S3 6 mg/kg MT-9 NRK-49F NRK-52E EMT HS-P MHC CD68 CD163 MHC II MCP-1 CD68 CD163 TGF- 1

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2 % /. S3 6 mg/kg mg/kg 5-7 MT-9 NRK-49F NRK-52E EMT HS-P MHC II CD68 CD163 CD68 CD163 MHC II MHC II HS-P in vitro MCP-1 CD68 CD163 TGF-1 MCP-1 CD68 CD163 MCP-1 TGF-1

3 CD68 CD163 MHC II T Th1 Th2 CD4T V D--SMA A VVDDAVDA -SMA -SMA TGF-1 PDGFTGF-1 -SMA TGF-1 -SMA TGF-1 BMP-1/-6 BMP-6 BMP-6 BMP-6 NRK-49F NRK-52E TGF-1 BMP-6 MT-9 TGF-1 -SMA -Wnt EMT CD31 vwf CD34A3 A3 CD34 DX DX BUN CD68 α-sma Thy-1 Thy-1 Thy-1 Thy-1 Thy-1 -SMA MT-9 TGF-1 Thy-1 -SMA Thy-1 TGF-1 Thy-1 -SMA PGE 2 NGAL COX-2 COX-1 PGE mpgespge 2 EP4 NRK-52E PGE 2 EP4 11-deoxy-PGE 1 NRK-52E NRK-52E TGF-1 11-deoxy-PGE 1 TGF-1 -SMA EMT TGF-1 E COX-2 COX-1 PGE 2 EP4 EMT NGAL NGAL TGF-1 mrna

4 NRK-52E TGF-1 EMT NGAL NGAL A3 A3 MFH A3 A3 A3 / A3 MCP Wijesundera, K.K., Izawa, T., Murakami, H., Tennakoon, A.H., Golbar, H.M., Kato-Ichikawa, C., Tanaka, M., Kuwamura, M., Yamate, J M1- and M2-macrophage polarization in thioacetamide (TAA)-induced rat liver lesions; a possible analysis for hepato-pathology. Histol Histopathol, 29: Tennakoon, A.H., Izawa, T., Wijesundera, K.K., Golbar, H.M., Tanaka, M., Ichikawa, C., Kuwamura, M., Yamate, J Characterization of glial fibrillary acidic protein (GFAP)-expressing hepatic stellate cells and myofibroblasts in thioacetamide (TAA)-induced rat liver injury. Exp Toxicol Pathol, 65: doi: /j.etp Wijesundera, K.K., Juniantito, V., Golbar, H.M., Fujisawa, K., Tanaka, M., Ichikawa, C., Izawa, T., Kuwamura, M., Yamate, J Expressions of Iba1 and galectin-3 (Gal-3) in thioacetamide (TAA)-induced acute rat liver lesions. Exp Toxicol Pathol, 65: doi: /j.etp Yuasa, T., Juniantito, V., Ichikawa, C., Yano, R., Izawa, T., Kuwamura, M., Yamate, J Thy-1 expression, a possible marker of early myofibroblast development, in renal tubulointerstitial fibrosis induced in rats by cisplatin. Exp Toxicol Pathol, 65: doi: /j.etp Juniantito, V., Izawa, T., Yuasa, T., Ichikawa, C., Tanaka, M., Kuwamura, M., Yamate, J Immunophenotypical analysis of myofibroblasts and mesenchymal cells in the bleomycin-induced rat scleroderma, with particular reference to their origin. Exp Toxicol Pathol, 65: doi: /j.etp Golbar, H.M., Izawa, T., Juniantito, V., Ichikawa, C., Tanaka, M., Kuwamura, M., Yamate, J Immunohistochemical characterization of macrophages and myofibroblasts in fibrotic liver lesions due to fasciola infection in cattle. J Vet Med Sci, 75: Hori, M., Juniantito, V., Izawa, T., Ichikawa, C., Tanaka, M., Tanaka, K., Takenaka, S., Kuwamura, M., Yamate, J Distribution of cells labelled by a novel somatic stem cell-recognizing antibody (A3) in pulmonary genesis and bleomycin induced pulmonary fibrosis in rats. J Comp Pathol, 148: doi: /j.jcpa Juniantito, V., Izawa, T., Yuasa, T., Ichikawa, C., Yano, R., Kuwamura, M., Yamate, J Immunophenotypical characterization of macrophages in rat bleomycin-induced scleroderma. Vet Pathol, 50: doi: / Suzuki Y, Yamaguchi I, Onoda N, Saito T, Myojo K, Imaizumi M, Takada C, Kimoto N, Takaba K, Yamate J Differential renal glomerular changes induced by 5/6 nephrectomization between common

5 marmoset monkeys (Callithrix jacchus) and rats. Exp Toxicol Pathol. 65: doi: /j.etp Juniantito, V., Izawa, T., Yuasa, T., Ichikawa, C., Yamamoto, E., Kuwamura, M., Yamate, J Immunophenotypical analyses of myofibroblasts in rat excisional wound healing: possible transdifferentiation of blood vessel pericytes and perifollicular dermal sheath cells into myofibroblasts. Histol Histopathol, 27: Golbar, H.M., Izawa, T., Murai, F., Kuwamura, M., Yamate, J Immunohistochemical analyses of the kinetics and distribution of macrophages, hepatic stellate cells and bile duct epithelia in the developing rat liver. Exp Toxicol Pathol, 64: 1-8. doi: /j.etp Yamamoto, E., Izawa, T., Kuwamura, M., Yamate, J Immunohistochemical expressions of main PGE2 biosynthesis-related enzymes and PGE2 receptor in rat nephrogenesis. J Toxicol Pathol, 24: doi: /tox Juniantito, V., Izawa, T., Yamamoto, E., Murai, F., Kuwamura, M., Yamate, J Heterogeneity of macrophage populations and expression of galectin-3 in cutaneous wound healing in rats. J Comp Pathol, 145: doi: /j.jcpa Fujisawa, K., Miyoshi, T., Tonomura, Y., Izawa, T., Kuwamura, M., Torii, M., Yamate, J Relationship of heat shock protein 25 with reactive macrophages in thioacetamide-induced rat liver injury. Exp Toxicol Pathol, 63: doi: /j.etp Golbar, H.M., Izawa, T., Yano, R., Ichikawa, C., Sawamoto, O., Kuwamura, M., LaMarre, J., Yamate, J Immunohistochemical characterization of macrophages and myofibroblasts in alpha-naphthylisothiocyanate (ANIT)-induced bile duct injury and subsequent fibrogenesis in rats. Toxicol Pathol, 39: doi: / Yuasa, T., Izawa, T., Kuwamura, M., Yamate, J Thy-1 expressing mesenchymal cells in rat nephrogenesis in correlation with cells immunoreactive for alpha-smooth muscle actin and vimentin. J Toxicol Pathol, 23: doi: /tox Juniantito, V., Izawa, T., Yamamoto, E., Kuwamura, M., Yamate, J The kinetics and distribution of different macrophage populations in the developing rat skin. Histol Histopathol, 25: Yamamoto, E., Izawa, T., Juniantito, V., Kuwamura, M., Sugiura, K., Takeuchi, T., Yamate, J Involvement of endogenous prostaglandin E2 in tubular epithelial regeneration through inhibition of apoptosis and epithelial-mesenchymal transition in cisplatin-induced rat renal lesions. Histol Histopathol, 25: Yamamoto, E., Izawa, T., Juniantito, V., Kuwamura, M., Yamate, J Relationship of cell proliferating marker expressions with PGE2 receptors in regenerating rat renal tubules after cisplatin injection. J Toxicol Pathol, 23: doi: /tox pp Participation of macrophage populations in GST-P-positive liver lesions induced in rats by repeated injections of thioacetamide (TAA). Wijesundera K, Izawa T, Katou-Ichikawa C, Tennakoon A, Murakami H, Golbar H, Kuwamura M, and Yamate J. ACVP & ASVCP 2013 Concurrent Annual Meeting. Montreal, Canada, Nov, Immunohistochemical characterization of macrophages and myofibroblasts in biliary cirrhosis due to liver fluke (Fasciola spp) infestation in cattle. Golbar HM, Juniantito V, Ichikawa C, Tanaka M, Izawa T, Kuwamura M, Yamate J. The Joint Meeting of the 5th Conference and Congress of Asian Society of Veterinary Pathology (ASVP) 2011 and the 10th Scientific Symposium of Indonesia Society of Veterinary Pathology (ISVP) Bogor, Indonesia, Nov, Immunohistochemical detection of macrophages and myofibroblasts in rat model of bleomycin-induced scleroderma. Juniantito V, Ichikawa C, Izawa T, Kuwamura M, Yamate J. The Joint Meeting of the 5th Conference and Congress of Asian Society of Veterinary Pathology (ASVP) 2011 and the 10th Scientific Symposium of Indonesia Society of Veterinary Pathology (ISVP) Bogor, Indonesia, Nov, Tennakoon AWijesundera K Golbar HM Different macrophage populations in pseudolobules (PLs) with or without

6 adipophilin expression in thioacetamide (TAA)-induced rat cirrhosiswijesundera K Tennakoon AGolbar HM α-naphthylisothiocyanateanit Golbar HM β M1/M2 macrophage polarization in thioacetamide (TAA)-induced acute rat liver lesionswijesundera KGolbar HM Expression of Iba1 and galectin-3 (Gal-3) in thioacetamide (TAA)-induced acute rat liver lesions. Wijesundera K Juniantito VGolbar HM Nestin expression in α-naphthylisocyanate (ANIT)-induced acute bile duct injury lesions in rats. Golbar HM Immunophenotypical properties of macrophages and myofibroblasts in fasciola-infested cirrhotic cattle liver Golbar HM Involvement of macrophages and myofibroblasts in chronic ANIT-induced peribiliary fibrosis in rat modelgolbar HM Heat shock protein 25 Adipophilin PGE2 Juniantito V Thy Comparisons of properties of macrophages and myofibroblasts between two different cutaneous fibrosis rat modelsjuniantito V : 1. Mechanisms of cutaneous wound healing, based on functional properties of macrophages and myofibroblasts. Yamate J pp

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