascade synthesis of spiropyrazolones. Supporting Information. NMR spectra and HPLC traces
Highly enantioselective cascade synthesis of spiropyrazolones Alex Zea a, Andrea-Nekane R. Alba a, Andrea Mazzanti b, Albert Moyano a and Ramon Rios a,c * Supporting Information NMR spectra and HPLC traces
Synthesis of novel 1,2,3-triazolyl derivatives of pregnane, androstane and D-homoandrostane. Tandem Click reaction/cu-catalyzed D-homo rearrangement
Electronic Supplementary Material (ESI) for Organic & Biomolecular Chemistry. This journal is The Royal Society of Chemistry 2014 Supporting Information Synthesis of novel 1,2,3-triazolyl derivatives of
Pd-Catalyzed Oxidative Cross-Coupling of N-Tosylhydrazones. with Arylboronic Acids
Supporting Information Pd-Catalyzed xidative Cross-Coupling of N-Tosylhydrazones with Arylboronic Acids Xia Zhao, a Jing Jing, a Kui Lu, a Yan Zhang a and Jianbo Wang* a,b a Beijing National Laboratory
Supporting Information
Supporting Information Metal-catalyzed Stereoselective and Protecting-group-free Synthesis of 1,2-cis-Glycosides Using 4,6-Dimethoxy-1,3,5-triazin-2-yl Glycosides as Glycosyl Donors Tomonari Tanaka,* 1
A New Type of Bis(sulfonamide)-Diamine Ligand for a Cu(OTf) 2 -Catalyzed Asymmetric Friedel-Crafts Alkylation Reaction of Indoles with Nitroalkenes
A ew Type of Bis(sulfonamide)-Diamine Ligand for a Cu(OTf) 2 -Catalyzed Asymmetric Friedel-Crafts Alkylation Reaction of Indoles with itroalkenes Jing Wu, Xincheng Li, Fan Wu, and Boshun Wan* Dalian Institute
Chiral Brønsted Acid Catalyzed Enantioselective Intermolecular Allylic Aminations. Minyang Zhuang and Haifeng Du*
Electronic Supplementary Material (ESI) for Organic & Biomolecular Chemistry. This journal is The Royal Society of Chemistry 2014 Chiral Brønsted Acid Catalyzed Enantioselective Intermolecular Allylic
Supporting Information. Experimental section
Electronic Supplementary Material (ESI) for RSC Advances. This journal is The Royal Society of Chemistry 2014 Supporting Information Experimental section General. Proton nuclear magnetic resonance ( 1
Mandelamide-Zinc Catalyzed Alkyne Addition to Heteroaromatic Aldehydes
1 Mandelamide-Zinc Catalyzed Alkyne Addition to Heteroaromatic Aldehydes Gonzalo Blay, Isabel Fernández, Alícia Marco-Aleixandre, and José R. Pedro Departament de Química Orgànica, Facultat de Química,
Supporting Information. Chemoselective Acylation of 2-Amino-8-quinolinol in the Generation of C2-Amides or C8-Esters
Electronic Supplementary Material (ESI) for RSC Advances. This journal is The Royal Society of Chemistry 2017 Supporting Information Chemoselective Acylation of 2-Amino-8-quinolinol in the Generation of
Supporting Information for: Intramolecular Hydrogen Bonding-Assisted Cyclocondensation of. 1,2,3-Triazole Synthesis
Supporting Information for: Intramolecular Hydrogen Bonding-Assisted Cyclocondensation of α-diazoketones with Various Amines: A Strategy for Catalytic Wolff 1,2,3-Triazole Synthesis Zikun Wang, a Xihe
Supplementary Material
Supplementary Material Control experiments S2 Characterization data for the products S2-S7 References S8 MR spectra for the products S9-S28 S1 Control experiments 2a (99.5 mg, 0.5 mmol), I 2 (50.8 mg,
Supporting Information
Supporting Information Wiley-VCH 2007 69451 Weinheim, Germany Supporting Information for Catalytic Enantioselective Conjugate Reduction of β,β- Disubstituted α,β-unsaturated sulfones Tomás Llamas, Ramón
Supporting Information
S1 Supporting Information Synthesis of 2-Arylated Hydroxytyrosol Derivatives via Suzuki-Myaura Cross-Coupling Roberta Bernini, a Sandro Cacchi, b* Giancarlo Fabrizi, b* Eleonora Filisti b a Dipartimento
Facile construction of the functionalized 4H-chromene via tandem. benzylation and cyclization. Jinmin Fan and Zhiyong Wang*
Facile construction of the functionalized 4H-chromene via tandem benzylation and cyclization Jinmin Fan and Zhiyong Wang* Hefei National Laboratory for Physical Science at Microscale, Joint- Lab of Green
Supporting Materials
Electronic Supplementary Material (ESI) for RSC Advances. This journal is The Royal Society of Chemistry 2016 Carbonylative Coupling of Aryl Tosylates/triflates with Arylboronic Acids under CO Atmosphere
Diastereoselective Access to Trans-2-Substituted Cyclopentylamines
Supporting Information Diastereoselective Access to Trans-2-Substituted Cyclopentylamines Antoine Joosten, Emilie Lambert, Jean-Luc Vasse, Jan Szymoniak jean-luc.vasse@univ-reims.fr jan.szymoniak@univ-reims.fr
The Supporting Information for
The Supporting Information for Synthesis of Azacyclic ucleoside Analogues via Asymmetric [3+2] Cycloaddition of 9-(2-tosylvinyl)-9H-purines Dan-Jie Zhang, Ming-Sheng Xie,* Gui-Rong Qu, Yao-Wei Gao, and
Supporting Information
Supporting Information Organocatalyzed Asymmetric 1,6-Conjugate Addition of para-quinone Methides with Dicyanoolefins Xuanyi Li, Xiuyan Xu, Weiwei Wei, Aijun Lin*, and Hequan Yao* State Key Laboratory
Supporting Information
Supporting Information 2017 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim Convenient and General Zinc-Catalyzed Borylation of Aryl Diazonium Salts and Aryltriazenes under Mild Conditions
Supporting Information
Supporting Information Wiley-VCH 2014 69451 Weinheim, Germany Copper-Catalyzed Coupling of Oxime Acetates with Sodium Sulfinates: An Efficient Synthesis of Sulfone Derivatives** Xiaodong Tang, Liangbin
Supporting Information
Supporting Information Wiley-VCH 2011 69451 Weinheim, Germany Ruthenium-Catalyzed xidative Annulation by Cleavage of C H/ H Bonds** Lutz Ackermann,* Alexander V. Lygin, and ora Hofmann anie_201101943_sm_miscellaneous_information.pdf