Supporting Information. Synthesis and biological evaluation of 2,3-Bis(het)aryl-4-azaindoles Derivatives as protein kinases inhibitors
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- Ἡσαΐας Αρβανίτης
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1 Supporting Information Synthesis and biological evaluation of 2,3-Bis(het)aryl-4-azaindoles Derivatives as protein kinases inhibitors Frédéric Pin, a Frédéric Buron, a Fabienne Saab, a Lionel Colliandre, a Stéphane Bourg, a Françoise Schoentgen, b Remy Le Guevel, c Christiane Guillouzo c and Sylvain Routier* a a ICOA, University of Orléans, UMR CNRS 6005, Rue de Chartres, BP 6759, Orléans CEDEX 2, France. Tel: ; sylvain.routier@univ-orleans.fr. b IMPMC UMR 7590 CNRS, Université Pierre et Marie Curie-Paris 6, Campus Jussieu, boîte courrier 115, 4 Place Jussieu, Paris Cedex 05, France. c Hôpital de Pontchaillou, INSERM U-522, Rennes Cedex, France. Content General methods Synthesis of ketones 8 to (2-Hydroxyphenyl)-2-(pyridine-4-yl)ethanone (9) (3-Hydroxyphenyl)-2-(pyridine-4-yl)ethanone (10) (4-Hydroxyphenyl)-2-(pyridine-4-yl)ethanone (11) (3-Fluorophenyl)-2-(pyridine-4-yl)ethanone (12) (6-Hydroxynaphthalen-2-yl)-2-(pyridine-4-yl)ethanone (13) (3,5-Dihydroxyphenyl)-2-(pyridine-4-yl)ethanone (14) (3-Hydroxyphenyl)-2-(pyridine-3-yl)ethanone (15) (3-Hydroxyphenyl)-2-(pyridine-2-yl)ethanone (16) Fisher reaction Methoxy-2-phenyl-3-(pyridin-4-yl)-4-azaindole (18) (2-Hydroxyphenyl)-5-methoxy-3-(pyridin-4-yl)-4-azaindole (19) (3-Hydroxyphenyl)-5-methoxy-3-(pyridin-4-yl)-4-azaindole (20) (4-Hydroxyphenyl)-5-methoxy-3-(pyridin-4-yl)-4-azaindole (21) (3-Fluorophenyl)-5-methoxy-3-(pyridin-4-yl)-4-azaindole (22) (3-Hydroxyphenyl)-5-methoxy-3-(pyridin-3-yl)-4-azaindole (25) (3-Hydroxyphenyl)-5-methoxy-3-(pyridin-2-yl)-4-azaindole (26)... 9 Ether deprotection Hydroxy-2-phenyl-3-(pyridin-4-yl)-4-azaindole (27) (3-Fluorophenyl)-5-hydroxy-3-(pyridin-4-yl)-4-azaindole (28)
2 General methods. 1 H NMR and 13 C NMR spectra were recorded on a broker DPX 250 or 400 MHz instrument using CDCl 3 or DMSO-d 6. The chemical shifts are reported in parts per million (δ scale) and all coupling constant (J) values are in Hertz (Hz). The splitting patterns are designated as follows: s (singlet), d (doublet), t (triplet), q (quartet), sept (septuplet), m (multiplet) and dd (doublet doublet). Melting points are uncorrected. IR absorption spectra were obtained on a Perkin Elmer PARAGON 1000 PC and values were reported in cm -1. MS spectra (Ion Spray) were performed on a Perkin Elmer Sciex PI 300. HRMS were performed by the Centre Commun de Spectrométire de Masse (Clermont Ferrand, France). Monitoring of the reactions was performed using silica gel TLC plates (silica Merck 60 F 254 ). Spots were visualized by UV light at 254 nm and 356 nm and revealed with KMnO 4 solution. Column chromatographies were performed using silica gel 60 ( mm, Merck). Synthesis of ketones 8 to 16. General procedure A: To a solution of picoline II (10.0 mmol) and ester III (10.0 mmol) in 20 ml of anhydrous THF at 0 C was added dropwise a solution of LiHMDS 1M in THF (20.0 mmol) for 15 minutes. The resulting solution was stirred at room temperature over night under N 2 atmosphere. Then, the solvent was evaporated under reduce pressure and the residue was diluted in AcOEt. The organic layer was washed with water, dried over anhydrous MgSO 4 and concentrated. To cleave the TBS group, the crude product was diluted in 60 ml of THF and treated by a solution of TBAF 1M in THF (20.0 mmol). The reaction was stirred for 2 h at room temperature and concentrated. Ketones 8 to 16 was purified by chromatography on a silica gel using a mixture of petroleum ether/acoet allowing an effective separation. 1-(2-Hydroxyphenyl)-2-(pyridine-4-yl)ethanone (9). Compound 9 was obtained as a yellow solid in 41% yield following the general procedure A. R f (AcOEt): 0.26; mp: 78 C; IR (ATR diamond): ν (cm -1 ) 994, 1160, 1220, 1271, 1333, 1413, 1488, 1604, 1638, 1720; 1 H NMR (250 MHz, CDCl 3 ): δ (ppm) 4.30 (s, 2H), 6.92 (ddd, 1H, J = 8.1, 7.2 and 1.2 Hz), 7.00 (d, 1H, J = 8.4 Hz), 7.20 (d, 2H, J = 5.8 Hz), 7.50 (ddd, 1H, J = 8.4, 7.2 and 1.6 Hz), 7.79 (dd, 1H, J = 8.1 and 1.6 Hz), 8.58 (d, 2H, J = 5.8 Hz), (s, 1H); 13 C NMR (100 MHz, CDCl 3 ): δ (ppm) 44.5 (CH 2 ), (C q ), (CH aro ), (CH aro ), (2CH aro ), (CH aro ), (CH aro ), (C q ), (2CH aro ), (C q ), (C=O); MS (IS) : m/z = [MH] +. 2
3 1-(3-Hydroxyphenyl)-2-(pyridine-4-yl)ethanone (10). Compound 10 was obtained as a yellow solid in 56% yield following the general procedure A. R f (AcOEt): 0.32; mp: 210 C; IR (ATR diamond): ν (cm -1 ) 1185, 1252, 1274, 1318, 1377, 1426, 1477, 1584, 1611, 1681, 2603, 2678; 1 H NMR (250 MHz, DMSO-d 6 ): δ (ppm) 4.46 (s, 2H), 7.08 (dd, 1H, J = 8.0 and 2.4 Hz), 7.31 (d, 2H, J = 5.7 Hz), (m, 2H), 7.56 (d, 1H, J = 7.8 Hz), 8.54 (d, 2H, J = 5.7 Hz), 9.87 (s, 1H); 13 C NMR (100 MHz, DMSO-d 6 ): δ (ppm) 44.0 (CH 2 ), (CH aro ), (CH aro ), (CH aro ), (2CH aro ), (CH aro ), (C q ), (C q ), (2CH aro ), (C q ), (C=O); MS (IS) : m/z = [MH] +. 1-(4-Hydroxyphenyl)-2-(pyridine-4-yl)ethanone (11). Compound 11 was obtained as a yellow solid in 67% yield following the general procedure A. R f (AcOEt): 0.25; mp: 235 C; IR (ATR diamond): ν (cm -1 ) 988, 1013, 1163, 1205, 1234, 1260, 1295, 1323, 1393, 1427, 1512, 1577, 1605, 1669, 2492, 2563; 1 H NMR (250 MHz, DMSO-d 6 ): δ (ppm) 4.39 (s, 2H), 6.92 (d, 2H, J = 8.7 Hz), 7.31 (d, 2H, J = 5.9 Hz), 7.98 (d, 2H, J = 8.7 Hz), 8.52 (d, 2H, J = 5.9 Hz), (s, 1H); 13 C NMR (100 MHz, DMSO-d 6 ): δ (ppm) 43.4 (CH 2 ), (2CH aro ), (2CH aro ), (C q ), (2CH aro ), (C q ), (2CH aro ), (C q ), (C=O); MS (IS) : m/z = [MH] +. 1-(3-Fluorophenyl)-2-(pyridine-4-yl)ethanone (12). Compound 12 was obtained as a white solid in 55% yield following the general procedure A without TBAF treatment. R f (AcOEt/PE 2/3): 0.27; mp: 60 C; IR (ATR diamond): ν (cm -1 ) 1001, 1061, 1148, 1247, 1323, 1422, 1443, 1588, 1687; 1 H NMR (250 MHz, CDCl 3 ): δ (ppm) 4.27 (s, 2H), 7.19 (d, 2H, J = 4.7 Hz), (m, 1H), (m, 1H),
4 7.71 (m, 1H), 7.78 (d, 1H, J = 7.7 Hz), 8.58 (s, 2H); 13 C NMR (100 MHz, CDCl 3 ): δ (ppm) 44.9 (CH 2 ), (d, CH aro, J = 22 Hz), (d, CH aro, J = 22 Hz), (d, CH aro, J = 3 Hz), (2CH aro ), (d, CH aro, J = 8 Hz), (d, C q, J = 6 Hz), (C q ), (2CH aro ), (d, C q, J = 249 Hz), (d, C=O, J = 2 Hz); MS (IS) : m/z = [MH] +. 1-(6-Hydroxynaphthalen-2-yl)-2-(pyridine-4-yl)ethanone (13). Compound 13 was obtained as a yellow solid in 53% yield following the general procedure A. R f (AcOEt): 0.20; mp: >250 C; IR (ATR diamond): ν (cm -1 ) 983, 1156, 1256, 1343, 1399, 1425, 1472, 1580, 1654, 1652, 2653, 2705; 1 H NMR (250 MHz, DMSO-d 6 ): δ (ppm) 4.55 (s, 2H), (m, 2H), 7.33 (d, 2H, J = 5.8 Hz), (m, 3H), 8.50 (d, 2H, J = 5.8 Hz), (m, 1H); 13 C NMR (100 MHz, DMSO-d 6 ): δ (ppm) 44.0 (CH 2 ), (CH aro ), (CH aro ), (2CH aro ), (CH aro ), (CH aro ), (CH aro ), (C q ), (CH aro ), (C q ), (C q ), (C q ), (2CH aro ), (C q ), (C=O); MS (IS) : m/z = [MH] +. 1-(3,5-Dihydroxyphenyl)-2-(pyridine-4-yl)ethanone (14). Compound 14 was obtained as a yellow solid in 22% yield following the general procedure A. R f (AcOEt): 0.10; mp: 205 C; IR (ATR diamond): ν (cm -1 ) 1190, 1255, 1280, 1310, 1370, 1420, 1470, 1580, 1634, 1682, 2650, 2692; 1 H NMR (250 MHz, DMSO-d 6 ): δ (ppm) 4.34 (s, 2H), 6.47 (s, 1H), 6.86 (d, 2H, J = 2.0 Hz), 7.25 (d, 2H, J = 5.6 Hz), 8.49 (d, 2H, J = 5.6 Hz), 9.69 (br s, 2H); 13 C NMR (100 MHz, DMSO-d 6 ): δ (ppm) 43.9 (CH 2 ), (2CH aro ), (CH aro ), (2CH aro ), (2C q ), (C q ), (2CH aro ), (C q ), (C=O); MS (IS) : m/z = [MH] +. 4
5 1-(3-Hydroxyphenyl)-2-(pyridine-3-yl)ethanone (15). To a solution of DIPA (380 µl, 2.68 mmol) in 2 ml of anhydrous THF at 0 C was added dropwise n-buli 1.6 M in hexane (1.70 ml, 2.72 mmol) and the resulting solution was stirred for 30 minutes. At the same temperature, a solution of 3-picoline (261 µl, 2.68 mmol) in 2 ml of anhydrous THF was introduced under N 2 atmosphere. 30 minutes later, the mixture was cooled at -78 C and a solution of ester 3 (650 mg, 2.44 mmol) in 3 ml of THF was added. The reaction was stirred at room temperature for 1 h. Then, the solvent was evaporated under reduce pressure and the residue was diluted in AcOEt. The organic layer was washed with water, dried over anhydrous MgSO 4 and concentrated. To cleave the TBS group, the crude product was diluted in 15 ml of THF and treated by a solution of TBAF 1M in THF (3.00 ml, 3.00 mmol). The reaction was stirred for 2 h at room temperature and concentrated. Ketone 15 was purified by chromatography on a silica gel using a mixture of petroleum ether/acoet (3/7) and was obtained as a white solid in 31% yield. R f (AcOEt/PE 8/2): 0.30; mp: 152 C; IR (ATR diamond): ν (cm -1 ) 1158, 1175, 1249, 1273, 1326, 1427, 1453, 1585, 1674, 2613, 2691; 1 H NMR (250 MHz, DMSO-d 6 ): δ (ppm) 4.46 (s, 2H), 7.09 (dd, 1H, J = 8.0, 1.8 Hz), (m, 3H), 7.58 (d, 1H, J = 7.8 Hz), 7.69 (d, 1H, J = 7.8 Hz), (m, 2H), 9.86 (s, 1H); 13 C NMR (100 MHz, DMSO-d 6 ): δ (ppm) 41.8 (CH 2 ), (CH aro ), (CH aro ), (CH aro ), (CH aro ), (CH aro ), (C q ), (CH aro ), (C q ), (CH aro ), (CH aro ), (C q ), (C=O); MS (IS) : m/z = [MH] +. 1-(3-Hydroxyphenyl)-2-(pyridine-2-yl)ethanone (16). Compound 16 was obtained as a white solid in 56% yield following the general procedure A. It was isolated in the mixture of two inseparable rotamers in proportions of 65:35. R f (AcOEt/PE 1/1): 0.40; mp: 187 C; IR (ATR diamond): ν (cm -1 ) 1010, 1151, 1174, 1249, 1270, 1330, 1453, 1590, 1675, 2617; 1 H NMR (250 MHz, DMSO-d 6 ): minority rotamer δ (ppm) 6.32 (s, 1H), (m, 1H), (m, 1H), (m, 4H), (m, 1H), 8.44 (d, 1H, J = 4.9 Hz), 9.58 (s, 1H), (br s, 1H). Majority rotamer δ (ppm) 5
6 4.51 (s, 2H), 7.06 (dd, 1H, J = 8.0 and 2.4 Hz), (m, 4H), 7.53 (d, 1H, J = 7.7 Hz), 7.77 (dd, 1H, J = 7.6 and 1.8 Hz), 8.51 (d, 1H, J = 4.8 Hz), 9.83 (s, 1H); 13 C NMR (100 MHz, DMSO-d 6 ): two inseparable rotamers δ (ppm) 47.7 (CH 2 ), 93.8 (CH), (CH aro ), (CH aro ), (CH aro ), (CH aro ), (CH aro ), (CH aro ), (CH aro ), (CH aro ), (CH aro ), (CH aro ), (CH aro ), (CH aro ), (CH aro ), (C q ), (C q ), (CH aro ), (CH aro ), (CH aro ), (C q ), (C q ), (C q ), (C q ), (C q ), (C=O); MS (IS) : m/z = [MH] +. Fisher reaction. General procedure B: A solution of 5-Hydrazinyl-2-methoxypyridine 17 (139 mg, 1.00 mmol), ketone 8-16 (1.00 mmol) and PTSA (476 mg, 2.50 mmol) in 15 ml of toluene was heated at reflux for 12 h with vigorous stirring. Then, the reaction was concentrated and the crude product was solubilized in CH 2 Cl 2. The organic layer was washed with a saturated solution of NaHCO 3, dried over anhydrous MgSO 4, filtered and evaporated. 4-azaindoles 18 to 26 was purified by chromatography on a silica gel using a mixture of petroleum ether/acoet allowing an effective separation. 5-Methoxy-2-phenyl-3-(pyridin-4-yl)-4-azaindole (18). Compound 18 was obtained as a yellow solid following the general procedure B in 52% yield. R f (AcOEt/PE 3/1): 0.40; mp: 272 C; IR (ATR diamond): ν (cm -1 ) 992, 1005, 1040, 1107, 1169, 1198, 1263, 1290, 1403, 1463, 1490, 1594; 1 H NMR (400 MHz, DMSO-d 6 ): δ (ppm) 3.95 (s, 3H), 6.72 (d, 1H, J = 8.7 Hz), (m, 5H), (m, 2H), 7.81 (d, 1H, J = 8.7 Hz), 8.50 (d, 2H, J = 5.9 Hz), (s, 1H); 13 C NMR (100 MHz, DMSO-d 6 ): δ (ppm) 52.7 (CH 3 ), (CH aro ), (C q ), (CH aro ), (2CH aro ), (C q ), (CH aro ), (2CH aro ), (2CH aro ), (C q ), (C q ), (C q ), (C q ), (2CH aro ), (C q ); HRMS (EIMS): m/z calcd for C 19 H 16 N 3 O: [M+H] +, found:
7 2-(2-Hydroxyphenyl)-5-methoxy-3-(pyridin-4-yl)-4-azaindole (19). Compound 19 was obtained as a yellow solid following the general procedure B in 9% yield. R f (AcOEt/PE 8/2): 0.24; mp: 260 C; IR (ATR diamond): ν (cm -1 ) 1020, 1069, 1100, 1195, 1215, 1268, 1284, 1402, 1439, 1579, 1604, 3332; 1 H NMR (400 MHz, DMSO-d 6 ): δ (ppm) 3.94 (s, 3H), 6.66 (d, 1H, J = 8.7 Hz), 6.90 (t, 1H, J = 7,3 Hz), 7.00 (d, 1H, J = 8.0 Hz), 7.24 (d, 1H, J = 7.3 Hz), 7.32 (t, 1H, J = 7.3 Hz), (m, 3H), 8.38 (d, 2H, J = 5.4 Hz), 9.80 (br s, 1H), (br s, 1H); 13 C NMR (100 MHz, DMSO-d 6 ): δ (ppm) 52.7 (CH 3 ), (CH aro ), (C q ), (CH aro ), (CH aro ), (C q ), (2CH aro ), (CH aro ), (C q ), (CH aro ), (CH aro ), (C q ), (C q ), (C q ), (2CH aro ), (C q ), (C q ); HRMS (EIMS): m/z calcd for C 19 H 16 N 3 O 2 : [M+H] +, found: (3-Hydroxyphenyl)-5-methoxy-3-(pyridin-4-yl)-4-azaindole (20). Compound 20 was obtained as a white solid following the general procedure B in 34% yield. R f (AcOEt): 0.39; mp: >260 C; IR (ATR diamond): ν (cm -1 ) 981, 1014, 1070, 1104, 1193, 1214, 1251, 1269, 1400, 1269, 1581, 1603, 3356; 1 H NMR (250 MHz, DMSO-d 6 ): δ (ppm) 3.95 (s, 3H), 6.71 (d, 1H, J = 8.7 Hz), (m, 1H), (m, 2H), 7.32 (t, 1H, J = 7.9 Hz), 7.66 (d, 2H, J = 6.1 Hz), 7.78 (d, 1H, J = 8.7 Hz), 8.50 (d, 2H, J = 6.1 Hz), 9.69 (s, 1H), (s, 1H); 13 C NMR (100 MHz, DMSO-d 6 ): δ (ppm) 52.7 (CH 3 ), (CH aro ), (C q ), (CH aro ), (CH aro ), (CH aro ), (CH aro ), (2CH aro ), (C q ), (CH aro ), (C q ), (C q ), (C q ), (C q ), (2CH aro ), (C q ), (C q ); HRMS (EIMS): m/z calcd for C 19 H 16 N 3 O 2 : [M+H] +, found:
8 2-(4-Hydroxyphenyl)-5-methoxy-3-(pyridin-4-yl)-4-azaindole (21). Compound 21 was obtained as a white solid following the general procedure B in 30% yield. R f (AcOEt): 0.34; mp: >260 C; IR (ATR diamond): ν (cm -1 ) 1010, 1025, 1105, 1198, 1218, 1255, 1275, 1404, 1460, 1606, 3270; 1 H NMR (400 MHz, DMSO-d 6 ): δ (ppm) 3.94 (s, 3H), 6.68 (d, 1H, J = 8.6 Hz), 6.90 (d, 2H, J = 8.5 Hz), 7.37 (d, 2H, J = 8.5 Hz), 7.67 (d, 2H, J = 6.0 Hz), 7.76 (d, 1H, J = 8.6 Hz), 8.48 (d, 2H, J = 6.0 Hz), 9.86 (br s, 1H), (br s, 1H); 13 C NMR (100 MHz, DMSO-d 6 ): δ (ppm) 52.7 (CH 3 ), (CH aro ), (C q ), (2CH aro ), (CH aro ), (C q ), (2CH aro ), (C q ), (2CH aro ), (C q ), (C q ), (C q ), (2CH aro ), (C q ), (C q ); HRMS (EIMS): m/z calcd for C 19 H 16 N 3 O 2 : [M+H] +, found: (3-Fluorophenyl)-5-methoxy-3-(pyridin-4-yl)-4-azaindole (22). Compound 22 was obtained as a yellow solid following the general procedure B in 30% yield. R f (AcOEt/PE 2/3): 0.21; mp: >260 C; IR (ATR diamond): ν (cm -1 ) 779, 807, 828, 976, 1010, 1030, 1107, 1166, 1188, 1267, 1399, 1467, 1492, 1592; 1 H NMR (250 MHz, DMSO-d 6 ): δ (ppm) 3.94 (s, 3H), 6.74 (d, 1H, J = 8.7 Hz), (m, 3H), (m, 1H), 7.62 (d, 2H, J = 6.0 Hz), 7.82 (d, 1H, J = 8.7 Hz), 8.53 (d, 2H, J = 6.0 Hz), (br s, 1H); 13 C NMR (100 MHz, DMSO-d 6 ): δ (ppm) 52.7 (CH 3 ), (CH aro ), (C q ), (d, CH aro, J = 22 Hz), (d, CH aro, J = 22 Hz), (CH aro ), (2CH aro ), (d, CH aro, J = 3 Hz), (C q ), (d, CH aro, J = 9 Hz), (d, C q, J = 9 Hz), (d, C q, J = 2 Hz), (C q ), (C q ), (2CH aro ), (C q ), (d, C q, J = 244 Hz); HRMS (EIMS): m/z calcd for C 19 H 15 N 3 OF: [M+H] +, found:
9 2-(3-Hydroxyphenyl)-5-methoxy-3-(pyridin-3-yl)-4-azaindole (25). Compound 25 was obtained as a yellow solid following the general procedure B in 19% yield. R f (CH 2 Cl 2 /EtOH 9/1): 0.43; mp: >260 C; IR (ATR diamond): ν (cm -1 ) 980, 1038, 1109, 1229, 1271, 1400, 1454, 1467, 1573, 3250; 1 H NMR (250 MHz, DMSO-d 6 ): δ (ppm) 3.91 (s, 3H), 6.69 (d, 1H, J = 8.7 Hz), 6.84 (d, 1H, J = 7.7 Hz), (m, 2H), 7.28 (t, 1H, J = 7.7 Hz), (m, 1H), 7.78 (d, 1H, J = 8.7 Hz), 7.98 (d, 1H, J = 7.7 Hz), 8.44 (d, 1H, J = 4.2 Hz), 8.78 (s, 1H), 9.65 (s, 1H), (br s, 1H); 13 C NMR (100 MHz, DMSO-d 6 ): δ (ppm) 52.6 (CH 3 ), (CH aro ), (C q ), (CH aro ), (CH aro ), (CH aro ), (CH aro ), (CH aro ), (C q ), (CH aro ), (C q ), (C q ), (CH aro ), (C q ), (C q ), (CH aro ), (CH aro ), (C q ), (C q ); HRMS (EIMS): m/z calcd for C 19 H 16 N 3 O 2 : [M+H] +, found: (3-Hydroxyphenyl)-5-methoxy-3-(pyridin-2-yl)-4-azaindole (26). Compound 26 was obtained as a brown solid following the general procedure B in 34% yield. R f (CH 2 Cl 2 /EtOH 9/1): 0.33; mp: 230 C; IR (ATR diamond): ν (cm -1 ) 1031, 1105, 1199, 1269, 1404, 1476, 1500, 1581, 3308; 1 H NMR (400 MHz, DMSO-d 6 ): δ (ppm) 3.91 (s, 3H), 6.68 (d, 1H, J = 8.6 Hz), 6.78 (d, 1H, J = 7.9 Hz), (m, 2H), (m, 2H), 7.77 (d, 1H, J = 8.6 Hz), 7.87 (t, 1H, J = 7.7 Hz), 8.12 (d, 1H, J = 7.9 Hz), 8.48 (d, 1H, J = 3.9 Hz), 9.48 (s, 1H), (br s, 1H); 13 C NMR (100 MHz, DMSO-d 6 ): δ (ppm) 52.6 (CH 3 ), (CH aro ), (C q ), (CH aro ), (CH aro ), (CH aro ), (CH aro ), (CH aro ), (CH aro ), (C q ), (CH aro ), (C q ), (CH aro ), (C q ), (C q ), (CH aro ), (C q ), (C q ), (C q ); HRMS (EIMS): m/z calcd for C 19 H 16 N 3 O 2 : [M+H] +, found:
10 Ether deprotection General procedure C: To a solution of 4-azaindole 18,22 (0.500 mmol) in 5 ml of CH 3 CN were added successively sodium iodide (375 mg, 2.5 mmol) and dropwise chlorotrimethylsilane (320 µl, 2.5 mmol). The resulting solution was heated at reflux for 2 h. The solvent was evaporated and the crude product was purified by chromatography on a silica gel using a mixture of CH 2 Cl 2 /MeOH allowing an effective separation. 5-Hydroxy-2-phenyl-3-(pyridin-4-yl)-4-azaindole (27). Compound 27 was obtained as a yellow solid following the general procedure C in 52% yield. R f (CH 2 Cl 2 /MeOH 4/1): 0.15; mp: >260 C; IR (ATR diamond): ν (cm -1 ) 1032, 1136, 1178, 1345, 1406, 1467, 1535, 1650, 3326; 1 H NMR (250 MHz, DMSO-d 6 ): δ (ppm) 6.34 (d, 1H, J = 9.0 Hz), (m, 7H), 7.42 (d, 1H, J = 9.0 Hz), 8.50 (d, 2H, J = 6.1 Hz), (br s, 1H), (br s, 1H); 13 C NMR (100 MHz, DMSO-d 6 ): δ (ppm) (C q ), (CH aro ), (CH aro ), (2CH aro ), (C q ), (CH aro ), (2CH aro ), (2CH aro ), (C q ), (C q ), (C q ), (C q ), (2CH aro ), (C q ); HRMS (EIMS): m/z calcd for C 18 H 14 N 3 O: [M+H] +, found: (3-Fluorophenyl)-5-hydroxy-3-(pyridin-4-yl)-4-azaindole (28). Compound 28 was obtained as a yellow solid following the general procedure C in 63% yield. R f (CH 2 Cl 2 /MeOH 4/1): 0.19; mp: >260 C; IR (ATR diamond): ν (cm -1 ) 784, 823, 1117, 1190, 1474, 1533, 1572, 1604, 3418; 1 H NMR (250 MHz, DMSO-d 6 ): δ (ppm) 6.32 (d, 1H, J = 9.0 Hz), (m, 3H), (m, 3H), 7.68 (d, 1H, J = 9.0 Hz), 8.50 (d, 2H, J = 5.2 Hz), (br s, 1H), (br s, 1H); 13 C NMR (100 MHz, DMSO-d 6 ): δ (ppm) (C q ), (CH aro ), (d, CH aro, J = 22 Hz), (d, CH aro, J = 22 Hz), (C q ), (d, CH aro, J = 2 Hz), (2CH aro ), (CH aro ), (d, CH aro, J = 8 Hz), (C q ), (C q ), (C q ), (C q ), (2CH aro ), (C q ), (d, C q, J = 244 Hz); HRMS (EIMS): m/z calcd for C 18 H 13 N 3 OF: [M+H] +, found:
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